{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,4]],"date-time":"2026-06-04T12:16:29Z","timestamp":1780575389245,"version":"3.54.1"},"reference-count":9,"publisher":"Springer Science and Business Media LLC","issue":"9","license":[{"start":{"date-parts":[[2025,5,28]],"date-time":"2025-05-28T00:00:00Z","timestamp":1748390400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2025,5,28]],"date-time":"2025-05-28T00:00:00Z","timestamp":1748390400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"name":"Unidade Local de Sa\u00fade de S\u00e3o Jos\u00e9"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Neurol Sci"],"published-print":{"date-parts":[[2025,9]]},"abstract":"<jats:title>Abstract<\/jats:title>\n          <jats:p>Cerebral venous thrombosis (CVT) accounts for 0.5-1% of all strokes and 24\u201350% of these patients develop acute symptomatic seizures (AS). Clinical and radiological characteristics have been associated with an increased risk of AS in CVT. We aimed to identify clinical and imaging predictors associated with a higher risk of AS in CVT patients.<\/jats:p>\n          <jats:p>We conducted a single-centre, retrospective cohort study and included all patients with CVT admitted to our stroke unit between January\/2011-December\/2022. Our primary outcome was AS occurence. Clinical and radiological characteristics were compared through a logistic binary regression, followed by a multivariable analysis.<\/jats:p>\n          <jats:p>We included 156 patients, 80.8% female and a mean age of 41.5\u2009\u00b1\u200915.2 years. Fifty-two patients (33.3%) had a seizure during follow-up, the majority as AS (30.1%). We found an increased risk of AS in patients with focal signs at presentation (OR 5.35), superior longitudinal sinus (SLS) or cortical vein involvement (OR 5.03; OR 3.94), hemorrhagic lesions or oedema (OR 3.88; OR 4.17) and lesions located in the frontal or the parietal lobe (OR 4.61; OR 4.61). A multivariable analysis was also conducted and only SLS involvement (OR 6.06), cortical vein involvement (OR 2.76) and hemorrhagic lesion (OR 3.47) remained statistically significant.<\/jats:p>\n          <jats:p>Seizures occurred in about a third of our CVT patients, the majority as AS. Haemorrhagic lesions, SLS and cortical vein involvement had a stronger association with AS that may raise our awareness for the risk of seizures in this population during the acute phase.<\/jats:p>","DOI":"10.1007\/s10072-025-08256-x","type":"journal-article","created":{"date-parts":[[2025,5,28]],"date-time":"2025-05-28T00:21:33Z","timestamp":1748391693000},"page":"4493-4496","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Seizure prediction in cerebral venous thrombosis\u2013 a retrospective single-centre observational study"],"prefix":"10.1007","volume":"46","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0700-7785","authenticated-orcid":false,"given":"Patr\u00edcia","family":"Faustino","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Diana","family":"Melancia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,5,28]]},"reference":[{"key":"8256_CR1","doi-asserted-by":"publisher","first-page":"106820","DOI":"10.1016\/j.eplepsyres.2021.106820","volume":"178","author":"Y Fang","year":"2021","unstructured":"Fang Y, Song G, Lin J, Ye X, Huang S (2021) Predicting the occurrence of early seizures after cerebral venous thrombosis using a comprehensive nomogram. Epilepsy Res 178:106820. https:\/\/doi.org\/10.1016\/j.eplepsyres.2021.106820","journal-title":"Epilepsy Res"},{"key":"8256_CR2","doi-asserted-by":"publisher","unstructured":"Lindgren E, Silvis SM, Hiltunen S et al (2021) Acute symptomatic seizures in cerebral venous thrombosis [published correction appears in Neurology.;96(13):639]. Neurology. 2020;95(12):e1706-e1715. https:\/\/doi.org\/10.1212\/WNL.0000000000010577","DOI":"10.1212\/WNL.0000000000010577"},{"issue":"1","key":"8256_CR3","doi-asserted-by":"publisher","first-page":"111","DOI":"10.3390\/life13010111","volume":"13","author":"F Col\u00f2","year":"2022","unstructured":"Col\u00f2 F, Brunetti V, Di Muro M et al (2022) Predicting factors for seizures after cerebral venous thrombosis: A retrospective single center cohort study. Life (Basel) 13(1):111 Published 2022 Dec 30. https:\/\/doi.org\/10.3390\/life13010111","journal-title":"Life (Basel)"},{"key":"8256_CR4","doi-asserted-by":"publisher","first-page":"107840","DOI":"10.1016\/j.clineuro.2023.107840","volume":"232","author":"L Dias","year":"2023","unstructured":"Dias L, Carvalho M (2023) Seizures in cerebral venous thrombosis - A retrospective analysis of a tertiary centre cohort. Clin Neurol Neurosurg 232:107840. https:\/\/doi.org\/10.1016\/j.clineuro.2023.107840","journal-title":"Clin Neurol Neurosurg"},{"issue":"4","key":"8256_CR5","doi-asserted-by":"publisher","first-page":"1152","DOI":"10.1161\/STROKEAHA.107.487363","volume":"39","author":"JM Ferro","year":"2008","unstructured":"Ferro JM, Canh\u00e3o P, Bousser MG, Stam J, Barinagarrementeria F, ISCVT Investigators (2008) Early seizures in cerebral vein and dural sinus thrombosis: risk factors and role of antiepileptics. Stroke 39(4):1152\u20131158. https:\/\/doi.org\/10.1161\/STROKEAHA.107.487363","journal-title":"Stroke"},{"key":"8256_CR6","doi-asserted-by":"publisher","first-page":"113","DOI":"10.1016\/j.seizure.2020.02.017","volume":"78","author":"D Uluduz","year":"2020","unstructured":"Uluduz D, Midi I, Duman T et al (2020) Epileptic seizures in cerebral venous sinus thrombosis: subgroup analysis of VENOST study. Seizure 78:113\u2013117. https:\/\/doi.org\/10.1016\/j.seizure.2020.02.017","journal-title":"Seizure"},{"issue":"12","key":"8256_CR7","doi-asserted-by":"publisher","first-page":"e1716","DOI":"10.1212\/WNL.0000000000010576","volume":"95","author":"M van S\u00e1nchez","year":"2020","unstructured":"van S\u00e1nchez M, Lindgren E, Silvis SM et al (2020) Late seizures in cerebral venous thrombosis. Neurology 95(12):e1716\u2013e1723. https:\/\/doi.org\/10.1212\/WNL.0000000000010576","journal-title":"Neurology"},{"issue":"2","key":"8256_CR8","doi-asserted-by":"publisher","first-page":"195","DOI":"10.1001\/archneur.59.2.195","volume":"59","author":"IE Silverman","year":"2002","unstructured":"Silverman IE, Restrepo L, Mathews GC (2002) Poststroke seizures. Arch Neurol 59(2):195\u2013201. https:\/\/doi.org\/10.1001\/archneur.59.2.195","journal-title":"Arch Neurol"},{"key":"8256_CR9","doi-asserted-by":"publisher","first-page":"126","DOI":"10.1097\/NRL.0000000000000288","volume":"25","author":"S Gazioglu","year":"2020","unstructured":"Gazioglu S, Yildirim A, Kokturk EG, Seker D, Altunayoglu Cakmak V, Velioglu SK (2020) Acute seizures in cerebral venous sinus thrombosis: risk factors and prognosis. Neurologist 25:126\u2013130. https:\/\/doi.org\/10.1097\/NRL.0000000000000288","journal-title":"Neurologist"}],"container-title":["Neurological Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10072-025-08256-x.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s10072-025-08256-x\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10072-025-08256-x.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,8,28]],"date-time":"2025-08-28T06:57:06Z","timestamp":1756364226000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s10072-025-08256-x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,5,28]]},"references-count":9,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2025,9]]}},"alternative-id":["8256"],"URL":"https:\/\/doi.org\/10.1007\/s10072-025-08256-x","relation":{},"ISSN":["1590-1874","1590-3478"],"issn-type":[{"value":"1590-1874","type":"print"},{"value":"1590-3478","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,5,28]]},"assertion":[{"value":"6 February 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"19 May 2025","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"28 May 2025","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"None.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}]}}