{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T19:25:50Z","timestamp":1790364350842,"version":"4.1.0"},"reference-count":35,"publisher":"Springer Science and Business Media LLC","issue":"11","license":[{"start":{"date-parts":[[2015,8,30]],"date-time":"2015-08-30T00:00:00Z","timestamp":1440892800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Eur J Clin Microbiol Infect Dis"],"published-print":{"date-parts":[[2015,11]]},"DOI":"10.1007\/s10096-015-2474-y","type":"journal-article","created":{"date-parts":[[2015,8,29]],"date-time":"2015-08-29T05:21:17Z","timestamp":1440825677000},"page":"2235-2241","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":51,"title":["Aspergillus fumigatus chronic colonization and lung function decline in cystic fibrosis may have a two-way relationship"],"prefix":"10.1007","volume":"34","author":[{"given":"M.","family":"Noni","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Katelari","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G.","family":"Dimopoulos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.-E.","family":"Doudounakis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.","family":"Tzoumaka-Bakoula","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"V.","family":"Spoulou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2015,8,30]]},"reference":[{"key":"2474_CR1","doi-asserted-by":"crossref","first-page":"723129","DOI":"10.1155\/2013\/723129","volume":"2013","author":"SH Chotirmall","year":"2013","unstructured":"Chotirmall SH, Al-Alawi M, Mirkovic B, Lavelle G, Logan PM, Greene CM, McElvaney NG (2013) