{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T18:29:06Z","timestamp":1788892146113,"version":"build-2803163510"},"reference-count":34,"publisher":"Springer Science and Business Media LLC","issue":"7","license":[{"start":{"date-parts":[[2026,6,8]],"date-time":"2026-06-08T00:00:00Z","timestamp":1780876800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2026,6,8]],"date-time":"2026-06-08T00:00:00Z","timestamp":1780876800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Neurol Sci"],"published-print":{"date-parts":[[2026,7]]},"DOI":"10.1007\/s10072-026-09166-2","type":"journal-article","created":{"date-parts":[[2026,6,8]],"date-time":"2026-06-08T04:04:25Z","timestamp":1780891465000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Early respiratory decline around diagnosis and short-term post-landmark outcomes in amyotrophic lateral sclerosis: a 6-month landmark cohort study"],"prefix":"10.1007","volume":"47","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7040-3273","authenticated-orcid":false,"given":"Kazuhiro","family":"Horiuchi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuntaro","family":"Nakamura","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kaede","family":"Ishikawa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sumire","family":"Nunomura","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kazuki","family":"Yamada","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takashi","family":"Inoue","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kei","family":"Oiwa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shintaro","family":"Fujii","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuki","family":"Oshima","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Akihiko","family":"Kudo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ichiro","family":"Yabe","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,6,8]]},"reference":[{"issue":"2","key":"9166_CR1","doi-asserted-by":"publisher","first-page":"162","DOI":"10.1056\/NEJMra1603471","volume":"377","author":"RH Brown Jr","year":"2017","unstructured":"Brown RH Jr, Al-Chalabi A (2017) Amyotrophic lateral sclerosis. N Engl J Med 377(2):162\u2013172. https:\/\/doi.org\/10.1056\/NEJMra1603471","journal-title":"N Engl J Med"},{"key":"9166_CR2","doi-asserted-by":"publisher","first-page":"17085","DOI":"10.1038\/nrdp.2017.85","volume":"3","author":"O Hardiman","year":"2017","unstructured":"Hardiman O, Al-Chalabi A, Chio A, Corr EM, Logroscino G, Robberecht W et al (2017) Amyotrophic lateral sclerosis. Nat Rev Dis Primers 3:17085. https:\/\/doi.org\/10.1038\/nrdp.2017.85","journal-title":"Nat Rev Dis Primers"},{"issue":"9769","key":"9166_CR3","doi-asserted-by":"publisher","first-page":"942","DOI":"10.1016\/S0140-6736(10)61156-7","volume":"377","author":"MC Kiernan","year":"2011","unstructured":"Kiernan MC, Vucic S, Cheah BC, Turner MR, Eisen A, Hardiman O et al (2011) Amyotrophic lateral sclerosis. Lancet 377(9769):942\u2013955. https:\/\/doi.org\/10.1016\/S0140-6736(10)61156-7","journal-title":"Lancet"},{"issue":"5\u20136","key":"9166_CR4","doi-asserted-by":"publisher","first-page":"310","DOI":"10.3109\/17482960802566824","volume":"10","author":"A Chio","year":"2009","unstructured":"Chio A, Logroscino G, Hardiman O, Swingler R, Mitchell D, Beghi E et al (2009) Prognostic factors in ALS: a critical review. Amyotroph Lateral Scler 10(5\u20136):310\u2013323. https:\/\/doi.org\/10.3109\/17482960802566824","journal-title":"Amyotroph Lateral Scler"},{"issue":"15","key":"9166_CR5","doi-asserted-by":"publisher","first-page":"1218","DOI":"10.1212\/WNL.0b013e3181bc0141","volume":"73","author":"RG Miller","year":"2009","unstructured":"Miller RG, Jackson CE, Kasarskis EJ, England JD, Forshew D, Johnston W et al (2009) Practice parameter update: the care of the patient with amyotrophic lateral sclerosis: drug, nutritional, and respiratory therapies (an evidence-based review). Neurology 