{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,15]],"date-time":"2026-04-15T09:14:06Z","timestamp":1776244446485,"version":"3.50.1"},"reference-count":24,"publisher":"Springer Science and Business Media LLC","issue":"4","license":[{"start":{"date-parts":[[2026,3,23]],"date-time":"2026-03-23T00:00:00Z","timestamp":1774224000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2026,3,23]],"date-time":"2026-03-23T00:00:00Z","timestamp":1774224000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"funder":[{"DOI":"10.13039\/501100020205","name":"Health Commission of Jiangxi Province","doi-asserted-by":"publisher","award":["202610452"],"award-info":[{"award-number":["202610452"]}],"id":[{"id":"10.13039\/501100020205","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Neurol Sci"],"published-print":{"date-parts":[[2026,4]]},"DOI":"10.1007\/s10072-026-08984-8","type":"journal-article","created":{"date-parts":[[2026,3,23]],"date-time":"2026-03-23T01:54:03Z","timestamp":1774230843000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Uncoupling of apnea-hypopnea index and oxygen desaturation in als: characterization and diagnostic implications of an \u201cAHI-SpO\u2082 dissociation\u201d phenotype"],"prefix":"10.1007","volume":"47","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6789-2013","authenticated-orcid":false,"given":"Xueming","family":"Li","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Weijiang","family":"Ding","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-9081-2640","authenticated-orcid":false,"given":"Enwang","family":"Xu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2026,3,23]]},"reference":[{"key":"8984_CR1","doi-asserted-by":"publisher","first-page":"147997312311759","DOI":"10.1177\/14799731231175915","volume":"20","author":"P Sales de Campos","year":"2023","unstructured":"Sales de Campos P, Olsen WL, Wymer JP, Smith BK (2023) Respiratory therapies for amyotrophic lateral sclerosis: a state of the art review. Chron Respir Dis 20:14799731231175915","journal-title":"Chron Respir Dis"},{"issue":"3","key":"8984_CR2","doi-asserted-by":"publisher","first-page":"391","DOI":"10.3934\/Neuroscience.2025021","volume":"12","author":"A Arachchige","year":"2025","unstructured":"Arachchige A, Rethinking ALS (2025) Current understanding and emerging therapeutic strategies. AIMS Neurosci 12(3):391\u2013405","journal-title":"AIMS Neurosci"},{"key":"8984_CR3","doi-asserted-by":"publisher","first-page":"37","DOI":"10.1016\/S0022-510X(99)00044-1","volume":"164","author":"K Kimura","year":"1999","unstructured":"Kimura K, Tachibana N, Kimura J, Shibasaki H (1999) Sleep-disordered breathing at an early stage of amyotrophic lateral sclerosis. J Neurol Sci 164:37\u201343","journal-title":"J Neurol Sci"},{"issue":"4","key":"8984_CR4","doi-asserted-by":"publisher","first-page":"547","DOI":"10.1016\/j.jsmc.2025.07.007","volume":"20","author":"K Tran","year":"2025","unstructured":"Tran K, Lussier BL (2025) Noninvasive ventilation in amyotrophic lateral sclerosis. Sleep Med Clin 20(4):547\u2013555","journal-title":"Sleep Med Clin"},{"issue":"10","key":"8984_CR5","doi-asserted-by":"publisher","first-page":"1043","DOI":"10.1136\/thorax-2022-219582","volume":"78","author":"HJ Evans","year":"2023","unstructured":"Evans HJ, Gibson NA, Bennett J et al (2023) British thoracic society guideline for diagnosing and monitoring paediatric sleep-disordered breathing. Thorax 78(10):1043\u20131054","journal-title":"Thorax"},{"issue":"7","key":"8984_CR6","doi-asserted-by":"publisher","first-page":"zsab030","DOI":"10.1093\/sleep\/zsab030","volume":"44","author":"A Malhotra","year":"2021","unstructured":"Malhotra A, Ayappa I, Ayas N et al (2021) Metrics of sleep apnea severity: beyond the apnea-hypopnea index. Sleep 44(7):zsab030","journal-title":"Sleep"},{"issue":"3","key":"8984_CR7","doi-asserted-by":"publisher","first-page":"664","DOI":"10.1378\/chest.110.3.664","volume":"110","author":"KA Ferguson","year":"1996","unstructured":"Ferguson KA, Strong MJ, Ahmad D, George CF (1996) Sleep-disordered breathing in amyotrophic lateral sclerosis. Chest 