{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T11:45:23Z","timestamp":1792755923230,"version":"4.5.0"},"reference-count":44,"publisher":"Springer Science and Business Media LLC","issue":"7","license":[{"start":{"date-parts":[[2014,1,22]],"date-time":"2014-01-22T00:00:00Z","timestamp":1390348800000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/2.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Eur J Clin Microbiol Infect Dis"],"published-print":{"date-parts":[[2014,7]]},"DOI":"10.1007\/s10096-013-2044-0","type":"journal-article","created":{"date-parts":[[2014,1,21]],"date-time":"2014-01-21T07:14:46Z","timestamp":1390288486000},"page":"1101-1111","source":"Crossref","is-referenced-by-count":114,"title":["Bronchial microbiome of severe COPD patients colonised by Pseudomonas aeruginosa"],"prefix":"10.1007","volume":"33","author":[{"given":"L.","family":"Millares","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R.","family":"Ferrari","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Gallego","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Garcia-Nu\u00f1ez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"V.","family":"P\u00e9rez-Brocal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Espasa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"X.","family":"Pomares","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.","family":"Monton","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Moya","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E.","family":"Mons\u00f3","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2014,1,22]]},"reference":[{"issue":"4","key":"2044_CR1","doi-asserted-by":"crossref","first-page":"288","DOI":"10.1016\/S0002-9343(00)00507-6","volume":"109","author":"AT Hill","year":"2000","unstructured":"Hill AT, Campbell EJ, Hill SL, Bayley DL, Stockley RA (2000) Association between airway bacterial load and markers of airway inflammation in patients with stable chronic bronchitis. Am J Med 109(4):288\u2013295","journal-title":"Am J Med"},{"issue":"7","key":"2044_CR2","doi-asserted-by":"crossref","first-page":"465","DOI":"10.1056\/NEJMoa012561","volume":"347","author":"S Sethi","year":"2002","unstructured":"Sethi S, Evans N, Grant BJ, Murphy TF (2002) New strains of bacteria and exacerbations of chronic obstructive pulmonary disease. N Engl J Med 347(7):465\u2013471","journal-title":"N Engl J Med"},{"issue":"5 Pt 1","key":"2044_CR3","doi-asserted-by":"crossref","first-page":"1498","DOI":"10.1164\/ajrccm.157.5.9711044","volume":"157","author":"N Soler","year":"1998","unstructured":"Soler N, Torres A, Ewig S, Gonzalez J, Celis R, El-Ebiary M, Hernandez C, Rodriguez-Roisin R (1998) Bronchial microbial patterns in severe exacerbations of chronic obstructive pulmonary disease (COPD) requiring mechanical ventilation. Am J Respir Crit Care Med 157(5 Pt 1):1498\u20131505","journal-title":"Am J Respir Crit Care Med"},{"issue":"6","key":"2044_CR4","doi-asserted-by":"crossref","first-page":"1542","DOI":"10.1378\/chest.113.6.1542","volume":"113","author":"J Eller","year":"1998","unstructured":"Eller J, Ede A, Schaberg T, Niederman MS, Mauch H, Lode H (1998) Infective exacerbations of chronic bronchitis: relation between bacteriologic etiology and lung function. Chest 113(6):1542\u20131548","journal-title":"Chest"},{"issue":"8","key":"2044_CR5","doi-asserted-by":"crossref","first-page":"891","DOI":"10.1001\/archinte.165.8.891","volume":"165","author":"A Rosell","year":"2005","unstructured":"Rosell A, Monso E, Soler N, Torres