{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T16:11:05Z","timestamp":1759335065652,"version":"build-2065373602"},"reference-count":38,"publisher":"Springer Science and Business Media LLC","issue":"10","license":[{"start":{"date-parts":[[2025,6,25]],"date-time":"2025-06-25T00:00:00Z","timestamp":1750809600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2025,6,25]],"date-time":"2025-06-25T00:00:00Z","timestamp":1750809600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"funder":[{"DOI":"10.13039\/501100003196","name":"Ministero della Salute","doi-asserted-by":"publisher","award":["RF-2016-02364801"],"award-info":[{"award-number":["RF-2016-02364801"]}],"id":[{"id":"10.13039\/501100003196","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Neurol Sci"],"published-print":{"date-parts":[[2025,10]]},"DOI":"10.1007\/s10072-025-08327-z","type":"journal-article","created":{"date-parts":[[2025,6,24]],"date-time":"2025-06-24T22:15:39Z","timestamp":1750803339000},"page":"5263-5271","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Cost-efficacy evaluation of a mindfulness-based program added to treatment as usual for the treatment of chronic migraine associated to medication overuse headache"],"prefix":"10.1007","volume":"46","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7433-7779","authenticated-orcid":false,"given":"Alberto","family":"Raggi","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5016-9301","authenticated-orcid":false,"given":"Domenico","family":"D\u2019Amico","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5051-0207","authenticated-orcid":false,"given":"Erika","family":"Guastafierro","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7285-123X","authenticated-orcid":false,"given":"Emilio","family":"Ciusani","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4834-2045","authenticated-orcid":false,"given":"Danilo Antonio","family":"Montisano","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3155-4850","authenticated-orcid":false,"given":"Alessandra","family":"Erbetta","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2034-0283","authenticated-orcid":false,"given":"Greta","family":"Demichelis","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9732-2353","authenticated-orcid":false,"given":"Davide","family":"Fedeli","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1197-5458","authenticated-orcid":false,"given":"Anna","family":"Nigri","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6535-1109","authenticated-orcid":false,"given":"Licia","family":"Grazzi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2025,6,25]]},"reference":[{"key":"8327_CR1","doi-asserted-by":"publisher","first-page":"1315","DOI":"10.1016\/S0140-6736(18)30478-1","volume":"391","author":"DW Dodick","year":"2018","unstructured":"Dodick DW (2018) Migraine Lancet 391:1315\u20131330. https:\/\/doi.org\/10.1016\/S0140-6736(18)30478-1","journal-title":"Migraine Lancet"},{"key":"8327_CR2","doi-asserted-by":"publisher","first-page":"189","DOI":"10.1186\/s10194-024-01889-x","volume":"25","author":"A Raggi","year":"2024","unstructured":"Raggi A, Leonardi M, Arruda M et al (2024) Hallmarks of primary headache: part 1 - migraine. J Headache Pain 25:189. https:\/\/doi.org\/10.1186\/s10194-024-01889-x","journal-title":"J Headache Pain"},{"key":"8327_CR3","doi-asserted-by":"publisher","first-page":"361","DOI":"10.1007\/s10194-012-0460-7","volume":"13","author":"LM Bloudek","year":"2012","unstructured":"Bloudek LM, Stokes M, Buse DC et al (2012) Cost of healthcare for patients with migraine in five European countries: results from the international burden of migraine study (IBMS). J Headache Pain 13:361\u2013378. https:\/\/doi.org\/10.1007\/s10194-012-0460-7","journal-title":"J Headache Pain"},{"issue":"Suppl 1","key":"8327_CR4","doi-asserted-by":"publisher","first-page":"17","DOI":"10.1111\/head.13301","volume":"58","author":"R Agosti","year":"2018","unstructured":"Agosti