{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,3]],"date-time":"2026-11-03T02:27:52Z","timestamp":1793672872825,"version":"4.5.1"},"reference-count":27,"publisher":"Springer Science and Business Media LLC","issue":"10","license":[{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Neurol Sci"],"published-print":{"date-parts":[[2026,10]]},"DOI":"10.1007\/s10072-026-09462-x","type":"journal-article","created":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T02:40:33Z","timestamp":1791168033000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Systemic inflammatory response syndrome and adverse outcomes in acute intracerebral hemorrhage: a meta-analysis"],"prefix":"10.1007","volume":"47","author":[{"given":"Lang","family":"Bu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Honghua","family":"Dai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hao","family":"Du","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4095-8427","authenticated-orcid":false,"given":"Yu","family":"Fan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,10,5]]},"reference":[{"issue":"2","key":"9462_CR1","doi-asserted-by":"publisher","first-page":"405","DOI":"10.1016\/j.ncl.2021.02.002","volume":"39","author":"CS Kase","year":"2021","unstructured":"Kase CS, Hanley DF (2021) Intracerebral Hemorrhage: Advances in Emergency Care. Neurol Clin 39(2):405\u2013418. https:\/\/doi.org\/10.1016\/j.ncl.2021.02.002","journal-title":"Neurol Clin"},{"issue":"2","key":"9462_CR2","doi-asserted-by":"publisher","first-page":"395","DOI":"10.1007\/s12028-023-01854-7","volume":"40","author":"DY Hwang","year":"2024","unstructured":"Hwang DY, Kim KS, Muehlschlegel S, Wartenberg KE, Rajajee V, Alexander SA, Busl KM, Creutzfeldt CJ, Fontaine GV, Hocker SE, Madzar D, Mahanes D, Mainali S, Sakowitz OW, Varelas PN, Weimar C, Westermaier T, Meixensberger J (2024) Guidelines for Neuroprognostication in Critically Ill Adults with Intracerebral Hemorrhage. Neurocrit Care 40(2):395\u2013414. https:\/\/doi.org\/10.1007\/s12028-023-01854-7","journal-title":"Neurocrit Care"},{"key":"9462_CR3","doi-asserted-by":"publisher","first-page":"239","DOI":"10.12688\/wellcomeopenres.19187.2","volume":"8","author":"C Kirby","year":"2023","unstructured":"Kirby C, Barrington J, Sondag L, Loan JJM, Schreuder FHBM, McColl BW, Klijn CJM, Al-Shahi Salman R, Samarasekera N (2023) Association between circulating inflammatory biomarkers and functional outcome or perihaematomal oedema after ICH: a systematic review & meta-analysis. Wellcome Open Res 8:239. https:\/\/doi.org\/10.12688\/wellcomeopenres.19187.2","journal-title":"Wellcome Open Res"},{"key":"9462_CR4","doi-asserted-by":"publisher","first-page":"1288377","DOI":"10.3389\/fneur.2023.1288377","volume":"14","author":"P Guo","year":"2024","unstructured":"Guo P, Zou W (2024) Neutrophil-to-lymphocyte ratio, white blood cell, and C-reactive protein predicts poor outcome and increased mortality in intracerebral hemorrhage patients: a meta-analysis. Front Neurol 14:1288377. https:\/\/doi.org\/10.3389\/fneur.2023.1288377","journal-title":"Front Neurol"},{"issue":"6","key":"9462_CR5","doi-asserted-by":"publisher","first-page":"959","DOI":"10.1177\/0271678X19841443","volume":"39","author":"AR Saand","year":"2019","unstructured":"Saand AR, Yu F, Chen J, Chou SH (2019) Systemic inflammation in hemorrhagic strokes - A novel neurological sign and therapeutic target? J Cereb Blood Flow Metab 39(6):959\u2013988. https:\/\/doi.org\/10.1177\/0271678X19841443","journal-title":"J Cereb Blood Flow Metab"},{"key":"9462_CR6","doi-asserted-by":"publisher","first-page":"1328729","DOI":"10.1155\/2022\/1328729","volume":"2022","author":"S Pan","year":"2022","unstructured":"Pan S, Lv Z, Wang R, Shu H, Yuan S, Yu Y, Shang Y (2022) Sepsis-Induced Brain Dysfunction: Pathogenesis, Diagnosis, and Treatment. Oxid Med Cell Longev 2022:1328729. https:\/\/doi.org\/10.1155\/2022\/1328729","journal-title":"Oxid Med Cell Longev"},{"issue":"5","key":"9462_CR7","doi-asserted-by":"publisher","first-page":"489","DOI":"10.17219\/acem\/145852","volume":"31","author":"Y Zhu","year":"2022","unstructured":"Zhu Y, Xie Z, Shen J, Zhou L, Liu Z, Ye D, Wu F, Ezzi SHA, Hmood ZS, Zhan R (2022) Association between systemic inflammatory response syndrome and hematoma expansion in intracerebral hemorrhage. Adv Clin Exp Med 31(5):489\u2013498. https:\/\/doi.org\/10.17219\/acem\/145852","journal-title":"Adv Clin Exp Med"},{"issue":"1","key":"9462_CR8","doi-asserted-by":"publisher","first-page":"133","DOI":"10.1007\/s12028-016-0255-9","volume":"25","author":"AK Boehme","year":"2016","unstructured":"Boehme AK, Hays AN, Kicielinski KP, Arora K, Lyerly NK, Gadpaille MJ, Shiue A, Albright H, Miller K, Elkind D, Harrigan MS MR (2016) Systemic Inflammatory Response Syndrome and Outcomes in Intracerebral Hemorrhage. Neurocrit Care 25(1):133\u2013140. https:\/\/doi.org\/10.1007\/s12028-016-0255-9","journal-title":"Neurocrit Care"},{"key":"9462_CR9","doi-asserted-by":"publisher","first-page":"247","DOI":"10.1016\/j.jcrc.2017.06.002","volume":"41","author":"M Di Napoli","year":"2017","unstructured":"Di Napoli M, Behrouz R, Topel CH, Misra V, Pomero F, Giraudo A, Pennati P, Masotti L, Schreuder FHBM, Staals J, Klijn CJM, Smith CJ, Parry-Jones AR, Slevin MA, Silver B, Willey JZ, Azarpazhooh MR, Vallejo JM, Nzwalo H, Popa-Wagner A, Godoy DA (2017) Hypoalbuminemia, systemic inflammatory response syndrome, and functional outcome in intracerebral hemorrhage. J Crit Care 41:247\u2013253. https:\/\/doi.org\/10.1016\/j.jcrc.2017.06.002","journal-title":"J Crit Care"},{"issue":"5","key":"9462_CR10","doi-asserted-by":"publisher","first-page":"e588","DOI":"10.1212\/NXI.0000000000000588","volume":"6","author":"M Hagen","year":"2019","unstructured":"Hagen M, Sembill JA, Spr\u00fcgel MI, Gerner ST, Mad\u017ear D, L\u00fccking H, H\u00f6lter P, Schwab S, Huttner HB, Kuramatsu JB (2019) Systemic inflammatory response syndrome and long-term outcome after intracerebral hemorrhage. Neurol Neuroimmunol Neuroinflamm 6(5):e588. https:\/\/doi.org\/10.1212\/NXI.0000000000000588","journal-title":"Neurol Neuroimmunol Neuroinflamm"},{"key":"9462_CR11","doi-asserted-by":"publisher","first-page":"148","DOI":"10.1016\/j.jocn.2020.04.118","volume":"77","author":"H Hoffman","year":"2020","unstructured":"Hoffman H, Jalal MS, Chin LS (2020) Prediction of mortality after evacuation of supratentorial intracerebral hemorrhage using NSQIP data. J Clin Neurosci 77:148\u2013156. https:\/\/doi.org\/10.1016\/j.jocn.2020.04.118","journal-title":"J Clin Neurosci"},{"issue":"7","key":"9462_CR12","doi-asserted-by":"publisher","first-page":"1640","DOI":"10.1016\/j.jstrokecerebrovasdis.2015.03.057","volume":"24","author":"J Kalita","year":"2015","unstructured":"Kalita J, Bastia J, Bhoi SK, Misra UK (2015) Systemic Inflammatory Response Syndrome Predicts Severity of Stroke and Outcome. J Stroke Cerebrovasc Dis 24(7):1640\u20131648. https:\/\/doi.org\/10.1016\/j.jstrokecerebrovasdis.2015.03.057","journal-title":"J Stroke Cerebrovasc Dis"},{"issue":"2","key":"9462_CR13","doi-asserted-by":"publisher","first-page":"e428","DOI":"10.1212\/NXI.0000000000000428","volume":"5","author":"AK Boehme","year":"2017","unstructured":"Boehme AK, Comeau ME, Langefeld CD, Lord A, Moomaw CJ, Osborne J, James ML, Martini S, Testai FD, Woo D, Elkind MSV (2017) Systemic inflammatory response syndrome, infection, and outcome in intracerebral hemorrhage. Neurol Neuroimmunol Neuroinflamm 5(2):e428. https:\/\/doi.org\/10.1212\/NXI.0000000000000428","journal-title":"Neurol