{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,7]],"date-time":"2026-07-07T07:20:19Z","timestamp":1783408819776,"version":"3.54.6"},"reference-count":35,"publisher":"Springer Science and Business Media LLC","issue":"7","license":[{"start":{"date-parts":[[2026,6,17]],"date-time":"2026-06-17T00:00:00Z","timestamp":1781654400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2026,6,17]],"date-time":"2026-06-17T00:00:00Z","timestamp":1781654400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Neurol Sci"],"published-print":{"date-parts":[[2026,7]]},"DOI":"10.1007\/s10072-026-09180-4","type":"journal-article","created":{"date-parts":[[2026,6,17]],"date-time":"2026-06-17T01:07:57Z","timestamp":1781658477000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Atrial natriuretic peptide can be biomarker for predicting atrial fibrillation in embolic stroke of undetermined source"],"prefix":"10.1007","volume":"47","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3447-4410","authenticated-orcid":false,"given":"Yuya","family":"Kobayashi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chinami","family":"Yuzawa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Minori","family":"Kurashina","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kazuki","family":"Kasuga","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoshiki","family":"Hanaoka","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yusaku","family":"Shimizu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Atsushi","family":"Sato","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kazuhiro","family":"Hongo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuji","family":"Ueno","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoshiki","family":"Sekijima","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,6,17]]},"reference":[{"key":"9180_CR1","doi-asserted-by":"publisher","first-page":"755","DOI":"10.1016\/0003-4975(95)00887-x","volume":"61","author":"JL Blackshear","year":"1996","unstructured":"Blackshear JL, Odell JA (1996) Appendage obliteration to reduce stroke in cardiac surgical patients with atrial fibrillation. Ann Thorac Surg 61:755\u2013759. https:\/\/doi.org\/10.1016\/0003-4975(95)00887-x","journal-title":"Ann Thorac Surg"},{"key":"9180_CR2","doi-asserted-by":"publisher","first-page":"e034758","DOI":"10.1161\/JAHA.123.034758","volume":"13","author":"LS Johnson","year":"2024","unstructured":"Johnson LS, Benz AP, Shoamanesh A, Eikelboom JW, Ezekowitz M, Giugliano RP et al (2024) Residual Stroke Risk Among Patients With Atrial Fibrillation Prescribed Oral Anticoagulants: A Patient-Level Meta\u2010Analysis From COMBINE AF. J Am Heart Association 13:e034758. https:\/\/doi.org\/10.1161\/JAHA.123.034758","journal-title":"J Am Heart Association"},{"key":"9180_CR3","doi-asserted-by":"publisher","first-page":"520","DOI":"10.1016\/j.amjcard.2013.04.017","volume":"112","author":"MP Turakhia","year":"2013","unstructured":"Turakhia MP, Hoang DD, Zimetbaum P, Miller JD, Froelicher VF, Kumar UN et al (2013) Diagnostic utility of a novel leadless arrhythmia monitoring device. Am J Cardiol 112:520\u2013524. https:\/\/doi.org\/10.1016\/j.amjcard.2013.04.017","journal-title":"Am J Cardiol"},{"key":"9180_CR4","doi-asserted-by":"publisher","first-page":"2478","DOI":"10.1056\/NEJMoa1313600","volume":"370","author":"T Sanna","year":"2014","unstructured":"Sanna T, Diener H-C, Passman RS, Lazzaro VD, Bernstein RA, Morillo CA et al (2014) Cryptogenic Stroke and Underlying Atrial Fibrillation. N Engl J Med 370:2478\u20132486. https:\/\/doi.org\/10.1056\/NEJMoa1313600","journal-title":"N Engl J Med"},{"key":"9180_CR5","doi-asserted-by":"publisher","first-page":"1909","DOI":"10.1056\/NEJMoa1901183","volume":"381","author":"MV Perez","year":"2019","unstructured":"Perez MV, Mahaffey KW, Hedlin H, Rumsfeld JS, Garcia A, Ferris T et al (2019) Large-Scale Assessment of a Smartwatch to Identify Atrial Fibrillation. N Engl J Med 381:1909\u20131917. https:\/\/doi.org\/10.1056\/NEJMoa1901183","journal-title":"N Engl J Med"},{"key":"9180_CR6","doi-asserted-by":"publisher","first-page":"1303","DOI":"10.1016\/j.amjcard.2011.12.022","volume":"109","author":"K Shibazaki","year":"2012","unstructured":"Shibazaki K, Kimura K, Fujii S, Sakai K, Iguchi Y (2012) Brain natriuretic peptide levels as a predictor for new atrial fibrillation during hospitalization in patients with acute ischemic stroke. Am J Cardiol 109:1303\u20131307. https:\/\/doi.org\/10.1016\/j.amjcard.2011.12.022","journal-title":"Am J Cardiol"},{"key":"9180_CR7","doi-asserted-by":"publisher","first-page":"175628642513703","DOI":"10.1177\/17562864251370312","volume":"18","author":"S Forlivesi","year":"2025","unstructured":"Forlivesi S, De Marco G, Riva L, Viola MM, Paolucci M, Gentile L et al (2025) Brain natriuretic peptide and echocardiographic parameters as biomarkers for predicting new atrial fibrillation detection after acute ischemic stroke. Ther Adv Neurol Disord 18:17562864251370312. https:\/\/doi.org\/10.1177\/17562864251370312","journal-title":"Ther Adv Neurol Disord"},{"key":"9180_CR8","doi-asserted-by":"publisher","first-page":"491","DOI":"10.1161\/01.res.69.2.491","volume":"69","author":"Y Ogawa","year":"1991","unstructured":"Ogawa Y, Nakao K, Mukoyama M, Hosoda K, Shirakami G, Arai H et al (1991) Natriuretic peptides as cardiac hormones in normotensive and spontaneously hypertensive rats. The ventricle is a major site of synthesis and secretion of brain natriuretic peptide. Circ Res 69:491\u2013500. https:\/\/doi.org\/10.1161\/01.res.69.2.491","journal-title":"Circ Res"},{"key":"9180_CR9","doi-asserted-by":"publisher","first-page":"429","DOI":"10.1016\/s1474-4422(13)70310-7","volume":"13","author":"RG Hart","year":"2014","unstructured":"Hart RG, Diener HC, Coutts SB, Easton JD, Granger CB, O\u2019Donnell MJ et al (2014) Embolic strokes of undetermined source: the case for a new clinical construct. Lancet Neurol 13:429\u2013438. https:\/\/doi.org\/10.1016\/s1474-4422(13)70310-7","journal-title":"Lancet Neurol"},{"key":"9180_CR10","doi-asserted-by":"publisher","unstructured":"Tzeis S, Gerstenfeld EP, Kalman J, Saad EB, Sepehri Shamloo A, Andrade JG et al (2024) 2024 European Heart Rhythm Association\/Heart Rhythm Society\/Asia Pacific Heart Rhythm Society\/Latin American Heart Rhythm Society expert consensus statement on catheter and surgical ablation of atrial fibrillation. EP Europace 26. https:\/\/doi.org\/10.1093\/europace\/euae043","DOI":"10.1093\/europace\/euae043"},{"key":"9180_CR11","doi-asserted-by":"publisher","first-page":"571","DOI":"10.1053\/ajkd.2003.50118","volume":"41","author":"PA McCullough","year":"2003","unstructured":"McCullough PA, Duc P, Omland T, McCord J, Nowak RM, Hollander JE et al (2003) B-type natriuretic peptide and renal function in the diagnosis of heart failure: an analysis from the Breathing Not Properly Multinational Study. Am J Kidney Dis 41:571\u2013579. https:\/\/doi.org\/10.1053\/ajkd.2003.50118","journal-title":"Am J Kidney Dis"},{"key":"9180_CR12","doi-asserted-by":"publisher","first-page":"467","DOI":"10.4065\/76.5.467","volume":"76","author":"TS Tsang","year":"2001","unstructured":"Tsang TS, Barnes ME, Bailey KR, Leibson CL, Montgomery SC, Takemoto Y et al (2001) Left atrial volume: important risk marker of incident atrial fibrillation in 1655 older men and women. Mayo Clin Proc 76:467\u2013475. https:\/\/doi.org\/10.4065\/76.5.467","journal-title":"Mayo Clin Proc"},{"key":"9180_CR13","doi-asserted-by":"publisher","first-page":"161","DOI":"10.1056\/NEJMoa020233","volume":"347","author":"AS Maisel","year":"2002","unstructured":"Maisel AS, Krishnaswamy P, Nowak RM, McCord J, Hollander JE, Duc P et al (2002) Rapid measurement of B-type natriuretic