R (2018) Migraine burden of disease: from the patient\u2019s experience to a socio-economic view. Headache 58(Suppl 1):17\u201332. https:\/\/doi.org\/10.1111\/head.13301","journal-title":"Headache"},{"key":"8327_CR5","doi-asserted-by":"publisher","first-page":"43","DOI":"10.1186\/s13561-023-00459-2","volume":"13","author":"A Eltrafi","year":"2023","unstructured":"Eltrafi A, Shrestha S, Ahmed A, Mistry H, Paudyal V, Khanal S (2023) Economic burden of chronic migraine in OECD countries: a systematic review. Health Econ Rev 13:43. https:\/\/doi.org\/10.1186\/s13561-023-00459-2","journal-title":"Health Econ Rev"},{"key":"8327_CR6","doi-asserted-by":"publisher","first-page":"e146026","DOI":"10.5812\/ijpr-146026","volume":"23","author":"H Mollaee","year":"2024","unstructured":"Mollaee H, Nadimi Parashkouhi S, Fatemi B, Seyedifar M, Soleymani F (2024) Cost-Utility analysis of erenumab compared to topiramate for preventive therapy of migraine in Iran. Iran J Pharm Res 23:e146026. https:\/\/doi.org\/10.5812\/ijpr-146026","journal-title":"Iran J Pharm Res"},{"key":"8327_CR7","doi-asserted-by":"publisher","first-page":"59","DOI":"10.1186\/s10194-024-01749-8","volume":"25","author":"E Griffin","year":"2024","unstructured":"Griffin E, Shirley G, Lee XY, Awad SF, Tyagi A, Goadsby PJ (2024) An economic evaluation of eptinezumab for the preventive treatment of migraine in the UK, with consideration for natural history and work productivity. J Headache Pain 25:59. https:\/\/doi.org\/10.1186\/s10194-024-01749-8","journal-title":"J Headache Pain"},{"key":"8327_CR8","doi-asserted-by":"publisher","first-page":"40","DOI":"10.1186\/s10194-024-01747-w","volume":"25","author":"P Pozo-Rosich","year":"2024","unstructured":"Pozo-Rosich P, Poveda JL, Crespo C, Mart\u00ednez M, Rodr\u00edguez JM, Irimia P (2024) Is erenumab an efficient alternative for the prevention of episodic and chronic migraine in spain?? Results of a cost-effectiveness analysis. J Headache Pain 25:40. https:\/\/doi.org\/10.1186\/s10194-024-01747-w","journal-title":"J Headache Pain"},{"key":"8327_CR9","doi-asserted-by":"publisher","first-page":"979","DOI":"10.1007\/s40261-019-00827-z","volume":"39","author":"TV Giannouchos","year":"2019","unstructured":"Giannouchos TV, Mitsikostas DD, Ohsfeldt RL, Vozikis A, Koufopoulou P (2019) Cost-Effectiveness analysis of erenumab versus OnabotulinumtoxinA for patients with chronic migraine attacks in Greece. Clin Drug Investig 39:979\u2013990. https:\/\/doi.org\/10.1007\/s40261-019-00827-z","journal-title":"Clin Drug Investig"},{"key":"8327_CR10","doi-asserted-by":"publisher","first-page":"1644","DOI":"10.1177\/0333102418796842","volume":"38","author":"M Sussman","year":"2018","unstructured":"Sussman M, Benner J, Neumann P, Menzin J (2018) Cost-effectiveness analysis of erenumab for the preventive treatment of episodic and chronic migraine: results from the US societal and payer perspectives. Cephalalgia 38:1644\u20131657. https:\/\/doi.org\/10.1177\/0333102418796842","journal-title":"Cephalalgia"},{"key":"8327_CR11","doi-asserted-by":"publisher","first-page":"78","DOI":"10.1007\/s11916-021-00993-w","volume":"25","author":"RG Rastogi","year":"2021","unstructured":"Rastogi RG, Arnold TL, Borrero-Mejias C et al (2021) Non-pharmacologic and Mindful-Based approaches for pediatric headache disorders: a review. Curr Pain Headache Rep 25:78. https:\/\/doi.org\/10.1007\/s11916-021-00993-w","journal-title":"Curr Pain Headache Rep"},{"key":"8327_CR12","doi-asserted-by":"publisher","first-page":"66","DOI":"10.1007\/s11916-020-00899-z","volume":"24","author":"D Vekhter","year":"2020","unstructured":"Vekhter D, Robbins MS, Minen M, Buse DC (2020) Efficacy and feasibility of behavioral treatments for migraine, headache, and pain in the acute care setting. Curr Pain Headache Rep 24:66. https:\/\/doi.org\/10.1007\/s11916-020-00899-z","journal-title":"Curr Pain Headache