{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,11]],"date-time":"2026-09-11T03:01:26Z","timestamp":1789095686254,"version":"build-2803163510"},"reference-count":47,"publisher":"Springer Science and Business Media LLC","issue":"10","license":[{"start":{"date-parts":[[2006,9,22]],"date-time":"2006-09-22T00:00:00Z","timestamp":1158883200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Eur J Clin Microbiol Infect Dis"],"published-print":{"date-parts":[[2006,10,16]]},"DOI":"10.1007\/s10096-006-0193-0","type":"journal-article","created":{"date-parts":[[2006,10,6]],"date-time":"2006-10-06T00:29:41Z","timestamp":1160094581000},"page":"633-641","source":"Crossref","is-referenced-by-count":40,"title":["Ertapenem versus cefepime for initial empirical treatment of pneumonia acquired in skilled-care facilities or in hospitals outside the intensive care unit"],"prefix":"10.1007","volume":"25","author":[{"given":"S. V.","family":"Yakovlev","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L. S.","family":"Stratchounski","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G. L.","family":"Woods","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B.","family":"Adeyi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K. A.","family":"McCarroll","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J. A.","family":"Ginanni","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"I. R.","family":"Friedland","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C. A.","family":"Wood","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M. J.","family":"DiNubile","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2006,9,22]]},"reference":[{"key":"193_CR1","doi-asserted-by":"crossref","first-page":"658","DOI":"10.1016\/0002-9343(83)90453-9","volume":"75","author":"PA Gross","year":"1983","unstructured":"Gross PA, van Antwerpen C (1983) Nosocomial infections and hospital deaths. A case-control study. Am J Med 75:658\u2013662","journal-title":"Am J Med"},{"key":"193_CR2","doi-asserted-by":"crossref","first-page":"1249","DOI":"10.1164\/ajrccm.159.4.9807050","volume":"159","author":"DK Heyland","year":"1999","unstructured":"Heyland DK, Cook DJ, Griffith L, Keenan SP, Brun-Buisson C (1999) The attributable morbidity and mortality of ventilator-associated pneumonia in the critically ill patient. The Canadian Critical Trials Group. Am J Respir Crit Care Med 159:1249\u20131256","journal-title":"Am J Respir Crit Care Med"},{"key":"193_CR3","doi-asserted-by":"crossref","first-page":"587","DOI":"10.2307\/30147436","volume":"15","author":"OC Tablan","year":"1994","unstructured":"Tablan OC, Anderson LJ, Arden NH, Breiman RF, Butler JC, McNeil MM (1994) Guideline for prevention of nosocomial pneumonia. The Hospital Infection Control Practices Advisory Committee, Centers for Disease Control and Prevention. Infect Control Hosp Epidemiol 15:587\u2013627","journal-title":"Infect Control Hosp Epidemiol"},{"key":"193_CR4","doi-asserted-by":"crossref","first-page":"1605","DOI":"10.1001\/jama.279.20.1605","volume":"279","author":"DJ Cook","year":"1998","unstructured":"Cook DJ, Kollef MH (1998) Risk factors for ICU-acquired pneumonia. JAMA 279:1605\u20131606","journal-title":"JAMA"},{"key":"193_CR5","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1016\/0002-9343(93)90060-3","volume":"94","author":"JY Fagon","year":"1993","unstructured":"Fagon JY, Chastre J, Hance AJ, Montravers P, Novara A, Gibert C (1993) Nosocomial pneumonia in ventilated patients: a cohort study evaluating attributable mortality and hospital stay. Am J Med 94:281\u2013288","journal-title":"Am J Med"},{"key":"193_CR6","doi-asserted-by":"crossref","first-page":"749","DOI":"10.2307\/30141317","volume":"18","author":"CA Greenaway","year":"1997","unstructured":"Greenaway CA, Embil J, Orr PH, McLeod J, Dyck B, Nicolle LE (1997) Nosocomial pneumonia on general medical and surgical wards in a tertiary-care hospital. Infect Control Hosp Epidemiol 18:749\u2013756","journal-title":"Infect Control Hosp Epidemiol"},{"key":"193_CR7","doi-asserted-by":"crossref","first-page":"266","DOI":"10.1007\/s11908-001-0029-0","volume":"3","author":"JR