{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T00:25:44Z","timestamp":1790987144845,"version":"4.1.0"},"reference-count":27,"publisher":"Springer Science and Business Media LLC","issue":"8","license":[{"start":{"date-parts":[[2014,2,20]],"date-time":"2014-02-20T00:00:00Z","timestamp":1392854400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Eur J Clin Microbiol Infect Dis"],"published-print":{"date-parts":[[2014,8]]},"DOI":"10.1007\/s10096-014-2074-2","type":"journal-article","created":{"date-parts":[[2014,2,19]],"date-time":"2014-02-19T00:14:42Z","timestamp":1392768882000},"page":"1339-1344","source":"Crossref","is-referenced-by-count":24,"title":["Comparison of flucytosine and fluconazole combined with amphotericin B for the treatment of HIV-associated cryptococcal meningitis: a systematic review and meta-analysis"],"prefix":"10.1007","volume":"33","author":[{"given":"Z.-W.","family":"Yao","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"X.","family":"Lu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.","family":"Shen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D.-F.","family":"Lin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2014,2,20]]},"reference":[{"key":"2074_CR1","doi-asserted-by":"crossref","first-page":"1182","DOI":"10.1097\/QAD.0b013e32832be0fc","volume":"23","author":"JN Jarvis","year":"2009","unstructured":"Jarvis JN, Boulle A, Loyse A, Bicanic T, Rebe K, Williams A, Harrison TS, Meintjes G (2009) High ongoing burden of cryptococcal disease in Africa despite antiretroviral roll out. AIDS 23:1182\u20131183","journal-title":"AIDS"},{"key":"2074_CR2","doi-asserted-by":"crossref","first-page":"698","DOI":"10.1093\/ije\/27.4.698","volume":"27","author":"M Okongo","year":"1998","unstructured":"Okongo M, Morgan D, Mayanja B, Ross A, Whitworth J (1998) Causes of death in a rural, population-based human immunodeficiency virus type 1 (HIV-1) natural history cohort in Uganda. Int J Epidemiol 27:698\u2013702","journal-title":"Int J Epidemiol"},{"key":"2074_CR3","doi-asserted-by":"crossref","first-page":"1031","DOI":"10.1097\/00002030-200205030-00009","volume":"16","author":"N French","year":"2002","unstructured":"French N, Gray K, Watera C, Nakiyingi J, Lugada E, Moore M, Lalloo D, Whitworth JA, Gilks CF (2002) Cryptococcal infection in a cohort of HIV-1-infected Ugandan adults. AIDS 16:1031\u20131038","journal-title":"AIDS"},{"key":"2074_CR4","doi-asserted-by":"crossref","first-page":"2441","DOI":"10.1056\/NEJMoa065711","volume":"357","author":"M Scarborough","year":"2007","unstructured":"Scarborough M, Gordon SB, Whitty CJ, French N, Njalale Y, Chitani A, Peto TE, Lalloo DG, Zijlstra EE (2007) Corticosteroids for bacterial meningitis in adults in sub-Saharan Africa. N Engl J Med 357:2441\u20132450","journal-title":"N Engl J Med"},{"key":"2074_CR5","doi-asserted-by":"crossref","first-page":"1401","DOI":"10.1097\/00002030-200007070-00013","volume":"14","author":"JG Hakim","year":"2000","unstructured":"Hakim JG, Gangaidzo IT, Heyderman RS, Mielke J, Mushangi E, Taziwa A, Robertson VJ, Musvaire P, Mason PR (2000) Impact of HIV infection on meningitis in Harare, Zimbabwe: a prospective study of 406 predominantly adult patients. AIDS 14:1401\u20131407","journal-title":"AIDS"},{"key":"2074_CR6","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1186\/1471-2334-10-67","volume":"10","author":"JN Jarvis","year":"2010","unstructured":"Jarvis JN, Meintjes G, Williams A, Brown Y, Crede T, Harrison TS (2010) Adult