{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,11]],"date-time":"2025-09-11T19:07:53Z","timestamp":1757617673546,"version":"3.44.0"},"reference-count":32,"publisher":"Springer Science and Business Media LLC","issue":"8","license":[{"start":{"date-parts":[[2025,4,2]],"date-time":"2025-04-02T00:00:00Z","timestamp":1743552000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2025,4,2]],"date-time":"2025-04-02T00:00:00Z","timestamp":1743552000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Neurol Sci"],"published-print":{"date-parts":[[2025,8]]},"DOI":"10.1007\/s10072-025-08139-1","type":"journal-article","created":{"date-parts":[[2025,4,4]],"date-time":"2025-04-04T03:25:18Z","timestamp":1743737118000},"page":"3803-3811","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Early and active treatment with fingolimod\u00a0for pediatric onset multiple sclerosis: the experience of an Italian pediatric center over the past 3 years."],"prefix":"10.1007","volume":"46","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2561-129X","authenticated-orcid":false,"given":"Carlotta","family":"Canavese","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marta","family":"Borgogno","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gloria","family":"Gallo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Martina","family":"Rosa-Brusin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alessia","family":"Teneggi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aba","family":"Tocchet","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daniele","family":"Marcotulli","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giovanni","family":"Morana","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2025,4,2]]},"reference":[{"issue":"9","key":"8139_CR1","doi-asserted-by":"publisher","first-page":"8251","DOI":"10.3390\/ijms24098251","volume":"24","author":"RI Teleanu","year":"2023","unstructured":"Teleanu RI, Niculescu AG, Vladacenco OA, Roza E, Perjoc RS, Teleanu DM (2023) The state of the Art of pediatric multiple sclerosis. Int J Mol Sci 24(9):8251. https:\/\/doi.org\/10.3390\/ijms24098251PMID: 37175954; PMCID: PMC10179691","journal-title":"Int J Mol Sci"},{"issue":"1","key":"8139_CR2","doi-asserted-by":"publisher","first-page":"27","DOI":"10.1186\/s12883-018-1026-3","volume":"18","author":"R Alroughani","year":"2018","unstructured":"Alroughani R, Boyko A (2018) Pediatric multiple sclerosis: a review. BMC Neurol 18(1):27. https:\/\/doi.org\/10.1186\/s12883-018-1026-3PMID: 29523094; PMCID: PMC5845207","journal-title":"BMC Neurol"},{"doi-asserted-by":"publisher","unstructured":"Kornbluh AB, Kahn I (2023) Pediatric Multiple Sclerosis. Semin Pediatr Neurol.;46:101054. https:\/\/doi.org\/10.1016\/j.spen.2023.101054. Epub 2023 May 11. PMID: 37451754","key":"8139_CR3","DOI":"10.1016\/j.spen.2023.101054"},{"doi-asserted-by":"publisher","unstructured":"Otallah S, Banwell B (2018) Pediatric Multiple Sclerosis: an Update. Curr Neurol Neurosci Rep.;18(11):76. https:\/\/doi.org\/10.1007\/s11910-018-0886-7. PMID: 30229541","key":"8139_CR4","DOI":"10.1007\/s11910-018-0886-7"},{"issue":"10","key":"8139_CR5","doi-asserted-by":"publisher","first-page":"1261","DOI":"10.1177\/1352458513484547","volume":"19","author":"LB Krupp","year":"2013","unstructured":"Krupp LB, Tardieu M, Amato MP, Banwell B, Chitnis T, Dale RC, Ghezzi A, Hintzen R, Kornberg A, Pohl D, Rostasy K, Tenembaum S, Wassmer E, International Pediatric Multiple Sclerosis Study Group (2013) International pediatric multiple sclerosis study group criteria for pediatric multiple sclerosis and immune-mediated central nervous system demyelinating disorders: revisions to the 2007 definitions. Mult Scler 19(10):1261\u20131267. https:\/\/doi.org\/10.1177\/1352458513484547Epub 