Lentino","year":"2001","unstructured":"Lentino JR (2001) Nosocomial pneumonia: more than just ventilator-associated. Curr Infect Dis Rep 3:266\u2013273","journal-title":"Curr Infect Dis Rep"},{"key":"193_CR8","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1179\/acb.2005.022","volume":"60","author":"D Myny","year":"2005","unstructured":"Myny D, Depuydt P, Colardyn F, Blot S (2005) Ventilator-associated pneumonia in a tertiary care ICU: analysis of risk factors for acquisition and mortality. Acta Clin Belg 60:114\u2013121","journal-title":"Acta Clin Belg"},{"key":"193_CR9","doi-asserted-by":"crossref","first-page":"735","DOI":"10.1007\/s00134-004-2201-0","volume":"30","author":"VL Yu","year":"2004","unstructured":"Yu VL, Singh N (2004) Excessive antimicrobial usage causes measurable harm to patients with suspected ventilator-associated pneumonia. Intensive Care Med 30:735\u2013738","journal-title":"Intensive Care Med"},{"key":"193_CR10","doi-asserted-by":"crossref","first-page":"1109","DOI":"10.1001\/archinte.1991.00400060053009","volume":"151","author":"JM Boyce","year":"1991","unstructured":"Boyce JM, Potter-Bynoe G, Dziobek L, Solomon SL (1991) Nosocomial pneumonia in Medicare patients. Hospital costs and reimbursement patterns under the prospective payment system. Arch Intern Med 151:1109\u20131114","journal-title":"Arch Intern Med"},{"key":"193_CR11","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1016\/0196-6553(84)90114-7","volume":"12","author":"CP Craig","year":"1984","unstructured":"Craig CP, Connelly S (1984) Effect of intensive care unit nosocomial pneumonia on duration of stay and mortality. Am J Infect Control 12:233\u2013238","journal-title":"Am J Infect Control"},{"issue":"Suppl 3B","key":"193_CR12","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1016\/0002-9343(91)90343-V","volume":"91","author":"DE Craven","year":"1991","unstructured":"Craven DE, Steger KA, Barber TW (1991) Preventing nosocomial pneumonia: state of the art and perspectives for the 1990s. Am J Med 91(Suppl 3B):44\u201353","journal-title":"Am J Med"},{"key":"193_CR13","doi-asserted-by":"crossref","first-page":"2184","DOI":"10.1097\/01.CCM.0000181731.53912.D9","volume":"33","author":"N Safdar","year":"2005","unstructured":"Safdar N, Dezfulian C, Collard HR, Saint S (2005) Clinical and economic consequences of ventilator-associated pneumonia: a systematic review. Crit Care Med 33:2184\u20132193","journal-title":"Crit Care Med"},{"key":"193_CR14","unstructured":"Carratala J, Neal S (2004) Health care-associated pneumonia: a new category of respiratory infection? Program and abstracts of the 44th Interscience Conference of Antimicrobial Agents and Chemotherapy. Abstract K-1236"},{"key":"193_CR15","doi-asserted-by":"crossref","first-page":"1405","DOI":"10.1086\/380488","volume":"37","author":"LA Mandell","year":"2003","unstructured":"Mandell LA, Bartlett JG, Dowell SF, File TM Jr, Musher DM, Whitney C (2003) Update of practice guidelines for the management of community-acquired pneumonia in immunocompetent adults. Clin Infect Dis 37:1405\u20131433","journal-title":"Clin Infect Dis"},{"key":"193_CR16","doi-asserted-by":"crossref","first-page":"1730","DOI":"10.1164\/ajrccm.163.7.at1010","volume":"163","author":"MS Niederman","year":"2001","unstructured":"Niederman MS, Mandell LA, Anzueto A, Bass JB, Broughton WA, Campbell GD, et al (2001) Guidelines for the management of adults with community-acquired pneumonia. Diagnosis, assessment of severity, antimicrobial therapy, and prevention. Am J Respir Crit Care Med 163:1730\u20131754","journal-title":"Am J Respir Crit Care Med"},{"key":"193_CR17","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1378\/chest.127.1.213","volume":"127","author":"N Sopena","year":"2005","unstructured":"Sopena N, Sabria M (2005) Multicenter study of hospital-acquired pneumonia in non-ICU patients. Chest 127:213\u2013219","journal-title":"Chest"},{"key":"193_CR18","doi-asserted-by":"crossref","first-page":"388","DOI":"10.1164\/rccm.200405-644ST","volume":"171","author":"AmericanThoracic