F, Angrill J, Riise G, Zalacain R, Morera J, Torres A (2005) Microbiologic determinants of exacerbation in chronic obstructive pulmonary disease. Arch Intern Med 165(8):891\u2013897","journal-title":"Arch Intern Med"},{"issue":"6","key":"2044_CR6","doi-asserted-by":"crossref","first-page":"459","DOI":"10.1007\/BF03256673","volume":"2","author":"D Lieberman","year":"2003","unstructured":"Lieberman D (2003) Pseudomonal infections in patients with COPD: epidemiology and management. Am J Respir Med 2(6):459\u2013468","journal-title":"Am J Respir Med"},{"issue":"5","key":"2044_CR7","doi-asserted-by":"crossref","first-page":"1072","DOI":"10.1183\/09031936.00003309","volume":"34","author":"C Garcia-Vidal","year":"2009","unstructured":"Garcia-Vidal C, Almagro P, Romani V, Rodriguez-Carballeira M, Cuchi E, Canales L, Blasco D, Heredia JL, Garau J (2009) Pseudomonas aeruginosa in patients hospitalised for COPD exacerbation: a prospective study. Eur Respir J 34(5):1072\u20131078","journal-title":"Eur Respir J"},{"issue":"1","key":"2044_CR8","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1378\/chest.116.1.40","volume":"116","author":"M Miravitlles","year":"1999","unstructured":"Miravitlles M, Espinosa C, Fernandez-Laso E, Martos JA, Maldonado JA, Gallego M (1999) Relationship between bacterial flora in sputum and functional impairment in patients with acute exacerbations of COPD. Study Group of Bacterial Infection in COPD. Chest 116(1):40\u201346","journal-title":"Chest"},{"issue":"12","key":"2044_CR9","doi-asserted-by":"crossref","first-page":"1928","DOI":"10.1086\/648404","volume":"200","author":"E Rakhimova","year":"2009","unstructured":"Rakhimova E, Wiehlmann L, Brauer AL, Sethi S, Murphy TF, Tummler B (2009) Pseudomonas aeruginosa population biology in chronic obstructive pulmonary disease. J Infect Dis 200(12):1928\u20131935","journal-title":"J Infect Dis"},{"issue":"6","key":"2044_CR10","doi-asserted-by":"crossref","first-page":"1138","DOI":"10.1183\/09031936.05.00055705","volume":"26","author":"M Woodhead","year":"2005","unstructured":"Woodhead M, Blasi F, Ewig S, Huchon G, Ieven M, Ortqvist A, Schaberg T, Torres A, van der Heijden G, Verheij TJ (2005) Guidelines for the management of adult lower respiratory tract infections. Eur Respir J 26(6):1138\u20131180","journal-title":"Eur Respir J"},{"issue":"8","key":"2044_CR11","doi-asserted-by":"crossref","first-page":"853","DOI":"10.1164\/rccm.200709-1413OC","volume":"177","author":"TF Murphy","year":"2008","unstructured":"Murphy TF, Brauer AL, Eschberger K, Lobbins P, Grove L, Cai X, Sethi S (2008) Pseudomonas aeruginosa in chronic obstructive pulmonary disease. Am J Respir Crit Care Med 177(8):853\u2013860","journal-title":"Am J Respir Crit Care Med"},{"issue":"12","key":"2044_CR12","doi-asserted-by":"crossref","first-page":"1526","DOI":"10.1086\/593186","volume":"47","author":"L Martinez-Solano","year":"2008","unstructured":"Martinez-Solano L, Macia MD, Fajardo A, Oliver A, Martinez JL (2008) Chronic Pseudomonas aeruginosa infection in chronic obstructive pulmonary disease. Clin Infect Dis 47(12):1526\u20131533","journal-title":"Clin Infect Dis"},{"key":"2044_CR13","doi-asserted-by":"crossref","first-page":"449","DOI":"10.2147\/COPD.S23655","volume":"6","author":"X Pomares","year":"2011","unstructured":"Pomares X, Monton C, Espasa M, Casabon J, Monso E, Gallego M (2011) Long-term azithromycin therapy in patients with severe COPD and repeated exacerbations. Int J Chron Obstruct Pulmon Dis 6:449\u2013456","journal-title":"Int