73(15):1218\u20131226. https:\/\/doi.org\/10.1212\/WNL.0b013e3181bc0141","journal-title":"Neurology"},{"issue":"2","key":"9166_CR6","doi-asserted-by":"publisher","first-page":"140","DOI":"10.1016\/S1474-4422(05)70326-4","volume":"5","author":"SC Bourke","year":"2006","unstructured":"Bourke SC, Tomlinson M, Williams TL, Bullock RE, Shaw PJ, Gibson GJ (2006) Effects of non-invasive ventilation on survival and quality of life in patients with amyotrophic lateral sclerosis: a randomised controlled trial. Lancet Neurol 5(2):140\u2013147. https:\/\/doi.org\/10.1016\/S1474-4422(05)70326-4","journal-title":"Lancet Neurol"},{"issue":"3","key":"9166_CR7","doi-asserted-by":"publisher","first-page":"390","DOI":"10.1136\/jnnp.2005.072660","volume":"77","author":"A Czaplinski","year":"2006","unstructured":"Czaplinski A, Yen AA, Appel SH (2006) Forced vital capacity (FVC) as an indicator of survival and disease progression in an ALS clinic population. J Neurol Neurosurg Psychiatry 77(3):390\u2013392. https:\/\/doi.org\/10.1136\/jnnp.2005.072660","journal-title":"J Neurol Neurosurg Psychiatry"},{"issue":"1","key":"9166_CR8","doi-asserted-by":"publisher","first-page":"66","DOI":"10.1212\/WNL.50.1.66","volume":"50","author":"N Stambler","year":"1998","unstructured":"Stambler N, Levy G, Cedarbaum JM, Stephenson GC, Williams MC, Maguire NM et al (1998) Prognostic indicators of survival in ALS. Neurology 50(1):66\u201372. https:\/\/doi.org\/10.1212\/WNL.50.1.66","journal-title":"Neurology"},{"issue":"1","key":"9166_CR9","doi-asserted-by":"publisher","first-page":"58","DOI":"10.1001\/jamaneurol.2017.3339","volume":"75","author":"JA Andrews","year":"2018","unstructured":"Andrews JA, Meng L, Kulke SF, Rudnicki SA, Wolff AA, Bozik ME et al (2018) Association between decline in slow vital capacity and respiratory insufficiency, use of assisted ventilation, tracheostomy, or death in patients with amyotrophic lateral sclerosis. JAMA Neurol 75(1):58\u201364. https:\/\/doi.org\/10.1001\/jamaneurol.2017.3339","journal-title":"JAMA Neurol"},{"issue":"1\u20132","key":"9166_CR10","doi-asserted-by":"publisher","first-page":"13","DOI":"10.1016\/S0022-510X(99)00210-5","volume":"169","author":"JM Cedarbaum","year":"1999","unstructured":"Cedarbaum JM, Stambler N, Malta E, Fuller C, Hilt D, Thurmond B et al (1999) The ALSFRS-R: a revised ALS functional rating scale. J Neurol Sci 169(1\u20132):13\u201321. https:\/\/doi.org\/10.1016\/S0022-510X(99)00210-5","journal-title":"J Neurol Sci"},{"issue":"1","key":"9166_CR11","doi-asserted-by":"publisher","first-page":"38","DOI":"10.1212\/01.WNL.0000148648.38313.64","volume":"64","author":"P Kaufmann","year":"2005","unstructured":"Kaufmann P, Levy G, Thompson JL, Delbene ML, Battista V, Gordon PH et al (2005) The ALSFRS-R predicts survival time in an ALS clinic population. Neurology 64(1):38\u201343. https:\/\/doi.org\/10.1212\/01.WNL.0000148648.38313.64","journal-title":"Neurology"},{"issue":"4","key":"9166_CR12","doi-asserted-by":"publisher","first-page":"492","DOI":"10.1093\/aje\/kwm324","volume":"167","author":"S Suissa","year":"2008","unstructured":"Suissa S (2008) Immortal time bias in pharmaco-epidemiology. Am J Epidemiol 167(4):492\u2013499. https:\/\/doi.org\/10.1093\/aje\/kwm324","journal-title":"Am J Epidemiol"},{"issue":"23","key":"9166_CR13","doi-asserted-by":"publisher","first-page":"2963","DOI":"10.1200\/JCO.2013.49.5283","volume":"31","author":"A Giobbie-Hurder","year":"2013","unstructured":"Giobbie-Hurder A, Gelber RD, Regan MM (2013) Challenges of guarantee-time bias. J Clin Oncol 31(23):2963\u20132969. https:\/\/doi.org\/10.1200\/JCO.2013.49.5283","journal-title":"J Clin Oncol"},{"issue":"11","key":"9166_CR14","doi-asserted-by":"publisher","first-page":"710","DOI":"10.1200\/JCO.1983.1.11.710","volume":"1","author":"JR Anderson","year":"1983","unstructured":"Anderson JR, Cain KC, Gelber RD (1983) Analysis of survival by tumor response and other posttreatment variables. J Clin Oncol 1(11):710\u2013719","journal-title":"J Clin Oncol"},{"issue":"2","key":"9166_CR15","doi-asserted-by":"publisher","first-page":"489","DOI":"10.1007\/s12561-016-9157-9","volume":"9","author":"H