{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T17:52:26Z","timestamp":1791827546829,"version":"4.3.4"},"reference-count":18,"publisher":"Springer Science and Business Media LLC","issue":"9","license":[{"start":{"date-parts":[[2026,8,24]],"date-time":"2026-08-24T00:00:00Z","timestamp":1787529600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2026,8,24]],"date-time":"2026-08-24T00:00:00Z","timestamp":1787529600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"funder":[{"DOI":"10.13039\/100019679","name":"Manisa Celal Bayar \u00dcniversitesi","doi-asserted-by":"publisher","award":["2023-078"],"award-info":[{"award-number":["2023-078"]}],"id":[{"id":"10.13039\/100019679","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Neurol Sci"],"published-print":{"date-parts":[[2026,9]]},"DOI":"10.1007\/s10072-026-09340-6","type":"journal-article","created":{"date-parts":[[2026,8,24]],"date-time":"2026-08-24T02:02:46Z","timestamp":1787536966000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Serum pentraxin-3 and systemic inflammatory biomarkers in Parkinson\u2019s disease with and without freezing of gait"],"prefix":"10.1007","volume":"47","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3778-8375","authenticated-orcid":false,"given":"Fatih","family":"\u00c7elik","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7888-5396","authenticated-orcid":false,"given":"Ya\u011fmur \u0130nalkac","family":"Gemici","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-2947-5678","authenticated-orcid":false,"given":"Fethi","family":"Akta\u015f","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0345-0264","authenticated-orcid":false,"given":"Cevval","family":"Ulman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0627-8914","authenticated-orcid":false,"given":"Melike","family":"Batum","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,8,24]]},"reference":[{"issue":"4","key":"9340_CR1","doi-asserted-by":"publisher","first-page":"368","DOI":"10.1136\/jnnp.2007.131045","volume":"79","author":"J Jankovic","year":"2008","unstructured":"Jankovic J (2008) Parkinson\u2019s disease: clinical features and diagnosis. J Neurol Neurosurg Psychiatry 79(4):368\u2013376","journal-title":"J Neurol Neurosurg Psychiatry"},{"issue":"11","key":"9340_CR2","doi-asserted-by":"publisher","first-page":"939","DOI":"10.1016\/S1474-4422(18)30295-3","volume":"17","author":"GBD 2016 Parkinson\u2019s Disease Collaborators","year":"2018","unstructured":"GBD 2016 Parkinson\u2019s Disease Collaborators (2018) Global, regional, and national burden of Parkinson\u2019s disease, 1990\u20132016: a systematic analysis for the Global Burden of Disease Study 2016. Lancet Neurol 17(11):939\u2013953. https:\/\/doi.org\/10.1016\/S1474-4422(18)30295-3","journal-title":"Lancet Neurol"},{"issue":"5","key":"9340_CR3","doi-asserted-by":"publisher","first-page":"464","DOI":"10.1016\/S1474-4422(09)70068-7","volume":"8","author":"KR Chaudhuri","year":"2009","unstructured":"Chaudhuri KR, Schapira AH (2009) Non-motor symptoms of Parkinson\u2019s disease: dopaminergic pathophysiology and treatment. Lancet Neurol 8(5):464\u2013474. https:\/\/doi.org\/10.1016\/S1474-4422(09)70068-7","journal-title":"Lancet Neurol"},{"issue":"3","key":"9340_CR4","doi-asserted-by":"publisher","first-page":"165","DOI":"10.1016\/S1353-8020(99)00062-0","volume":"6","author":"N Giladi","year":"2000","unstructured":"Giladi N, Shabtai H, Simon ES, Biran S, Tal J, Korczyn AD (2000) Construction of freezing of gait questionnaire for patients with Parkinsonism. Parkinsonism Relat Disord 6(3):165\u2013170. https:\/\/doi.org\/10.1016\/S1353-8020(99)00062-0","journal-title":"Parkinsonism Relat Disord"},{"issue":"8","key":"9340_CR5","doi-asserted-by":"publisher","first-page":"734","DOI":"10.1016\/S1474-4422(11)70143-0","volume":"10","author":"JG Nutt","year":"2011","unstructured":"Nutt JG, Bloem BR, Giladi N, Hallett M, Horak FB, Nieuwboer A (2011) Freezing of gait: moving forward on a mysterious clinical phenomenon. Lancet Neurol 10(8):734\u2013744. https:\/\/doi.org\/10.1016\/S1474-4422(11)70143-0","journal-title":"Lancet Neurol"},{"issue":"6","key":"9340_CR6","doi-asserted-by":"publisher","first-page":"644","DOI":"10.1016\/j.parkreldis.2015.03.028","volume":"21","author":"M Amboni","year":"2015","unstructured":"Amboni M, Stocchi F, Abbruzzese G, Morgante L, Onofrj M, Ruggieri S et al (2015) Prevalence and associated features of self-reported freezing of gait in Parkinson\u2019s disease: the DEEP FOG study. Parkinsonism Relat Disord 21(6):644\u2013649. https:\/\/doi.org\/10.1016\/j.parkreldis.2015.03.028","journal-title":"Parkinsonism Relat Disord"},{"issue":"1-2","key":"9340_CR7","doi-asserted-by":"publisher","first-page":"173","DOI":"10.1016\/j.jns.2006.05.015","volume":"248","author":"N Giladi","year":"2006","unstructured":"Giladi N, Hausdorff JM (2006) The role of mental function in the pathogenesis of freezing of gait in Parkinson\u2019s disease. J Neurol Sci 248(1\u20132):173\u2013176. https:\/\/doi.org\/10.1016\/j.jns.2006.05.015","journal-title":"J Neurol Sci"},{"issue":"5","key":"9340_CR8","doi-asserted-by":"publisher","first-page":"333","DOI":"10.1016\/j.parkreldis.2008.08.006","volume":"15","author":"SJ Lewis","year":"2009","unstructured":"Lewis SJ, Barker RA (2009) A pathophysiological model of freezing of gait in Parkinson\u2019s disease. Parkinsonism Relat Disord 15(5):333\u2013338. https:\/\/doi.org\/10.1016\/j.parkreldis.2008.08.006","journal-title":"Parkinsonism Relat Disord"},{"key":"9340_CR9","doi-asserted-by":"publisher","first-page":"2122","DOI":"10.3389\/fimmu.2018.02122","volume":"9","author":"X Chen","year":"2018","unstructured":"Chen X, Hu Y, Cao Z, Liu Q, Cheng Y (2018) Cerebrospinal fluid inflammatory cytokine aberrations in Alzheimer\u2019s disease, Parkinson\u2019s disease and amyotrophic lateral sclerosis: a systematic review and meta-analysis. Front Immunol 9:2122. https:\/\/doi.org\/10.3389\/fimmu.2018.02122","journal-title":"Front Immunol"},{"issue":"Suppl 1","key":"9340_CR10","doi-asserted-by":"publisher","first-page":"S210","DOI":"10.1016\/S1353-8020(11)70065-7","volume":"18","author":"EC Hirsch","year":"2012","unstructured":"Hirsch EC, Vyas S, Hunot S (2012) Neuroinflammation in Parkinson\u2019s disease. Parkinsonism Relat Disord 18(Suppl 1):S210\u2013S212. https:\/\/doi.org\/10.1016\/S1353-8020(11)70065-7","journal-title":"Parkinsonism Relat Disord"},{"issue":"2","key":"9340_CR11","doi-asserted-by":"publisher","first-page":"623","DOI":"10.1152\/physrev.00016.2017","volume":"98","author":"C Garlanda","year":"2018","unstructured":"Garlanda C, Bottazzi B, Magrini E, Inforzato A, Mantovani A (2018) PTX3, a humoral pattern recognition molecule, in innate immunity, tissue repair, and cancer. Physiol Rev 98(2):623\u2013639. https:\/\/doi.org\/10.1152\/physrev.00016.2017","journal-title":"Physiol Rev"},{"issue":"1","key":"9340_CR12","doi-asserted-by":"publisher","first-page":"55","DOI":"10.1016\/j.bbi.2008.07.003","volume":"23","author":"M Reale","year":"2009","unstructured":"Reale M, Iarlori C, Thomas A, Gambi D, Perfetti B, Di Nicola M et al (2009) Peripheral cytokines profile in Parkinson\u2019s disease. Brain Behav Immun 23(1):55\u201363. https:\/\/doi.org\/10.1016\/j.bbi.2008.07.003","journal-title":"Brain Behav Immun"},{"issue":"2","key":"9340_CR13","doi-asserted-by":"publisher","first-page":"158","DOI":"10.1016\/j.neulet.2008.06.040","volume":"441","author":"B Brodacki","year":"2008","unstructured":"Brodacki B, Staszewski J, Toczy\u0142owska B, Koz\u0142owska E, Drela N, Chalimoniuk M et al (2008) Serum interleukin (IL)-2, IL-10, IL-6, IL-4, TNF-\u03b1, and INF-\u03b3 concentrations are elevated in patients with atypical and idiopathic parkinsonism. Neurosci Lett 441(2):158\u2013162. https:\/\/doi.org\/10.1016\/j.neulet.2008.06.040","journal-title":"Neurosci