Neuroimmunol Neuroinflamm"},{"key":"9462_CR14","doi-asserted-by":"publisher","first-page":"33","DOI":"10.1016\/j.jocn.2023.07.008","volume":"115","author":"C Pisco","year":"2023","unstructured":"Pisco C, Pedro T, Aires A, Fonseca L, Fonseca S, Castro P (2023) The effect of neutrophil-to-lymphocyte ratio and systemic inflammatory response on perihematomal edema after intracerebral hemorrhage. J Clin Neurosci 115:33\u201337. https:\/\/doi.org\/10.1016\/j.jocn.2023.07.008","journal-title":"J Clin Neurosci"},{"issue":"10","key":"9462_CR15","doi-asserted-by":"publisher","first-page":"e1","DOI":"10.1016\/j.jclinepi.2009.06.006","volume":"62","author":"A Liberati","year":"2009","unstructured":"Liberati A, Altman DG, Tetzlaff J, Mulrow C, Gotzsche PC, Ioannidis JP, Clarke M, Devereaux PJ, Kleijnen J, Moher D (2009) The PRISMA statement for reporting systematic reviews and meta-analyses of studies that evaluate health care interventions: explanation and elaboration. J Clin Epidemiol 62(10):e1\u201334. https:\/\/doi.org\/10.1016\/j.jclinepi.2009.06.006S0895-4356(09)00180-2 [pii]","journal-title":"J Clin Epidemiol"},{"key":"9462_CR16","unstructured":"Wells G, Shea B, O\u2019Connell D, Peterson J, Welch V, Losos M, Tugwell P The Newcastle\u2013Ottawa Scale (NOS) for assessing the quality if nonrandomized studies in meta-analyses. http:\/\/www.ohri.ca\/programs\/clinical_epidemiology\/oxford.asp. Assessed 20 Dec 2025"},{"issue":"4","key":"9462_CR17","doi-asserted-by":"publisher","first-page":"1088","DOI":"10.2307\/2533446","volume":"50","author":"CB Begg","year":"1994","unstructured":"Begg CB, Mazumdar M (1994) Operating characteristics of a rank correlation test for publication bias. Biometrics 50(4):1088\u20131101","journal-title":"Biometrics"},{"issue":"7109","key":"9462_CR18","doi-asserted-by":"publisher","first-page":"629","DOI":"10.1136\/bmj.315.7109.629","volume":"315","author":"M Egger","year":"1997","unstructured":"Egger M, Davey Smith G, Schneider M, Minder C (1997) Bias in meta-analysis detected by a simple, graphical test. BMJ 315(7109):629\u2013634","journal-title":"BMJ"},{"key":"9462_CR19","doi-asserted-by":"publisher","first-page":"917","DOI":"10.2147\/JIR.S394635","volume":"16","author":"L Liu","year":"2023","unstructured":"Liu L, Wang A, Wang D, Guo J, Zhang X, Zhao X, Wang W (2023) Systemic Inflammatory Response Syndrome on Admission and Clinical Outcomes After Intracerebral Hemorrhage. J Inflamm Res 16:917\u2013926. https:\/\/doi.org\/10.2147\/JIR.S394635","journal-title":"J Inflamm Res"},{"key":"9462_CR20","doi-asserted-by":"publisher","first-page":"105870","DOI":"10.1016\/j.jstrokecerebrovasdis.2021.105870","volume":"30","author":"KR Melmed","year":"2021","unstructured":"Melmed KR, Carroll E, Lord AS, Boehme AK, Ishida K, Zhang C, Torres JL, Yaghi S, Czeisler BM, Frontera JA, Lewis A (2021) Systemic Inflammatory Response Syndrome is Associated with Hematoma Expansion in Intracerebral Hemorrhage. J Stroke Cerebrovasc Dis 30:105870. https:\/\/doi.org\/10.1016\/j.jstrokecerebrovasdis.2021.105870","journal-title":"J Stroke Cerebrovasc Dis"},{"issue":"3","key":"9462_CR21","doi-asserted-by":"publisher","first-page":"266","DOI":"10.1097\/JS9.0000000000000191","volume":"109","author":"H Chu","year":"2023","unstructured":"Chu H, Huang C, Zhou Z, Tang Y, Dong Q, Guo Q (2023) Inflammatory score predicts early hematoma expansion and poor outcomes in patients with intracerebral hemorrhage. Int J Surg 109(3):266\u2013276. https:\/\/doi.org\/10.1097\/JS9.0000000000000191","journal-title":"Int J Surg"},{"issue":"6","key":"9462_CR22","doi-asserted-by":"publisher","first-page":"1781","DOI":"10.1161\/STROKEAHA.110.596718","volume":"42","author":"J