{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T16:11:01Z","timestamp":1759335061307,"version":"build-2065373602"},"reference-count":39,"publisher":"Springer Science and Business Media LLC","issue":"10","license":[{"start":{"date-parts":[[2025,7,11]],"date-time":"2025-07-11T00:00:00Z","timestamp":1752192000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2025,7,11]],"date-time":"2025-07-11T00:00:00Z","timestamp":1752192000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Neurol Sci"],"published-print":{"date-parts":[[2025,10]]},"DOI":"10.1007\/s10072-025-08351-z","type":"journal-article","created":{"date-parts":[[2025,7,11]],"date-time":"2025-07-11T03:39:52Z","timestamp":1752205192000},"page":"4943-4953","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Prevalence of neurological manifestation in familial mediterranean fever patients: systematic review &amp; meta-analysis"],"prefix":"10.1007","volume":"46","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2175-1597","authenticated-orcid":false,"given":"Mohammad","family":"Hamad","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-9576-3896","authenticated-orcid":false,"given":"Tala","family":"Mohammad","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-3729-3924","authenticated-orcid":false,"given":"Mira","family":"Bishtawi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-3849-9981","authenticated-orcid":false,"given":"Randa","family":"Shahwan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6488-4664","authenticated-orcid":false,"given":"Jaber H.","family":"Jaradat","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0466-933X","authenticated-orcid":false,"given":"Wafa\u2019 A.","family":"Hazaymeh","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Omar F.","family":"Jbarah","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ethar","family":"Hazaimeh","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2025,7,11]]},"reference":[{"key":"8351_CR1","doi-asserted-by":"publisher","first-page":"1591","DOI":"10.3906\/sag-2008-11","volume":"50","author":"A TUFAN","year":"2020","unstructured":"TUFAN A, LACHMANN HJ (2020) Familial mediterranean fever, from pathogenesis to treatment: a contemporary review. Turk J Med Sci 50:1591\u20131610. https:\/\/doi.org\/10.3906\/sag-2008-11","journal-title":"Turk J Med Sci"},{"key":"8351_CR2","doi-asserted-by":"publisher","first-page":"9584","DOI":"10.3390\/ijms24119584","volume":"24","author":"M Lancieri","year":"2023","unstructured":"Lancieri M, Bustaffa M, Palmeri S et al (2023) An update on Familial mediterranean fever. Int J Mol Sci 24:9584. https:\/\/doi.org\/10.3390\/ijms24119584","journal-title":"Int J Mol Sci"},{"key":"8351_CR3","doi-asserted-by":"publisher","first-page":"e61","DOI":"10.1016\/j.lpm.2018.08.014","volume":"48","author":"H Ozdogan","year":"2019","unstructured":"Ozdogan H, Ugurlu S (2019) Familial mediterranean fever. Presse Med 48:e61\u2013e76. https:\/\/doi.org\/10.1016\/j.lpm.2018.08.014","journal-title":"Presse Med"},{"key":"8351_CR4","doi-asserted-by":"publisher","first-page":"511","DOI":"10.5152\/TURKARCHPEDIATR.2022.21368","volume":"57","author":"PC Bekta\u015f","year":"2022","unstructured":"Bekta\u015f PC, Tufan AK, \u00c7etin N et al (2022) Neurological face of Familial mediterranean fever. Turkish Archives Pediatr 57:511\u2013515. https:\/\/doi.org\/10.5152\/TURKARCHPEDIATR.2022.21368","journal-title":"Turkish Archives Pediatr"},{"key":"8351_CR5","doi-asserted-by":"publisher","first-page":"473","DOI":"10.1038\/sj.ejhg.5200658","volume":"9","author":"I Touitou","year":"2001","unstructured":"Touitou I (2001) The spectrum of Familial mediterranean fever (FMF) mutations. Eur J Hum Genet 9:473\u2013483. https:\/\/doi.org\/10.1038\/sj.ejhg.5200658","journal-title":"Eur J Hum Genet"},{"key":"8351_CR6","doi-asserted-by":"publisher","first-page":"97","DOI":"10.14712\/18059694.2014.47","volume":"57","author":"A