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The voice characteristics of 23 Parkinson's disease patients without medication were evaluated preoperative, 3\u00a0months and 6\u00a0months after surgery. The voice handicap index (VHI) scale was used to evaluate the subjective voice function of patients. LingWAVES voice analysis software was used to collect patient and healthy control data and perform voice acoustic analysis. We further analyzed the correlation between postoperative tissue activation volume and voice characteristics.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      The subjective VHI scores improved significantly at 3\u00a0months postoperatively (p\u2009=\u20090.025), but there was no significant difference at 6\u00a0months postoperatively (p\u2009=\u20090.283). The parameters including dysphonia severity index (DSI), fundamental frequency perturbation (Jitter) and amplitude perturbation (Shimmer) were significantly improved three and six months postoperatively compared with baseline (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.05). There was a negative correlation between the improvement rate of DSI and the VTA overlap within limbic STN in the left hemisphere six months postoperatively (R\n                      <jats:sup>2<\/jats:sup>\n                      \u2009=\u20090.4413,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>STN-DBS can improve the voice characteristics of Parkinson's disease patients in the early stage after surgery, the improvement rate of DSI was negatively correlated with the VTA overlap within limbic STN in the left hemisphere.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1007\/s10072-025-08622-9","type":"journal-article","created":{"date-parts":[[2026,1,6]],"date-time":"2026-01-06T02:59:23Z","timestamp":1767668363000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Effects of STN-DBS treatment on voice characteristics in patients with Parkinson's Disease"],"prefix":"10.1007","volume":"47","author":[{"ORCID":"https:\/\/orcid.org\/0009-0008-7526-6205","authenticated-orcid":false,"given":"Xinru","family":"Hu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yue","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qi","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jingchao","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haitao","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuanyuan","family":"Cheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peipei","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yang","family":"Yu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Siquan","family":"Liang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jialing","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,1,6]]},"reference":[{"issue":"10291","key":"8622_CR1","doi-asserted-by":"publisher","first-page":"2284","DOI":"10.1016\/S0140-6736(21)00218-X","volume":"397","author":"BR Bloem","year":"2021","unstructured":"Bloem BR, Okun MS, Klein C (2021) Parkinson\u2019s disease. 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