meningitis in a setting of high HIV and TB prevalence: findings from 4961 suspected cases. BMC Infect Dis 10:67","journal-title":"BMC Infect Dis"},{"key":"2074_CR7","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1086\/649858","volume":"50","author":"JR Perfect","year":"2010","unstructured":"Perfect JR, Dismukes WE, Dromer F, Goldman DL, Graybill JR, Hamill RJ, Harrison TS, Larsen RA, Lortholary O, Nguyen MH, Pappas PG, Powderly WG, Singh N, Sobel JD, Sorrell TC (2010) Clinical practice guidelines for the management of cryptococcal disease: 2010 update by the infectious diseases society of America. Clin Infect Dis 50:291\u2013322","journal-title":"Clin Infect Dis"},{"key":"2074_CR8","doi-asserted-by":"crossref","first-page":"76","DOI":"10.7196\/sajhivmed.899","volume":"14","author":"NP Govender","year":"2013","unstructured":"Govender NP, Meintjes G, Bicanic T, Dawood H, Harrison TS, Jarvis JN, Karstaedt AS, Maartens G, McCarthy KM, Rabie H, Variava E, Venter WDF, Boulware DR, Chiller T, Meya DB, Scriven J (2013) Guideline for the prevention, diagnosis and management of cryptococcal meningitis among HIV-infected persons: 2013 update. Southern African HIV Clinicians Society. S Afr J HIV Med 14:76\u201386","journal-title":"S Afr J HIV Med"},{"key":"2074_CR9","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1056\/NEJM199201093260202","volume":"326","author":"MS Saag","year":"1992","unstructured":"Saag MS, Powderly WG, Cloud GA, Robinson P, Grieco MH, Sharkey PK, Thompson SE, Sugar AM, Tuazon CU, Fisher JF, Hyslop N, Jacobson JM, Hafner R, Dismukes WE (1992) Comparison of amphotericin B with fluconazole in the treatment of acute AIDS-associated cryptococcal meningitis. The NIAID Mycoses Study Group and the AIDS Clinical Trials Group. N Engl J Med 326:83\u201389","journal-title":"N Engl J Med"},{"key":"2074_CR10","doi-asserted-by":"crossref","first-page":"985","DOI":"10.1128\/AAC.48.3.985-991.2004","volume":"48","author":"RA Larsen","year":"2004","unstructured":"Larsen RA, Bauer M, Thomas AM, Graybill JR (2004) Amphotericin B and fluconazole, a potent combination therapy for cryptococcal meningitis. Antimicrob Agents Chemother 48:985\u2013991","journal-title":"Antimicrob Agents Chemother"},{"key":"2074_CR11","doi-asserted-by":"crossref","first-page":"1764","DOI":"10.1016\/S0140-6736(04)16301-0","volume":"363","author":"AE Brouwer","year":"2004","unstructured":"Brouwer AE, Rajanuwong A, Chierakul W, Griffin GE, Larsen RA, White NJ, Harrison TS (2004) Combination antifungal therapies for HIV-associated cryptococcal meningitis: a randomised trial. Lancet 363:1764\u20131767","journal-title":"Lancet"},{"key":"2074_CR12","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1086\/588792","volume":"47","author":"T Bicanic","year":"2008","unstructured":"Bicanic T, Wood R, Meintjes G, Rebe K, Brouwer A, Loyse A, Bekker LG, Jaffar S, Harrison T (2008) High-dose amphotericin B with flucytosine for the treatment of cryptococcal meningitis in HIV-infected patients: a randomized trial. Clin Infect Dis 47:123\u2013130","journal-title":"Clin Infect Dis"},{"key":"2074_CR13","doi-asserted-by":"crossref","first-page":"1291","DOI":"10.1056\/NEJMoa1110404","volume":"368","author":"JN Day","year":"2013","unstructured":"Day JN, Chau TT, Wolbers M, Mai PP, Dung NT, Mai NH, Phu NH, Nghia HD, Phong ND, Thai CQ, Thai le H, Chuong LV, Sinh DX, Duong VA, Hoang TN, Diep PT, Campbell JI, Sieu TP, Baker SG, Chau NV, Hien TT, Lalloo DG, Farrar JJ (2013) Combination antifungal therapy