Rep"},{"key":"8327_CR13","doi-asserted-by":"publisher","first-page":"459","DOI":"10.1186\/s12913-020-05172-y","volume":"20","author":"C Perlini","year":"2020","unstructured":"Perlini C, Donisi V, Del Piccolo L (2020) From research to clinical practice: a systematic review of the implementation of psychological interventions for chronic headache in adults. BMC Health Serv Res 20:459. https:\/\/doi.org\/10.1186\/s12913-020-05172-y","journal-title":"BMC Health Serv Res"},{"key":"8327_CR14","doi-asserted-by":"publisher","first-page":"103862","DOI":"10.1016\/j.amsu.2022.103862","volume":"78","author":"M Aemaz Ur Rehman","year":"2022","unstructured":"Aemaz Ur Rehman M, Waseem R, Habiba U et al (2022) Efficacy of mindfulness-based intervention for the treatment of chronic headaches: A systematic review and meta-analysis. Ann Med Surg (Lond) 78:103862. https:\/\/doi.org\/10.1016\/j.amsu.2022.103862","journal-title":"Ann Med Surg (Lond)"},{"key":"8327_CR15","doi-asserted-by":"publisher","first-page":"1192","DOI":"10.1177\/0333102416667023","volume":"36","author":"F Andrasik","year":"2016","unstructured":"Andrasik F, Grazzi L, D\u2019Amico D et al (2016) Mindfulness and headache: A new old treatment, with new findings. Cephalalgia 36:1192\u20131205. https:\/\/doi.org\/10.1177\/0333102416667023","journal-title":"Cephalalgia"},{"key":"8327_CR16","doi-asserted-by":"publisher","first-page":"86","DOI":"10.1186\/s10194-023-01630-0","volume":"24","author":"L Grazzi","year":"2023","unstructured":"Grazzi L, D\u2019Amico D, Guastafierro E et al (2023) Efficacy of mindfulness added to treatment as usual in patients with chronic migraine and medication overuse headache: a phase-III single-blind randomized-controlled trial (the MIND-CM study). J Headache Pain 24:86. https:\/\/doi.org\/10.1186\/s10194-023-01630-0","journal-title":"J Headache Pain"},{"key":"8327_CR17","doi-asserted-by":"publisher","unstructured":"Headache Classification Committee of the International Headache Society (IHS) (2018) The International Classification of Headache Disorders, 3rd edition. Cephalalgia. 38:1-211. https:\/\/doi.org\/10.1177\/0333102417738202","DOI":"10.1177\/0333102417738202"},{"key":"8327_CR18","doi-asserted-by":"publisher","first-page":"62","DOI":"10.1111\/ene.14034","volume":"27","author":"A Raggi","year":"2020","unstructured":"Raggi A, Leonardi M, Sansone E, Curone M, Grazzi L, D\u2019Amico D (2020) The cost and the value of treatment of medication overuse headache in italy: a longitudinal study based on patient-derived data. Eur J Neurol 27:62\u2013e1. https:\/\/doi.org\/10.1111\/ene.14034","journal-title":"Eur J Neurol"},{"key":"8327_CR19","unstructured":"Federfarma (2025) https:\/\/www.federfarma.it\/Farmaci-e-farmacie\/Cerca-un-farmaco.aspx Accessed 28 January 2025"},{"key":"8327_CR20","doi-asserted-by":"publisher","DOI":"10.1016\/j.euroneuro.2011.08.008","author":"A Gustavsson","year":"2011","unstructured":"Gustavsson A, Svensson M, Jacobi F et al (2011) Cost of disorders of the brain in Europe 2010. Eur Neuropsychopharmacol. https:\/\/doi.org\/10.1016\/j.euroneuro.2011.08.008. 21:718\u2013\u200979","journal-title":"Eur Neuropsychopharmacol"},{"key":"8327_CR21","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468-1331.2011.03590.x","author":"J Olesen","year":"2012","unstructured":"Olesen J, Gustavsson A, Svensson M et al (2012) The economic cost of brain disorders in Europe. Eur J Neurol. https:\/\/doi.org\/10.1111\/j.1468-1331.2011.03590.x. 19:155\u2013\u200962","journal-title":"Eur J Neurol"},{"key":"8327_CR22","volume-title":"Statistical power analysis for the behavioural sciences","author":"J Cohen","year":"1969","unstructured":"Cohen J (1969) Statistical power analysis for the behavioural sciences. Academic, New York"},{"key":"8327_CR23","unstructured":"Regione Lombardia (2022) Nomenclatore tariffario di specialistica ambulatoriale - dicembre 2022 aggiornamento Accessed 28 January 