Putter","year":"2017","unstructured":"Putter H, van Houwelingen HC (2017) Understanding landmarking and its relation with time-dependent Cox regression. Stat Biosci 9(2):489\u2013503. https:\/\/doi.org\/10.1007\/s12561-016-9157-9","journal-title":"Stat Biosci"},{"issue":"12","key":"9166_CR16","doi-asserted-by":"publisher","first-page":"1373","DOI":"10.1016\/S0895-4356(96)00236-3","volume":"49","author":"P Peduzzi","year":"1996","unstructured":"Peduzzi P, Concato J, Kemper E, Holford TR, Feinstein AR (1996) A simulation study of the number of events per variable in logistic regression analysis. J Clin Epidemiol 49(12):1373\u20131379. https:\/\/doi.org\/10.1016\/S0895-4356(96)00236-3","journal-title":"J Clin Epidemiol"},{"issue":"6","key":"9166_CR17","doi-asserted-by":"publisher","first-page":"710","DOI":"10.1093\/aje\/kwk052","volume":"165","author":"E Vittinghoff","year":"2007","unstructured":"Vittinghoff E, McCulloch CE (2007) Relaxing the rule of ten events per variable in logistic and Cox regression. Am J Epidemiol 165(6):710\u2013718. https:\/\/doi.org\/10.1093\/aje\/kwk052","journal-title":"Am J Epidemiol"},{"issue":"5","key":"9166_CR18","doi-asserted-by":"publisher","first-page":"293","DOI":"10.1080\/146608200300079536","volume":"1","author":"BR Brooks","year":"2000","unstructured":"Brooks BR, Miller RG, Swash M, Munsat TL, World Federation of Neurology Research Group on Motor Neuron Diseases (2000) El Escorial revisited: revised criteria for the diagnosis of amyotrophic lateral sclerosis. Amyotroph Lateral Scler Other Motor Neuron Disord 1(5):293\u2013299. https:\/\/doi.org\/10.1080\/146608200300079536","journal-title":"Amyotroph Lateral Scler Other Motor Neuron Disord"},{"issue":"3","key":"9166_CR19","doi-asserted-by":"publisher","first-page":"497","DOI":"10.1016\/j.clinph.2007.09.143","volume":"119","author":"M de Carvalho","year":"2008","unstructured":"de Carvalho M, Dengler R, Eisen A, England JD, Kaji R, Kimura J et al (2008) Electrodiagnostic criteria for diagnosis of ALS. Clin Neurophysiol 119(3):497\u2013503. https:\/\/doi.org\/10.1016\/j.clinph.2007.09.143","journal-title":"Clin Neurophysiol"},{"issue":"8","key":"9166_CR20","doi-asserted-by":"publisher","first-page":"1975","DOI":"10.1016\/j.clinph.2020.04.005","volume":"131","author":"JM Shefner","year":"2020","unstructured":"Shefner JM, Al-Chalabi A, Baker MR, Cui LY, de Carvalho M, Eisen A et al (2020) A proposal for new diagnostic criteria for ALS. Clin Neurophysiol 131(8):1975\u20131978. https:\/\/doi.org\/10.1016\/j.clinph.2020.04.005","journal-title":"Clin Neurophysiol"},{"issue":"1","key":"9166_CR21","doi-asserted-by":"publisher","first-page":"239","DOI":"10.1093\/biomet\/69.1.239","volume":"69","author":"D Schoenfeld","year":"1982","unstructured":"Schoenfeld D (1982) Partial residuals for the proportional hazards regression model. Biometrika 69(1):239\u2013241. https:\/\/doi.org\/10.1093\/biomet\/69.1.239","journal-title":"Biometrika"},{"issue":"3","key":"9166_CR22","doi-asserted-by":"publisher","first-page":"515","DOI":"10.1093\/biomet\/81.3.515","volume":"81","author":"PM Grambsch","year":"1994","unstructured":"Grambsch PM, Therneau TM (1994) Proportional hazards tests and diagnostics based on weighted residuals. Biometrika 81(3):515\u2013526. https:\/\/doi.org\/10.1093\/biomet\/81.3.515","journal-title":"Biometrika"},{"key":"9166_CR23","doi-asserted-by":"publisher","first-page":"152","DOI":"10.1186\/1471-2288-13-152","volume":"13","author":"P Royston","year":"2013","unstructured":"Royston P, Parmar MKB (2013) Restricted mean survival time: an alternative to the hazard ratio for the design and analysis of randomized trials with a time-to-event outcome. BMC Med Res Methodol 13:152. https:\/\/doi.org\/10.1186\/1471-2288-13-152","journal-title":"BMC Med Res Methodol"},{"issue":"22","key":"9166_CR24","doi-asserted-by":"publisher","first-page":"2380","DOI":"10.1200\/JCO.2014.55.2208","volume":"32","author":"H Uno","year":"2014","unstructured":"Uno H, Claggett B, Tian L, Inoue E, Gallo P, Miyata T et al (2014) Moving