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The study was designed and carried out according to the Declaration of Helsinki and approved by the IRCCS San Raffaele Pisana Ethics Committee. All participants signed an informed consent prior to the start of any study procedures.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"NA.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"Fabrizio Stocchi reports honoraria and consulting fees from Britannia Pharmaceuticals, Contera, Lundbeck, Novartis, Teva, Chiesi, Lusofarmaco, Abbvie, Neuroderm, Roche, Biogen, ACimmune and Zambon. Marika Alborghetti has been sponsored by Lundbeck Italia and NextStepPharma for educational activity, received travel grants from Zambon and Lundbeck Italia, and research grants from Sapienza University of Rome, outside of the present work. All the other authors declare that there are no additional disclosures to report.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}]}}