J Chron Obstruct Pulmon Dis"},{"issue":"12","key":"2044_CR14","doi-asserted-by":"crossref","first-page":"1534","DOI":"10.1086\/593187","volume":"47","author":"TF Murphy","year":"2008","unstructured":"Murphy TF (2008) The many faces of Pseudomonas aeruginosa in chronic obstructive pulmonary disease. Clin Infect Dis 47(12):1534\u20131536","journal-title":"Clin Infect Dis"},{"issue":"8","key":"2044_CR15","doi-asserted-by":"crossref","first-page":"535","DOI":"10.1111\/j.1348-0421.2002.tb02731.x","volume":"46","author":"H Hayashi","year":"2002","unstructured":"Hayashi H, Sakamoto M, Benno Y (2002) Phylogenetic analysis of the human gut microbiota using 16S rDNA clone libraries and strictly anaerobic culture-based methods. Microbiol Immunol 46(8):535\u2013548","journal-title":"Microbiol Immunol"},{"issue":"11","key":"2044_CR16","doi-asserted-by":"crossref","first-page":"4799","DOI":"10.1128\/AEM.65.11.4799-4807.1999","volume":"65","author":"A Suau","year":"1999","unstructured":"Suau A, Bonnet R, Sutren M, Godon JJ, Gibson GR, Collins MD, Dore J (1999) Direct analysis of genes encoding 16S rRNA from complex communities reveals many novel molecular species within the human gut. Appl Environ Microbiol 65(11):4799\u20134807","journal-title":"Appl Environ Microbiol"},{"issue":"7","key":"2044_CR17","doi-asserted-by":"crossref","first-page":"e22702","DOI":"10.1371\/journal.pone.0022702","volume":"6","author":"CD Sibley","year":"2011","unstructured":"Sibley CD, Grinwis ME, Field TR, Eshaghurshan CS, Faria MM, Dowd SE, Parkins MD, Rabin HR, Surette MG (2011) Culture enriched molecular profiling of the cystic fibrosis airway microbiome. PLoS One 6(7):e22702","journal-title":"PLoS One"},{"issue":"8","key":"2044_CR18","doi-asserted-by":"crossref","first-page":"957","DOI":"10.1164\/rccm.201104-0655OC","volume":"184","author":"ES Charlson","year":"2011","unstructured":"Charlson ES, Bittinger K, Haas AR, Fitzgerald AS, Frank I, Yadav A, Bushman FD, Collman RG (2011) Topographical continuity of bacterial populations in the healthy human respiratory tract. Am J Respir Crit Care Med 184(8):957\u2013963","journal-title":"Am J Respir Crit Care Med"},{"issue":"2","key":"2044_CR19","doi-asserted-by":"crossref","first-page":"e16384","DOI":"10.1371\/journal.pone.0016384","volume":"6","author":"JR Erb-Downward","year":"2011","unstructured":"Erb-Downward JR, Thompson DL, Han MK, Freeman CM, McCloskey L, Schmidt LA, Young VB, Toews GB, Curtis JL, Sundaram B, Martinez FJ, Huffnagle GB (2011) Analysis of the lung microbiome in the \u201chealthy\u201d smoker and in COPD. PLoS One 6(2):e16384","journal-title":"PLoS One"},{"issue":"1","key":"2044_CR20","doi-asserted-by":"crossref","first-page":"e8578","DOI":"10.1371\/journal.pone.0008578","volume":"5","author":"M Hilty","year":"2010","unstructured":"Hilty M, Burke C, Pedro H, Cardenas P, Bush A, Bossley C, Davies J, Ervine A, Poulter L, Pachter L, Moffatt MF, Cookson WO (2010) Disordered microbial communities in asthmatic airways. PLoS One 5(1):e8578","journal-title":"PLoS One"},{"issue":"9","key":"2044_CR21","doi-asserted-by":"crossref","first-page":"1151","DOI":"10.1007\/s10096-009-0749-x","volume":"28","author":"F Armougom","year":"2009","unstructured":"Armougom F, Bittar F, Stremler N, Rolain JM, Robert C, Dubus JC, Sarles J, Raoult D, La Scola B (2009) Microbial diversity in the sputum of a cystic fibrosis patient studied with 16S rDNA pyrosequencing. Eur J Clin Microbiol Infect Dis 28(9):1151\u20131154","journal-title":"Eur J Clin Microbiol Infect