2013 Apr 9. PMID: 23572237","journal-title":"Mult Scler"},{"issue":"9","key":"8139_CR6","doi-asserted-by":"publisher","first-page":"1039","DOI":"10.1111\/dmcn.14212","volume":"61","author":"S Duignan","year":"2019","unstructured":"Duignan S, Brownlee W, Wassmer E, Hemingway C, Lim M, Ciccarelli O, Hacohen Y (2019) Paediatric multiple sclerosis: a new era in diagnosis and treatment. Dev Med Child Neurol 61(9):1039\u20131049. https:\/\/doi.org\/10.1111\/dmcn.14212Epub 2019 Apr 1. PMID: 30932181","journal-title":"Dev Med Child Neurol"},{"issue":"4","key":"8139_CR7","doi-asserted-by":"publisher","first-page":"442","DOI":"10.3390\/brainsci11040442","volume":"11","author":"E Portaccio","year":"2021","unstructured":"Portaccio E, De Meo E, Bellinvia A, Amato MP (2021) Cognitive issues in pediatric multiple sclerosis. Brain Sci 11(4):442. https:\/\/doi.org\/10.3390\/brainsci11040442PMID: 33808278; PMCID: PMC8065790","journal-title":"Brain Sci"},{"doi-asserted-by":"crossref","unstructured":"Fernandez-Carbonell C, Charvet LE, Krupp LB (2021) Enhancing Mood, Cognition, and Quality of Life in Pediatric Multiple Sclerosis. Paediatr Drugs.;23(4):317\u2013329. doi: 10.1007\/s40272-021-00451-5. Epub 2021 May 17. PMID: 33997945; PMCID: PMC8275506","key":"8139_CR8","DOI":"10.1007\/s40272-021-00451-5"},{"issue":"1","key":"8139_CR9","doi-asserted-by":"publisher","first-page":"45","DOI":"10.1007\/s40263-021-00887-w","volume":"36","author":"D Jakimovski","year":"2022","unstructured":"Jakimovski D, Awan S, Eckert SP, Farooq O, Weinstock-Guttman B (2022) Multiple sclerosis in children: differential diagnosis, prognosis, and Disease-Modifying treatment. CNS Drugs 36(1):45\u201359. https:\/\/doi.org\/10.1007\/s40263-021-00887-wEpub 2021 Dec 23. PMID: 34940954; PMCID: PMC8697541","journal-title":"CNS Drugs"},{"doi-asserted-by":"publisher","unstructured":"Macaron G, Feng J, Moodley M, Rensel M (2019) Newer Treatment Approaches in Pediatric-Onset Multiple Sclerosis. Curr Treat Options Neurol.;21(10):50. https:\/\/doi.org\/10.1007\/s11940-019-0592-z. PMID: 31560095","key":"8139_CR10","DOI":"10.1007\/s11940-019-0592-z"},{"doi-asserted-by":"publisher","unstructured":"Chitnis T, Arnold DL, Banwell B, Br\u00fcck W, Ghezzi A, Giovannoni G, Greenberg B, Krupp L, Rost\u00e1sy K, Tardieu M, Waubant E, Wolinsky JS, Bar-Or A, Stites T, Chen Y, Putzki N, Merschhemke M, G\u00e4rtner J, PARADIGMS Study Group (2018). Trial of Fingolimod versus Interferon Beta-1a in Pediatric Multiple Sclerosis. N Engl J Med.;379(11):1017\u20131027. https:\/\/doi.org\/10.1056\/NEJMoa1800149. PMID: 30207920","key":"8139_CR11","DOI":"10.1056\/NEJMoa1800149"},{"issue":"1","key":"8139_CR12","doi-asserted-by":"publisher","first-page":"58","DOI":"10.1136\/jnnp-2019-321124","volume":"91","author":"K Deiva","year":"2020","unstructured":"Deiva K, Huppke P, Banwell B, Chitnis T, G\u00e4rtner J, Krupp L, Waubant E, Stites T, Pearce GL, Merschhemke M (2020) Consistent control of disease activity with Fingolimod versus IFN \u03b2-1a in paediatric-onset multiple sclerosis: further insights from PARADIGMS. J Neurol Neurosurg Psychiatry 91(1):58\u201366. https:\/\/doi.org\/10.1136\/jnnp-2019-321124Epub 2019 Aug 29. PMID: 31467033; PMCID: PMC6952840","journal-title":"J Neurol Neurosurg Psychiatry"},{"doi-asserted-by":"publisher","unstructured":"Zaffaroni M (2021) Fingolimod in pediatric-onset multiple sclerosis. Neurol Sci.;42(Suppl 1):1\u20134. https:\/\/doi.org\/10.1007\/s10072-021-05294-z. Epub 2021 May 4. PMID: 33945033","key":"8139_CR13","DOI":"10.1007\/s10072-021-05294-z"},{"doi-asserted-by":"publisher","unstructured":"Baroncini D, Simone M, Iaffaldano P, Brescia Morra V, Lanzillo R, Filippi M, Romeo M, Patti F, Chisari CG, Cocco