2025) https:\/\/www.regione.lombardia.it\/wps\/portal\/istituzionale\/HP\/servizi-e-informazioni\/enti-e-operatori\/sistema-welfare\/normativa-e-documenti-welfare"},{"issue":"4","key":"8327_CR24","doi-asserted-by":"publisher","first-page":"631","DOI":"10.1016\/j.ncl.2019.06.001","volume":"37","author":"RC Burch","year":"2019","unstructured":"Burch RC, Buse DC, Lipton RB (2019) Migraine: epidemiology, burden, and comorbidity. Neurol Clin 37(4):631\u2013649. https:\/\/doi.org\/10.1016\/j.ncl.2019.06.001","journal-title":"Neurol Clin"},{"issue":"1","key":"8327_CR25","doi-asserted-by":"publisher","first-page":"40","DOI":"10.1186\/1129-2377-14-40","volume":"14","author":"SH Schramm","year":"2013","unstructured":"Schramm SH, Obermann M, Katsarava Z, Diener HC, Moebus S, Yoon MS (2013) Epidemiological profiles of patients with chronic migraine and chronic tension-type headache. J Headache Pain 14(1):40. https:\/\/doi.org\/10.1186\/1129-2377-14-40","journal-title":"J Headache Pain"},{"key":"8327_CR26","doi-asserted-by":"publisher","first-page":"635","DOI":"10.1080\/03007995.2024.2316864","volume":"40","author":"OJ Varnado","year":"2024","unstructured":"Varnado OJ, Vu M, Buysman EK et al (2024) Treatment patterns of galcanezumab versus standard of care preventive migraine medications over 24 months: a US retrospective claims study. Curr Med Res Opin 40:635\u2013646. https:\/\/doi.org\/10.1080\/03007995.2024.2316864","journal-title":"Curr Med Res Opin"},{"key":"8327_CR27","doi-asserted-by":"publisher","first-page":"5","DOI":"10.1186\/s10194-022-01536-3","volume":"24","author":"E Troy","year":"2023","unstructured":"Troy E, Shrukalla AA, Buture A et al (2023) Medium-term real-world data for erenumab in 177 treatment resistant or difficult to treat chronic migraine patients: persistence and patient reported outcome measures after 17\u201330 months. J Headache Pain 24:5. https:\/\/doi.org\/10.1186\/s10194-022-01536-3","journal-title":"J Headache Pain"},{"key":"8327_CR28","doi-asserted-by":"publisher","first-page":"170","DOI":"10.1007\/s00415-025-12911-w","volume":"272","author":"P Barbanti","year":"2025","unstructured":"Barbanti P, Aurilia C, Torelli P et al (2025) Three-year treatment with anti-CGRP monoclonal antibodies modifies migraine course: the prospective, multicenter I-GRAINE study. J Neurol 272:170. https:\/\/doi.org\/10.1007\/s00415-025-12911-w","journal-title":"J Neurol"},{"key":"8327_CR29","doi-asserted-by":"publisher","first-page":"2605","DOI":"10.1007\/s00415-024-12192-9","volume":"271","author":"P Barbanti","year":"2024","unstructured":"Barbanti P, Aurilia C, Egeo G et al (2024) Impact of multiple treatment cycles with anti-CGRP monoclonal antibodies on migraine course: focus on discontinuation periods. Insights from the multicenter, prospective, I-GRAINE study. J Neurol 271:2605\u20132614. https:\/\/doi.org\/10.1007\/s00415-024-12192-9","journal-title":"J Neurol"},{"key":"8327_CR30","doi-asserted-by":"publisher","first-page":"477","DOI":"10.1080\/14737175.2024.2332754","volume":"24","author":"S Alabbad","year":"2024","unstructured":"Alabbad S, Figueredo N, Yuan H, Silberstein S (2024) Developments in targeting calcitonin gene-related peptide. Expert Rev Neurother 24:477\u2013485. https:\/\/doi.org\/10.1080\/14737175.2024.2332754","journal-title":"Expert Rev Neurother"},{"key":"8327_CR31","doi-asserted-by":"publisher","first-page":"743","DOI":"10.1007\/s11916-024-01259-x","volume":"28","author":"S Cho","year":"2024","unstructured":"Cho S, Kim BK (2024) Long-Term outcome after discontinuation of CGRP-Targeting therapy for migraine. Curr Pain Headache Rep 28:743\u2013751. https:\/\/doi.org\/10.1007\/s11916-024-01259-x","journal-title":"Curr Pain Headache Rep"},{"key":"8327_CR32","doi-asserted-by":"publisher","first-page":"60","DOI":"10.1186\/s10194-019-1009-9","volume":"20","author":"P Martelletti","year":"2019","unstructured":"Martelletti P, Edvinsson L, Ashina M (2019) Shaping the future of migraine targeting Calcitonin-Gene-Related-Peptide