for cryptococcal meningitis. N Engl J Med 368:1291\u20131302","journal-title":"N Engl J Med"},{"key":"2074_CR14","doi-asserted-by":"crossref","first-page":"e1000097","DOI":"10.1371\/journal.pmed.1000097","volume":"6","author":"D Moher","year":"2009","unstructured":"Moher D, Liberati A, Tetzlaff J, Altman DG; Prisma Group (2009) Preferred reporting items for systematic reviews and meta-analyses: the PRISMA statement. PLoS Med 6:e1000097","journal-title":"PLoS Med"},{"key":"2074_CR15","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1016\/j.pain.2006.06.018","volume":"126","author":"KY Ho","year":"2006","unstructured":"Ho KY, Gan TJ, Habib AS (2006) Gabapentin and postoperative pain\u2014a systematic review of randomized controlled trials. Pain 126:91\u2013101","journal-title":"Pain"},{"key":"2074_CR16","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1136\/bmj.323.7303.42","volume":"323","author":"P J\u00fcni","year":"2001","unstructured":"J\u00fcni P, Altman DG, Egger M (2001) Systematic reviews in health care: assessing the quality of controlled clinical trials. BMJ 323:42\u201346","journal-title":"BMJ"},{"key":"2074_CR17","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1093\/cid\/cir745","volume":"54","author":"A Loyse","year":"2012","unstructured":"Loyse A, Wilson D, Meintjes G, Jarvis JN, Bicanic T, Bishop L, Rebe K, Williams A, Jaffar S, Bekker LG, Wood R, Harrison TS (2012) Comparison of the early fungicidal activity of high-dose fluconazole, voriconazole, and flucytosine as second-line drugs given in combination with amphotericin B for the treatment of HIV-associated cryptococcal meningitis. Clin Infect Dis 54:121\u2013128","journal-title":"Clin Infect Dis"},{"key":"2074_CR18","doi-asserted-by":"crossref","first-page":"e2870","DOI":"10.1371\/journal.pone.0002870","volume":"3","author":"F Dromer","year":"2008","unstructured":"Dromer F, Bernede-Bauduin C, Guillemot D, Lortholary O; French Cryptococcosis Study Group (2008) Major role for amphotericin B-flucytosine combination in severe cryptococcosis. PLoS One 3:e2870","journal-title":"PLoS One"},{"key":"2074_CR19","doi-asserted-by":"crossref","first-page":"e21","DOI":"10.1371\/journal.pmed.0040021","volume":"4","author":"F Dromer","year":"2007","unstructured":"Dromer F, Mathoulin-P\u00e9lissier S, Launay O, Lortholary O; French Cryptococcosis Study Group (2007) Determinants of disease presentation and outcome during cryptococcosis: the CryptoA\/D Study. PLoS Med 4:e21","journal-title":"PLoS Med"},{"key":"2074_CR20","doi-asserted-by":"crossref","first-page":"1377","DOI":"10.1007\/s10096-013-1915-8","volume":"32","author":"FP Gullo","year":"2013","unstructured":"Gullo FP, Rossi SA, Sardi Jde C, Teodoro VL, Mendes-Giannini MJ, Fusco-Almeida AM (2013) Cryptococcosis: epidemiology, fungal resistance, and new alternatives for treatment. Eur J Clin Microbiol Infect Dis 32:1377\u20131391","journal-title":"Eur J Clin Microbiol Infect Dis"},{"key":"2074_CR21","doi-asserted-by":"crossref","first-page":"636","DOI":"10.1111\/j.1468-1293.2012.01022.x","volume":"13","author":"T Bicanic","year":"2012","unstructured":"Bicanic T, Ogden D, Whitney L, Loyse A, Jarvis J (2012) British HIV Association opportunistic infection guidelines: in defence of amphotericin B deoxycholate. HIV Med 13:636\u2013637","journal-title":"HIV Med"},{"key":"2074_CR22","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1007\/s11908-010-0113-4","volume":"12","author":"KD Brizendine","year":"2010","unstructured":"Brizendine