{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,27]],"date-time":"2026-05-27T15:19:59Z","timestamp":1779895199177,"version":"3.53.1"},"reference-count":23,"publisher":"Springer Science and Business Media LLC","issue":"6","license":[{"start":{"date-parts":[[2008,11,20]],"date-time":"2008-11-20T00:00:00Z","timestamp":1227139200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Eur J Clin Microbiol Infect Dis"],"published-print":{"date-parts":[[2009,6]]},"DOI":"10.1007\/s10096-008-0671-7","type":"journal-article","created":{"date-parts":[[2008,11,19]],"date-time":"2008-11-19T13:45:43Z","timestamp":1227102343000},"page":"671-676","source":"Crossref","is-referenced-by-count":14,"title":["In vivo and in vitro detection of a superantigenic toxin Vbeta signature in two forms of streptococcal toxic shock syndrome"],"prefix":"10.1007","volume":"28","author":[{"given":"D.","family":"Thomas","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T.","family":"Perpoint","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"O.","family":"Dauwalder","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G.","family":"Lina","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B.","family":"Floccard","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.-C.","family":"Richard","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Bouvet","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D.","family":"Peyramond","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B.","family":"Allaouchiche","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.","family":"Chidiac","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F.","family":"Vandenesch","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"Etienne","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T.","family":"Ferry","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2008,11,20]]},"reference":[{"key":"671_CR1","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1146\/annurev.micro.55.1.77","volume":"55","author":"JK McCormick","year":"2001","unstructured":"McCormick JK, Yarwood JM, Schlievert PM (2001) Toxic shock syndrome and bacterial superantigens: an update. Annu Rev Microbiol 55:77\u2013104. doi: 10.1146\/annurev.micro.55.1.77","journal-title":"Annu Rev Microbiol"},{"key":"671_CR2","doi-asserted-by":"crossref","first-page":"470","DOI":"10.1128\/CMR.13.3.470","volume":"13","author":"MW Cunningham","year":"2000","unstructured":"Cunningham MW (2000) Pathogenesis of group A streptococcal infections. Clin Microbiol Rev 13:470\u2013511. doi: 10.1128\/CMR.13.3.470-511.2000","journal-title":"Clin Microbiol Rev"},{"key":"671_CR3","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1128\/IAI.59.1.211-215.1991","volume":"59","author":"CE Yu","year":"1991","unstructured":"Yu CE, Ferretti JJ (1991) Frequency of the erythrogenic toxin B and C genes (speB and speC) among clinical isolates of group A streptococci. Infect Immun 59:211\u2013215","journal-title":"Infect Immun"},{"key":"671_CR4","doi-asserted-by":"crossref","first-page":"450","DOI":"10.1086\/519936","volume":"45","author":"J Darenberg","year":"2007","unstructured":"Darenberg J, Luca-Harari B, Jasir A et al (2007) Molecular and clinical characteristics of invasive group A streptococcal infection in Sweden. Clin Infect Dis 45:450\u2013458. doi: 10.1086\/519936","journal-title":"Clin Infect Dis"},{"key":"671_CR5","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1084\/jem.186.3.375","volume":"186","author":"PL Li","year":"1997","unstructured":"Li PL, Tiedemann RE, Moffat SL, Fraser JD (1997) The superantigen streptococcal pyrogenic exotoxin C (SPE-C) exhibits a novel mode of action. J Exp Med 186:375\u2013383. doi: 10.1084\/jem.186.3.375","journal-title":"J Exp Med"},{"key":"671_CR6","doi-asserted-by":"crossref","first-page":"140","DOI":"10.1111\/j.1365-2249.1994.tb06620.x","volume":"98","author":"C Michie","year":"1994","unstructured":"Michie C, Scott A, Cheesbrough J, Beverley P, Pasvol G (1994) Streptococcal toxic shock-like syndrome: evidence of superantigen activity and its effects on T lymphocyte subsets