with the Disease-Modifying migraine drugs (DMMDs). J Headache Pain 20:60. https:\/\/doi.org\/10.1186\/s10194-019-1009-9","journal-title":"J Headache Pain"},{"key":"8327_CR33","doi-asserted-by":"publisher","first-page":"394","DOI":"10.1186\/s12883-022-02914-9","volume":"22","author":"P Pozo-Rosich","year":"2022","unstructured":"Pozo-Rosich P, Dodick DW, Ettrup A, Hirman J, Cady R (2022) Shift in diagnostic classification of migraine after initiation of preventive treatment with eptinezumab: post hoc analysis of the PROMISE studies. BMC Neurol 22:394. https:\/\/doi.org\/10.1186\/s12883-022-02914-9","journal-title":"BMC Neurol"},{"key":"8327_CR34","doi-asserted-by":"publisher","first-page":"744796","DOI":"10.3389\/fneur.2021.744796","volume":"12","author":"V Grozeva","year":"2021","unstructured":"Grozeva V, M\u00ednguez-Olaondo A, Vila-Pueyo M (2021) Experiment in vivo: how COVID-19 lifestyle modifications affect migraine. Front Neurol 12:744796. https:\/\/doi.org\/10.3389\/fneur.2021.744796","journal-title":"Front Neurol"},{"key":"8327_CR35","doi-asserted-by":"publisher","first-page":"41","DOI":"10.1186\/s10194-022-01400-4","volume":"23","author":"M Castaldo","year":"2022","unstructured":"Castaldo M, Waliszewska-Pros\u00f3\u0142 M, Koutsokera M et al (2022) Headache onset after vaccination against SARS-CoV-2: a systematic literature review and meta-analysis. J Headache Pain 23:41. https:\/\/doi.org\/10.1186\/s10194-022-01400-4","journal-title":"J Headache Pain"},{"key":"8327_CR36","doi-asserted-by":"publisher","first-page":"93","DOI":"10.1186\/s10194-022-01450-8","volume":"23","author":"C Tana","year":"2022","unstructured":"Tana C, Bentivegna E, Cho SJ et al (2022) Long COVID headache. J Headache Pain 23:93. https:\/\/doi.org\/10.1186\/s10194-022-01450-8","journal-title":"J Headache Pain"},{"key":"8327_CR37","doi-asserted-by":"publisher","first-page":"195","DOI":"10.1038\/s41582-021-00475-y","volume":"17","author":"L Grazzi","year":"2021","unstructured":"Grazzi L, Rizzoli P (2021) Lessons from lockdown - behavioural interventions in migraine. Nat Rev Neurol 17:195\u2013196. https:\/\/doi.org\/10.1038\/s41582-021-00475-y","journal-title":"Nat Rev Neurol"},{"key":"8327_CR38","doi-asserted-by":"publisher","first-page":"140","DOI":"10.1186\/s10194-023-01666-2","volume":"24","author":"P Martelletti","year":"2023","unstructured":"Martelletti P, Leonardi M, Ashina M et al (2023) Rethinking headache as a global public health case model for reaching the SDG 3 HEALTH by 2030. J Headache Pain 24:140. https:\/\/doi.org\/10.1186\/s10194-023-01666-2","journal-title":"J Headache Pain"}],"container-title":["Neurological Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10072-025-08327-z.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s10072-025-08327-z\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10072-025-08327-z.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T03:11:38Z","timestamp":1759288298000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s10072-025-08327-z"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,6,25]]},"references-count":38,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2025,10]]}},"alternative-id":["8327"],"URL":"https:\/\/doi.org\/10.1007\/s10072-025-08327-z","relation":{},"ISSN":["1590-1874","1590-3478"],"issn-type":[{"type":"print","value":"1590-1874"},{"type":"electronic","value":"1590-3478"}],"subject":[],"published":{"date-parts":[[2025,6,25]]},"assertion":[{"value":"20 March 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"21 June 2025","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"25 June 2025","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The study was approved by the Ethical Committee of the Besta Institute (approval no. 51\/2018).","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval"}},{"value":"The authors declare no competing interests.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}]}}