{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,9]],"date-time":"2026-05-09T09:07:27Z","timestamp":1778317647126,"version":"3.51.4"},"reference-count":38,"publisher":"Springer Science and Business Media LLC","issue":"10","license":[{"start":{"date-parts":[[2015,7,26]],"date-time":"2015-07-26T00:00:00Z","timestamp":1437868800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Eur J Clin Microbiol Infect Dis"],"published-print":{"date-parts":[[2015,10]]},"DOI":"10.1007\/s10096-015-2459-x","type":"journal-article","created":{"date-parts":[[2015,7,25]],"date-time":"2015-07-25T12:12:04Z","timestamp":1437826324000},"page":"2103-2110","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":19,"title":["Clinical and antimicrobial efficacy of a controlled-release device containing chlorhexidine in the treatment of chronic periodontitis"],"prefix":"10.1007","volume":"34","author":[{"given":"S.","family":"Pattnaik","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"N.","family":"Anand","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S. C.","family":"Chandrasekaran","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L.","family":"Chandrashekar","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K.","family":"Mahalakshmi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"Satpathy","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2015,7,26]]},"reference":[{"issue":"9499","key":"2459_CR1","doi-asserted-by":"crossref","first-page":"1809","DOI":"10.1016\/S0140-6736(05)67728-8","volume":"366","author":"BL Pihlstrom","year":"2005","unstructured":"Pihlstrom BL, Michalowicz BS, Johnson NW (2005) Periodontal diseases. Lancet 366(9499):1809\u20131820","journal-title":"Lancet"},{"key":"2459_CR2","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1111\/j.1600-0757.2004.03671.x","volume":"36","author":"T Nishihara","year":"2000","unstructured":"Nishihara T, Koseki T (2000) Microbial etiology of periodontitis. Periodontol 36:14\u201326","journal-title":"Periodontol"},{"issue":"5","key":"2459_CR3","doi-asserted-by":"crossref","first-page":"324","DOI":"10.1111\/j.1600-051X.1997.tb00765.x","volume":"24","author":"AD Haffajee","year":"1997","unstructured":"Haffajee AD, Cugini MA, Dibart S, Smith C, Kent RL Jr, Socransky SS (1997) The effect of SRP on the clinical and microbiological parameters of periodontal diseases. J Clin Periodontol 24(5):324\u2013334","journal-title":"J Clin Periodontol"},{"issue":"5","key":"2459_CR4","doi-asserted-by":"crossref","first-page":"516","DOI":"10.1111\/j.1600-0765.1983.tb00388.x","volume":"18","author":"LM Golub","year":"1983","unstructured":"Golub LM, Lee HM, Lehrer G, Nemiroff A, McNamara TF, Kaplan R, Ramamurthy NS (1983) Minocycline reduces gingival collagenolytic activity during diabetes. Preliminary observations and a proposed new mechanism of action. J Periodontal Res 18(5):516\u2013526","journal-title":"J Periodontal Res"},{"issue":"4","key":"2459_CR5","first-page":"557","volume":"45","author":"CM Ardila","year":"2010","unstructured":"Ardila CM, Granada MI, Guzm\u00e1n IC (2010) Antibiotic resistance of subgingival species in chronic periodontitis patients. J Periodontal Res 45(4):557\u2013563","journal-title":"J Periodontal Res"},{"issue":"1","key":"2459_CR6","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1111\/prd.12075","volume":"67","author":"M Feres","year":"2015","unstructured":"Feres M, Figueiredo LC, Soares GMS, Faveri M (2015) Systemic antibiotics in the treatment of periodontitis. Periodontol 2000 67(1):131\u2013186","journal-title":"Periodontol 