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Currently, few studies have investigated the relationships between serum markers and neuroimaging changes associated with depression in PD patients.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Objective<\/jats:title>\n            <jats:p>To explore the correlations among depression, serum SIRT3 levels, and brain structural and functional alterations in PD patients.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Methods<\/jats:title>\n            <jats:p>The Hamilton Depression Scale\u201017 (HAMD-17) was used to assess depression. Serum SIRT3 levels were measured using an enzyme-linked immunosorbent assay (ELISA). Voxel-based morphometry (VBM) and resting-state functional magnetic resonance imaging (rs-fMRI) were used to examine structural and functional alterations.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Results<\/jats:title>\n            <jats:p>Compared to healthy individuals, serum SIRT3 levels were lower in PD patients, especially in those with depression. PD patients with depression had lower total gray matter volume\/total intracranial volume (GMV\/TIV) ratio, and GMVs of the right amygdala, lower fractional amplitude of low-frequency fluctuations (fALFF) values of the left middle frontal gyrus (<jats:italic>MidFG.L<\/jats:italic>) and left superior parietal lobule (<jats:italic>SPL.L<\/jats:italic>), and altered functional connectivity(FC) primarily involving the Salience Network (<jats:italic>SN<\/jats:italic>) and the default Mode Network (<jats:italic>DMN<\/jats:italic>) compared to those without depression. Serum SIRT3 levels, total GMV\/TIV ratios, and fALFF values of the <jats:italic>MidFG.L<\/jats:italic> and <jats:italic>SPL.L<\/jats:italic> have diagnostic value for PD patients with depression, and their combination can improve predictive accuracy.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Conclusions<\/jats:title>\n            <jats:p>Depression in PD patients is associated with lower serum SIRT3 levels, right amygdala atrophy, decreased spontaneous activity in <jats:italic>MidFG.L<\/jats:italic> and <jats:italic>SPL.L<\/jats:italic>, and altered FC in the <jats:italic>DMN<\/jats:italic> and <jats:italic>SN<\/jats:italic>.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1007\/s10072-025-08170-2","type":"journal-article","created":{"date-parts":[[2025,4,21]],"date-time":"2025-04-21T16:45:05Z","timestamp":1745253905000},"page":"3663-3676","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Serum sirtuin 3 levels and multimodal abnormalities in brain structure and function in Parkinson\u2019s disease patients with depression"],"prefix":"10.1007","volume":"46","author":[{"given":"Zonghan","family":"She","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xuelin","family":"Qi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoxue","family":"Shi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haoran","family":"Peng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jinhua","family":"Zheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5825-1927","authenticated-orcid":false,"given":"Jianjun","family":"Ma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yunfei","family":"Sun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mengyan","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yingyun","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qing","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qi","family":"Gu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Siyuan","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xue","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,4,21]]},"reference":[{"key":"8170_CR1","doi-asserted-by":"publisher","first-page":"e150252","DOI":"10.1172\/JCI150252","volume":"131","author":"K Kieburtz","year":"2021","unstructured":"Kieburtz K, Dorsey ER (2021) Parkinson disease risks: correctly identifying environmental factors for a chronic disease. 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