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NDs frequently manifest varying levels of chronic fatigue, a phenomenon whose underlying mechanisms remain obscure. This condition significantly impairs the quality of life for patients and presents a formidable challenge to our nation\u2019s healthcare system. This paper delves into the potential mechanisms, assessments, and therapeutic approaches for Parkinson\u2019s Disease and Multiple System Atrophy in the context of chronic fatigue. The objective of this study is to enhance the understanding of chronic fatigue in NDs, as well as to contribute to the advancement of its diagnosis and treatment methodologies.<\/jats:p>","DOI":"10.1007\/s10072-025-08254-z","type":"journal-article","created":{"date-parts":[[2025,6,10]],"date-time":"2025-06-10T00:39:14Z","timestamp":1749515954000},"page":"4791-4804","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Research progress of chronic fatigue in neurodegenerative diseases"],"prefix":"10.1007","volume":"46","author":[{"given":"Luxuan","family":"Xia","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liye","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenyang","family":"Tian","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qianyu","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinning","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shenghua","family":"Kang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yao","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoxue","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenxuan","family":"Guo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jingmei","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuanxin","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhigang","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-3049-7759","authenticated-orcid":false,"given":"Nannan","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,6,10]]},"reference":[{"issue":"11","key":"8254_CR1","doi-asserted-by":"publisher","first-page":"1712","DOI":"10.1002\/mds.27461","volume":"33","author":"M Siciliano","year":"2018","unstructured":"Siciliano M, Trojano L, Santangelo G, De Micco R, Tedeschi G, Tessitore A (2018) Fatigue in Parkinson\u2019s disease: A systematic review and meta-analysis. 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