{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,3]],"date-time":"2026-11-03T02:27:16Z","timestamp":1793672836374,"version":"4.5.1"},"reference-count":5,"publisher":"Springer Science and Business Media LLC","issue":"10","license":[{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Neurol Sci"],"published-print":{"date-parts":[[2026,10]]},"DOI":"10.1007\/s10072-026-09465-8","type":"journal-article","created":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T02:20:46Z","timestamp":1791253246000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Pontine warning syndrome successfully managed with acute tirofiban infusion"],"prefix":"10.1007","volume":"47","author":[{"ORCID":"https:\/\/orcid.org\/0009-0009-9042-9866","authenticated-orcid":false,"given":"Antonio","family":"Esposito","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mariagiovanna","family":"Castiglia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eduardo","family":"Gragnano","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fiore","family":"Manganelli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emanuele","family":"Spina","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,10,6]]},"reference":[{"key":"9465_CR1","doi-asserted-by":"publisher","first-page":"22","DOI":"10.1136\/svn-2018-000163","volume":"4","author":"W Li","year":"2019","unstructured":"Li W, Wu Y, Li XS et al (2019) Intravenous tirofiban therapy for patients with capsular warning syndrome. Stroke Vasc Neurol 4:22\u201327. https:\/\/doi.org\/10.1136\/svn-2018-000163","journal-title":"Stroke Vasc Neurol"},{"key":"9465_CR2","doi-asserted-by":"publisher","first-page":"2025","DOI":"10.1056\/NEJMoa2214299","volume":"388","author":"W Zi","year":"2023","unstructured":"Zi W, Song J, Kong W et al (2023) Tirofiban for stroke without large or medium-sized vessel occlusion. N Engl J Med 388:2025\u20132036. https:\/\/doi.org\/10.1056\/NEJMoa2214299","journal-title":"N Engl J Med"},{"key":"9465_CR3","doi-asserted-by":"publisher","first-page":"594","DOI":"10.1001\/jamaneurol.2024.0868","volume":"81","author":"W Zhao","year":"2024","unstructured":"Zhao W, Li S, Li C et al (2024) Effects of tirofiban on neurological deterioration in patients with acute ischemic stroke: a randomized clinical trial. JAMA Neurol 81:594\u2013602. https:\/\/doi.org\/10.1001\/jamaneurol.2024.0868","journal-title":"JAMA Neurol"},{"key":"9465_CR4","doi-asserted-by":"publisher","first-page":"1949","DOI":"10.1001\/jama.2026.5245","volume":"335","author":"INSTANT Trial Authors for the INSTANT Investigators","year":"2026","unstructured":"INSTANT Trial Authors for the INSTANT Investigators (2026) Intravenous tirofiban after tenecteplase in acute ischemic stroke: the INSTANT randomized clinical trial. JAMA 335:1949\u20131958. https:\/\/doi.org\/10.1001\/jama.2026.5245","journal-title":"JAMA"},{"key":"9465_CR5","doi-asserted-by":"publisher","first-page":"e316","DOI":"10.1161\/STR.0000000000000513","volume":"57","author":"S Prabhakaran","year":"2026","unstructured":"Prabhakaran S, Gonzalez NR, Zachrison KS et al (2026) 2026 Guideline for the Early Management of Patients With Acute Ischemic Stroke: A Guideline From the American Heart Association\/American Stroke Association. Stroke 57:e316\u2013e436. https:\/\/doi.org\/10.1161\/STR.0000000000000513","journal-title":"Stroke"}],"container-title":["Neurological Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10072-026-09465-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s10072-026-09465-8","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10072-026-09465-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,11,3]],"date-time":"2026-11-03T02:02:49Z","timestamp":1793671369000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s10072-026-09465-8"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,10]]},"references-count":5,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2026,10]]}},"alternative-id":["9465"],"URL":"https:\/\/doi.org\/10.1007\/s10072-026-09465-8","relation":{},"ISSN":["1590-1874","1590-3478"],"issn-type":[{"value":"1590-1874","type":"print"},{"value":"1590-3478","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,10]]},"assertion":[{"value":"18 August 2026","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"30 September 2026","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"6 October 2026","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"According to the policies of the Ethics Committee of Federico II University Hospital, ethical approval was not required for this single-patient case report.","order":1,"name":"Ethics","label":"Ethics approval","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"Written informed consent for publication of the patient\u2019s clinical data and accompanying images was obtained.","order":2,"name":"Ethics","label":"Consent to publish","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare no competing interests related to this manuscript.","order":3,"name":"Ethics","label":"Competing interests","group":{"name":"EthicsHeading","label":"Declarations"}}],"article-number":"846"}}