2000"},{"issue":"11 Suppl","key":"2459_CR7","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1902\/jop.1985.56.11s.81","volume":"56","author":"JM Goodson","year":"1985","unstructured":"Goodson JM, Hogan PE, Dunham SL (1985) Clinical responses following periodontal treatment by local drug delivery. J Periodontol 56(11 Suppl):81\u201387","journal-title":"J Periodontol"},{"issue":"4","key":"2459_CR8","doi-asserted-by":"crossref","first-page":"304","DOI":"10.4103\/0972-124X.92559","volume":"15","author":"R Kalsi","year":"2011","unstructured":"Kalsi R, Vandana KL, Prakash S (2011) Effect of local drug delivery in chronic periodontitis patients: A meta-analysis. J Indian Soc Periodontol 15(4):304\u2013309","journal-title":"J Indian Soc Periodontol"},{"issue":"5","key":"2459_CR9","doi-asserted-by":"crossref","first-page":"515","DOI":"10.1590\/S1678-77572010000500015","volume":"18","author":"FB Zanatta","year":"2010","unstructured":"Zanatta FB, Antoniazzi RP, R\u00f6sing CK (2010) Staining and calculus formation after 0.12% chlorhexidine rinses in plaque-free and plaque covered surfaces: a randomized trial. J Appl Oral Sci 18(5):515\u2013521","journal-title":"J Appl Oral Sci"},{"key":"2459_CR10","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1159\/000329667","volume":"15","author":"V Zijnge","year":"2012","unstructured":"Zijnge V, Ammann T, Thurnheer T, Gm\u00fcr R (2012) Subgingival biofilm structure. Front Oral Biol 15:1\u201316","journal-title":"Front Oral Biol"},{"issue":"2","key":"2459_CR11","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1111\/j.1600-051X.1998.tb02419.x","volume":"25","author":"SS Socransky","year":"1998","unstructured":"Socransky SS, Haffajee AD, Cugini MA, Smith C, Kent RL Jr (1998) Microbial complexes in subgingival plaque. J Clin Periodontol 25(2):134\u2013144","journal-title":"J Clin Periodontol"},{"issue":"6","key":"2459_CR12","doi-asserted-by":"crossref","first-page":"Suppl:610","DOI":"10.1902\/jop.1967.38.6.610","volume":"38","author":"H L\u00f6e","year":"1967","unstructured":"L\u00f6e H (1967) The Gingival Index, the Plaque Index and the Retention Index Systems. J Periodontol 38(6):Suppl:610\u2013616","journal-title":"J Periodontol"},{"issue":"5","key":"2459_CR13","doi-asserted-by":"crossref","first-page":"462","DOI":"10.1177\/154405910508400512","volume":"84","author":"A Sharma","year":"2005","unstructured":"Sharma A, Inagaki S, Honma K, Sfintescu C, Baker PJ, Evans RT (2005) Tannerella forsythia-induced alveolar bone loss in mice involves leucine-rich-repeat BspA protein. J Dent Res 84(5):462\u2013467","journal-title":"J Dent Res"},{"issue":"11 Pt 2","key":"2459_CR14","doi-asserted-by":"crossref","first-page":"953","DOI":"10.1111\/j.1600-051X.1998.tb02397.x","volume":"25","author":"WJ Killoy","year":"1998","unstructured":"Killoy WJ (1998) The use of locally delivered chlorhexidine in the treatment of periodontitis. Clinical results. J Clin Periodontol 25(11 Pt 2):953\u2013958, discussion 978\u2013979","journal-title":"J Clin Periodontol"},{"issue":"12","key":"2459_CR15","doi-asserted-by":"crossref","first-page":"1017","DOI":"10.1111\/j.1600-051X.1998.tb02407.x","volume":"25","author":"WA Soskolne","year":"1998","unstructured":"Soskolne WA, Chajek T, Flashner M, Landau I, Stabholtz A, Kolatch B, Lerner EI (1998) An in vivo study of the chlorhexidine release profile of the PerioChip in the gingival crevicular fluid, plasma and urine. J Clin Periodontol 25(12):1017\u20131021","journal-title":"J Clin Periodontol"},{"issue":"9","key":"2459_CR16","doi-asserted-by":"crossref","first-page":"989","DOI":"10.1902\/jop.1998.69.9.989","volume":"69","author":"MK