Lett"},{"issue":"11","key":"9340_CR14","doi-asserted-by":"publisher","first-page":"1316","DOI":"10.1001\/jamaneurol.2016.2742","volume":"73","author":"XY Qin","year":"2016","unstructured":"Qin XY, Zhang SP, Cao C, Loh YP, Cheng Y (2016) Aberrations in peripheral inflammatory cytokine levels in Parkinson disease: a systematic review and meta-analysis. JAMA Neurol 73(11):1316\u20131324. https:\/\/doi.org\/10.1001\/jamaneurol.2016.2742","journal-title":"JAMA Neurol"},{"issue":"s1","key":"9340_CR15","doi-asserted-by":"publisher","first-page":"S183","DOI":"10.3233\/JPD-223277","volume":"12","author":"M Zimmermann","year":"2022","unstructured":"Zimmermann M, Brockmann K (2022) Blood and cerebrospinal fluid biomarkers of inflammation in Parkinson\u2019s disease. J Parkinsons Dis 12(s1):S183\u2013S200. https:\/\/doi.org\/10.3233\/JPD-223277","journal-title":"J Parkinsons Dis"},{"issue":"13","key":"9340_CR16","doi-asserted-by":"publisher","first-page":"2364","DOI":"10.1002\/mds.23871","volume":"26","author":"HW Lee","year":"2011","unstructured":"Lee HW, Choi J, Suk K (2011) Increases of pentraxin 3 plasma levels in patients with Parkinson\u2019s disease. Mov Disord 26(13):2364\u20132370. https:\/\/doi.org\/10.1002\/mds.23871","journal-title":"Mov Disord"},{"issue":"37","key":"9340_CR17","doi-asserted-by":"publisher","first-page":"E8637","DOI":"10.1073\/pnas.1812345115","volume":"115","author":"R Gordon","year":"2018","unstructured":"Gordon R, Albornoz EA, Christie DC, Langley MR, Kumar A, Huang W et al (2018) Inflammasome inhibition prevents \u03b1-synuclein pathology and dopaminergic neurodegeneration in models of Parkinson\u2019s disease. Proc Natl Acad Sci U S A 115(37):E8637\u2013E8646. https:\/\/doi.org\/10.1073\/pnas.1812345115","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"2","key":"9340_CR18","doi-asserted-by":"publisher","first-page":"282","DOI":"10.1177\/1877718X241308487","volume":"15","author":"SA Factor","year":"2025","unstructured":"Factor SA, Weinshenker D, McKay JL (2025) A possible pathway to freezing of gait in Parkinson\u2019s disease. J Parkinsons Dis 15(2):282\u2013290. https:\/\/doi.org\/10.1177\/1877718X241308487","journal-title":"J Parkinsons Dis"}],"container-title":["Neurological Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10072-026-09340-6.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s10072-026-09340-6","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10072-026-09340-6.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T17:34:11Z","timestamp":1791826451000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s10072-026-09340-6"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,8,24]]},"references-count":18,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2026,9]]}},"alternative-id":["9340"],"URL":"https:\/\/doi.org\/10.1007\/s10072-026-09340-6","relation":{},"ISSN":["1590-1874","1590-3478"],"issn-type":[{"value":"1590-1874","type":"print"},{"value":"1590-3478","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,8,24]]},"assertion":[{"value":"26 May 2026","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"14 August 2026","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"24 August 2026","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"All participants provided written informed consent, and the study protocol was approved by the local ethics committee of Manisa Celal Bayar University (Ethic Number: 15.02.2023\u201320.478.486\/1683).","order":1,"name":"Ethics","label":"Ethical statement","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the study reported in this paper.","order":2,"name":"Ethics","label":"Competing interests","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"Informed consent was obtained from all individual participants included in the study.","order":3,"name":"Ethics","label":"Informed consent statement","group":{"name":"EthicsHeading","label":"Declarations"}}],"article-number":"728"}}