{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T17:52:31Z","timestamp":1791827551709,"version":"4.3.4"},"reference-count":22,"publisher":"Springer Science and Business Media LLC","issue":"9","license":[{"start":{"date-parts":[[2026,8,15]],"date-time":"2026-08-15T00:00:00Z","timestamp":1786752000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2026,8,15]],"date-time":"2026-08-15T00:00:00Z","timestamp":1786752000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Neurol Sci"],"published-print":{"date-parts":[[2026,9]]},"DOI":"10.1007\/s10072-026-09329-1","type":"journal-article","created":{"date-parts":[[2026,8,15]],"date-time":"2026-08-15T03:17:40Z","timestamp":1786763860000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Olfactory function after nasoseptal flap reconstruction in skull base surgery: a systematic review and meta-analysis"],"prefix":"10.1007","volume":"47","author":[{"ORCID":"https:\/\/orcid.org\/0009-0003-6923-4008","authenticated-orcid":false,"given":"Lucas","family":"Velasco Magalhaes Fernandes","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-1572-3337","authenticated-orcid":false,"given":"Joao Victor","family":"Silva Correia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5986-1345","authenticated-orcid":false,"given":"Leandro","family":"Castro Velasco","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,8,15]]},"reference":[{"key":"9329_CR1","doi-asserted-by":"publisher","unstructured":"Cavallo LM, Somma T, Solari D, Iannuzzo G, Frio F, Baiano C, Cappabianca P (2019) Endoscopic Endonasal Transsphenoidal Surgery: History and Evolution. World Neurosurg. 127:686\u2013694. https:\/\/doi.org\/10.1016\/j.wneu.2019.03.048","DOI":"10.1016\/j.wneu.2019.03.048"},{"issue":"2","key":"9329_CR2","doi-asserted-by":"publisher","first-page":"425","DOI":"10.3171\/2017.4.JNS162451","volume":"129","author":"BA Strickland","year":"2018","unstructured":"Strickland BA, Lucas J, Harris B, Kulubya E, Bakhsheshian J, Liu C, Wrobel B, Carmichael JD, Weiss M, Zada G (2018) Identification and repair of intraoperative cerebrospinal fluid leaks in endonasal transsphenoidal pituitary surgery: surgical experience in a series of 1002 patients. J Neurosurg 129(2):425\u2013429. https:\/\/doi.org\/10.3171\/2017.4.JNS162451","journal-title":"J Neurosurg"},{"key":"9329_CR3","doi-asserted-by":"publisher","unstructured":"Hadad G, Bassagasteguy L, Carrau RL, Mataza JC, Kassam A, Snyderman CH, Mintz A (2006) A novel reconstructive technique after endoscopic expanded endonasal approaches: vascular pedicle nasoseptal flap. Laryngoscope. ;116(10):1882-6. https:\/\/doi.org\/10.1097\/01.mlg.0000234933.37779.e4","DOI":"10.1097\/01.mlg.0000234933.37779.e4"},{"key":"9329_CR4","doi-asserted-by":"publisher","first-page":"bjaf023","DOI":"10.1093\/chemse\/bjaf023","volume":"50","author":"A Oleszkiewicz","year":"2025","unstructured":"Oleszkiewicz A, Croy I, Hummel T (2025) The impact of olfactory loss on quality of life: a 2025 review. Chem Senses 50:bjaf023. https:\/\/doi.org\/10.1093\/chemse\/bjaf023","journal-title":"Chem Senses"},{"issue":"12","key":"9329_CR5","doi-asserted-by":"publisher","first-page":"1164","DOI":"10.1017\/S0022215121004667","volume":"136","author":"CH Gui","year":"2022","unstructured":"Gui CH, Tham AC (2022) Quality of life after endoscopic skull base surgery with a nasoseptal flap: a systematic review. J Laryngol Otol 136(12):1164\u20131169. https:\/\/doi.org\/10.1017\/S0022215121004667","journal-title":"J Laryngol Otol"},{"key":"9329_CR6","doi-asserted-by":"publisher","unstructured":"Alobid I, Ense\u00f1at J, Mari\u00f1o-S\u00e1nchez F, de Notaris M, Centellas S, Mullol J, Bernal-Sprekelsen M (2013) Impairment of olfaction and mucociliary clearance after expanded endonasal approach using vascularized septal flap reconstruction for skull base tumors. Neurosurgery. 