Kucuk","year":"2014","unstructured":"Kucuk A, Gezer IA, Ucar R, Karahan AY (2014) Familial mediterranean fever. Acta medica (Hradec Kralove. Czech Republic) 57:97\u2013104. https:\/\/doi.org\/10.14712\/18059694.2014.47","journal-title":"Czech Republic)"},{"key":"8351_CR7","doi-asserted-by":"publisher","first-page":"50","DOI":"10.1038\/sj.ejhg.5200916","volume":"11","author":"M La Regina","year":"2003","unstructured":"La Regina M, Nucera G, Diaco M et al (2003) Familial mediterranean fever is no longer a rare disease in Italy. Eur J Hum Genet 11:50\u201356. https:\/\/doi.org\/10.1038\/sj.ejhg.5200916","journal-title":"Eur J Hum Genet"},{"key":"8351_CR8","doi-asserted-by":"publisher","first-page":"446","DOI":"10.1016\/j.semarthrit.2019.05.002","volume":"49","author":"Y Hua","year":"2019","unstructured":"Hua Y, Wu D, Shen M et al (2019) Phenotypes and genotypes of Chinese adult patients with systemic autoinflammatory diseases. Semin Arthritis Rheum 49:446\u2013452. https:\/\/doi.org\/10.1016\/j.semarthrit.2019.05.002","journal-title":"Semin Arthritis Rheum"},{"key":"8351_CR9","doi-asserted-by":"publisher","first-page":"1447","DOI":"10.1002\/art.24458","volume":"61","author":"E Ben-Chetrit","year":"2009","unstructured":"Ben-Chetrit E, Touitou I (2009) Familial mediterranean fever in the world. Arthritis Care Res 61:1447\u20131453. https:\/\/doi.org\/10.1002\/art.24458","journal-title":"Arthritis Care Res"},{"key":"8351_CR10","doi-asserted-by":"publisher","unstructured":"Migita K, Izumi Y, Jiuchi Y et al (2016) Familial mediterranean fever is no longer a rare disease in Japan. Arthritis Res Therapy 18. https:\/\/doi.org\/10.1186\/s13075-016-1071-5","DOI":"10.1186\/s13075-016-1071-5"},{"key":"8351_CR11","doi-asserted-by":"publisher","first-page":"1372","DOI":"10.1093\/rheumatology\/kez410","volume":"59","author":"B Balc\u0131-Peynircio\u011flu","year":"2019","unstructured":"Balc\u0131-Peynircio\u011flu B, Kaya-Ak\u00e7a \u00dc, Ar\u0131c\u0131 ZS et al (2019) Comorbidities in Familial mediterranean fever: analysis of 2000 genetically confirmed patients. Rheumatology 59:1372\u20131380. https:\/\/doi.org\/10.1093\/rheumatology\/kez410","journal-title":"Rheumatology"},{"key":"8351_CR12","doi-asserted-by":"publisher","first-page":"1049","DOI":"10.3390\/medicina57101049","volume":"57","author":"R Siligato","year":"2021","unstructured":"Siligato R, Gembillo G, Calabrese V et al (2021) Amyloidosis and glomerular diseases in Familial mediterranean fever. Med (B Aires) 57:1049. https:\/\/doi.org\/10.3390\/medicina57101049","journal-title":"Med (B Aires)"},{"key":"8351_CR13","doi-asserted-by":"publisher","first-page":"60","DOI":"10.1111\/j.1368-504x.2005.00290.x","volume":"59","author":"I Karachaliou","year":"2005","unstructured":"Karachaliou I, Karachalios G, Charalabopoulos A, Charalabopoulos K (2005) Meningitis associated with Familial mediterranean fever: meningitis and Familial mediterranean fever. Int J Clin Pract 59:60\u201361. https:\/\/doi.org\/10.1111\/j.1368-504x.2005.00290.x","journal-title":"Int J Clin Pract"},{"key":"8351_CR14","doi-asserted-by":"publisher","first-page":"1146","DOI":"10.1111\/j.1468-1331.2011.03356.x","volume":"18","author":"G Yahalom","year":"2011","unstructured":"Yahalom G, Kivity S, Lidar M et al (2011) Familial mediterranean fever (FMF) and multiple sclerosis: an association study in one of the world\u2019s largest FMF cohorts: MS in FMF. Eur J Neurol 18:1146\u20131150. https:\/\/doi.org\/10.1111\/j.1468-1331.2011.03356.x","journal-title":"Eur J Neurol"},{"key":"8351_CR15","doi-asserted-by":"publisher","first-page":"256","DOI":"10.5606\/archrheumatol.2015.5606","volume":"30","author":"F \u0130ncecik","year":"2015","unstructured":"\u0130ncecik F (2015) Pseudotumor cerebri in a child with Familial mediterranean fever. Arch