beyond the hazard ratio in quantifying the between-group difference in survival analysis. J Clin Oncol 32(22):2380\u20132385. https:\/\/doi.org\/10.1200\/JCO.2014.55.2208","journal-title":"J Clin Oncol"},{"issue":"7\u20138","key":"9166_CR25","doi-asserted-by":"publisher","first-page":"661","DOI":"10.1080\/21678421.2024.2359556","volume":"25","author":"J Rooney","year":"2024","unstructured":"Rooney J, Murray D, Meldrum D, Al-Chalabi A, Bunte T, Chiwera T et al (2024) REVEALS-a longitudinal cohort study of multifaceted respiratory assessment in ALS. Amyotroph Lateral Scler Frontotemporal Degener 25(7\u20138):661\u2013671. https:\/\/doi.org\/10.1080\/21678421.2024.2359556","journal-title":"Amyotroph Lateral Scler Frontotemporal Degener"},{"issue":"sup1","key":"9166_CR26","doi-asserted-by":"publisher","first-page":"61","DOI":"10.1080\/21678421.2025.2454923","volume":"26","author":"S Sennfalt","year":"2025","unstructured":"Sennfalt S, Al-Chalabi A, Caravaca Puchades A, Chio A, Corcia P, Galvin M et al (2025) Respiratory function, survival, and NIV prevalence over time in ALS - a PRECISION ALS study. Amyotroph Lateral Scler Frontotemporal Degener 26(sup1):61\u201372. https:\/\/doi.org\/10.1080\/21678421.2025.2454923","journal-title":"Amyotroph Lateral Scler Frontotemporal Degener"},{"issue":"2","key":"9166_CR27","doi-asserted-by":"publisher","first-page":"e000829","DOI":"10.1136\/bmjno-2024-000829","volume":"6","author":"SI Terao","year":"2024","unstructured":"Terao SI, Nosaki Y, Murao A, Torii R, Ogawa N, Miura N et al (2024) Onset of age, site and respiratory symptoms are strongly associated with respiratory decline in sporadic amyotrophic lateral sclerosis: a long-term longitudinal study. BMJ Neurol Open 6(2):e000829. https:\/\/doi.org\/10.1136\/bmjno-2024-000829","journal-title":"BMJ Neurol Open"},{"issue":"4","key":"9166_CR28","doi-asserted-by":"publisher","first-page":"627","DOI":"10.3233\/JND-221658","volume":"10","author":"M Sarasate","year":"2023","unstructured":"Sarasate M, Gonzalez N, Cordoba-Izquierdo A, Prats E, Gonzalez-Moro JMR, Marti S et al (2023) Impact of Early Non-Invasive Ventilation in Amyotrophic Lateral Sclerosis: A multicenter Randomized Controlled Trial. J Neuromuscul Dis 10(4):627\u2013637. https:\/\/doi.org\/10.3233\/JND-221658","journal-title":"J Neuromuscul Dis"},{"issue":"5","key":"9166_CR29","doi-asserted-by":"publisher","first-page":"1099","DOI":"10.1002\/mus.28250","volume":"70","author":"JV Jimenez","year":"2024","unstructured":"Jimenez JV, Tang MJ, Wilson MW, Morrison AH, Ackrivo J, Choi PJ (2024) Initiation of noninvasive ventilation in patients with amyotrophic lateral sclerosis. Muscle Nerve 70(5):1099\u20131103. https:\/\/doi.org\/10.1002\/mus.28250","journal-title":"Muscle Nerve"},{"issue":"9","key":"9166_CR30","doi-asserted-by":"publisher","first-page":"585","DOI":"10.1056\/NEJM199403033300901","volume":"330","author":"G Bensimon","year":"1994","unstructured":"Bensimon G, Lacomblez L, Meininger V (1994) A controlled trial of riluzole in amyotrophic lateral sclerosis. N Engl J Med 330(9):585\u2013591. https:\/\/doi.org\/10.1056\/NEJM199403033300901","journal-title":"N Engl J Med"},{"issue":"7\u20138","key":"9166_CR31","doi-asserted-by":"publisher","first-page":"610","DOI":"10.3109\/21678421.2014.959024","volume":"15","author":"K Abe","year":"2014","unstructured":"Abe K, Itoyama Y, Sobue G, Tsuji S, Aoki M, Doyu M et al (2014) Confirmatory double-blind, parallel-group, placebo-controlled study of edaravone in ALS. Amyotroph Lateral Scler Frontotemporal Degener 15(7\u20138):610\u2013617. https:\/\/doi.org\/10.3109\/21678421.2014.959024","journal-title":"Amyotroph Lateral Scler Frontotemporal Degener"},{"issue":"7","key":"9166_CR32","doi-asserted-by":"publisher","first-page":"505","DOI":"10.1016\/S1474-4422(17)30115-1","volume":"16","author":"Writing Group on behalf of the Edaravone (MCI-186) ALS 19 Study Group","year":"2017","unstructured":"Writing Group on behalf of the Edaravone (MCI-186) ALS 19 Study Group (2017) Safety and efficacy of edaravone