Jeffcoat","year":"1998","unstructured":"Jeffcoat MK, Bray KS, Ciancio SG, Dentino AR, Fine DH, Gordon JM, Gunsolley JC, Killoy WJ, Lowenguth RA, Magnusson NI, Offenbacher S, Palcanis KG, Proskin HM, Finkelman RD, Flashner M (1998) Adjunctive use of a subgingival controlled-release chlorhexidine chip reduces probing depth and improves attachment level compared with scaling and root planing alone. J Periodontol 69(9):989\u2013997","journal-title":"J Periodontol"},{"issue":"2","key":"2459_CR17","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1902\/jop.2008.070308","volume":"79","author":"M Paolantonio","year":"2008","unstructured":"Paolantonio M, D\u2019Angelo M, Grassi RF, Perinetti G, Piccolomini R, Pizzo G, Annunziata M, D\u2019Archivio D, D\u2019Ercole S, Nardi G, Guida L (2008) Clinical and microbiologic effects of subgingival controlled-release delivery of chlorhexidine chip in the treatment of periodontitis: a multicenter study. J Periodontol 79(2):271\u2013282","journal-title":"J Periodontol"},{"issue":"1","key":"2459_CR18","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1034\/j.1600-051x.2001.280114.x","volume":"28","author":"PA Heasman","year":"2001","unstructured":"Heasman PA, Heasman L, Stacey F, McCracken GI (2001) Local delivery of chlorhexidine gluconate (PerioChip) in periodontal maintenance patients. J Clin Periodontol 28(1):90\u201395","journal-title":"J Clin Periodontol"},{"issue":"10","key":"2459_CR19","doi-asserted-by":"crossref","first-page":"875","DOI":"10.1034\/j.1600-051X.2002.291001.x","volume":"29","author":"DC Grisi","year":"2002","unstructured":"Grisi DC, Salvador SL, Figueiredo LC, Souza SL, Novaes AB, Grisi MF (2002) Effect of a controlled-release chlorhexidine chip on clinical and microbiological parameters of periodontal syndrome. J Clin Periodontol 29(10):875\u2013881","journal-title":"J Clin Periodontol"},{"issue":"12","key":"2459_CR20","doi-asserted-by":"crossref","first-page":"783","DOI":"10.1902\/jop.1988.59.12.783","volume":"59","author":"WB Kaldahl","year":"1988","unstructured":"Kaldahl WB, Kalkwarf KL, Patil KD, Dyer JK, Bates RE Jr (1988) Evaluation of four modalities of periodontal therapy. Mean probing depth, probing attachment level and recession changes. J Periodontol 59(12):783\u2013793","journal-title":"J Periodontol"},{"issue":"6","key":"2459_CR21","doi-asserted-by":"crossref","first-page":"997","DOI":"10.1902\/jop.2007.060122","volume":"78","author":"J Carvalho","year":"2007","unstructured":"Carvalho J, Novak MJ, Mota LF (2007) Evaluation of the effect of subgingival placement of chlorhexidine chips as an adjunct to scaling and root planing. J Periodontol 78(6):997\u20131001","journal-title":"J Periodontol"},{"issue":"3","key":"2459_CR22","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1902\/jop.2006.050105","volume":"77","author":"T Mizrak","year":"2006","unstructured":"Mizrak T, G\u00fcnc\u00fc GN, Caglayan F, Balci TA, Aktar GS, Ipek F (2006) Effect of a controlled-release chlorhexidine chip on clinical and microbiological parameters and prostaglandin E2 levels in gingival crevicular fluid. J Periodontol 77(3):437\u2013443","journal-title":"J Periodontol"},{"issue":"6","key":"2459_CR23","doi-asserted-by":"crossref","first-page":"608","DOI":"10.1902\/jop.2002.73.6.608","volume":"73","author":"N Azmak","year":"2002","unstructured":"Azmak N, Atilla G, Luoto H, Sorsa T (2002) The effect of subgingival controlled-release delivery of chlorhexidine chip on clinical parameters and matrix