peptide in the emergency diagnosis of heart failure. N Engl J Med 347:161\u2013167. https:\/\/doi.org\/10.1056\/NEJMoa020233","journal-title":"N Engl J Med"},{"key":"9180_CR14","doi-asserted-by":"publisher","first-page":"724","DOI":"10.1161\/01.CIR.89.2.724","volume":"89","author":"SM Vaziri","year":"1994","unstructured":"Vaziri SM, Larson MG, Benjamin EJ, Levy D (1994) Echocardiographic predictors of nonrheumatic atrial fibrillation. Framingham Heart Study Circulation 89:724\u2013730. https:\/\/doi.org\/10.1161\/01.CIR.89.2.724","journal-title":"Framingham Heart Study Circulation"},{"key":"9180_CR15","doi-asserted-by":"publisher","first-page":"1692","DOI":"10.1016\/j.jstrokecerebrovasdis.2018.01.028","volume":"27","author":"B Ricci","year":"2018","unstructured":"Ricci B, Chang AD, Hemendinger M, Dakay K, Cutting S, Burton T et al (2018) A Simple Score That Predicts Paroxysmal Atrial Fibrillation on Outpatient Cardiac Monitoring after Embolic Stroke of Unknown Source. J Stroke Cerebrovasc Dis 27:1692\u20131696. https:\/\/doi.org\/10.1016\/j.jstrokecerebrovasdis.2018.01.028","journal-title":"J Stroke Cerebrovasc Dis"},{"key":"9180_CR16","doi-asserted-by":"publisher","first-page":"1237550","DOI":"10.3389\/fneur.2023.1237550","volume":"14","author":"A Alonso","year":"2023","unstructured":"Alonso A, Kraus J, Ebert A, Nikolayenko V, Kruska M, Sandikci V et al (2023) Left atrial area index provides the best prediction of atrial fibrillation in ischemic stroke patients: results from the LAETITIA observational study. Front Neurol 14:1237550. https:\/\/doi.org\/10.3389\/fneur.2023.1237550","journal-title":"Front Neurol"},{"key":"9180_CR17","doi-asserted-by":"publisher","first-page":"1196","DOI":"10.1161\/STROKEAHA.115.008681","volume":"46","author":"JF Scheitz","year":"2015","unstructured":"Scheitz JF, Erdur H, Haeusler KG, Audebert HJ, Roser M, Laufs U et al (2015) Insular Cortex Lesions, Cardiac Troponin, and Detection of Previously Unknown Atrial Fibrillation in Acute Ischemic Stroke. Stroke 46:1196\u20131201. https:\/\/doi.org\/10.1161\/STROKEAHA.115.008681","journal-title":"Stroke"},{"key":"9180_CR18","doi-asserted-by":"publisher","first-page":"8","DOI":"10.1016\/j.cardiores.2005.06.008","volume":"68","author":"JR Dietz","year":"2005","unstructured":"Dietz JR (2005) Mechanisms of atrial natriuretic peptide secretion from the atrium. Cardiovasc Res 68:8\u201317. https:\/\/doi.org\/10.1016\/j.cardiores.2005.06.008","journal-title":"Cardiovasc Res"},{"key":"9180_CR19","doi-asserted-by":"publisher","first-page":"541","DOI":"10.1177\/33.6.3158698","volume":"33","author":"C Chapeau","year":"1985","unstructured":"Chapeau C, Gutkowska J, Schiller PW, Milne RW, Thibault G, Garcia R et al (1985) Localization of immunoreactive synthetic atrial natriuretic factor (ANF) in the heart of various animal species. J Histochem Cytochem 33:541\u2013550. https:\/\/doi.org\/10.1177\/33.6.3158698","journal-title":"J Histochem Cytochem"},{"key":"9180_CR20","doi-asserted-by":"publisher","first-page":"R699","DOI":"10.1152\/ajpregu.1988.254.4.R699","volume":"254","author":"BA Benjamin","year":"1988","unstructured":"Benjamin BA, Metzler CH, Peterson TV (1988) Chronic atrial appendectomy alters sodium excretion in conscious monkeys. Am J Physiol 254:R699\u2013R705. https:\/\/doi.org\/10.1152\/ajpregu.1988.254.4.R699","journal-title":"Am J Physiol"},{"key":"9180_CR21","doi-asserted-by":"publisher","first-page":"724","DOI":"10.1161\/01.res.70.4.724","volume":"70","author":"JM Stewart","year":"1992","unstructured":"Stewart JM, Dean R, Brown M, Diasparra D, Zeballos GA, Schustek M et al (1992) Bilateral atrial appendectomy abolishes increased plasma atrial natriuretic peptide release and blunts sodium and water excretion during volume loading in conscious dogs. Circ Res 70:724\u2013732. https:\/\/doi.org\/10.1161\/01.res.70.4.724","journal-title":"Circ Res"},{"key":"9180_CR22","doi-asserted-by":"publisher","first-page":"213","DOI":"10.1016\/s0022-5223(98)70119-9","volume":"116","author":"F Yoshihara","year":"1998","unstructured":"Yoshihara F, Nishikimi T, Kosakai Y, Isobe F, Matsuoka H, Takishita S et al (1998) Atrial natriuretic peptide secretion and body fluid balance after bilateral atrial appendectomy by the maze procedure. J Thorac Cardiovasc Surg 116:213\u2013219. https:\/\/doi.org\/10.1016\/s0022-5223(98)70119-9","journal-title":"J Thorac Cardiovasc Surg"},{"key":"9180_CR23","doi-asserted-by":"publisher","unstructured":"Ruskoaho H, Lang RE, Toth M, Ganten D, Unger T (1987) Release and regulation of atrial natriuretic peptide (ANP). Eur Heart J 8 Suppl B 99\u2013109. https:\/\/doi.org\/10.1093\/eurheartj\/8.suppl_b.99","DOI":"10.1093\/eurheartj\/8.suppl_b.99"},{"key":"9180_CR24","doi-asserted-by":"publisher","first-page":"101","DOI":"10.1007\/bf00870995","volume":"31","author":"K Nakao","year":"1986","unstructured":"Nakao K, Sugawara A, Morii N, Sakamoto M, Yamada T, Itoh H et al (1986) The pharmacokinetics of alpha-human atrial natriuretic polypeptide in healthy subjects. Eur J Clin Pharmacol 31:101\u2013103. https:\/\/doi.org\/10.1007\/bf00870995","journal-title":"Eur J Clin Pharmacol"},{"key":"9180_CR25","doi-asserted-by":"publisher","first-page":"5","DOI":"10.1093\/europace\/euz212","volume":"22","author":"N Karim","year":"2019","unstructured":"Karim N, Ho SY, Nicol E, Li W, Zemrak F, Markides V et al (2019) The left atrial appendage in humans: structure, physiology, and pathogenesis. EP Europace 22:5\u201318. https:\/\/doi.org\/10.1093\/europace\/euz212","journal-title":"EP Europace"},{"key":"9180_CR26","doi-asserted-by":"publisher","first-page":"961","DOI":"10.1016\/0735-1097(94)90644-0","volume":"23","author":"D Fatkin","year":"1994","unstructured":"Fatkin D, Kelly RP, Feneley MP (1994) Relations between left atrial appendage blood flow velocity, spontaneous echocardiographic contrast and thromboembolic risk in vivo. J Am Coll Cardiol 23:961\u2013969. https:\/\/doi.org\/10.1016\/0735-1097(94)90644-0","journal-title":"J Am Coll Cardiol"},{"key":"9180_CR27","doi-asserted-by":"publisher","first-page":"e34351","DOI":"10.1371\/journal.pone.0034351","volume":"7","author":"R Wachter","year":"2012","unstructured":"Wachter R, Lahno R, Haase B, Weber-Kr\u00fcger M, Seegers J, Edelmann F et al (2012) Natriuretic Peptides for the Detection of Paroxysmal Atrial Fibrillation in Patients with Cerebral Ischemia \u2013 the Find-AF Study. PLoS ONE 7:e34351. https:\/\/doi.org\/10.1371\/journal.pone.0034351","journal-title":"PLoS ONE"},{"key":"9180_CR28","doi-asserted-by":"publisher","first-page":"1808","DOI":"10.1111\/j.1742-4658.2011.08082.x","volume":"278","author":"LR Potter","year":"2011","unstructured":"Potter LR (2011) Natriuretic peptide metabolism, clearance and degradation. FEBS J 278:1808\u20131817. https:\/\/doi.org\/10.1111\/j.1742-4658.2011.08082.x","journal-title":"FEBS J"},{"key":"9180_CR29","doi-asserted-by":"publisher","first-page":"92","DOI":"10.1016\/s1071-9164(00)90010-1","volume":"6","author":"S Inoue","year":"2000","unstructured":"Inoue S, Murakami Y, Sano K, Katoh H, Shimada T (2000) Atrium as a source of brain natriuretic polypeptide in patients with atrial fibrillation. J Card Fail 6:92\u201396. https:\/\/doi.org\/10.1016\/s1071-9164(00)90010-1","journal-title":"J Card Fail"},{"key":"9180_CR30","doi-asserted-by":"publisher","first-page":"557","DOI":"10.1139\/y11-054","volume":"89","author":"KN Pandey","year":"2011","unstructured":"Pandey KN (2011) Guanylyl cyclase \/ atrial natriuretic peptide receptor-A: role in the pathophysiology of cardiovascular regulation. Can J Physiol Pharmacol 89:557\u2013573. https:\/\/doi.org\/10.1139\/y11-054","journal-title":"Can J Physiol Pharmacol"},{"key":"9180_CR31","doi-asserted-by":"publisher","first-page":"303","DOI":"10.1111\/eci.12234","volume":"44","author":"H