{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,16]],"date-time":"2026-06-16T22:56:22Z","timestamp":1781650582543,"version":"3.54.5"},"reference-count":13,"publisher":"Springer Science and Business Media LLC","issue":"5","license":[{"start":{"date-parts":[[2026,4,18]],"date-time":"2026-04-18T00:00:00Z","timestamp":1776470400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2026,4,18]],"date-time":"2026-04-18T00:00:00Z","timestamp":1776470400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Neurol Sci"],"published-print":{"date-parts":[[2026,5]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Anti-Sez6L2 (seizure-related 6 homolog-like 2) antibody\u2013associated autoimmune cerebellar ataxia is an exceptionally rare neuroimmunological disorder, with only a limited number of cases reported to date. Its clinical spectrum and optimal therapeutic strategies remain incompletely characterized.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Case presentation<\/jats:title>\n                    <jats:p>We report a 77-year-old woman who developed a subacute-to-chronic progressive cerebellar ataxia accompanied by oculomotor abnormalities, a forward-leaning posture, and gait initiation failure.. Neuroimaging studies revealed no structural or neoplastic lesions sufficient to account for the neurological deterioration. Cell-based assays detected anti-Sez6L2 IgG antibodies in both serum and cerebrospinal fluid. The patient exhibited only limited and unsustained improvement following first-line immunotherapies, including corticosteroids and intravenous immunoglobulin. After confirmation of an antibody-mediated mechanism, treatment was escalated to B-cell\u2013depleting therapy with rituximab, resulting in clinical improvement accompanied by a reduction in cerebrospinal fluid antibody titers.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>This case represents a rare presentation of anti-Sez6L2 antibody\u2013associated autoimmune cerebellar ataxia and provides additional clinical and immunological evidence supporting the relevance of this antibody. Furthermore, it suggests that rituximab may represent a potentially valuable therapeutic option in patients with insufficient responses to first-line immunotherapies.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1007\/s10072-026-09017-0","type":"journal-article","created":{"date-parts":[[2026,4,18]],"date-time":"2026-04-18T00:56:52Z","timestamp":1776473812000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Anti-Sez6L2 antibody\u2013associated autoimmune cerebellar ataxia: a rare case with implications of rituximab therapy"],"prefix":"10.1007","volume":"47","author":[{"given":"Ya","family":"Gao","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-7562-450X","authenticated-orcid":false,"given":"Ruisheng","family":"Duan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,4,18]]},"reference":[{"key":"9017_CR1","doi-asserted-by":"publisher","DOI":"10.1186\/s42466-022-00218-4","volume":"4","author":"A Kather","year":"2022","unstructured":"Kather A, Holtbernd F, Brunkhorst R et al (2022) Anti-SEZ6L2 antibodies in paraneoplastic cerebellar syndrome: case report and review of the literature. 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