{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T21:56:01Z","timestamp":1792706161876,"version":"4.5.0"},"reference-count":35,"publisher":"Springer Science and Business Media LLC","issue":"9","license":[{"start":{"date-parts":[[2012,3,1]],"date-time":"2012-03-01T00:00:00Z","timestamp":1330560000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Eur J Clin Microbiol Infect Dis"],"published-print":{"date-parts":[[2012,9]]},"DOI":"10.1007\/s10096-012-1581-2","type":"journal-article","created":{"date-parts":[[2012,2,29]],"date-time":"2012-02-29T08:18:09Z","timestamp":1330503489000},"page":"2391-2400","source":"Crossref","is-referenced-by-count":20,"title":["Severe cochlear inflammation and vestibular syndrome in an experimental model of Streptococcus suis infection in mice"],"prefix":"10.1007","volume":"31","author":[{"given":"M. C.","family":"Dom\u00ednguez-Punaro","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"U.","family":"Koedel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T.","family":"Hoegen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.","family":"Demel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Klein","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Gottschalk","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2012,3,1]]},"reference":[{"key":"1581_CR1","first-page":"769","volume-title":"Diseases of swine","author":"R Higgins","year":"2006","unstructured":"Higgins R, Gottschalk M (2006) Streptococcocal diseases. In: Straw BE, D\u2019Allaire S, Mengeling WL, Taylor DJ (eds) Diseases of swine. Blackwell Publishing, Ames, IA, pp 769\u2013783"},{"key":"1581_CR2","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1017\/S1466252307001247","volume":"8","author":"M Gottschalk","year":"2007","unstructured":"Gottschalk M, Segura M, Xu J (2007) Streptococcus suis infections in humans: the Chinese experience and the situation in North America. Anim Health Res Rev 8:29\u201345","journal-title":"Anim Health Res Rev"},{"key":"1581_CR3","doi-asserted-by":"crossref","first-page":"e151","DOI":"10.1371\/journal.pmed.0030151","volume":"3","author":"J Tang","year":"2006","unstructured":"Tang J, Wang C, Feng Y, Yang W, Song H, Chen Z, Yu H, Pan X, Zhou X, Wang H, Wu B, Wang H, Zhao H, Lin Y, Yue J, Wu Z, He X, Gao F, Khan AH, Wang J, Zhao GP, Wang Y, Wang X, Chen Z, Gao GF (2006) Streptococcal toxic shock syndrome caused by Streptococcus suis serotype 2. PLoS Med 3:e151","journal-title":"PLoS Med"},{"key":"1581_CR4","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1093\/clinids\/10.1.131","volume":"10","author":"JP Arends","year":"1988","unstructured":"Arends JP, Zanen HC (1988) Meningitis caused by Streptococcus suis in humans. Rev Infect Dis 10:131\u2013137","journal-title":"Rev Infect Dis"},{"key":"1581_CR5","doi-asserted-by":"crossref","first-page":"617","DOI":"10.1086\/596763","volume":"48","author":"HFL Wertheim","year":"2009","unstructured":"Wertheim HFL, Trung Nghia HD, Taylor W, Schultsz C (2009) Streptococcus suis: an emerging human pathogen. Clin Infect Dis 48:617\u2013625","journal-title":"Clin Infect Dis"},{"key":"1581_CR6","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1086\/594371","volume":"199","author":"M Segura","year":"2009","unstructured":"Segura M (2009) Streptococcus suis: an emerging human threat. J Infect Dis 199:4\u20136","journal-title":"J Infect Dis"},{"key":"1581_CR7","doi-asserted-by":"crossref","first-page":"659","DOI":"10.1086\/527385","volume":"46","author":"NT Mai","year":"2008","unstructured":"Mai NT, Hoa NT, Nga TV, Linh LD, Chau TT, Sinh DX, Phu NH, Chuong LV, Diep TS, Campbell J, Nghia HD, Minh TN, Chau NV, de Jong MD, Chinh NT, Hien TT, Farrar J, Schultsz C (2008) Streptococcus suis meningitis in adults in Vietnam. Clin Infect Dis 46:659\u2013667","journal-title":"Clin Infect Dis"},{"issue":"5","key":"1581_CR8","doi-asserted-by":"crossref","first-page":"366","DOI":"10.1016\/j.clineuro.2004.10.006","volume":"107","author":"AC