Dis"},{"key":"2044_CR22","unstructured":"Updated 2013 Global Initiative for Chronic Obstructive Lung Disease. Global strategy for the diagnosis, management, and prevention of chronic obstructive pulmonary disease. www.goldcopd.com"},{"issue":"2","key":"2044_CR23","doi-asserted-by":"crossref","first-page":"196","DOI":"10.7326\/0003-4819-106-2-196","volume":"106","author":"NR Anthonisen","year":"1987","unstructured":"Anthonisen NR, Manfreda J, Warren CP, Hershfield ES, Harding GK, Nelson NA (1987) Antibiotic therapy in exacerbations of chronic obstructive pulmonary disease. Ann Intern Med 106(2):196\u2013204","journal-title":"Ann Intern Med"},{"issue":"9","key":"2044_CR24","doi-asserted-by":"crossref","first-page":"690","DOI":"10.1111\/j.1469-0691.2005.01217.x","volume":"11","author":"R Canton","year":"2005","unstructured":"Canton R, Cobos N, de Gracia J, Baquero F, Honorato J, Gartner S, Alvarez A, Salcedo A, Oliver A, Garcia-Quetglas E (2005) Antimicrobial therapy for pulmonary pathogenic colonisation and infection by Pseudomonas aeruginosa in cystic fibrosis patients. Clin Microbiol Infect 11(9):690\u2013703","journal-title":"Clin Microbiol Infect"},{"issue":"11","key":"2044_CR25","doi-asserted-by":"crossref","first-page":"629","DOI":"10.1157\/13128330","volume":"44","author":"M Vendrell","year":"2008","unstructured":"Vendrell M, de Gracia J, Olveira C, Martinez MA, Giron R, Maiz L, Canton R, Coll R, Escribano A, Sole A (2008) Diagnosis and treatment of bronchiectasis. Spanish Society of Pneumology and Thoracic Surgery. Arch Bronconeumol 44(11):629\u2013640","journal-title":"Arch Bronconeumol"},{"issue":"23","key":"2044_CR26","doi-asserted-by":"crossref","first-page":"7537","DOI":"10.1128\/AEM.01541-09","volume":"75","author":"PD Schloss","year":"2009","unstructured":"Schloss PD, Westcott SL, Ryabin T, Hall JR, Hartmann M, Hollister EB, Lesniewski RA, Oakley BB, Parks DH, Robinson CJ, Sahl JW, Stres B, Thallinger GG, Van Horn DJ, Weber CF (2009) Introducing mothur: open-source, platform-independent, community-supported software for describing and comparing microbial communities. Appl Environ Microbiol 75(23):7537\u20137541","journal-title":"Appl Environ Microbiol"},{"issue":"5","key":"2044_CR27","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1038\/nmeth.f.303","volume":"7","author":"JG Caporaso","year":"2010","unstructured":"Caporaso JG, Kuczynski J, Stombaugh J, Bittinger K, Bushman FD, Costello EK, Fierer N, Pena AG, Goodrich JK, Gordon JI, Huttley GA, Kelley ST, Knights D, Koenig JE, Ley RE, Lozupone CA, McDonald D, Muegge BD, Pirrung M, Reeder J, Sevinsky JR, Turnbaugh PJ, Walters WA, Widmann J, Yatsunenko T, Zaneveld J, Knight R (2010) QIIME allows analysis of high-throughput community sequencing data. Nat Methods 7(5):335\u2013336","journal-title":"Nat Methods"},{"issue":"6","key":"2044_CR28","doi-asserted-by":"crossref","first-page":"R60","DOI":"10.1186\/gb-2011-12-6-r60","volume":"12","author":"N Segata","year":"2011","unstructured":"Segata N, Izard J, Waldron L, Gevers D, Miropolsky L, Garrett WS, Huttenhower C (2011) Metagenomic biomarker discovery and explanation. Genome Biol 12(6):R60","journal-title":"Genome Biol"},{"key":"2044_CR29","first-page":"265","volume":"11","author":"A Chao","year":"1984","unstructured":"Chao A (1984) Nonparametric estimation of the number of classes in a population. Scand J Stat 11:265\u2013270","journal-title":"Scand J Stat"},{"issue":"4","key":"2044_CR30","first-page":"306","volume":"14","author":"CE Shannon","year":"1997","unstructured":"Shannon CE (1997) The mathematical theory of communication. 