{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,30]],"date-time":"2026-10-30T17:48:16Z","timestamp":1793382496667,"version":"4.5.0"},"reference-count":10,"publisher":"Springer Science and Business Media LLC","issue":"12","license":[{"start":{"date-parts":[[2025,10,18]],"date-time":"2025-10-18T00:00:00Z","timestamp":1760745600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2025,10,18]],"date-time":"2025-10-18T00:00:00Z","timestamp":1760745600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Neurol Sci"],"published-print":{"date-parts":[[2025,12]]},"DOI":"10.1007\/s10072-025-08547-3","type":"journal-article","created":{"date-parts":[[2025,10,18]],"date-time":"2025-10-18T00:18:19Z","timestamp":1760746699000},"page":"6933-6937","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Investigating the impact of white matter hyperintensities on longitudinal progression in progressive supranuclear palsy"],"prefix":"10.1007","volume":"46","author":[{"given":"Maria Francesca","family":"Tepedino","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesco","family":"Diana","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna Rosa","family":"Avallone","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria Teresa","family":"Pellecchia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sofia","family":"Cuoco","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marco","family":"Aiello","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Renzo","family":"Manara","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paolo","family":"Barone","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9025-137X","authenticated-orcid":false,"given":"Marina","family":"Picillo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,10,18]]},"reference":[{"key":"8547_CR1","doi-asserted-by":"publisher","first-page":"853","DOI":"10.1002\/mds.26987","volume":"32","author":"GH Hoglinger","year":"2017","unstructured":"Hoglinger GH, Respondek G, Stamelou M et al (2017) Clinical diagnosis of progressive supranuclear palsy: the movement disorder society criteria. Mov Disord 32:853\u2013864. https:\/\/pubmed.ncbi.nlm.nih.gov\/28467028\/","journal-title":"Mov Disord"},{"issue":"8","key":"8547_CR2","doi-asserted-by":"publisher","first-page":"822","DOI":"10.1016\/S1474-4422(13)70124-8","volume":"12","author":"JM Wardlaw","year":"2013","unstructured":"Wardlaw JM, Smith EE, Geert J, Biessels GJ et al (2013) Neuroimaging standards for research into small vessel disease and its contribution to ageing and neurodegeneration. Lancet Neurol 12(8):822\u2013838. https:\/\/pubmed.ncbi.nlm.nih.gov\/23867200\/","journal-title":"Lancet Neurol"},{"key":"8547_CR3","doi-asserted-by":"publisher","first-page":"892","DOI":"10.1016\/j.nicl.2018.09.025","volume":"20","author":"M Dadar","year":"2018","unstructured":"Dadar M, Zeighami Y, Yau Y et al (2018) White matter hyperintensities are linked to future cognitive decline in de novo parkinson\u2019s disease patients. NeuroImage: Clinical 20:892\u2013900","journal-title":"NeuroImage: Clinical"},{"issue":"12","key":"8547_CR4","doi-asserted-by":"publisher","first-page":"3711","DOI":"10.1111\/ene.16002","volume":"30","author":"J Gan","year":"2023","unstructured":"Gan J, Shi Z, Liu S (2023) White matter hyperintensities in cognitive impairment with lewy body disease: a multicentre study. Eur J Neurol 30(12):3711\u20133721","journal-title":"Eur J Neurol"},{"issue":"8","key":"8547_CR5","doi-asserted-by":"publisher","first-page":"3738","DOI":"10.1002\/alz.13057","volume":"19","author":"A Garnier-Crussard","year":"2023","unstructured":"Garnier-Crussard A, Cotton F, Krolak-Salmon P, Ch\u00e9telat G (2023) White matter hyperintensities in Alzheimer\u2019s disease: beyond vascular contribution. Alzheimers Dement 19(8):3738\u20133748","journal-title":"Alzheimers Dement"},{"issue":"4","key":"8547_CR6","doi-asserted-by":"publisher","first-page":"920","DOI":"10.1111\/ene.15692","volume":"30","author":"DC Carvalho de Abreu","year":"2023","unstructured":"Carvalho de Abreu DC, Pieruccini-Faria F, Sarquis-Adamson Y et al (2023) White matter hyperintensity burden predicts cognitive but not motor decline in parkinson\u2019s disease: results from the Ontario neurodegenerative disease research initiative. Eur J Neurol 30(4):920\u2013933. https:\/\/pubmed.ncbi.nlm.nih.gov\/36692250\/","journal-title":"Eur J Neurol"},{"issue":"10","key":"8547_CR7","doi-asserted-by":"publisher","first-page":"6866","DOI":"10.1007\/s00415-024-12662-0","volume":"271","author":"MF Tepedino","year":"2024","unstructured":"Tepedino MF, Diana F, Abate F et al (2024) The contribution of white matter changes to clinical phenotype in progressive supranuclear palsy. J Neurol 271(10):6866\u20136875","journal-title":"J Neurol"},{"key":"8547_CR8","doi-asserted-by":"publisher","first-page":"1362","DOI":"10.1093\/brain\/awn065","volume":"131","author":"SS O\u2019Sullivan","year":"2008","unstructured":"O\u2019Sullivan SS, Massey LA, Williams DR et al (2008) Clinical outcomes of progressive supranuclear palsy and multiple system atrophy. Brain 131:1362\u20131372. https:\/\/pubmed.ncbi.nlm.nih.gov\/18385183\/","journal-title":"Brain"},{"issue":"2","key":"8547_CR9","doi-asserted-by":"publisher","first-page":"315","DOI":"10.1002\/mds.28864","volume":"37","author":"PG Scamarcia","year":"2022","unstructured":"Scamarcia PG, Agosta F, Spinelli EG et al (2022) Longitudinal white matter damage evolution in Parkinson\u2019s disease. Mov Disord 37(2):315\u2013324","journal-title":"Mov Disord"},{"key":"8547_CR10","doi-asserted-by":"publisher","DOI":"10.1016\/j.nicl.2019.101870","volume":"23","author":"V Pozorski","year":"2019","unstructured":"Pozorski V, Oh JM, Okonkwo O et al (2019) Cross-sectional and longitudinal associations between total and regional white matter hyper- intensity volume and cognitive and motor function in Parkinson\u2019s disease. NeuroImage: Clinical 23:101870","journal-title":"NeuroImage: Clinical"}],"container-title":["Neurological Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10072-025-08547-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s10072-025-08547-3\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10072-025-08547-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,12,5]],"date-time":"2025-12-05T00:40:38Z","timestamp":1764895238000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s10072-025-08547-3"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,10,18]]},"references-count":10,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2025,12]]}},"alternative-id":["8547"],"URL":"https:\/\/doi.org\/10.1007\/s10072-025-08547-3","relation":{},"ISSN":["1590-1874","1590-3478"],"issn-type":[{"value":"1590-1874","type":"print"},{"value":"1590-3478","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,10,18]]},"assertion":[{"value":"16 May 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"17 September 2025","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"18 October 2025","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare no conflict of interest.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Statements and declarations"}},{"value":"Dr Marina Picillo\u00a0is supported by the Italian Ministry of Health and Fondazione della Societ\u00e0\u00a0Italiana di Neurologia and received speaker honoraria by Italfarmaco and Abbvie;\u00a0Prof Paolo Barone received consultancies as a member of the advisory board for\u00a0Zambon, Lundbeck, UCB, Chiesi, Abbvie and Acorda; the other authors report no\u00a0financial diclosures.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests (from the past year)"}}]}}