Hui","year":"2005","unstructured":"Hui AC, Ng KC, Tong PY, Mok V, Chow KM, Wu A, Wong LK (2005) Bacterial meningitis in Hong Kong: 10-years\u2019 experience. Clin Neurol Neurosurg 107(5):366\u2013370","journal-title":"Clin Neurol Neurosurg"},{"key":"1581_CR9","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1016\/j.jinf.2005.02.012","volume":"52","author":"S Wangkaew","year":"2006","unstructured":"Wangkaew S, Chaiwarith R, Tharavichitkul P, Supparatpinyo K (2006) Streptococcus suis infection: a series of 41 cases from Chiang Mai University Hospital. J Infect 52:455\u2013460","journal-title":"J Infect"},{"key":"1581_CR10","doi-asserted-by":"crossref","first-page":"392","DOI":"10.1016\/j.jinf.2008.08.006","volume":"57","author":"W Wangsomboonsiri","year":"2008","unstructured":"Wangsomboonsiri W, Luksananun T, Saksornchai S, Ketwong K, Sungkanuparph S (2008) Streptococcus suis infection and risk factors for mortality. J Infect 57:392\u2013396","journal-title":"J Infect"},{"key":"1581_CR11","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1016\/j.medmal.2008.01.002","volume":"38","author":"H Bahloul","year":"2008","unstructured":"Bahloul H, Mofredj A, Mrabet A, Gineyt G, Rousselier P (2008) Streptococcus suis meningitis after oral contamination? Med Mal Infect 38:281\u2013282","journal-title":"Med Mal Infect"},{"key":"1581_CR12","doi-asserted-by":"crossref","first-page":"371","DOI":"10.2217\/fmb.10.2","volume":"5","author":"M Gottschalk","year":"2010","unstructured":"Gottschalk M, Xu J, Calzas C, Segura M (2010) Streptococcus suis: a new emerging or an old neglected zoonotic pathogen? Future Microbiol 5:371\u2013391","journal-title":"Future Microbiol"},{"key":"1581_CR13","doi-asserted-by":"crossref","first-page":"3587","DOI":"10.1128\/IAI.01568-07","volume":"76","author":"N Fittipaldi","year":"2008","unstructured":"Fittipaldi N, Sekizaki T, Takamatsu D, Harel J, Dom\u00ednguez-Punaro MC, Von Aulock S, Draing C, Marois C, Kobisch M, Gottschalk M (2008) D-alanylation of lipoteichoic acid contributes to the virulence of Streptococcus suis. Infect Immun 76:3587\u20133594","journal-title":"Infect Immun"},{"key":"1581_CR14","doi-asserted-by":"crossref","first-page":"1120","DOI":"10.1111\/j.1365-2958.2008.06463.x","volume":"70","author":"N Fittipaldi","year":"2008","unstructured":"Fittipaldi N, Sekizaki T, Takamatsu D, Dom\u00ednguez-Punaro MC, Harel J, Bui NK, Vollmer W, Gottschalk M (2008) Significant contribution of the pgdA gene to the virulence of Streptococcus suis. Mol Microbiol 70:1120\u20131135","journal-title":"Mol Microbiol"},{"key":"1581_CR15","doi-asserted-by":"crossref","first-page":"1842","DOI":"10.4049\/jimmunol.179.3.1842","volume":"179","author":"MC Dom\u00ednguez-Punaro","year":"2007","unstructured":"Dom\u00ednguez-Punaro MC, Segura M, Plante MM, Lacouture S, Rivest S, Gottschalk M (2007) Streptococcus suis serotype 2, an important swine and human pathogen, induces strong systemic and cerebral inflammatory responses in a mouse model of infection. J Immunol 179:1842\u20131854","journal-title":"J Immunol"},{"issue":"12","key":"1581_CR16","doi-asserted-by":"crossref","first-page":"5074","DOI":"10.1128\/IAI.00698-10","volume":"78","author":"MC Dom\u00ednguez-Punaro","year":"2010","unstructured":"Dom\u00ednguez-Punaro MC, Segura M, Contreras I, Lachance C, Houde M, Lecours MP, Olivier M, Gottschalk M (2010) In vitro characterization of the microglial inflammatory response to Streptococcus suis, an important emerging zoonotic agent of meningitis. Infect Immun 78(12):5074\u20135085","journal-title":"Infect Immun"},{"key":"1581_CR17","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1016\/j.jneuroim.2011.02.005","volume":"234","author":"H Zheng","year":"2011","unstructured":"Zheng H, Dom\u00ednguez-Punaro MC, Segura M, Lachance C, Rivest S, Xu J, Houde M, Gottschalk M (2011) Toll-like receptor 2 is partially