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While inpatient mortality in adult-onset FIRES has been suggested to be higher than in pediatric patients, little is known about the factors associated with survival, hampering research into developing prognostic and stratification models and also posing a challenge for clinical communications and decision making.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We report a fatal case of FIRES in a 21-year-old lady and performed a review of literature involving adult-onset FIRES from 1 Aug 2022 to 17 Aug 2024, analyzing the data to identify factors associated with survival of the initial hospital stay.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Including our case, 49 patients of adult-onset FIRES were identified. Of the 47 patients who had MRI brain scan findings described at any time during the illness, 35 patients (74.5%) had abnormal findings in at least one scan, and the most common site of abnormality was the temporal lobe (59.6%). A total of 41 patients survived the initial hospital stay (83.7%). The presence of MRI temporal lobe abnormalities was associated with survival at discharge (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.013), and the association remained significant on multivariate analysis with corticosteroid usage.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>In adult-onset FIRES, MRI temporal lobe abnormalities may be associated with survival beyond the acute phase. Our study findings suggest that the site of MRI abnormalities in FIRES may have value in the clinical stratification and prognostication of adult-onset FIRES.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1007\/s10072-025-08728-0","type":"journal-article","created":{"date-parts":[[2026,1,12]],"date-time":"2026-01-12T07:13:23Z","timestamp":1768202003000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Febrile infection-related epilepsy syndrome (FIRES) in adults: a case report and review of factors associated with survival"],"prefix":"10.1007","volume":"47","author":[{"ORCID":"https:\/\/orcid.org\/0009-0001-4413-708X","authenticated-orcid":false,"given":"Zhibin","family":"Tan","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-9907-935X","authenticated-orcid":false,"given":"Hua Chan","family":"Ling","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0091-5599","authenticated-orcid":false,"given":"You Jiang","family":"Tan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7705-1998","authenticated-orcid":false,"given":"Jia Yi","family":"Shen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-0382-6545","authenticated-orcid":false,"given":"Zhi En","family":"Chan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-1355-9990","authenticated-orcid":false,"given":"Wilson","family":"Chan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9045-0715","authenticated-orcid":false,"given":"Tushar","family":"Gosavi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1420-0970","authenticated-orcid":false,"given":"Shih Hui","family":"Lim","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2026,1,12]]},"reference":[{"issue":"4","key":"8728_CR1","doi-asserted-by":"publisher","first-page":"739","DOI":"10.1111\/epi.14016","volume":"59","author":"LJ Hirsch","year":"2018","unstructured":"Hirsch LJ, Gaspard N, van Baalen A, Nabbout R, Demeret S, Loddenkemper T, Navarro V, Specchio N, Lagae L, Rossetti AO, Hocker S, Gofton TE, Abend NS, Gilmore EJ, Hahn C, Khosravani H, Rosenow F, Trinka E (2018) Proposed consensus definitions for new-onset refractory status epilepticus (NORSE), febrile infection-related epilepsy syndrome (FIRES), and related conditions. 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Nonetheless, the authors have obtained written consent from the patient\u2019s next-of-kin for this publication, along with its associated images and data, which have been anonymized.The review in this study was performed with publicly available data gleaned from the cited references. In accordance with the Declaration of Helsinki, all data has been anonymized.We confirm that we have read the Journal\u2019s position on issues involved in ethical publication and affirm that this report is consistent with those guidelines.\n                      Conflict of interest\n                      None of the authors has any conflict of interest to disclose.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}}],"article-number":"147"}}