E, Fenu G, Salemi G, Ragonese P, Inglese M, Cellerino M, Margari L, Comi G, Zaffaroni M, Ghezzi A, Italian MS (2021) registry. Risk of Persistent Disability in Patients With Pediatric-Onset Multiple Sclerosis. JAMA Neurol.;78(6):726\u2013735. https:\/\/doi.org\/10.1001\/jamaneurol.2021.1008. PMID: 33938921; PMCID: PMC8094039","key":"8139_CR14","DOI":"10.1001\/jamaneurol.2021.1008"},{"doi-asserted-by":"publisher","unstructured":"Ghezzi A, Chitnis T, K-Laflamme A, Meinert R, H\u00e4ring DA, Pohl D (2019) Long-Term Effect of Immediate Versus Delayed Fingolimod Treatment in Young Adult Patients with Relapsing-Remitting Multiple Sclerosis: Pooled Analysis from the FREEDOMS\/FREEDOMS II Trials. Neurol Ther.;8(2):461\u2013475. https:\/\/doi.org\/10.1007\/s40120-019-0146-z. Epub 2019 Jul 19. Erratum in: Neurol Ther. 2020;9(1):193\u2013195. doi: 10.1007\/s40120-020-00178-4. PMID: 31325110; PMCID: PMC6858894","key":"8139_CR15","DOI":"10.1007\/s40120-019-0146-z"},{"issue":"2","key":"8139_CR16","doi-asserted-by":"publisher","first-page":"162","DOI":"10.1016\/S1474-4422(17)30470-2","volume":"17","author":"AJ Thompson","year":"2018","unstructured":"Thompson AJ, Banwell BL, Barkhof F, Carroll WM, Coetzee T, Comi G, Correale J, Fazekas F, Filippi M, Freedman MS, Fujihara K, Galetta SL, Hartung HP, Kappos L, Lublin FD, Marrie RA, Miller AE, Miller DH, Montalban X, Mowry EM, Sorensen PS, Tintor\u00e9 M, Traboulsee AL, Trojano M, Uitdehaag BMJ, Vukusic S, Waubant E, Weinshenker BG, Reingold SC, Cohen JA (2018) Diagnosis of multiple sclerosis: 2017 revisions of the McDonald criteria. Lancet Neurol 17(2):162\u2013173. https:\/\/doi.org\/10.1016\/S1474-4422(17)30470-2Epub 2017 Dec 21. PMID: 29275977","journal-title":"Lancet Neurol"},{"doi-asserted-by":"publisher","unstructured":"Sadaka Y, Verhey LH, Shroff MM, Branson HM, Arnold DL, Narayanan S, Sled JG, Bar-Or A, Sadovnick AD, McGowan M, Marrie RA, Banwell B, Canadian Pediatric Demyelinating Disease Network (2012). 2010 McDonald criteria for diagnosing pediatric multiple sclerosis. Ann Neurol.;72(2):211\u2013\u200923. https:\/\/doi.org\/10.1002\/ana.23575. PMID: 22926854","key":"8139_CR17","DOI":"10.1002\/ana.23575"},{"doi-asserted-by":"publisher","unstructured":"Carotenuto A, Di Monaco C, Papetti L, Borriello G, Signoriello E, Masciulli C, Tomassini V, De Luca G, Ianniello A, Lus G, Novarella F, Spiezia AL, Di Somma D, Moccia M, Petracca M, Iacovazzo C, Servillo G, Portaccio E, Triassi M, Amato MP, Pozzilli C, Valeriani M, Brescia Morra V, Lanzillo R (2024) Pediatric-onset Multiple Sclerosis treatment: a multicentre observational study comparing natalizumab with fingolimod. J Neurol. Aug 23. https:\/\/doi.org\/10.1007\/s00415-024-12610-y. Epub ahead of print. PMID: 39177751","key":"8139_CR18","DOI":"10.1007\/s00415-024-12610-y"},{"doi-asserted-by":"publisher","unstructured":"Spelman T, Simoneau G, Hyde R, Kuhelj R, Alroughani R, Ozakbas S, Karabudak R, Yamout BI, Khoury SJ, Terzi M, Boz C, Horakova D, Kubala Havrdova E, Weinstock-Guttman B, Patti F, Altintas A, Mrabet S, Gouider R, Inshasi J, Shaygannejad V, Eichau S, Ward WL, Butzkueven H (2024) MSBase Investigators. Comparative Effectiveness of Natalizumab, Fingolimod, and Injectable Therapies in Pediatric-Onset Multiple Sclerosis: A Registry-Based Study. Neurology.;102(7):e208114. https:\/\/doi.org\/10.1212\/WNL.0000000000208114. Epub 2024 Mar 6. Erratum in: Neurology. 