Rheumatol 30:256\u2013258. https:\/\/doi.org\/10.5606\/archrheumatol.2015.5606","journal-title":"Arch Rheumatol"},{"key":"8351_CR16","doi-asserted-by":"publisher","first-page":"1007","DOI":"10.1007\/s40120-023-00457-w","volume":"12","author":"A Motahharynia","year":"2023","unstructured":"Motahharynia A, Alavi Tabatabaei G, Sarrafi R et al (2023) Familial mediterranean fever and transverse myelitis: A causal relation?? Neurol Ther 12:1007\u20131013. https:\/\/doi.org\/10.1007\/s40120-023-00457-w","journal-title":"Neurol Ther"},{"key":"8351_CR17","doi-asserted-by":"publisher","first-page":"29","DOI":"10.1007\/s00296-019-04443-0","volume":"40","author":"H Bodur","year":"2019","unstructured":"Bodur H, Yurdakul FG, \u00c7ay HF et al (2019) Familial mediterranean fever: assessment of clinical manifestations, pregnancy, genetic mutational analyses, and disease severity in a National cohort. Rheumatol Int 40:29\u201340. https:\/\/doi.org\/10.1007\/s00296-019-04443-0","journal-title":"Rheumatol Int"},{"key":"8351_CR18","doi-asserted-by":"crossref","unstructured":"Munn Z, Barker T, Moola S et al Methodological quality of case series studies: an introduction to the JBI critical appraisal tool. journals.lww.comZ Munn, TH Barker, S Moola, C Tufanaru, C Stern, A McArthur, M Stephenson, E AromatarisJBI evidence synthesis, 2020\u2022journals.lww.com","DOI":"10.11124\/JBISRIR-D-19-00099"},{"key":"8351_CR19","doi-asserted-by":"publisher","first-page":"153","DOI":"10.1136\/EBMENTAL-2019-300117","volume":"22","author":"S Balduzzi","year":"2019","unstructured":"Balduzzi S, R\u00fccker G, Schwarzer G (2019) How to perform a meta-analysis with R: A practical tutorial. Evid Based Ment Health 22:153\u2013160. https:\/\/doi.org\/10.1136\/EBMENTAL-2019-300117","journal-title":"Evid Based Ment Health"},{"key":"8351_CR20","doi-asserted-by":"publisher","first-page":"363","DOI":"10.1002\/JRSM.1547","volume":"13","author":"CB Migliavaca","year":"2022","unstructured":"Migliavaca CB, Stein C, Colpani V et al (2022) Meta-analysis of prevalence: I2 statistic and how to deal with heterogeneity. Res Synth Methods 13:363\u2013367. https:\/\/doi.org\/10.1002\/JRSM.1547","journal-title":"Res Synth Methods"},{"key":"8351_CR21","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/S12874-021-01381-Z\/FIGURES\/5","volume":"21","author":"TH Barker","year":"2021","unstructured":"Barker TH, Migliavaca CB, Stein C et al (2021) Conducting proportional meta-analysis in different types of systematic reviews: a guide for synthesisers of evidence. BMC Med Res Methodol 21:1\u20139. https:\/\/doi.org\/10.1186\/S12874-021-01381-Z\/FIGURES\/5","journal-title":"BMC Med Res Methodol"},{"key":"8351_CR22","doi-asserted-by":"publisher","unstructured":"Lin L, Xu C (2020) Arcsine-based transformations for meta-analysis of proportions: pros, cons, and alternatives. Health Sci Rep 3. https:\/\/doi.org\/10.1002\/HSR2.178","DOI":"10.1002\/HSR2.178"},{"key":"8351_CR23","doi-asserted-by":"publisher","first-page":"1539","DOI":"10.1002\/SIM.1186","volume":"21","author":"JPT Higgins","year":"2002","unstructured":"Higgins JPT, Thompson SG (2002) Quantifying heterogeneity in a meta-analysis. Stat Med 21:1539\u20131558. https:\/\/doi.org\/10.1002\/SIM.1186","journal-title":"Stat Med"},{"key":"8351_CR24","doi-asserted-by":"publisher","unstructured":"Egger M, Smith GD, Altman DG (2008) Systematic Reviews in Health Care: Meta-Analysis in Context: Second Edition. Systematic Reviews in Health Care: Meta-Analysis in Context: Second Edition 1\u2013487. https:\/\/doi.org\/10.1002\/9780470693926","DOI":"10.1002\/9780470693926"},{"key":"8351_CR25","doi-asserted-by":"publisher","first-page":"079","DOI":"10.1055\/s-0036-1593374","volume":"48","author":"M Canpolat","year":"2017","unstructured":"Canpolat M, Gumus H, Gunduz Z et al (2017) Neurological manifestations in Familial mediterranean