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CSF A\u03b242 levels were associated with gait speed, balance, and mobility outcomes, while p-tau, p-tau181, p-tau217, and t-tau correlated with mobility impairments, dual-task performance, and reduced physical function. Higher neurofilament light chain (NfL) levels were linked to poorer Short Physical Performance Battery (SPPB) performance, slower gait speed, and lower grip strength. One study found serum IL-8 associated with mobility outcomes.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>AD-related biomarkers, particularly A\u03b242, p-tau, p-tau181, p-tau217, t-tau, and NfL, show consistent associations with gait disturbances, mobility decline, and reduced physical function. Motor changes may precede cognitive decline, supporting their potential as early indicators of neurodegeneration.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1007\/s10072-026-09253-4","type":"journal-article","created":{"date-parts":[[2026,7,31]],"date-time":"2026-07-31T06:30:02Z","timestamp":1785479402000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Motor performance and its association with Alzheimer\u2019s-related biomarkers: a systematic review"],"prefix":"10.1007","volume":"47","author":[{"given":"Mar\u00eda Fernanda","family":"Serna","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mildrey","family":"Mosquera","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Herney Andr\u00e9s","family":"Garc\u00eda-Perdomo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,7,31]]},"reference":[{"issue":"2","key":"9253_CR1","doi-asserted-by":"publisher","first-page":"16","DOI":"10.1007\/s12152-023-09522-5","volume":"16","author":"J Lee","year":"2023","unstructured":"Lee J (2023) Mild cognitive impairment in relation to Alzheimer\u2019s disease: an investigation of principles, classifications, ethics, and problems. 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