Takase","year":"2014","unstructured":"Takase H, Dohi Y (2014) Kidney function crucially affects B-type natriuretic peptide (BNP), N-terminal proBNP and their relationship. Eur J Clin Invest 44:303\u2013308. https:\/\/doi.org\/10.1111\/eci.12234","journal-title":"Eur J Clin Invest"},{"key":"9180_CR32","doi-asserted-by":"publisher","unstructured":"Morseth B, Geelhoed B, Linneberg A, Johansson L, Kuulasmaa K, Salomaa V et al (2021) Age-specific atrial fibrillation incidence, attributable risk factors and risk of stroke and mortality: results from the MORGAM Consortium. Open Heart 8. https:\/\/doi.org\/10.1136\/openhrt-2021-001624","DOI":"10.1136\/openhrt-2021-001624"},{"key":"9180_CR33","doi-asserted-by":"publisher","first-page":"843","DOI":"10.1136\/hrt.2005.071233","volume":"92","author":"M Weber","year":"2006","unstructured":"Weber M, Hamm C (2006) Role of B-type natriuretic peptide (BNP) and NT-proBNP in clinical routine. Heart 92:843\u2013849. https:\/\/doi.org\/10.1136\/hrt.2005.071233","journal-title":"Heart"},{"key":"9180_CR34","doi-asserted-by":"publisher","first-page":"7539","DOI":"10.1038\/s41598-022-11233-5","volume":"12","author":"ML Mojica-Pisciotti","year":"2022","unstructured":"Mojica-Pisciotti ML, Panovsk\u00fd R, Mas\u00e1rov\u00e1 L, Pe\u0161l M, St\u00e1rek Z, Hole\u010dek T et al (2022) Left atrium phasic impairments in paroxysmal atrial fibrillation patients assessed by cardiovascular magnetic resonance feature tracking. Sci Rep 12:7539. https:\/\/doi.org\/10.1038\/s41598-022-11233-5","journal-title":"Sci Rep"},{"key":"9180_CR35","doi-asserted-by":"publisher","first-page":"263","DOI":"10.1161\/circep.114.002521","volume":"8","author":"C Dussault","year":"2015","unstructured":"Dussault C, Toeg H, Nathan M, Wang ZJ, Roux JF, Secemsky E (2015) Electrocardiographic monitoring for detecting atrial fibrillation after ischemic stroke or transient ischemic attack: systematic review and meta-analysis. Circ Arrhythm Electrophysiol 8:263\u2013269. https:\/\/doi.org\/10.1161\/circep.114.002521","journal-title":"Circ Arrhythm Electrophysiol"}],"container-title":["Neurological Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10072-026-09180-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s10072-026-09180-4","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10072-026-09180-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,7]],"date-time":"2026-07-07T07:03:05Z","timestamp":1783407785000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s10072-026-09180-4"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,6,17]]},"references-count":35,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2026,7]]}},"alternative-id":["9180"],"URL":"https:\/\/doi.org\/10.1007\/s10072-026-09180-4","relation":{},"ISSN":["1590-1874","1590-3478"],"issn-type":[{"value":"1590-1874","type":"print"},{"value":"1590-3478","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,6,17]]},"assertion":[{"value":"26 February 2026","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"8 June 2026","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"17 June 2026","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"This study was approved by the Ethics Committee of Ina Central Hospital (approval no. 23\u2009\u2212\u20094) and conducted in accordance with the revised Declaration of Helsinki (2013 version). This study is registered with UMIN Clinical Trial Registry, Japan (UMIN000052177).","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval"}},{"value":"Written informed consent was obtained from all participants or relatives before enrollment.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Informed consent"}},{"value":"The authors declare that they have no conflicts of interest.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}],"article-number":"571"}}