metalloproteinase-8 levels in gingival crevicular fluid. J Periodontol 73(6):608\u2013615","journal-title":"J Periodontol"},{"issue":"8","key":"2459_CR24","doi-asserted-by":"crossref","first-page":"1131","DOI":"10.1902\/jop.2011.100287","volume":"82","author":"JR Gonzales","year":"2011","unstructured":"Gonzales JR, Harnack L, Schmitt-Corsitto G, Boedeker RH, Chakraborty T, Domann E, Meyle J (2011) A novel approach to the use of subgingival controlled-release chlorhexidine delivery in chronic periodontitis: a randomized clinical trial. J Periodontol 82(8):1131\u20131139","journal-title":"J Periodontol"},{"issue":"2","key":"2459_CR25","doi-asserted-by":"crossref","first-page":"268","DOI":"10.4103\/0976-9668.136134","volume":"5","author":"AJ Kumar","year":"2014","unstructured":"Kumar AJ, Ramesh Reddy BV, Chava VK (2014) Effect of chlorhexidine chip in the treatment of chronic periodontitis. J Nat Sci Biol Med 5(2):268\u2013272","journal-title":"J Nat Sci Biol Med"},{"issue":"5","key":"2459_CR26","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1034\/j.1600-0765.2002.01003.x","volume":"37","author":"N Daneshmand","year":"2002","unstructured":"Daneshmand N, Jorgensen MG, Nowzari H, Morrison JL, Slots J (2002) Initial effect of controlled release chlorhexidine on subgingival microorganisms. J Periodontal Res 37(5):375\u2013379","journal-title":"J Periodontal Res"},{"issue":"6","key":"2459_CR27","first-page":"ZC22","volume":"8","author":"S Medaiah","year":"2014","unstructured":"Medaiah S, Srinivas M, Melath A, Girish S, Polepalle T, Dasari AB (2014) Chlorhexidine chip in the treatment of chronic periodontitis\u2014a clinical study. J Clin Diagn Res 8(6):ZC22\u2013ZC25","journal-title":"J Clin Diagn Res"},{"issue":"1\u20133","key":"2459_CR28","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1111\/j.1574-6968.1992.tb05705.x","volume":"100","author":"T Kuyyakanond","year":"1992","unstructured":"Kuyyakanond T, Quesnel LB (1992) The mechanism of action of chlorhexidine. FEMS Microbiol Lett 100(1\u20133):211\u2013215","journal-title":"FEMS Microbiol Lett"},{"issue":"7","key":"2459_CR29","doi-asserted-by":"crossref","first-page":"3338","DOI":"10.1128\/AAC.00206-11","volume":"55","author":"A Corbin","year":"2011","unstructured":"Corbin A, Pitts B, Parker A, Stewart PS (2011) Antimicrobial penetration and efficacy in an in vitro oral biofilm model. Antimicrob Agents Chemother 55(7):3338\u20133344","journal-title":"Antimicrob Agents Chemother"},{"issue":"1","key":"2459_CR30","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1111\/j.1600-051X.1992.tb01146.x","volume":"19","author":"G Dahl\u00e9n","year":"1992","unstructured":"Dahl\u00e9n G, Manji F, Baelum V, Fejerskov O (1992) Putative periodontopathogens in \u201cdiseased\u201d and \u201cnon-diseased\u201d persons exhibiting poor oral hygiene. J Clin Periodontol 19(1):35\u201342","journal-title":"J Clin Periodontol"},{"issue":"11","key":"2459_CR31","doi-asserted-by":"crossref","first-page":"1023","DOI":"10.1034\/j.1600-051X.2002.291107.x","volume":"29","author":"AJ Winkelhoff van","year":"2002","unstructured":"van Winkelhoff AJ, Loos BG, van der Reijden WA, van der Velden U (2002) Porphyromonas gingivalis, Bacteroides forsythus and other putative periodontal pathogens in subjects with and without periodontal destruction. J Clin Periodontol 29(11):1023\u20131028","journal-title":"J Clin Periodontol"},{"issue":"9","key":"2459_CR32","doi-asserted-by":"crossref","first-page":"648","DOI":"10.1034\/j.1600-051x.2000.027009648.x","volume":"27","author":"LA