{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,29]],"date-time":"2026-10-29T11:01:54Z","timestamp":1793271714390,"version":"4.5.0"},"reference-count":11,"publisher":"Springer Science and Business Media LLC","issue":"11","license":[{"start":{"date-parts":[[2025,9,16]],"date-time":"2025-09-16T00:00:00Z","timestamp":1757980800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2025,9,16]],"date-time":"2025-09-16T00:00:00Z","timestamp":1757980800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Neurol Sci"],"published-print":{"date-parts":[[2025,11]]},"abstract":"<jats:title>Abstract<\/jats:title>\n          <jats:sec>\n            <jats:title>Background<\/jats:title>\n            <jats:p>Myopia has been reported as a rare adverse effect of aripiprazole, a third-generation antidopaminergic medication used for the treatment of different neuropsychiatric conditions, including psychotic disorders, affective disorders, and obsessive-compulsive disorder.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Case description<\/jats:title>\n            <jats:p>We document the rare case of a 29-year-old woman diagnosed with a neurodevelopmental tic disorder (Tourette syndrome) who developed bilateral myopia while taking aripiprazole 15\u00a0mg daily as a first-line anti-tic agent. Her myopia completely regressed following a decrease in the dose of aripiprazole from 15\u00a0mg to 10\u00a0mg daily.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Discussion<\/jats:title>\n            <jats:p>To date, a total of 11 cases presenting with aripiprazole-induced reversible myopia (9 females, age range 19\u201334 years) have been reported. In addition to broadening the spectrum of the treated conditions, our case report raises the possibility of dose-dependent mechanisms underlying the development of myopia, at least in selected cases.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1007\/s10072-025-08496-x","type":"journal-article","created":{"date-parts":[[2025,9,16]],"date-time":"2025-09-16T00:20:26Z","timestamp":1757982026000},"page":"6027-6030","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Aripiprazole-induced reversible myopia in a patient with tourette syndrome"],"prefix":"10.1007","volume":"46","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0925-1255","authenticated-orcid":false,"given":"Andrea E.","family":"Cavanna","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elisa","family":"Capriolo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Virginia","family":"Caimi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gabriele","family":"Arienti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna","family":"Riva","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Renata","family":"Nacinovich","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefano","family":"Seri","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,9,16]]},"reference":[{"key":"8496_CR1","doi-asserted-by":"publisher","first-page":"57","DOI":"10.14744\/bej.2020.71677","volume":"5","author":"Y Bulgu","year":"2020","unstructured":"Bulgu Y, Genc S (2020) Aripiprazole-induced acute transient bilateral myopia: a case report. Balkan Med J 5:57\u201358. https:\/\/doi.org\/10.14744\/bej.2020.71677","journal-title":"Balkan Med J"},{"key":"8496_CR2","doi-asserted-by":"publisher","DOI":"10.1097\/JCP.0000000000002036","author":"G Kavak Sinano\u011flu","year":"2025","unstructured":"Kavak Sinano\u011flu G, Yavrum F (2025) Aripiprazole-related acute myopia: a case report. J Clin Psychopharmacol. https:\/\/doi.org\/10.1097\/JCP.0000000000002036","journal-title":"J Clin Psychopharmacol"},{"key":"8496_CR3","first-page":"147","volume":"19","author":"H Kaya","year":"2009","unstructured":"Kaya H, Yilbas B, Dilbaz N et al (2009) Aripiprazole induced acute myopia: a case report. 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Cutan Ocul Toxicol 31:74\u201376. https:\/\/doi.org\/10.3109\/15569527.2011.603106","journal-title":"Cutan Ocul Toxicol"},{"key":"8496_CR6","doi-asserted-by":"publisher","first-page":"230","DOI":"10.5152\/balkanmedj.2015.15292","volume":"32","author":"H Karada\u011f","year":"2015","unstructured":"Karada\u011f H, Acar M, \u00d6zdel K (2015) Aripiprazole induced acute transient bilateral myopia: a case report. Balkan Med J 32:230\u2013232. https:\/\/doi.org\/10.5152\/balkanmedj.2015.15292","journal-title":"Balkan Med J"},{"key":"8496_CR7","doi-asserted-by":"publisher","first-page":"68","DOI":"10.5455\/bcp.20150813023217","volume":"26","author":"M G\u00fcne\u015f","year":"2016","unstructured":"G\u00fcne\u015f M, Demir S, Bulut M et al (2016) Acute unilateral myopia induced by add-on aripiprazole: a case report. Bull Clin Psychopharmacol 26:68\u201371. https:\/\/doi.org\/10.5455\/bcp.20150813023217","journal-title":"Bull Clin Psychopharmacol"},{"key":"8496_CR8","doi-asserted-by":"publisher","first-page":"130","DOI":"10.4103\/ijo.IJO_907_16","volume":"66","author":"KV Praveen Kumar","year":"2018","unstructured":"Praveen Kumar KV, Chiranjeevi P, Alam MS (2018) Aripiprazole-induced transient myopia: a rare entity. Indian J Ophthalmol 66:130\u2013131. https:\/\/doi.org\/10.4103\/ijo.IJO_907_16","journal-title":"Indian J Ophthalmol"},{"key":"8496_CR9","doi-asserted-by":"publisher","DOI":"10.3371\/CSRP.TAJP.121218","author":"T Abreu","year":"2019","unstructured":"Abreu T, Pinheiro J (2019) Aripiprazole induced myopia: case report and literature review. Clin Schizophr Relat Psychoses. https:\/\/doi.org\/10.3371\/CSRP.TAJP.121218","journal-title":"Clin Schizophr Relat Psychoses"},{"key":"8496_CR10","doi-asserted-by":"publisher","first-page":"516","DOI":"10.14744\/nci.2019.65625","volume":"7","author":"T Cumurcu","year":"2020","unstructured":"Cumurcu T, Cumurcu BE, Yesil B et al (2020) Aripiprazole-induced transient myopia. North Clin Istanb 7:516\u2013518. https:\/\/doi.org\/10.14744\/nci.2019.65625","journal-title":"North Clin Istanb"},{"key":"8496_CR11","doi-asserted-by":"publisher","first-page":"501","DOI":"10.2165\/11533180-000000000-00000","volume":"24","author":"S Richa","year":"2010","unstructured":"Richa S, Yazbek JC (2010) Ocular adverse effects of common psychotropic agents: a review. CNS Drugs 24:501\u2013526. https:\/\/doi.org\/10.2165\/11533180-000000000-00000","journal-title":"CNS Drugs"}],"container-title":["Neurological Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10072-025-08496-x.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s10072-025-08496-x\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10072-025-08496-x.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,20]],"date-time":"2025-10-20T18:02:32Z","timestamp":1760983352000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s10072-025-08496-x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,9,16]]},"references-count":11,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2025,11]]}},"alternative-id":["8496"],"URL":"https:\/\/doi.org\/10.1007\/s10072-025-08496-x","relation":{},"ISSN":["1590-1874","1590-3478"],"issn-type":[{"value":"1590-1874","type":"print"},{"value":"1590-3478","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,9,16]]},"assertion":[{"value":"19 July 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"29 August 2025","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"16 September 2025","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"Written informed consent was obtained from the patient described in this study.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Informed consent"}},{"value":"The study was performed in accordance with internal institutional ethical guidelines from BSMHFT and University of Birmingham for case reports, which requires informed consent from all patients\/supervisors for the work and its publication.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Research involving human participants"}},{"value":"The authors have no relevant financial or non-financial interests to disclose. No funding was received to assist with the preparation of this manuscript.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflicts of interest"}}]}}