Aronowski","year":"2011","unstructured":"Aronowski J, Zhao X (2011) Molecular pathophysiology of cerebral hemorrhage: secondary brain injury. Stroke 42(6):1781\u20131786. https:\/\/doi.org\/10.1161\/STROKEAHA.110.596718","journal-title":"Stroke"},{"issue":"11","key":"9462_CR23","doi-asserted-by":"publisher","first-page":"3323","DOI":"10.1161\/STROKEAHA.110.608257","volume":"42","author":"Y Yang","year":"2011","unstructured":"Yang Y, Rosenberg GA (2011) Blood-brain barrier breakdown in acute and chronic cerebrovascular disease. Stroke 42(11):3323\u20133328. https:\/\/doi.org\/10.1161\/STROKEAHA.110.608257","journal-title":"Stroke"},{"issue":"2","key":"9462_CR24","doi-asserted-by":"publisher","first-page":"131","DOI":"10.1023\/a:1007074420772","volume":"20","author":"NJ Abbott","year":"2000","unstructured":"Abbott NJ (2000) Inflammatory mediators and modulation of blood-brain barrier permeability. Cell Mol Neurobiol 20(2):131\u2013147. https:\/\/doi.org\/10.1023\/a:1007074420772","journal-title":"Cell Mol Neurobiol"},{"issue":"12","key":"9462_CR25","doi-asserted-by":"publisher","first-page":"1329","DOI":"10.2174\/1389450118666170329152305","volume":"1","author":"SR Burchell","year":"2017","unstructured":"Burchell SR, Tang J, Zhang JH (2017) Hematoma Expansion Following Intracerebral Hemorrhage: Mechanisms Targeting the Coagulation Cascade and Platelet Activation. Curr Drug Targets 1(12):1329\u20131344. https:\/\/doi.org\/10.2174\/1389450118666170329152305","journal-title":"Curr Drug Targets"},{"key":"9462_CR26","doi-asserted-by":"publisher","first-page":"187","DOI":"10.3389\/fneur.2016.00187","volume":"7","author":"J Guan","year":"2016","unstructured":"Guan J, Hawryluk GW (2016) Targeting Secondary Hematoma Expansion in Spontaneous Intracerebral Hemorrhage - State of the Art. Front Neurol 7:187. https:\/\/doi.org\/10.3389\/fneur.2016.00187","journal-title":"Front Neurol"},{"issue":"7568","key":"9462_CR27","doi-asserted-by":"publisher","first-page":"597","DOI":"10.1136\/bmj.333.7568.597","volume":"333","author":"J Lau","year":"2006","unstructured":"Lau J, Ioannidis JP, Terrin N, Schmid CH, Olkin I (2006) The case of the misleading funnel plot. BMJ 333(7568):597\u2013600. https:\/\/doi.org\/10.1136\/bmj.333.7568.597","journal-title":"BMJ"}],"container-title":["Neurological Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10072-026-09462-x.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s10072-026-09462-x","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10072-026-09462-x.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,11,3]],"date-time":"2026-11-03T02:03:12Z","timestamp":1793671392000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s10072-026-09462-x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,10]]},"references-count":27,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2026,10]]}},"alternative-id":["9462"],"URL":"https:\/\/doi.org\/10.1007\/s10072-026-09462-x","relation":{},"ISSN":["1590-1874","1590-3478"],"issn-type":[{"value":"1590-1874","type":"print"},{"value":"1590-3478","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,10]]},"assertion":[{"value":"15 May 2026","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"30 September 2026","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"5 October 2026","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"Not applicable.","order":1,"name":"Ethics","label":"Ethical approval","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"Not applicable.","order":2,"name":"Ethics","label":"Consent for publication","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare no competing interests.","order":3,"name":"Ethics","label":"Competing interests","group":{"name":"EthicsHeading","label":"Declarations"}}],"article-number":"844"}}