{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,26]],"date-time":"2026-10-26T18:51:35Z","timestamp":1793040695100,"version":"4.5.0"},"reference-count":11,"publisher":"Springer Science and Business Media LLC","issue":"2","license":[{"start":{"date-parts":[[2026,1,27]],"date-time":"2026-01-27T00:00:00Z","timestamp":1769472000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2026,1,27]],"date-time":"2026-01-27T00:00:00Z","timestamp":1769472000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Neurol Sci"],"published-print":{"date-parts":[[2026,2]]},"DOI":"10.1007\/s10072-026-08821-y","type":"journal-article","created":{"date-parts":[[2026,1,27]],"date-time":"2026-01-27T05:26:07Z","timestamp":1769491567000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Sustained efficacy and safety of levodopa-carbidopa intestinal gel in advanced Parkinson\u2019s disease: a 10-year observational study"],"prefix":"10.1007","volume":"47","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8492-7991","authenticated-orcid":false,"given":"Hatice \u00d6merciko\u011flu","family":"\u00d6zden","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dilcem","family":"\u015eim\u015fek","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Merve Bikem","family":"U\u00e7ar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fatma Nazl\u0131 Durmaz","family":"\u00c7elik","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dilek","family":"G\u00fcnal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,1,27]]},"reference":[{"issue":"6","key":"8821_CR1","doi-asserted-by":"publisher","first-page":"2854","DOI":"10.1007\/s12325-021-01747-1","volume":"38","author":"A Antonini","year":"2021","unstructured":"Antonini A, Odin P, Pahwa R, Aldred J, Alobaidi A, Jalundhwala YJ, Kukreja P, Bergmann L, Inguva S, Bao Y et al (2021) The Long-Term impact of Levodopa\/Carbidopa intestinal gel on \u2018Off\u2019-time in patients with advanced Parkinson\u2019s disease: A systematic review. Adv Ther 38(6):2854\u20132890","journal-title":"Adv Ther"},{"key":"8821_CR2","first-page":"229","volume":"5","author":"W Poewe","year":"2010","unstructured":"Poewe W, Antonini A, Zijlmans JC, Burkhard PR, Vingerhoets F (2010) Levodopa in the treatment of Parkinson\u2019s disease: an old drug still going strong. Clin Interv Aging 5:229\u2013238","journal-title":"Clin Interv Aging"},{"issue":"1","key":"8821_CR3","doi-asserted-by":"publisher","first-page":"60","DOI":"10.1002\/mdc3.13361","volume":"9","author":"V Viljaharju","year":"2022","unstructured":"Viljaharju V, Mertsalmi T, Pauls KAM, Koivu M, Eerola-Rautio J, Udd M, Pekkonen E (2022) Single-Center study of 103 consecutive Parkinson\u2019s disease patients with Levodopa-Carbidopa intestinal gel. Mov Disord Clin Pract 9(1):60\u201368","journal-title":"Mov Disord Clin Pract"},{"issue":"10","key":"8821_CR4","doi-asserted-by":"publisher","first-page":"5606","DOI":"10.1007\/s00415-022-11269-7","volume":"269","author":"F Garr\u00ec","year":"2022","unstructured":"Garr\u00ec F, Russo FP, Carrer T, Weis L, Pistonesi F, Mainardi M, Sandre M, Savarino E, Farinati F, Del Sorbo F et al (2022) Long-term safety, discontinuation and mortality in an Italian cohort with advanced Parkinson\u2019s disease on levodopa\/carbidopa intestinal gel infusion. J Neurol 269(10):5606\u20135614","journal-title":"J Neurol"},{"issue":"2","key":"8821_CR5","doi-asserted-by":"publisher","first-page":"141","DOI":"10.1016\/S1474-4422(13)70293-X","volume":"13","author":"CW Olanow","year":"2014","unstructured":"Olanow CW, Kieburtz K, Odin P, Espay AJ, Standaert DG, Fernandez HH, Vanagunas A, Othman AA, Widnell KL, Robieson WZ et al (2014) Continuous intrajejunal infusion of levodopa-carbidopa intestinal gel for patients with advanced Parkinson\u2019s disease: a randomised, controlled, double-blind, double-dummy study. Lancet Neurol 13(2):141\u2013149","journal-title":"Lancet Neurol"},{"issue":"3","key":"8821_CR6","doi-asserted-by":"publisher","first-page":"379","DOI":"10.1017\/cjn.2023.251","volume":"51","author":"C Vekhande","year":"2024","unstructured":"Vekhande C, Hamed M, Tremain G, Mah J, Shetty A, Lazarescu A, Suchowersky O (2024) Levodopa-Carbidopa intestinal gel for Parkinson\u2019s