1963. MD Comput 14(4):306\u2013317","journal-title":"MD Comput"},{"key":"2044_CR31","doi-asserted-by":"crossref","first-page":"325","DOI":"10.2307\/1942268","volume":"27","author":"JR Bray","year":"1957","unstructured":"Bray JR, Curtis JT (1957) An ordination of the upland forest communities of southern Wisconsin. Ecol Monogr 27:325\u2013349","journal-title":"Ecol Monogr"},{"issue":"10","key":"2044_CR32","doi-asserted-by":"crossref","first-page":"1067","DOI":"10.1164\/rccm.201210-1913OC","volume":"187","author":"A Morris","year":"2013","unstructured":"Morris A, Beck JM, Schloss PD, Campbell TB, Crothers K, Curtis JL, Flores SC, Fontenot AP, Ghedin E, Huang L, Jablonski K, Kleerup E, Lynch SV, Sodergren E, Twigg H, Young VB, Bassis CM, Venkataraman A, Schmidt TM, Weinstock GM (2013) Comparison of the respiratory microbiome in healthy nonsmokers and smokers. Am J Respir Crit Care Med 187(10):1067\u20131075","journal-title":"Am J Respir Crit Care Med"},{"issue":"7","key":"2044_CR33","doi-asserted-by":"crossref","first-page":"512","DOI":"10.1513\/pats.200701-002FM","volume":"4","author":"JL Curtis","year":"2007","unstructured":"Curtis JL, Freeman CM, Hogg JC (2007) The immunopathogenesis of chronic obstructive pulmonary disease: insights from recent research. Proc Am Thorac Soc 4(7):512\u2013521","journal-title":"Proc Am Thorac Soc"},{"issue":"2","key":"2044_CR34","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1136\/gut.2005.073817","volume":"55","author":"C Manichanh","year":"2006","unstructured":"Manichanh C, Rigottier-Gois L, Bonnaud E, Gloux K, Pelletier E, Frangeul L, Nalin R, Jarrin C, Chardon P, Marteau P, Roca J, Dore J (2006) Reduced diversity of faecal microbiota in Crohn\u2019s disease revealed by a metagenomic approach. Gut 55(2):205\u2013211","journal-title":"Gut"},{"issue":"43","key":"2044_CR35","doi-asserted-by":"crossref","first-page":"16413","DOI":"10.1073\/pnas.0809363105","volume":"105","author":"RB Sartor","year":"2008","unstructured":"Sartor RB (2008) Therapeutic correction of bacterial dysbiosis discovered by molecular techniques. Proc Natl Acad Sci U S A 105(43):16413\u201316414","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"9","key":"2044_CR36","doi-asserted-by":"crossref","first-page":"427","DOI":"10.1016\/j.tim.2011.06.005","volume":"19","author":"DN Frank","year":"2011","unstructured":"Frank DN, Zhu W, Sartor RB, Li E (2011) Investigating the biological and clinical significance of human dysbioses. Trends Microbiol 19(9):427\u2013434","journal-title":"Trends Microbiol"},{"issue":"3","key":"2044_CR37","doi-asserted-by":"crossref","first-page":"444","DOI":"10.1086\/318075","volume":"183","author":"JL Burns","year":"2001","unstructured":"Burns JL, Gibson RL, McNamara S, Yim D, Emerson J, Rosenfeld M, Hiatt P, McCoy K, Castile R, Smith AL, Ramsey BW (2001) Longitudinal assessment of Pseudomonas aeruginosa in young children with cystic fibrosis. J Infect Dis 183(3):444\u2013452","journal-title":"J Infect Dis"},{"issue":"2","key":"2044_CR38","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1002\/ppul.10127","volume":"34","author":"J Emerson","year":"2002","unstructured":"Emerson J, Rosenfeld M, McNamara S, Ramsey B, Gibson RL (2002) Pseudomonas aeruginosa and other predictors of mortality and morbidity in young children with cystic fibrosis. Pediatr Pulmonol 34(2):91\u2013100","journal-title":"Pediatr Pulmonol"},{"issue":"22","key":"2044_CR39","doi-asserted-by":"crossref","first-page":"2958","DOI":"10.1001\/jama.287.22.2958","volume":"287","author":"SE