2024;103(1):e209573. doi: 10.1212\/WNL.0000000000209573. PMID: 38447093; PMCID: PMC11033984","key":"8139_CR19","DOI":"10.1212\/WNL.0000000000208114"},{"key":"8139_CR20","doi-asserted-by":"publisher","first-page":"141","DOI":"10.2147\/PHMT.S220817","volume":"10","author":"J Feng","year":"2019","unstructured":"Feng J, Rensel M (2019) Review of the safety, efficacy and tolerability of Fingolimod. Pediatr Health Med Ther 10:141\u2013146 PMID: 31814792; PMCID: PMC6858833. The Treatment Of Pediatric Patients With Relapsing-Remitting Forms Of Multiple Sclerosis (RRMS)","journal-title":"Pediatr Health Med Ther"},{"key":"8139_CR21","doi-asserted-by":"publisher","first-page":"1294574","DOI":"10.3389\/fnins.2024.1294574","volume":"18","author":"R Faustino","year":"2024","unstructured":"Faustino R, Lopes C, Jantarada A, Mendon\u00e7a A, Raposo R, Ferr\u00e3o C, Freitas J, Mateus C, Pinto A, Almeida E, Gomes N, Marques L, Palavra F (2024) Neuroimaging characterization of multiple sclerosis lesions in pediatric patients: an exploratory radiomics approach. Front Neurosci 18:1294574. https:\/\/doi.org\/10.3389\/fnins.2024.1294574PMID: 38370435; PMCID: PMC10869542","journal-title":"Front Neurosci"},{"key":"8139_CR22","doi-asserted-by":"publisher","first-page":"209","DOI":"10.1016\/j.yapd.2019.03.003","volume":"66","author":"MM Langille","year":"2019","unstructured":"Langille MM, Rutatangwa A, Francisco C (2019) Pediatric multiple sclerosis: A review. Adv Pediatr 66:209\u2013229. https:\/\/doi.org\/10.1016\/j.yapd.2019.03.003Epub 2019 Apr 20. PMID: 31230695","journal-title":"Adv Pediatr"},{"doi-asserted-by":"publisher","unstructured":"Fadda G, Yea C, O\u2019Mahony J, Waters P, Yeh EA, Marrie RA, Arnold D, Bar-Or A, Banwell B, Canadian Pediatric Demyelinating Disease Study Group (2024) Ann Neurol 95(4):700\u2013705. https:\/\/doi.org\/10.1002\/ana.26890Epub 2024 Feb 27. PMID: 38411340 Epstein-Barr Virus Strongly Associates With Pediatric Multiple Sclerosis, But Not Myelin Oligodendrocyte Glycoprotein-Antibody-Associated Disease","key":"8139_CR23","DOI":"10.1002\/ana.26890"},{"issue":"1","key":"8139_CR24","doi-asserted-by":"publisher","first-page":"51","DOI":"10.1038\/s41579-022-00770-5","volume":"21","author":"SS Soldan","year":"2023","unstructured":"Soldan SS, Lieberman PM (2023) Epstein-Barr virus and multiple sclerosis. Nat Rev Microbiol 21(1):51\u201364. https:\/\/doi.org\/10.1038\/s41579-022-00770-5Epub 2022 Aug 5. PMID: 35931816; PMCID: PMC9362539","journal-title":"Nat Rev Microbiol"},{"issue":"4","key":"8139_CR25","doi-asserted-by":"publisher","first-page":"949","DOI":"10.3390\/v15040949","volume":"15","author":"BA Rousseau","year":"2023","unstructured":"Rousseau BA, Bhaduri-McIntosh S (2023) Inflammation and Epstein-Barr virus at the crossroads of multiple sclerosis and Post-Acute sequelae of COVID-19 infection. Viruses 15(4):949. https:\/\/doi.org\/10.3390\/v15040949PMID: 37112929; PMCID: PMC10141000","journal-title":"Viruses"},{"issue":"5","key":"8139_CR26","doi-asserted-by":"publisher","first-page":"684","DOI":"10.3390\/cells12050684","volume":"12","author":"WD Fernandes de Souza","year":"2023","unstructured":"Fernandes de Souza WD, Fonseca DMD, Sartori A (2023) COVID-19 and multiple sclerosis: A complex relationship possibly aggravated by low vitamin D levels. Cells 12(5):684. https:\/\/doi.org\/10.3390\/cells12050684PMID: 36899820; PMCID: PMC10000583","journal-title":"Cells"},{"issue":"14","key":"8139_CR27","doi-asserted-by":"publisher","first-page":"1938","DOI":"10.1177\/1352458519891984","volume":"26","author":"AI Wallack","year":"2020","unstructured":"Wallack AI, Waltz M, Casper TC et al (2020) Cognitive processing speed in pediatrc onset multiple sclerosis: baseline characteristics of impairment and prediction of decline. Mult Scler 26(14):1938\u20131947","journal-title":"Mult Scler"},{"issue":"Suppl 1","key":"8139_CR28","doi-asserted-by":"publisher","first-page":"19","DOI":"10.1007\/s10072-021-05076-7","volume":"42","author":"MAN Ferilli","year":"2021","unstructured":"Ferilli MAN, Papetti L, Valeriani M (2021) Fingolimod in pediatric