disease over 11 years: one center\u2019s Real-World experience. Can J Neurol Sci 51(3):379\u2013386","journal-title":"Can J Neurol Sci"},{"key":"8821_CR7","doi-asserted-by":"publisher","first-page":"1835","DOI":"10.2147\/NDT.S256988","volume":"16","author":"VA Constantin","year":"2020","unstructured":"Constantin VA, Sz\u00e1sz JA, Orb\u00e1n-Kis K, Rosca EC, Popovici M, Cornea A, Bancu LA, Ciorba M, Mih\u00e1ly I, Nagy E et al (2020) Levodopa-Carbidopa intestinal gel infusion therapy discontinuation: A Ten-Year retrospective analysis of 204 treated patients. Neuropsychiatr Dis Treat 16:1835\u20131844","journal-title":"Neuropsychiatr Dis Treat"},{"key":"8821_CR8","doi-asserted-by":"publisher","first-page":"98","DOI":"10.1016\/j.parkreldis.2019.10.004","volume":"76","author":"CA Artusi","year":"2020","unstructured":"Artusi CA, Balestrino R, Imbalzano G, Bortolani S, Montanaro E, Tuttobene S, Fabbri M, Zibetti M, Lopiano L (2020) Beyond 10 years of Levodopa intestinal infusion experience: analysis of mortality and its predictors. Parkinsonism Relat Disord 76:98\u2013103","journal-title":"Parkinsonism Relat Disord"},{"issue":"3","key":"8821_CR9","doi-asserted-by":"publisher","first-page":"935","DOI":"10.3233\/JPD-201978","volume":"10","author":"HR Moes","year":"2020","unstructured":"Moes HR, Groenendal-Laurensse J, Drent M, Tissingh G, van Laar T (2020) Predictors of time to discontinuation of Levodopa-Carbidopa intestinal gel infusion: A retrospective cohort study. J Parkinsons Dis 10(3):935\u2013944","journal-title":"J Parkinsons Dis"},{"issue":"4","key":"8821_CR10","doi-asserted-by":"publisher","first-page":"268","DOI":"10.1016\/j.neurol.2019.07.024","volume":"176","author":"AS Blaise","year":"2020","unstructured":"Blaise AS, Baille G, Carri\u00e8re N, Devos D, Dujardin K, Grolez G, Kreisler A, Kyheng M, Moreau C, Mutez E et al (2020) Safety and effectiveness of levodopa-carbidopa intestinal gel for advanced Parkinson\u2019s disease: A large single-center study. Rev Neurol (Paris) 176(4):268\u2013276","journal-title":"Rev Neurol (Paris)"},{"issue":"7","key":"8821_CR11","doi-asserted-by":"publisher","first-page":"1360","DOI":"10.1002\/mds.29066","volume":"37","author":"G Deuschl","year":"2022","unstructured":"Deuschl G, Antonini A, Costa J, \u015ami\u0142owska K, Berg D, Corvol JC, Fabbrini G, Ferreira J, Foltynie T, Mir P et al (2022) European academy of Neurology\/Movement disorder Society-European section guideline on the treatment of Parkinson\u2019s disease: I. Invasive therapies. Mov Disord 37(7):1360\u20131374","journal-title":"Mov Disord"}],"container-title":["Neurological Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10072-026-08821-y.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s10072-026-08821-y","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10072-026-08821-y.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,2,17]],"date-time":"2026-02-17T17:02:56Z","timestamp":1771347776000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s10072-026-08821-y"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,1,27]]},"references-count":11,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2026,2]]}},"alternative-id":["8821"],"URL":"https:\/\/doi.org\/10.1007\/s10072-026-08821-y","relation":{},"ISSN":["1590-1874","1590-3478"],"issn-type":[{"value":"1590-1874","type":"print"},{"value":"1590-3478","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,1,27]]},"assertion":[{"value":"6 August 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"8 January 2026","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"27 January 2026","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"This study was approved by the Marmara University Faculty of Medicine Ethics Committee (Approval No: 09.2025.25\u20130637) and was conducted in accordance with the Declaration of Helsinki. Written informed consent was obtained from all participants or their legal representatives.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"<!--Emphasis Type='Bold' removed-->Ethical"}},{"value":"The authors declare that they have no conflict of interest relevant to this work.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}],"article-number":"204"}}