in well-defined patients with amyotrophic lateral sclerosis: a randomised, double-blind, placebo-controlled trial. Lancet Neurol 16(7):505\u2013512. https:\/\/doi.org\/10.1016\/S1474-4422(17)30115-1","journal-title":"Lancet Neurol"},{"issue":"6","key":"9166_CR33","doi-asserted-by":"publisher","first-page":"666","DOI":"10.1136\/jnnp-2018-319611","volume":"90","author":"C Moglia","year":"2019","unstructured":"Moglia C, Calvo A, Grassano M, Canosa A, Manera U, D\u2019Ovidio F et al (2019) Early weight loss in amyotrophic lateral sclerosis: outcome relevance and clinical correlates in a population-based cohort. J Neurol Neurosurg Psychiatry 90(6):666\u2013673. https:\/\/doi.org\/10.1136\/jnnp-2018-319611","journal-title":"J Neurol Neurosurg Psychiatry"},{"issue":"9934","key":"9166_CR34","doi-asserted-by":"publisher","first-page":"2065","DOI":"10.1016\/S0140-6736(14)60222-1","volume":"383","author":"AM Wills","year":"2014","unstructured":"Wills AM, Hubbard J, Macklin EA, Glass J, Tandan R, Simpson EP et al (2014) Hypercaloric enteral nutrition in patients with amyotrophic lateral sclerosis: a randomised, double-blind, placebo-controlled phase 2 trial. Lancet 383(9934):2065\u20132072. https:\/\/doi.org\/10.1016\/S0140-6736(14)60222-1","journal-title":"Lancet"}],"container-title":["Neurological Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10072-026-09166-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s10072-026-09166-2","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10072-026-09166-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,7]],"date-time":"2026-07-07T07:07:38Z","timestamp":1783408058000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s10072-026-09166-2"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,6,8]]},"references-count":34,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2026,7]]}},"alternative-id":["9166"],"URL":"https:\/\/doi.org\/10.1007\/s10072-026-09166-2","relation":{},"ISSN":["1590-1874","1590-3478"],"issn-type":[{"value":"1590-1874","type":"print"},{"value":"1590-3478","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,6,8]]},"assertion":[{"value":"7 March 2026","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"1 June 2026","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"8 June 2026","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"This study was conducted in accordance with the principles of the Declaration of Helsinki. The study protocol was approved by the Institutional Review Board of Hakodate Municipal Hospital (Approval No. 2025-319). The requirement for informed consent was waived due to the retrospective design with institutional opt-out.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval"}},{"value":"The requirement for consent to publish was waived due to the retrospective design, use of de-identified data, and institutional opt-out.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent to publish"}},{"value":"The requirement for informed consent to participate was waived due to the retrospective design with institutional opt-out.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent to participate"}},{"value":"During the preparation of this work, the authors used ChatGPT (OpenAI) in order to improve the English language expression, assist in structuring the manuscript, and generate Python scripts for statistical analysis. After using this tool\/service, the authors reviewed and edited the content as needed and take full responsibility for the content of the publication.","order":5,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declaration of Generative AI and AI-assisted technologies"}},{"value":"KH, KY, and IY have received honoraria for lectures and chairing from Mitsubishi Tanabe Pharma Corporation and Eisai Co., Ltd. IY has also received honoraria for lectures and chairing from Sanofi. The other authors report no relevant financial or non-financial competing interests to declare.","order":6,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interest"}}],"article-number":"550"}}