in vivo. Clin Exp Immunol 98:140\u2013144","journal-title":"Clin Exp Immunol"},{"key":"671_CR7","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1093\/infdis\/171.1.74","volume":"171","author":"R Watanabe-Ohnishi","year":"1995","unstructured":"Watanabe-Ohnishi R, Low DE, McGeer A et al (1995) Selective depletion of V beta-bearing T cells in patients with severe invasive group A streptococcal infections and streptococcal toxic shock syndrome. Ontario Streptococcal Study Project. J Infect Dis 171:74\u201384","journal-title":"J Infect Dis"},{"key":"671_CR8","doi-asserted-by":"crossref","first-page":"8941","DOI":"10.1073\/pnas.86.22.8941","volume":"86","author":"YW Choi","year":"1989","unstructured":"Choi YW, Kotzin B, Herron L, Callahan J, Marrack P, Kappler J (1989) Interaction of Staphylococcus aureus toxin \u201csuperantigens\u201d with human T cells. Proc Natl Acad Sci USA 86:8941\u20138945. doi: 10.1073\/pnas.86.22.8941","journal-title":"Proc Natl Acad Sci USA"},{"key":"671_CR9","doi-asserted-by":"crossref","first-page":"387","DOI":"10.3201\/eid0903.020360","volume":"9","author":"Y Matsuda","year":"2003","unstructured":"Matsuda Y, Kato H, Yamada R et al (2003) Early and definitive diagnosis of toxic shock syndrome by detection of marked expansion of T-cell-receptor VBeta2-positive T cells. Emerg Infect Dis 9:387\u2013389","journal-title":"Emerg Infect Dis"},{"key":"671_CR10","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/S0022-1759(03)00260-6","volume":"283","author":"C MacIsaac","year":"2003","unstructured":"MacIsaac C, Curtis N, Cade J, Visvanathan K (2003) Rapid analysis of the Vbeta repertoire of CD4 and CD8 T lymphocytes in whole blood. J Immunol Methods 283:9\u201315. doi: 10.1016\/S0022-1759(03)00260-6","journal-title":"J Immunol Methods"},{"key":"671_CR11","doi-asserted-by":"crossref","first-page":"3523","DOI":"10.1128\/IAI.68.6.3523-3534.2000","volume":"68","author":"S Chatellier","year":"2000","unstructured":"Chatellier S, Ihendyane N, Kansal RG et al (2000) Genetic relatedness and superantigen expression in group A Streptococcus serotype M1 isolates from patients with severe and nonsevere invasive diseases. Infect Immun 68:3523\u20133534. doi: 10.1128\/IAI.68.6.3523-3534.2000","journal-title":"Infect Immun"},{"key":"671_CR12","doi-asserted-by":"crossref","first-page":"3127","DOI":"10.1128\/JCM.30.12.3127-3131.1992","volume":"30","author":"SD Tyler","year":"1992","unstructured":"Tyler SD, Johnson WM, Huang JC et al (1992) Streptococcal erythrogenic toxin genes: detection by polymerase chain reaction and association with disease in strains isolated in Canada from 1940 to 1991. J Clin Microbiol 30:3127\u20133131","journal-title":"J Clin Microbiol"},{"key":"671_CR13","doi-asserted-by":"crossref","first-page":"3747","DOI":"10.4049\/jimmunol.146.11.3747","volume":"46","author":"J Abe","year":"1991","unstructured":"Abe J, Forrester J, Nakahara T, Lafferty A, Kotzin BL, Leung DY (1991) Selective stimulation of human T cells with streptococcal erythrogenic toxins A and B. J Immunol 46:3747\u20133750","journal-title":"J Immunol"},{"key":"671_CR14","doi-asserted-by":"crossref","first-page":"710","DOI":"10.1172\/JCI116641","volume":"92","author":"JA Mollick","year":"1993","unstructured":"Mollick JA, Miller GG, Musser JM, Cook RG, Grossman D, Rich RR (1993) A novel superantigen isolated from pathogenic strains of Streptococcus pyogenes with aminoterminal homology to staphylococcal enterotoxins B and C. J Clin Invest 92:710\u2013719. doi: 10.1172\/JCI116641","journal-title":"J Clin Invest"},{"key":"671_CR15","doi-asserted-by":"crossref","first-page":"677","DOI":"10.1016\/S0929-6646(08)60112-6","volume":"107","author":"C Chiang-Ni","year":"2008","unstructured":"Chiang-Ni C, Wu JJ (2008) Effects of streptococcal pyrogenic exotoxin B on pathogenesis of Streptococcus pyogenes. J Formos Med Assoc 107:677\u2013685. doi: 10.1016\/S0929-6646(08)60112-6","journal-title":"J Formos Med Assoc"},{"key":"671_CR16","doi-asserted-by":"crossref","first-page":"2416","DOI":"10.1128\/IAI.69.4.2416-2427.2001","volume":"69","author":"MC