Xim\u00e9nez-Fyvie","year":"2000","unstructured":"Xim\u00e9nez-Fyvie LA, Haffajee AD, Socransky SS (2000) Comparison of the microbiota of supra- and subgingival plaque in health and periodontitis. J Clin Periodontol 27(9):648\u2013657","journal-title":"J Clin Periodontol"},{"key":"2459_CR33","doi-asserted-by":"crossref","first-page":"476068","DOI":"10.1155\/2014\/476068","volume":"2014","author":"J Mysak","year":"2014","unstructured":"Mysak J, Podzimek S, Sommerova P, Lyuya-Mi Y, Bartova J, Janatova T, Prochazkova J, Duskova J (2014) Porphyromonas gingivalis: major periodontopathic pathogen overview. J Immunol Res 2014:476068","journal-title":"J Immunol Res"},{"issue":"3-4","key":"2459_CR34","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1515\/bchm.1997.378.3-4.223","volume":"378","author":"J Potempa","year":"1997","unstructured":"Potempa J, Pike R, Travis J (1997) Titration and mapping of the active site of cysteine proteinases from Porphyromonas gingivalis (gingipains) using peptidyl chloromethanes. Biol Chem 378(3-4):223\u2013230","journal-title":"Biol Chem"},{"issue":"8","key":"2459_CR35","doi-asserted-by":"crossref","first-page":"464","DOI":"10.1111\/j.1600-0765.1999.tb02282.x","volume":"34","author":"MA Curtis","year":"1999","unstructured":"Curtis MA, Kuramitsu HK, Lantz M, Macrina FL, Nakayama K, Potempa J, Reynolds EC, Aduse-Opoku J (1999) Molecular genetics and nomenclature of proteases of Porphyromonas gingivalis. J Periodontal Res 34(8):464\u2013472","journal-title":"J Periodontal Res"},{"issue":"3","key":"2459_CR36","doi-asserted-by":"crossref","first-page":"422","DOI":"10.1128\/JCM.28.3.422-425.1990","volume":"28","author":"BJ Moncla","year":"1990","unstructured":"Moncla BJ, Braham P, Hillier SL (1990) Sialidase (neuraminidase) activity among gram-negative anaerobic and capnophilic bacteria. J Clin Microbiol 28(3):422\u2013425","journal-title":"J Clin Microbiol"},{"issue":"10","key":"2459_CR37","doi-asserted-by":"crossref","first-page":"766","DOI":"10.1111\/j.1600-051X.1991.tb00070.x","volume":"18","author":"SS Socransky","year":"1991","unstructured":"Socransky SS, Haffajee AD, Smith C, Dibart S (1991) Relation of counts of microbial species to clinical status at the sampled site. J Clin Periodontol 18(10):766\u2013775","journal-title":"J Clin Periodontol"},{"issue":"3","key":"2459_CR38","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1128\/JCM.22.3.333-335.1985","volume":"22","author":"AC Tanner","year":"1985","unstructured":"Tanner AC, Strzempko MN, Belsky CA, McKinley GA (1985) API ZYM and API An-Ident reactions of fastidious oral gram-negative species. J Clin Microbiol 22(3):333\u2013335","journal-title":"J Clin Microbiol"}],"container-title":["European Journal of Clinical Microbiology &amp; Infectious Diseases"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s10096-015-2459-x.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s10096-015-2459-x\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s10096-015-2459-x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,9,6]],"date-time":"2020-09-06T06:01:55Z","timestamp":1599372115000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s10096-015-2459-x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,7,26]]},"references-count":38,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2015,10]]}},"alternative-id":["2459"],"URL":"https:\/\/doi.org\/10.1007\/s10096-015-2459-x","relation":{},"ISSN":["0934-9723","1435-4373"],"issn-type":[{"value":"0934-9723","type":"print"},{"value":"1435-4373","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,7,26]]}}}