involved in the activation of murine astrocytes by Streptococcus suis, an important zoonotic agent of meningitis. J Neuroimmunol 234:71\u201383","journal-title":"J Neuroimmunol"},{"key":"1581_CR18","first-page":"654","volume":"91","author":"S Rusmeechan","year":"2008","unstructured":"Rusmeechan S, Sribusara P (2008) Streptococcus suis meningitis: the newest serious infectious disease. J Med Assoc Thai 91:654\u2013658","journal-title":"J Med Assoc Thai"},{"key":"1581_CR19","doi-asserted-by":"crossref","first-page":"857","DOI":"10.1017\/S0022215109004939","volume":"123","author":"N Navacharoen","year":"2009","unstructured":"Navacharoen N, Chantharochavong V, Hanprasertpong C, Kangsanarak J, Lekagul S (2009) Hearing and vestibular loss in Streptococcus suis infection from swine and traditional raw pork exposure in northern Thailand. J Laryngol Otol 123:857\u2013862","journal-title":"J Laryngol Otol"},{"key":"1581_CR20","doi-asserted-by":"crossref","first-page":"3901","DOI":"10.1128\/IAI.00350-08","volume":"76","author":"MC Dom\u00ednguez-Punaro","year":"2008","unstructured":"Dom\u00ednguez-Punaro MC, Segura M, Radzioch D, Rivest S, Gottschalk M (2008) Comparison of the susceptibilities of C57BL\/6 and A\/J mouse strains to Streptococcus suis serotype 2 infection. Infect Immun 76:3901\u20133910","journal-title":"Infect Immun"},{"key":"1581_CR21","first-page":"97","volume":"27","author":"M Kobish","year":"1995","unstructured":"Kobish M, Gottschalk M, Morvan P, Cariolet R, B\u00e9n\u00e9vent G, Joloy JP (1995) Experimental infection of SPF piglets with Streptococcus suis serotype 2. J Rech Porc Fr 27:97\u2013101","journal-title":"J Rech Porc Fr"},{"key":"1581_CR22","doi-asserted-by":"crossref","first-page":"1437","DOI":"10.1093\/brain\/awh171","volume":"127","author":"U Koedel","year":"2004","unstructured":"Koedel U, Rupprecht T, Angele B, Heesemann J, Wagner H, Pfister HW, Kirschning CJ (2004) MyD88 is required for mounting a robust host immune response to Streptococcus pneumoniae in the CNS. Brain 127:1437\u20131445","journal-title":"Brain"},{"key":"1581_CR23","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1111\/j.1750-3639.2003.tb00012.x","volume":"13","author":"M Klein","year":"2003","unstructured":"Klein M, Koedel U, Pfister HW, Kastenbauer S (2003) Morphological correlates of acute and permanent hearing loss during experimental pneumococcal meningitis. Brain Pathol 13:123\u2013132","journal-title":"Brain Pathol"},{"issue":"195","key":"1581_CR24","doi-asserted-by":"crossref","first-page":"1189","DOI":"10.1086\/512859","volume":"2007","author":"M Klein","year":"2007","unstructured":"Klein M, Schmidt C, Kastenbauer S, Paul R, Kirschning CJ, Wagner H, Popp B, Pfister HW, Koedel U (2007) MyD88-dependent immune response contributes to hearing loss in experimental pneumococcal meningitis. J Infect Dis 2007(195):1189\u20131193","journal-title":"J Infect Dis"},{"key":"1581_CR25","doi-asserted-by":"crossref","first-page":"710","DOI":"10.1093\/clind\/24.4.710","volume":"24","author":"PA Tambyah","year":"1997","unstructured":"Tambyah PA, Kumarasinghe G, Chan HL, Lee KO (1997) Streptococcus suis infection complicated by purpura fulminans and rhabdomyolysis: case report and review. Clin Infect Dis 24:710\u2013712","journal-title":"Clin Infect Dis"},{"key":"1581_CR26","doi-asserted-by":"crossref","first-page":"815","DOI":"10.2460\/javma.1980.177.09.815","volume":"177","author":"DF Kohn","year":"1980","unstructured":"Kohn DF, MacKenzie WF (1980) Inner ear disease characterized by rolling in C3H mice. J Am Vet Med Assoc 177:815\u2013817","journal-title":"J Am Vet Med Assoc"},{"key":"1581_CR27","doi-asserted-by":"crossref","first-page":"743","DOI":"10.1136\/pgmj.62.730.743","volume":"62","author":"NI McNeil","year":"1986","unstructured":"McNeil NI, Gordon T (1986) Meningitis caused by Streptococcus suis type II. Postgrad Med J 62:743\u2013744","journal-title":"Postgrad Med