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Padovani has been supported by grants of the Italian Ministry of University and Research PRIN COCOON (2017MYJ5TH) and PRIN 2021 RePlast (20202THZAW), the H2020 IMI IDEA-FAST (ID853981), Italian Ministry of Health, Grant\/Award Number: RF-2018-12366209, RF-2019-12369272 and PNRR-Health PNRR-MAD-2022-12376110.N.T. received compensation for consulting services\/speaking fees from Amylyx Pharmaceutical, Zambon Biotech SA, Biogen and Italfarmaco. He received research funding from the Italian Ministry of Health, the Italian Ministry of University and Research and AriSLA. He is associate editor of Frontiers in Aging Neuroscience. F.V. is associate editor of Journal of Alzheimer disease. V.S. received compensation for consulting services and\/or speaking activities from AveXis, Cytokinetics, Italfarmaco, Liquidweb S.r.l., Novartis Pharma AG and Zambon. Receives or has received research supports form the Italian Ministry of Health, AriSLA, and E-Rare Joint Transnational Call. 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