110(3):664\u2013669","journal-title":"Chest"},{"issue":"7","key":"8984_CR8","doi-asserted-by":"publisher","first-page":"3953","DOI":"10.1007\/s00415-024-12455-5","volume":"271","author":"B Bjelica","year":"2024","unstructured":"Bjelica B, Bartels MB, Hesebeck-Brinckmann J, Petri S (2024) Non-motor symptoms in patients with amyotrophic lateral sclerosis: current state and future directions. J Neurol 271(7):3953\u20133977","journal-title":"J Neurol"},{"issue":"2","key":"8984_CR9","first-page":"78","volume":"43","author":"P Banfi","year":"2024","unstructured":"Banfi P, Buscemi A, Compalati E, Pisoni M, Mantero M, Lax A (2024) Enhancing respiratory function in neuromuscular disease: the role of non-invasive ventilation. A narrative review. Acta Myol 43(2):78\u201382","journal-title":"Acta Myol"},{"issue":"171","key":"8984_CR10","doi-asserted-by":"publisher","first-page":"230166","DOI":"10.1183\/16000617.0166-2023","volume":"33","author":"MR Bonsignore","year":"2024","unstructured":"Bonsignore MR, Mazzuca E, Baiamonte P, Bouckaert B, Verbeke W, Pevernagie DA (2024) REM sleep obstructive sleep apnoea. Eur Respiratory Rev 33(171):230166","journal-title":"Eur Respiratory Rev"},{"issue":"11","key":"8984_CR11","doi-asserted-by":"publisher","first-page":"e32250","DOI":"10.1016\/j.heliyon.2024.e32250","volume":"10","author":"A Nuredini","year":"2024","unstructured":"Nuredini A, Bottignole D, Stragliati F et al (2024) Unraveling sleep respiratory dysfunction in amyotrophic lateral sclerosis: beyond the apnea-hypopnea index and sleep-related hypoxia. Heliyon 10(11):e32250","journal-title":"Heliyon"},{"issue":"11","key":"8984_CR12","doi-asserted-by":"publisher","first-page":"4321","DOI":"10.1007\/s00415-021-10563-0","volume":"268","author":"M Engel","year":"2021","unstructured":"Engel M, Glatz C, Helmle C, Young P, Dr\u00e4ger B, Boentert M (2021) Respiratory parameters on diagnostic sleep studies predict survival in patients with amyotrophic lateral sclerosis. J Neurol 268(11):4321\u20134331","journal-title":"J Neurol"},{"key":"8984_CR13","doi-asserted-by":"publisher","first-page":"101154","DOI":"10.1016\/j.resmer.2025.101154","volume":"87","author":"C Drouet","year":"2025","unstructured":"Drouet C, Priou P, Gagnadoux F, Trzepizur W (2025) Constraints to the initiation of home non-invasive ventilation and short-term efficacy in different diagnostic groups (as a prelude to an ambulatory shift). Respiratory Med Res 87:101154","journal-title":"Respiratory Med Res"},{"issue":"5","key":"8984_CR14","doi-asserted-by":"publisher","first-page":"293","DOI":"10.1080\/146608200300079536","volume":"1","author":"BR Brooks","year":"2000","unstructured":"Brooks BR, Miller RG, Swash M, Munsat TLWorld federation of neurology research group on motor neuron diseases (2000) El escorial revisited: revised criteria for the diagnosis of amyotrophic lateral sclerosis. Amyotroph Lateral Scler Other Motor Neuron Disord 1(5):293\u2013299","journal-title":"Amyotroph Lateral Scler Other Motor Neuron Disord"},{"issue":"5","key":"8984_CR15","doi-asserted-by":"publisher","first-page":"1202","DOI":"10.1164\/ajrccm\/144.5.1202","volume":"144","author":"Lung function testing","year":"1991","unstructured":"Lung function testing (1991) : selection of reference values and interpretative strategies. American Thoracic Society. Am Rev Respir Dis 144(5):1202\u20131218","journal-title":"Am Rev Respir Dis"},{"issue":"5","key":"8984_CR16","doi-asserted-by":"publisher","first-page":"665","DOI":"10.5664\/jcsm.6576","volume":"13","author":"RB Berry","year":"2017","unstructured":"Berry RB, Brooks R, Gamaldo C et al (2017) AASM Scoring manual updates for 2017 (Version 2.4). J Clin Sleep Med 13(5):665\u2013666","journal-title":"J Clin Sleep Med"},{"issue":"3","key":"8984_CR17","doi-asserted-by":"publisher","first-page":"479","DOI":"10.5664\/jcsm.6506","volume":"13","author":"VK Kapur","year":"2017","unstructured":"Kapur VK, Auckley DH, Chowdhuri S et al (2017) Clinical practice guideline for diagnostic testing for adult obstructive sleep apnea: an american academy of sleep medicine clinical practice guideline. J Clin Sleep Med 13(3):479\u2013504","journal-title":"J Clin Sleep