Enright","year":"2001","unstructured":"Enright MC, Spratt BG, Kalia A, Cross JH, Bessen DE (2001) Multilocus sequence typing of Streptococcus pyogenes and the relationships between emm type and clone. Infect Immun 69:2416\u20132427. doi: 10.1128\/IAI.69.4.2416-2427.2001","journal-title":"Infect Immun"},{"key":"671_CR17","doi-asserted-by":"crossref","first-page":"927","DOI":"10.2353\/ajpath.2006.060112","volume":"169","author":"MR Graham","year":"2006","unstructured":"Graham MR, Virtaneva K, Porcella SF et al (2006) Analysis of the transcriptome of group A Streptococcus in mouse soft tissue infection. Am J Pathol 169:927\u2013942. doi: 10.2353\/ajpath.2006.060112","journal-title":"Am J Pathol"},{"key":"671_CR18","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1080\/00365540410020866","volume":"37","author":"A Norrby-Teglund","year":"2005","unstructured":"Norrby-Teglund A, Muller MP, Mcgeer A et al (2005) Successful management of severe group A streptococcal soft tissue infections using an aggressive medical regimen including intravenous polyspecific immunoglobulin together with a conservative surgical approach. Scand J Infect Dis 37:166\u2013172. doi: 10.1080\/00365540500372960","journal-title":"Scand J Infect Dis"},{"key":"671_CR19","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1056\/NEJMra021333","volume":"348","author":"RS Hotchkiss","year":"2003","unstructured":"Hotchkiss RS, Karl IE (2003) The pathophysiology and treatment of sepsis. N Engl J Med 348:138\u2013150. doi: 10.1056\/NEJMra021333","journal-title":"N Engl J Med"},{"key":"671_CR20","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1097\/00024382-200004000-00008","volume":"3","author":"RJ Middelveld","year":"2000","unstructured":"Middelveld RJ, Alving K (2000) Synergistic septicemic action of the gram-positive bacterial cell wall components peptidoglycan and lipoteichoic acid in the pig in vivo. Shock 3:297\u2013306","journal-title":"Shock"},{"key":"671_CR21","doi-asserted-by":"crossref","first-page":"1071","DOI":"10.1007\/s00018-003-2283-9","volume":"60","author":"S Rossi Paccani","year":"2003","unstructured":"Rossi Paccani S, Boncristiano M, Baldari CT (2003) Molecular mechanisms underlying suppression of lymphocyte responses by nonsteroidal antiinflammatory drugs. Cell Mol Life Sci 60:1071\u20131083","journal-title":"Cell Mol Life Sci"},{"key":"671_CR22","doi-asserted-by":"crossref","first-page":"1238","DOI":"10.1099\/jmm.0.2008\/001156-0","volume":"57","author":"R Commons","year":"2008","unstructured":"Commons R, Rogers S, Gooding T et al (2008) Superantigen genes in group A streptococcal isolates and their relationship with emm types. J Med Microbiol 57:1238\u20131246. doi: 10.1099\/jmm.0.2008\/001156-0","journal-title":"J Med Microbiol"},{"key":"671_CR23","doi-asserted-by":"crossref","first-page":"6711","DOI":"10.4049\/jimmunol.166.11.6711","volume":"166","author":"T Proft","year":"2001","unstructured":"Proft T, Arcus VL, Handley V, Baker EN, Fraser D (2001) Immunological and biochemical characterization of streptococcal pyrogenic exotoxins I and J (SPE-I and SOE-J) from Streptococcus pyogenes. J Immunol 166:6711\u20136719","journal-title":"J Immunol"}],"container-title":["European Journal of Clinical Microbiology & Infectious Diseases"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s10096-008-0671-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s10096-008-0671-7\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s10096-008-0671-7","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,5,21]],"date-time":"2023-05-21T04:30:24Z","timestamp":1684643424000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s10096-008-0671-7"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008,11,20]]},"references-count":23,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2009,6]]}},"alternative-id":["671"],"URL":"https:\/\/doi.org\/10.1007\/s10096-008-0671-7","relation":{},"ISSN":["0934-9723","1435-4373"],"issn-type":[{"value":"0934-9723","type":"print"},{"value":"1435-4373","type":"electronic"}],"subject":[],"published":{"date-parts":[[2008,11,20]]}}}