72(4):540-6. https:\/\/doi.org\/10.1227\/NEU.0b013e318282a535","DOI":"10.1227\/NEU.0b013e318282a535"},{"key":"9329_CR7","doi-asserted-by":"publisher","unstructured":"Seo MY, Nam DH, Kong DS, Lee SH, Noh Y, Jung YG, Kim HY, Chung SK, Lee KE, Hong SD (2020) Extended approach or usage of nasoseptal flap is a risk factor for olfactory dysfunction after endoscopic anterior skullbase surgery: results from 928 patients in a single tertiary center. Rhinology. 58(6):574\u2013580. https:\/\/doi.org\/10.4193\/Rhin20.020","DOI":"10.4193\/Rhin20.020"},{"issue":"3","key":"9329_CR8","doi-asserted-by":"publisher","first-page":"353","DOI":"10.1177\/1945892420957505","volume":"35","author":"CT Chou","year":"2021","unstructured":"Chou CT, Valappil B, Mattos JL, Snyderman CH, Gardner PA, Fernandez-Miranda JC, Wang EW (2021) The effect of nasoseptal flap elevation on post-operative olfaction and sinonasal quality of life: a prospective double-blinded randomized controlled trial. Am J Rhinol Allergy 35(3):353\u2013360. https:\/\/doi.org\/10.1177\/1945892420957505","journal-title":"Am J Rhinol Allergy"},{"key":"9329_CR9","doi-asserted-by":"crossref","unstructured":"Page MJ, McKenzie JE, Bossuyt PM, Boutron I, Hoffmann TC, Mulrow CD et al (2021) The PRISMA 2020 statement: an updated guideline for reporting systematic reviews. BMJ. n71","DOI":"10.1136\/bmj.n71"},{"key":"9329_CR10","unstructured":"Higgins JPT, Thomas J, Chandler J, Cumpston M, Li T, Page MJ, Welch VA (eds) (2022) Cochrane Handbook for Systematic Reviews of Interventions version 6.3 (updated February 2022). Cochrane, Available from training.cochrane.org\/handbook"},{"issue":"1","key":"9329_CR11","doi-asserted-by":"publisher","first-page":"210","DOI":"10.1186\/s13643-016-0384-4","volume":"5","author":"M Ouzzani","year":"2016","unstructured":"Ouzzani M, Hammady H, Fedorowicz Z, Elmagarmid A (2016) Rayyan-a web and mobile app for systematic reviews. Syst Rev 5(1):210. https:\/\/doi.org\/10.1186\/s13643-016-0384-4","journal-title":"Syst Rev"},{"key":"9329_CR12","doi-asserted-by":"crossref","unstructured":"Sterne JAC, Savovi\u0107 J, Page MJ, Elbers RG, Blencowe NS, Boutron I et al (2019) RoB 2: a revised tool for assessing risk of bias in randomised trials. BMJ. l4898","DOI":"10.1136\/bmj.l4898"},{"key":"9329_CR13","doi-asserted-by":"crossref","unstructured":"Sterne JA, Hern\u00e1n MA, Reeves BC, Savovi\u0107 J, Berkman ND, Viswanathan M et al (2016) ROBINS-I: a tool for assessing risk of bias in non-randomised studies of interventions. BMJ. i4919","DOI":"10.1136\/bmj.i4919"},{"key":"9329_CR14","doi-asserted-by":"publisher","first-page":"924","DOI":"10.1136\/bmj.39489.470347.AD","volume":"336","author":"GH Guyatt","year":"2008","unstructured":"Guyatt GH, Oxman AD, Vist GE et al (2008) GRADE: an emerging consensus on rating quality of evidence and strength of recommendations. BMJ 336:924\u2013926. https:\/\/doi.org\/10.1136\/bmj.39489.470347.AD","journal-title":"BMJ"},{"issue":"1","key":"9329_CR15","doi-asserted-by":"publisher","first-page":"62","DOI":"10.1002\/alr.21069","volume":"3","author":"S Tam","year":"2013","unstructured":"Tam S, Duggal N, Rotenberg BW (2013) Olfactory outcomes following endoscopic pituitary surgery with or without septal flap reconstruction: a randomized controlled trial. Int Forum Allergy Rhinol 3(1):62\u20135. https:\/\/doi.org\/10.1002\/alr.21069","journal-title":"Int Forum Allergy Rhinol"},{"issue":"4","key":"9329_CR16","doi-asserted-by":"publisher","first-page":"e699","DOI":"10.1055\/s-0043-1761168","volume":"27","author":"BM Koo","year":"2023","unstructured":"Koo BM, Jeong JI (2023) Long-term Recovery Patterns of Olfactory Function after Trans-sphenoidal Approach with Nasoseptal Flap Elevation. Int Arch Otorhinolaryngol 27(4):e699\u2013e705. https:\/\/doi.org\/10.1055\/s-0043-1761168","journal-title":"Int Arch Otorhinolaryngol"},{"issue":"4","key":"9329_CR17","doi-asserted-by":"publisher","first-page":"410","DOI":"10.1055\/s-0039-3400751","volume":"82","author":"KC Ting","year":"2019","unstructured":"Ting KC, Wang WH, Kuan EC, Lin YY, Lan MY (2019) Bilateral Smell Preservation is Routinely Possible following Endoscopic Endonasal Approach for Sellar\/Suprasellar Lesions. J Neurol Surg B Skull Base 82(4):410\u2013416. https:\/\/doi.org\/10.1055\/s-0039-3400751","journal-title":"J