J"},{"key":"1581_CR28","doi-asserted-by":"crossref","first-page":"190","DOI":"10.1354\/vp.38-2-190","volume":"38","author":"LW Madsen","year":"2001","unstructured":"Madsen LW, Svensmark B, Elvestad K, Jensen HE (2001) Otitis interna is a frequent sequela to Streptococcus suis meningitis in pigs. Vet Pathol 38:190\u2013195","journal-title":"Vet Pathol"},{"key":"1581_CR29","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1016\/S0882-4010(02)00192-4","volume":"34","author":"S Lun","year":"2003","unstructured":"Lun S, Perez-Casal J, Connor W, Willson P (2003) Role of suilysin in pathogenesis of Streptococcus suis capsular serotype 2. Microb Pathog 34:27\u201337","journal-title":"Microb Pathog"},{"key":"1581_CR30","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1016\/j.pneurobio.2006.11.008","volume":"80","author":"M Klein","year":"2006","unstructured":"Klein M, Koedel U, Pfister HW (2006) Oxidative stress in pneumococcal meningitis: a future target for adjunctive therapy? Prog Neurobiol 80:269\u2013280","journal-title":"Prog Neurobiol"},{"key":"1581_CR31","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1016\/j.neures.2009.12.008","volume":"66","author":"K Wakabayashi","year":"2010","unstructured":"Wakabayashi K, Fujioka M, Kanzaki S, Okano HJ, Shibata S, Yamashita D, Masuda M, Mihara M, Ohsugi Y, Ogawa K, Okano H (2010) Blockade of interleukin-6 signaling suppressed cochlear inflammatory response and improved hearing impairment in noise-damaged mice cochlea. Neurosci Res 66:345\u2013352","journal-title":"Neurosci Res"},{"key":"1581_CR32","doi-asserted-by":"crossref","first-page":"721","DOI":"10.1016\/S1473-3099(02)00450-4","volume":"2","author":"U Koedel","year":"2002","unstructured":"Koedel U, Scheld WM, Pfister HW (2002) Pathogenesis and pathophysiology of pneumococcal meningitis. Lancet Infect Dis 2:721\u2013736","journal-title":"Lancet Infect Dis"},{"key":"1581_CR33","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1111\/j.1462-5822.2008.01255.x","volume":"11","author":"T Tenenbaum","year":"2009","unstructured":"Tenenbaum T, Papandreou T, Gellrich D, Friedrichs U, Seibt A, Adam R, Wewer C, Galla HJ, Schwerk C, Schroten H (2009) Polar bacterial invasion and translocation of Streptococcus suis across the blood-cerebrospinal fluid barrier in vitro. Cell Microbiol 11:323\u2013336","journal-title":"Cell Microbiol"},{"key":"1581_CR34","doi-asserted-by":"crossref","first-page":"549","DOI":"10.1016\/S0891-5520(05)70094-5","volume":"13","author":"U Koedel","year":"1999","unstructured":"Koedel U, Pfister HW (1999) Models of experimental bacterial meningitis. Role and limitations. Infect Dis Clin North Am 13:549\u2013577","journal-title":"Infect Dis Clin North Am"},{"key":"1581_CR35","first-page":"133","volume":"32","author":"N Tsao","year":"2002","unstructured":"Tsao N, Chang WW, Liu CC, Lei HY (2002) Development of hematogenous pneumococcal meningitis in adult mice: the role of TNF-alpha. FEMS Immunol Med Microbiol 32:133\u2013140","journal-title":"FEMS Immunol Med Microbiol"}],"container-title":["European Journal of Clinical Microbiology & Infectious Diseases"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s10096-012-1581-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s10096-012-1581-2\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s10096-012-1581-2","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,3,22]],"date-time":"2025-03-22T05:47:13Z","timestamp":1742622433000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s10096-012-1581-2"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,3,1]]},"references-count":35,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2012,9]]}},"alternative-id":["1581"],"URL":"https:\/\/doi.org\/10.1007\/s10096-012-1581-2","relation":{},"ISSN":["0934-9723","1435-4373"],"issn-type":[{"value":"0934-9723","type":"print"},{"value":"1435-4373","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,3,1]]}}}