Society","year":"2005","unstructured":"AmericanThoracic Society (2005) Guidelines for the management of adults with hospital-acquired, ventilator-associated, and healthcare-associated pneumonia. Am J Respir Crit Care Med 171:388\u2013416","journal-title":"Am J Respir Crit Care Med"},{"key":"193_CR19","doi-asserted-by":"crossref","first-page":"939","DOI":"10.1016\/j.idc.2004.08.001","volume":"18","author":"DE Craven","year":"2004","unstructured":"Craven DE, Palladino R, McQuillen DP (2004) Healthcare-associated pneumonia in adults: management principles to improve outcomes. Infect Dis Clin North Am 18:939\u2013962","journal-title":"Infect Dis Clin North Am"},{"key":"193_CR20","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1055\/s-2000-9929","volume":"21","author":"A Chalfine","year":"2000","unstructured":"Chalfine A, Timsit JF, Acar J (2000) Antibiotic resistance in nosocomial pulmonary pathogens. Semin Respir Crit Care Med 21:45\u201351","journal-title":"Semin Respir Crit Care Med"},{"key":"193_CR21","doi-asserted-by":"crossref","first-page":"1583","DOI":"10.1016\/S0025-7125(05)70397-7","volume":"85","author":"JT Cross Jr","year":"2001","unstructured":"Cross JT Jr, Campbell GD Jr (2001) Therapy of nosocomial pneumonia. Med Clin North Am 85:1583\u20131594","journal-title":"Med Clin North Am"},{"key":"193_CR22","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1055\/s-2000-9931","volume":"21","author":"H Lode","year":"2000","unstructured":"Lode H, Raffenberg M, Geerdes-Fenge H, Mauch H (2000) Monotherapy of nosocomial pneumonia. Semin Respir Crit Care Med 21:9\u201317","journal-title":"Semin Respir Crit Care Med"},{"key":"193_CR23","doi-asserted-by":"crossref","first-page":"1915","DOI":"10.1128\/AAC.45.6.1915-1918.2001","volume":"45","author":"PC Fuchs","year":"2001","unstructured":"Fuchs PC, Barry AL, Brown SD (2001) In vitro activities of ertapenem (MK-0826) against clinical bacterial isolates from 11 North American medical centers. Antimicrob Agents Chemother 45:1915\u20131918","journal-title":"Antimicrob Agents Chemother"},{"key":"193_CR24","doi-asserted-by":"crossref","first-page":"1860","DOI":"10.1128\/AAC.45.6.1860-1867.2001","volume":"45","author":"DM Livermore","year":"2001","unstructured":"Livermore DM, Carter MW, Bagel S, Wiedemann B, Baquero F, Loza E, Endtz HP, van Den Braak N, Fernandes CJ, Fernandes L, Frimodt-Moller N, Rasmussen LS, Giamarellou H, Giamarellos-Bourboulis E, Jarlier V, Nguyen J, Nord CE, Struelens MJ, Nonhoff C, Turnidge J, Bell J, Zbinden R, Pfister S, Mixson L, Shungu DL (2001) In vitro activities of ertapenem (MK-0826) against recent clinical bacteria collected in Europe and Australia. Antimicrob Agents Chemother 45:1860\u20131867","journal-title":"Antimicrob Agents Chemother"},{"key":"193_CR25","doi-asserted-by":"crossref","first-page":"2831","DOI":"10.1128\/AAC.45.10.2831-2837.2001","volume":"45","author":"DM Livermore","year":"2001","unstructured":"Livermore DM, Oakton KJ, Carter MW, Warner M (2001) Activity of ertapenem (MK-0826) versus Enterobacteriaceae with potent beta-lactamases. Antimicrob Agents Chemother 45:2831\u20132837","journal-title":"Antimicrob Agents Chemother"},{"key":"193_CR26","doi-asserted-by":"crossref","first-page":"538","DOI":"10.1093\/jac\/dkg404","volume":"52","author":"PM Shah","year":"2003","unstructured":"Shah PM, Isaacs RD (2003) Ertapenem, the first of a new group of carbapenems. J Antimicrob Chemother 52:538\u2013542","journal-title":"J Antimicrob Chemother"},{"key":"193_CR27","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1586\/14787210.3.1.23","volume":"3","author":"GG Zhanel","year":"2005","unstructured":"Zhanel GG, Johanson C, Embil JM, Noreddin A, Gin A, Vercaigne L, Hoban DJ (2005) Ertapenem: review of a new carbapenem. Expert Rev Anti Infect Ther 3:23\u201339","journal-title":"Expert Rev Anti Infect Ther"},{"key":"193_CR28","doi-asserted-by":"crossref","first-page":"380","DOI":"10.1056\/NEJMra041359","volume":"352","author":"GA Jacoby","year":"2005","unstructured":"Jacoby GA, Munoz-Price LS (2005) The new \u03b2-lactamases. N Engl J Med 352:380\u2013391","journal-title":"N Engl J Med"},{"key":"193_CR29","doi-asserted-by":"crossref","first-page":"657","DOI":"10.1128\/CMR.18.4.657-686.2005","volume":"18","author":"DL Paterson","year":"2005","unstructured":"Paterson DL, Bonomo RA (2005) Extended-spectrum beta-lactamases: a clinical update. Clin Microbiol Rev 18:657\u2013686","journal-title":"Clin Microbiol Rev"},{"key":"193_CR30","doi-asserted-by":"crossref","first-page":"1253","DOI":"10.1093\/jac\/dkg237","volume":"51","author":"RM Gesser","year":"2003","unstructured":"Gesser RM, McCarroll K, Teppler H, Woods GL (2003) Efficacy of ertapenem in the treatment of serious infections caused by Enterobacteriaceae: analysis of pooled clinical trial data. J Antimicrob Chemother 51:1253\u20131260","journal-title":"J Antimicrob Chemother"},{"issue":"Suppl 2","key":"193_CR31","first-page":"75","volume":"53","author":"H Teppler","year":"2004","unstructured":"Teppler H, Gesser RM, Friedland IR, Woods GL, Meibohm A, Herman G, Mistry G, Isaacs R (2004) Safety and tolerability of ertapenem. J Antimicrob Chemother 53(Suppl 2):75\u201381","journal-title":"J Antimicrob Chemother"},{"key":"193_CR32","doi-asserted-by":"crossref","first-page":"1770","DOI":"10.1016\/S0149-2918(02)80078-9","volume":"24","author":"N Vetter","year":"2002","unstructured":"Vetter N, Cambronero-Hernandez E, Rohlf J, Simon S, Carides A, Oliveria T, Isaacs R (2002) A prospective, randomized, double-blind multicenter comparison of parenteral ertapenem and ceftriaxone for the treatment of hospitalized adults with community-acquired pneumonia. Clin Ther 24:1770\u20131785","journal-title":"Clin Ther"},{"key":"193_CR33","doi-asserted-by":"crossref","first-page":"1526","DOI":"10.1046\/j.1532-5415.2003.51507.x","volume":"51","author":"GL Woods","year":"2003","unstructured":"Woods GL, Isaacs RD, McCarroll KA, Friedland IR (2003) Ertapenem therapy for community-acquired pneumonia in the elderly. J Am Geriatr Soc 51:1526\u20131532","journal-title":"J Am Geriatr Soc"},{"issue":"Suppl 1","key":"193_CR34","first-page":"5","volume":"15","author":"TR Beam Jr","year":"1992","unstructured":"Beam Jr TR, Gilbert DN, Kunin CM (1992) General guidelines for the clinical evaluation of anti-infective drug products. Infectious Diseases Society of America and the Food and Drug Administration. Clin Infect Dis 15(Suppl 1):5\u201332","journal-title":"Clin Infect Dis"},{"key":"193_CR35","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1002\/sim.4780040211","volume":"4","author":"O Miettinen","year":"1985","unstructured":"Miettinen O, Nurminen M (1985) Comparative analysis of two rates. Stat Med 4:213\u2013226","journal-title":"Stat Med"},{"key":"193_CR36","doi-asserted-by":"crossref","first-page":"2183","DOI":"10.1378\/chest.122.6.2183","volume":"122","author":"G Hoffken","year":"2002","unstructured":"Hoffken G, Niederman MS (2002) Nosocomial pneumonia: the importance of a de-escalating strategy for antibiotic treatment of pneumonia in the ICU. Chest 122:2183\u20132196","journal-title":"Chest"},{"key":"193_CR37","doi-asserted-by":"crossref","first-page":"328","DOI":"10.1097\/00001786-200410000-00007","volume":"19","author":"DD Keith","year":"2004","unstructured":"Keith DD, Garrett KM, Hickox G, Echols B, Comeau E (2004) Ventilator-associated pneumonia: improved clinical outcomes. J Nurs Care Qual 19:328\u2013333","journal-title":"J Nurs Care Qual"},{"key":"193_CR38","first-page":"714","volume":"50","author":"MH Kollef","year":"2005","unstructured":"Kollef MH (2005) What is ventilator-associated pneumonia and why is it important? Respir Care 50:714\u2013721","journal-title":"Respir Care"},{"key":"193_CR39","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1177\/0885066603254249","volume":"18","author":"RM Mehta","year":"2003","unstructured":"Mehta RM, Niederman MS (2003) Nosocomial pneumonia in the intensive care unit: controversies and dilemmas. J Intensive Care Med 18:175\u2013188","journal-title":"J Intensive Care Med"},{"key":"193_CR40","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1086\/313954","volume":"31","author":"JG