fever: results of 22 children from a reference center in kayseri, an urban area in central anatolia, Turkey. Neuropediatrics 48:079\u2013085. https:\/\/doi.org\/10.1055\/s-0036-1593374","journal-title":"Neuropediatrics"},{"key":"8351_CR26","doi-asserted-by":"publisher","first-page":"15","DOI":"10.2147\/OARRR.S238649","volume":"12","author":"F Salehzadeh","year":"2020","unstructured":"Salehzadeh F, Azami A, Motezarre M et al (2020) Neurological manifestations in Familial mediterranean fever: A genotype-phenotype correlation study. Open Access Rheumatol 12:15\u201319. https:\/\/doi.org\/10.2147\/OARRR.S238649","journal-title":"Open Access Rheumatol"},{"key":"8351_CR27","doi-asserted-by":"publisher","first-page":"973","DOI":"10.1007\/s00431-021-04286-7","volume":"181","author":"O Biro","year":"2021","unstructured":"Biro O, Gileles-Hillel A, Dor-Wollman T et al (2021) Neurological and neurodevelopmental symptoms in children with Familial mediterranean fever and their siblings. Eur J Pediatr 181:973\u2013978. https:\/\/doi.org\/10.1007\/s00431-021-04286-7","journal-title":"Eur J Pediatr"},{"key":"8351_CR28","doi-asserted-by":"publisher","first-page":"e2269","DOI":"10.1212\/WNL.0000000000012930","volume":"97","author":"S Misra","year":"2021","unstructured":"Misra S, Kolappa K, Prasad M et al (2021) Frequency of neurologic manifestations in COVID-19: A systematic review and Meta-analysis. Neurology 97:e2269. https:\/\/doi.org\/10.1212\/WNL.0000000000012930","journal-title":"Neurology"},{"key":"8351_CR29","doi-asserted-by":"publisher","first-page":"788","DOI":"10.1002\/mus.26877","volume":"61","author":"ME Kloosterziel","year":"2020","unstructured":"Kloosterziel ME, Tavy DLJ, Arends S et al (2020) Meralgia paresthetica: nerve stimulator-guided injection with methylprednisolone\/lidocaine, a double\u2010blind randomized placebo\u2010controlled study. Muscle Nerve 61:788\u2013791. https:\/\/doi.org\/10.1002\/mus.26877","journal-title":"Muscle Nerve"},{"key":"8351_CR30","doi-asserted-by":"publisher","first-page":"77","DOI":"10.1016\/j.clineuro.2004.11.013","volume":"108","author":"G Bademci","year":"2005","unstructured":"Bademci G, Erdemoglu AK, Evliyaoglu C et al (2005) Bilateral carpal tunnel syndrome associated to Familial mediterranean fever. Clin Neurol Neurosurg 108:77\u201379. https:\/\/doi.org\/10.1016\/j.clineuro.2004.11.013","journal-title":"Clin Neurol Neurosurg"},{"key":"8351_CR31","doi-asserted-by":"publisher","first-page":"417","DOI":"10.1016\/j.pediatrneurol.2013.07.010","volume":"49","author":"S I\u015fikay","year":"2013","unstructured":"I\u015fikay S, Yilmaz K, Yi\u01e7iter R et al (2013) Colchicine treatment in children with Familial mediterranean fever: is it a risk factor for neuromyopathy? Pediatr Neurol 49:417\u2013419. https:\/\/doi.org\/10.1016\/j.pediatrneurol.2013.07.010","journal-title":"Pediatr Neurol"},{"key":"8351_CR32","doi-asserted-by":"publisher","first-page":"152150","DOI":"10.1016\/J.SEMARTHRIT.2022.152150","volume":"58","author":"T McEwan","year":"2023","unstructured":"McEwan T, Bhambra J, Liew DF, Robinson PC (2023) Systematic review of Colchicine neuromyopathy: risk factors, duration and resolution. Semin Arthritis Rheum 58:152150. https:\/\/doi.org\/10.1016\/J.SEMARTHRIT.2022.152150","journal-title":"Semin Arthritis Rheum"},{"key":"8351_CR33","doi-asserted-by":"publisher","first-page":"75","DOI":"10.1097\/md.0b013e3181d5dca7","volume":"89","author":"U Kalyoncu","year":"2010","unstructured":"Kalyoncu U, Eker A, Oguz KK et al (2010) Familial mediterranean fever and central nervous system involvement: A case series. Medicine 89:75\u201384. https:\/\/doi.org\/10.1097\/md.0b013e3181d5dca7","journal-title":"Medicine"},{"key":"8351_CR34","doi-asserted-by":"publisher","first-page":"717","DOI":"10.1016\/j.mehy.2012.02.017","volume":"78","author":"M Alpayci","year":"2012","unstructured":"Alpayci