West","year":"2002","unstructured":"West SE, Zeng L, Lee BL, Kosorok MR, Laxova A, Rock MJ, Splaingard MJ, Farrell PM (2002) Respiratory infections with Pseudomonas aeruginosa in children with cystic fibrosis: early detection by serology and assessment of risk factors. JAMA 287(22):2958\u20132967","journal-title":"JAMA"},{"issue":"10","key":"2044_CR40","doi-asserted-by":"crossref","first-page":"1019","DOI":"10.1007\/s12325-008-0105-2","volume":"25","author":"R Dal Negro","year":"2008","unstructured":"Dal Negro R, Micheletto C, Tognella S, Visconti M, Turati C (2008) Tobramycin nebulizer solution in severe COPD patients colonized with Pseudomonas aeruginosa: effects on bronchial inflammation. Adv Ther 25(10):1019\u20131030","journal-title":"Adv Ther"},{"issue":"7","key":"2044_CR41","doi-asserted-by":"crossref","first-page":"476","DOI":"10.1016\/S0954-6111(99)90090-2","volume":"93","author":"R Orriols","year":"1999","unstructured":"Orriols R, Roig J, Ferrer J, Sampol G, Rosell A, Ferrer A, Vallano A (1999) Inhaled antibiotic therapy in non-cystic fibrosis patients with bronchiectasis and chronic bronchial infection by Pseudomonas aeruginosa. Respir Med 93(7):476\u2013480","journal-title":"Respir Med"},{"issue":"5","key":"2044_CR42","doi-asserted-by":"crossref","first-page":"456","DOI":"10.1136\/thoraxjnl-2011-201183","volume":"67","author":"MK Han","year":"2012","unstructured":"Han MK, Huang YJ, Lipuma JJ, Boushey HA, Boucher RC, Cookson WO, Curtis JL, Erb-Downward J, Lynch SV, Sethi S, Toews GB, Young VB, Wolfgang MC, Huffnagle GB, Martinez FJ (2012) Significance of the microbiome in obstructive lung disease. Thorax 67(5):456\u2013463","journal-title":"Thorax"},{"issue":"12","key":"2044_CR43","doi-asserted-by":"crossref","first-page":"e1002808","DOI":"10.1371\/journal.pcbi.1002808","volume":"8","author":"XC Morgan","year":"2012","unstructured":"Morgan XC, Huttenhower C (2012) Chapter 12: Human microbiome analysis. PLoS Comput Biol 8(12):e1002808","journal-title":"PLoS Comput Biol"},{"issue":"10","key":"2044_CR44","doi-asserted-by":"crossref","first-page":"1224","DOI":"10.1164\/rccm.201302-0341OC","volume":"188","author":"PL Molyneaux","year":"2013","unstructured":"Molyneaux PL, Mallia P, Cox MJ, Footitt J, Willis-Owen SA, Homola D, Trujillo-Torralbo MB, Elkin S, Kon OM, Cookson WO, Moffatt MF, Johnston SL (2013) Outgrowth of the bacterial airway microbiome after rhinovirus exacerbation of chronic obstructive pulmonary disease. Am J Respir Crit Care Med 188(10):1224\u20131231","journal-title":"Am J Respir Crit Care Med"}],"container-title":["European Journal of Clinical Microbiology & Infectious Diseases"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s10096-013-2044-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s10096-013-2044-0\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s10096-013-2044-0","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,8,14]],"date-time":"2020-08-14T10:44:46Z","timestamp":1597401886000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s10096-013-2044-0"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,1,22]]},"references-count":44,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2014,7]]}},"alternative-id":["2044"],"URL":"https:\/\/doi.org\/10.1007\/s10096-013-2044-0","relation":{},"ISSN":["0934-9723","1435-4373"],"issn-type":[{"value":"0934-9723","type":"print"},{"value":"1435-4373","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,1,22]]}}}