Bartlett","year":"2000","unstructured":"Bartlett JG, Dowell SF, Mandell LA, File Jr TM, Musher DM, Fine MJ (2000) Practice guidelines for the management of community-acquired pneumonia in adults. Clin Infect Dis 31:347\u2013382","journal-title":"Clin Infect Dis"},{"key":"193_CR41","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1159\/000086574","volume":"51","author":"R Ramphal","year":"2005","unstructured":"Ramphal R (2005) Importance of adequate initial antimicrobial therapy. Chemotherapy 51:171\u2013176","journal-title":"Chemotherapy"},{"key":"193_CR42","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1093\/jac\/43.3.389","volume":"43","author":"M Joshi","year":"1999","unstructured":"Joshi M, Bernstein J, Solomkin J, Wester BA, Kuye O (1999) Piperacillin\/tazobactam plus tobramycin versus ceftazidime plus tobramycin for the treatment of patients with nosocomial lower respiratory tract infection. J Antimicrob Chemother 43:389\u2013397","journal-title":"J Antimicrob Chemother"},{"key":"193_CR43","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1086\/318486","volume":"32","author":"E Rubinstein","year":"2001","unstructured":"Rubinstein E, Cammarata S, Oliphant T, Wunderink R (2001) Linezolid (PNU-100766) versus vancomycin in the treatment of hospitalized patients with nosocomial pneumonia: a randomized, double-blind, multicenter study. Clin Infect Dis 32:402\u2013412","journal-title":"Clin Infect Dis"},{"key":"193_CR44","first-page":"1530","volume":"49","author":"MH Kollef","year":"2004","unstructured":"Kollef MH (2004) Appropriate empiric antimicrobial therapy of nosocomial pneumonia: the role of the carbapenems. Respir Care 49:1530\u20131541","journal-title":"Respir Care"},{"key":"193_CR45","doi-asserted-by":"crossref","first-page":"670","DOI":"10.1086\/381550","volume":"38","author":"E Paramythiotou","year":"2004","unstructured":"Paramythiotou E, Lucet J-C, Timsit J-F, Vanjak D, Paugam-Burtz C, Trouillet J-L, Belloc S, Kassis N, Karabinis A, Andremont A (2004) Acquisition of multidrug-resistant Pseudomonas aeruginosa in patients in intensive care units: role of antibiotics with antipseudomonal activity. Clin Infect Dis 38:670\u2013677","journal-title":"Clin Infect Dis"},{"key":"193_CR46","doi-asserted-by":"crossref","first-page":"1492","DOI":"10.1097\/01.CCM.0000169879.97129.7B","volume":"33","author":"P Apfalter","year":"2005","unstructured":"Apfalter P, Stoiser B, Barousch W, Nehr M, Kramer L, Burgmann H (2005) Community-acquired bacteria frequently detected by means of quantitative polymerase chain reaction in nosocomial early-onset ventilator-associated pneumonia. Crit Care Med 33:1492\u20131498","journal-title":"Crit Care Med"},{"key":"193_CR47","doi-asserted-by":"crossref","first-page":"753","DOI":"10.1046\/j.1469-0691.2002.00461.x","volume":"8","author":"PS Hicks","year":"2002","unstructured":"Hicks PS, Pelak B, Woods GL, Bartizal KF, Motyl M (2002) Comparative in vitro activity of ertapenem against bacterial pathogens isolated from patients with lower respiratory tract infections. Clin Microbiol Infect 8:753\u2013757","journal-title":"Clin Microbiol Infect"}],"container-title":["European Journal of Clinical Microbiology & Infectious Diseases"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s10096-006-0193-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s10096-006-0193-0\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s10096-006-0193-0","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,5,29]],"date-time":"2019-05-29T09:30:25Z","timestamp":1559122225000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s10096-006-0193-0"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006,9,22]]},"references-count":47,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2006,10,16]]}},"alternative-id":["193"],"URL":"https:\/\/doi.org\/10.1007\/s10096-006-0193-0","relation":{},"ISSN":["0934-9723","1435-4373"],"issn-type":[{"value":"0934-9723","type":"print"},{"value":"1435-4373","type":"electronic"}],"subject":[],"published":{"date-parts":[[2006,9,22]]}}}