{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T14:47:08Z","timestamp":1791989228205,"version":"4.4.0"},"reference-count":5,"publisher":"Springer Science and Business Media LLC","issue":"11","license":[{"start":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T00:00:00Z","timestamp":1791936000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T00:00:00Z","timestamp":1791936000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Neurol Sci"],"published-print":{"date-parts":[[2026,11]]},"DOI":"10.1007\/s10072-026-09469-4","type":"journal-article","created":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T14:09:09Z","timestamp":1791986949000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Psychiatric symptoms as early indicators in multiple sclerosis: clinical features and implications for disability progression"],"prefix":"10.1007","volume":"47","author":[{"given":"C.","family":"Esposto","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T.","family":"Guerra","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D.","family":"Paolicelli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2308-1731","authenticated-orcid":false,"given":"P.","family":"Iaffaldano","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,10,14]]},"reference":[{"issue":"1","key":"9469_CR1","doi-asserted-by":"publisher","first-page":"14","DOI":"10.3109\/09540261003589323","volume":"22","author":"T Paparrigopoulos","year":"2010","unstructured":"Paparrigopoulos T, Ferentinos P, Kouzoupis A, Koutsis G, Papadimitriou GN (2010) The neuropsychiatry of multiple sclerosis: Focus on disorders of mood, affect and behaviour. Int Rev Psychiatry 22(1):14\u201321","journal-title":"Int Rev Psychiatry"},{"issue":"9","key":"9469_CR2","doi-asserted-by":"publisher","first-page":"507","DOI":"10.1038\/nrneurol.2014.139","volume":"10","author":"A Feinstein","year":"2014","unstructured":"Feinstein A, Magalhaes S, Richard JF, Audet B, Moore C (2014) The link between multiple sclerosis and depression. Nat Reviews Neurol 10(9):507\u2013517","journal-title":"Nat Reviews Neurol"},{"key":"9469_CR3","doi-asserted-by":"publisher","unstructured":"Chalah MA, Ayache SS (2017 Oct-Dec) Psychiatric event in multiple sclerosis: could it be the tip of the iceberg? Braz J Psychiatry 39(4):365\u2013368. https:\/\/doi.org\/10.1590\/1516-4446-2016-2105","DOI":"10.1590\/1516-4446-2016-2105"},{"issue":"2","key":"9469_CR4","doi-asserted-by":"publisher","first-page":"31","DOI":"10.4274\/jmsr.galenos.2022.2022-8-1","volume":"2","author":"Y Inanc","year":"2022","unstructured":"Inanc Y, Kaya T (2022) Psychiatric Disorders in Multiple Sclerosis. J Mult Scler Res 2(2):31\u201335. https:\/\/doi.org\/10.4274\/jmsr.galenos.2022.2022-8-1","journal-title":"J Mult Scler Res"},{"issue":"6","key":"9469_CR5","doi-asserted-by":"publisher","first-page":"742","DOI":"10.1177\/1352458510365157","volume":"16","author":"S Lo Fermo","year":"2010","unstructured":"Lo Fermo S, Barone R, Patti F, Laisa P, Cavallaro TL, Nicoletti A, Zappia M (2010) Outcome of psychiatric symptoms presenting at onset of multiple sclerosis: a retrospective study. Mult Scler 16(6):742\u2013748. https:\/\/doi.org\/10.1177\/1352458510365157 Epub 2010 Mar 29. PMID: 20350959","journal-title":"Mult Scler"}],"container-title":["Neurological Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10072-026-09469-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s10072-026-09469-4","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10072-026-09469-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T14:09:10Z","timestamp":1791986950000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s10072-026-09469-4"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,10,14]]},"references-count":5,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2026,11]]}},"alternative-id":["9469"],"URL":"https:\/\/doi.org\/10.1007\/s10072-026-09469-4","relation":{},"ISSN":["1590-1874","1590-3478"],"issn-type":[{"value":"1590-1874","type":"print"},{"value":"1590-3478","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,10,14]]},"assertion":[{"value":"28 November 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"1 October 2026","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"14 October 2026","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"Data about the cohort considered in the study, were collected from the database of the Italian Multiple Sclerosis Register (RISM), of which our centre is a part. RISM was approved by the ethical committee at the \u201cAzienda Ospedaliera\/Universitaria\u2014Policlinico of Bari\u201d (Study REGISTRO SM001, approved on 08\/07\/2016). Patients signed an informed consent that allows to use clinical data for research purposes.","order":1,"name":"Ethics","label":"Ethical approval","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"On behalf of all authors, the corresponding author states that there is no conflict of interest for the current study.","order":2,"name":"Ethics","label":"Conflict of interest","group":{"name":"EthicsHeading","label":"Declarations"}}],"article-number":"854"}}