Neurol Surg B Skull Base"},{"issue":"7","key":"9329_CR18","doi-asserted-by":"publisher","first-page":"621","DOI":"10.1001\/jamaoto.2020.0673","volume":"146","author":"JJ Lee","year":"2020","unstructured":"Lee JJ, Thompson ZS, Piccirillo JF, Klatt-Cromwell CN, Orlowski HLP, Kallogjeri D, Pipkorn P, Schneider JS (2020) Risk Factors for Patient-Reported Olfactory Dysfunction After Endoscopic Transsphenoidal Hypophysectomy. JAMA Otolaryngol Head Neck Surg 146(7):621\u2013629","journal-title":"JAMA Otolaryngol Head Neck Surg"},{"issue":"2","key":"9329_CR19","doi-asserted-by":"publisher","first-page":"227","DOI":"10.1016\/j.anl.2019.07.002","volume":"47","author":"F Kuwata","year":"2020","unstructured":"Kuwata F, Kikuchi M, Ishikawa M, Tanji M, Sakamoto T, Yamashita M, Matsunaga M, Omori K, Nakagawa T (2020) Long-term olfactory function outcomes after pituitary surgery by endoscopic endonasal transsphenoidal approach. Auris Nasus Larynx 47(2):227\u2013232. https:\/\/doi.org\/10.1016\/j.anl.2019.07.002","journal-title":"Auris Nasus Larynx"},{"key":"9329_CR20","doi-asserted-by":"publisher","first-page":"1602","DOI":"10.1002\/lary.24107","volume":"123","author":"S-W Kim","year":"2013","unstructured":"Kim S-W, Park KB, Khalmuratova R, Lee H-K, Jeon S-Y, Kim DW (2013) Clinical and histologic studies of olfactory outcomes after nasoseptal flap harvesting. Laryngoscope 123:1602\u20131606. https:\/\/doi.org\/10.1002\/lary.24107","journal-title":"Laryngoscope"},{"issue":"10","key":"9329_CR21","doi-asserted-by":"publisher","first-page":"4925","DOI":"10.1007\/s00405-022-07298-7","volume":"279","author":"IT Heian","year":"2022","unstructured":"Heian IT, Helvik AS, Hummel T, \u00d8ie MR, Nordg\u00e5rd S, Bratt M, Thorstensen WM (2022) Measured and self-reported olfactory function in voluntary Norwegian adults. Eur Arch Otorhinolaryngol 279(10):4925\u20134933. https:\/\/doi.org\/10.1007\/s00405-022-07298-7","journal-title":"Eur Arch Otorhinolaryngol"},{"key":"9329_CR22","doi-asserted-by":"publisher","DOI":"10.1177\/01455613251351770","author":"KS Patel","year":"2025","unstructured":"Patel KS, Ebert CS, Kong KA (2025) Comparative review of olfactory assessment methods. Ear Nose Throat J. https:\/\/doi.org\/10.1177\/01455613251351770","journal-title":"Ear Nose Throat J"}],"container-title":["Neurological Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10072-026-09329-1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s10072-026-09329-1","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10072-026-09329-1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T17:34:26Z","timestamp":1791826466000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s10072-026-09329-1"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,8,15]]},"references-count":22,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2026,9]]}},"alternative-id":["9329"],"URL":"https:\/\/doi.org\/10.1007\/s10072-026-09329-1","relation":{},"ISSN":["1590-1874","1590-3478"],"issn-type":[{"value":"1590-1874","type":"print"},{"value":"1590-3478","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,8,15]]},"assertion":[{"value":"24 March 2026","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"9 August 2026","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"15 August 2026","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"Not applicable.","order":1,"name":"Ethics","label":"Ethical approval","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"Not applicable.","order":2,"name":"Ethics","label":"Consent to participate","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"Not applicable.","order":3,"name":"Ethics","label":"Consent to publish","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"Not applicable.","order":4,"name":"Ethics","label":"Clinical trial number","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors have no conflicts of interest to declare.","order":5,"name":"Ethics","label":"Conflict of interest","group":{"name":"EthicsHeading","label":"Declarations"}}],"article-number":"710"}}