Med"},{"issue":"1","key":"8984_CR18","doi-asserted-by":"publisher","first-page":"e000170","DOI":"10.1136\/bmjresp-2016-000170","volume":"4","author":"BR O\u2019Driscoll","year":"2017","unstructured":"O\u2019Driscoll BR, Howard LS, Earis J, Mak V (2017) British thoracic society guideline for oxygen use in adults in healthcare and emergency settings. BMJ Open Respir Res 4(1):e000170","journal-title":"BMJ Open Respir Res"},{"issue":"8","key":"8984_CR19","first-page":"1459","volume":"59","author":"AL Platon","year":"2023","unstructured":"Platon AL, Stelea CG, Boi\u0219teanu O et al (2023) An update on obstructive sleep apnea syndrome-a literature review. Med (Kaunas) 59(8):1459","journal-title":"Med (Kaunas)"},{"issue":"10","key":"8984_CR20","first-page":"1284","volume":"14","author":"F Silva","year":"2024","unstructured":"Silva F, Silva J, Salgueira S, Mendes A, Matos E, Conde B (2024) Sleep disturbances in amyotrophic lateral sclerosis and prognostic impact-a retrospective study. Life (Basel) 14(10):1284","journal-title":"Life (Basel)"},{"issue":"12","key":"8984_CR21","doi-asserted-by":"publisher","first-page":"907","DOI":"10.1007\/s11910-023-01322-x","volume":"23","author":"R Vetrivelan","year":"2023","unstructured":"Vetrivelan R, Bandaru SS (2023) Neural Control of REM Sleep and motor atonia: current perspectives. Curr Neurol Neurosci Rep 23(12):907\u2013923","journal-title":"Curr Neurol Neurosci Rep"},{"issue":"6","key":"8984_CR22","doi-asserted-by":"publisher","first-page":"e0258614","DOI":"10.1371\/journal.pone.0258614","volume":"17","author":"BR Brooks","year":"2022","unstructured":"Brooks BR, Heiman-Patterson T, Wiedau-Pazos M, Liu S, Zhang J, Apple S (2022) Edaravone efficacy in amyotrophic lateral sclerosis with reduced forced vital capacity: post-hoc analysis of study 19 (MCI186-19) [clinical trial NCT01492686]. PLoS ONE 17(6):e0258614","journal-title":"PLoS ONE"},{"issue":"6","key":"8984_CR23","doi-asserted-by":"publisher","first-page":"1611","DOI":"10.1111\/ene.15779","volume":"30","author":"H Alarcan","year":"2023","unstructured":"Alarcan H, Cotet C, L\u00e9pine N et al (2023) Evaluation of arterial blood gas parameters as prognostic markers in amyotrophic lateral sclerosis. Eur J Neurol 30(6):1611\u20131618","journal-title":"Eur J Neurol"},{"issue":"sup1","key":"8984_CR24","doi-asserted-by":"publisher","first-page":"33","DOI":"10.1080\/21678421.2021.1887263","volume":"22","author":"U Manera","year":"2021","unstructured":"Manera U, Torrieri MC, Moglia C et al (2021) Arterial blood gas analysis: base excess and carbonate are predictive of noninvasive ventilation adaptation and survival in amyotrophic lateral sclerosis. Amyotroph Lateral Scler Frontotemporal Degener 22(sup1):33\u201339","journal-title":"Amyotroph Lateral Scler Frontotemporal Degener"}],"container-title":["Neurological Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10072-026-08984-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s10072-026-08984-8","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10072-026-08984-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,15]],"date-time":"2026-04-15T08:39:09Z","timestamp":1776242349000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s10072-026-08984-8"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,3,23]]},"references-count":24,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2026,4]]}},"alternative-id":["8984"],"URL":"https:\/\/doi.org\/10.1007\/s10072-026-08984-8","relation":{},"ISSN":["1590-1874","1590-3478"],"issn-type":[{"value":"1590-1874","type":"print"},{"value":"1590-3478","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,3,23]]},"assertion":[{"value":"4 January 2026","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"13 March 2026","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"23 March 2026","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"This study involving human participant were conducted under the approval by the research ethics committee of The Second Affiliated Hospital of Nanchang University.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical statement"}},{"value":"There is no conflict of interest between the authors.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}],"article-number":"364"}}