M, Bozan N, Erdem S et al (2012) The possible underlying pathophysiological mechanisms for development of multiple sclerosis in Familial mediterranean fever. Med Hypotheses 78:717\u2013720. https:\/\/doi.org\/10.1016\/j.mehy.2012.02.017","journal-title":"Med Hypotheses"},{"key":"8351_CR35","doi-asserted-by":"publisher","first-page":"591395","DOI":"10.3389\/fneur.2020.591395","volume":"11","author":"M Pozzato","year":"2021","unstructured":"Pozzato M, Micaglio E, Starvaggi Cucuzza C et al (2021) Case report: efficacy of rituximab in a patient with Familial mediterranean fever and multiple sclerosis. Front Neurol 11:591395. https:\/\/doi.org\/10.3389\/fneur.2020.591395","journal-title":"Front Neurol"},{"key":"8351_CR36","doi-asserted-by":"publisher","first-page":"973","DOI":"10.1007\/S00431-021-04286-7\/METRICS","volume":"181","author":"O Biro","year":"2022","unstructured":"Biro O, Gileles-Hillel A, Dor-Wollman T et al (2022) Neurological and neurodevelopmental symptoms in children with Familial mediterranean fever and their siblings. Eur J Pediatr 181:973\u2013978. https:\/\/doi.org\/10.1007\/S00431-021-04286-7\/METRICS","journal-title":"Eur J Pediatr"},{"key":"8351_CR37","doi-asserted-by":"publisher","first-page":"422","DOI":"10.1093\/mr\/roab009","volume":"32","author":"E Lavi","year":"2021","unstructured":"Lavi E, Maree A, Eisenstein EM et al (2021) Increased prevalence of attention-deficit hyperactivity disorder symptomatology in patients with Familial mediterranean fever. Mod Rheumatol 32:422\u2013426. https:\/\/doi.org\/10.1093\/mr\/roab009","journal-title":"Mod Rheumatol"},{"key":"8351_CR38","doi-asserted-by":"publisher","first-page":"12","DOI":"10.1016\/j.psyneuen.2012.09.017","volume":"38","author":"A Buske-Kirschbaum","year":"2013","unstructured":"Buske-Kirschbaum A, Schmitt J, Plessow F et al (2013) Psychoendocrine and psychoneuroimmunological mechanisms in the comorbidity of atopic eczema and attention deficit\/hyperactivity disorder. Psychoneuroendocrinology 38:12\u201323. https:\/\/doi.org\/10.1016\/j.psyneuen.2012.09.017","journal-title":"Psychoneuroendocrinology"},{"key":"8351_CR39","doi-asserted-by":"publisher","first-page":"e0142233","DOI":"10.1371\/journal.pone.0142233","volume":"10","author":"CM Faggion Jr","year":"2015","unstructured":"Faggion CM Jr, Wu Y-C, Scheidgen M, Tu Y-K (2015) Correction: effect of risk of Bias on the effect size of Meta-Analytic estimates in randomized controlled trials in periodontology and implant dentistry. PLoS ONE 10:e0142233\u2013e0142233. https:\/\/doi.org\/10.1371\/journal.pone.0142233","journal-title":"PLoS ONE"}],"container-title":["Neurological Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10072-025-08351-z.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s10072-025-08351-z\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10072-025-08351-z.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T03:16:55Z","timestamp":1759288615000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s10072-025-08351-z"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,7,11]]},"references-count":39,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2025,10]]}},"alternative-id":["8351"],"URL":"https:\/\/doi.org\/10.1007\/s10072-025-08351-z","relation":{},"ISSN":["1590-1874","1590-3478"],"issn-type":[{"type":"print","value":"1590-1874"},{"type":"electronic","value":"1590-3478"}],"subject":[],"published":{"date-parts":[[2025,7,11]]},"assertion":[{"value":"15 July 2024","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"1 July 2025","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"11 July 2025","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"Not applicable","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"The authors declare No conflict of interest.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}]}}