KD, Pappas PG (2010) Cryptococcal meningitis: current approaches to management in patients with and without AIDS. Curr Infect Dis Rep 12:299\u2013305","journal-title":"Curr Infect Dis Rep"},{"key":"2074_CR23","doi-asserted-by":"crossref","first-page":"710","DOI":"10.1086\/313757","volume":"30","author":"MS Saag","year":"2000","unstructured":"Saag MS, Graybill RJ, Larsen RA, Pappas PG, Perfect JR, Powderly WG, Sobel JD, Dismukes WE (2000) Practice guidelines for the management of cryptococcal disease. Infectious Diseases Society of America. Clin Infect Dis 30:710\u2013718","journal-title":"Clin Infect Dis"},{"key":"2074_CR24","doi-asserted-by":"crossref","first-page":"702","DOI":"10.1086\/604716","volume":"49","author":"T Bicanic","year":"2009","unstructured":"Bicanic T, Muzoora C, Brouwer AE, Meintjes G, Longley N, Taseera K, Rebe K, Loyse A, Jarvis J, Bekker LG, Wood R, Limmathurotsakul D, Chierakul W, Stepniewska K, White NJ, Jaffar S, Harrison TS (2009) Independent association between rate of clearance of infection and clinical outcome of HIV-associated cryptococcal meningitis: analysis of a combined cohort of 262 patients. Clin Infect Dis 49:702\u2013709","journal-title":"Clin Infect Dis"},{"key":"2074_CR25","doi-asserted-by":"crossref","first-page":"338","DOI":"10.1086\/649861","volume":"50","author":"JC Nussbaum","year":"2010","unstructured":"Nussbaum JC, Jackson A, Namarika D, Phulusa J, Kenala J, Kanyemba C, Jarvis JN, Jaffar S, Hosseinipour MC, Kamwendo D, van der Horst CM, Harrison TS (2010) Combination flucytosine and high-dose fluconazole compared with fluconazole monotherapy for the treatment of cryptococcal meningitis: a randomized trial in Malawi. Clin Infect Dis 50:338\u2013344","journal-title":"Clin Infect Dis"},{"key":"2074_CR26","unstructured":"Bicanic T, Jarvis J, Loyse A, Jackson A, Muzoora C, Wilson D, van der Horst C, Wood R, Meintjes G, Harrison T (2011) Determinants of acute outcome and long-term survival in HIV-associated cryptococcal meningitis: results from a combined cohort of 523 patients. In: Abstracts of the 18th Conference on Retroviruses and Opportunistic Infections, Boston, MA, February\/March 2011, abstract P-123"},{"key":"2074_CR27","doi-asserted-by":"crossref","first-page":"2435","DOI":"10.1093\/jac\/dkt221","volume":"68","author":"A Loyse","year":"2013","unstructured":"Loyse A, Dromer F, Day J, Lortholary O, Harrison TS (2013) Flucytosine and cryptococcosis: time to urgently address the worldwide accessibility of a 50-year-old antifungal. J Antimicrob Chemother 68:2435\u20132444","journal-title":"J Antimicrob Chemother"}],"container-title":["European Journal of Clinical Microbiology & Infectious Diseases"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s10096-014-2074-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s10096-014-2074-2\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s10096-014-2074-2","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,5,29]],"date-time":"2019-05-29T09:35:10Z","timestamp":1559122510000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s10096-014-2074-2"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,2,20]]},"references-count":27,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2014,8]]}},"alternative-id":["2074"],"URL":"https:\/\/doi.org\/10.1007\/s10096-014-2074-2","relation":{},"ISSN":["0934-9723","1435-4373"],"issn-type":[{"value":"0934-9723","type":"print"},{"value":"1435-4373","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,2,20]]}}}