multiple sclerosis: three case reports. Neurol Sci 42(Suppl 1):19\u201323. https:\/\/doi.org\/10.1007\/s10072-021-05076-7Epub 2021 Jan 22. PMID: 33483884","journal-title":"Neurol Sci"},{"key":"8139_CR29","doi-asserted-by":"publisher","first-page":"205031212311719","DOI":"10.1177\/20503121231171996","volume":"11","author":"B Piri Cinar","year":"2023","unstructured":"Piri Cinar B, Konuskan B, Anlar B, Ozakbas S (2023) Narrative review based on Fingolimod therapy in pediatric MS. SAGE Open Med 11:20503121231171996. https:\/\/doi.org\/10.1177\/20503121231171996PMID: 37181277; PMCID: PMC10170592","journal-title":"SAGE Open Med"},{"issue":"1","key":"8139_CR30","doi-asserted-by":"publisher","first-page":"50","DOI":"10.1136\/archdischild-2021-322317","volume":"108","author":"L Chapman","year":"2023","unstructured":"Chapman L (2023) Fingolimod significantly reduces MRI activity in paediatric-onset multiple sclerosis (MS). Arch Dis Child Educ Pract Ed 108(1):50. https:\/\/doi.org\/10.1136\/archdischild-2021-322317Epub 2021 Jul 9. PMID: 34244234","journal-title":"Arch Dis Child Educ Pract Ed"},{"issue":"5","key":"8139_CR31","doi-asserted-by":"publisher","first-page":"483","DOI":"10.1136\/jnnp-2019-322138","volume":"91","author":"DL Arnold","year":"2020","unstructured":"Arnold DL, Banwell B, Bar-Or A, Ghezzi A, Greenberg BM, Waubant E, Giovannoni G, Wolinsky JS, G\u00e4rtner J, Rost\u00e1sy K, Krupp L, Tardieu M, Br\u00fcck W, Stites TE, Pearce GL, H\u00e4ring DA, Merschhemke M, Chitnis T, PARADIGMS Study Investigators (2020) Effect of Fingolimod on MRI outcomes in patients with paediatric-onset multiple sclerosis: results from the phase 3 PARADIGMS study. J Neurol Neurosurg Psychiatry 91(5):483\u2013492. https:\/\/doi.org\/10.1136\/jnnp-2019-322138Epub 2020 Mar 4. PMID: 32132224; PMCID: PMC7231437","journal-title":"J Neurol Neurosurg Psychiatry"},{"issue":"4","key":"8139_CR32","doi-asserted-by":"publisher","first-page":"949","DOI":"10.1007\/s40120-024-00633-6","volume":"13","author":"A Ghezzi","year":"2024","unstructured":"Ghezzi A (2024) Old and new strategies in the treatment of pediatric multiple sclerosis: A personal view for a new treatment approach. Neurol Ther 13(4):949\u2013963. https:\/\/doi.org\/10.1007\/s40120-024-00633-6Epub 2024 Jun 1. PMID: 38822947; PMCID: PMC11263277","journal-title":"Neurol Ther"}],"container-title":["Neurological Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10072-025-08139-1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s10072-025-08139-1\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10072-025-08139-1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,9,6]],"date-time":"2025-09-06T08:47:58Z","timestamp":1757148478000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s10072-025-08139-1"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,4,2]]},"references-count":32,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2025,8]]}},"alternative-id":["8139"],"URL":"https:\/\/doi.org\/10.1007\/s10072-025-08139-1","relation":{},"ISSN":["1590-1874","1590-3478"],"issn-type":[{"type":"print","value":"1590-1874"},{"type":"electronic","value":"1590-3478"}],"subject":[],"published":{"date-parts":[[2025,4,2]]},"assertion":[{"value":"13 January 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"19 March 2025","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"2 April 2025","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors confirm that the paper is original, has not been previously published elsewhere in any form or language and it is not simultaneously under consideration by any other journal.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"The authors declare no competing interest.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}]}}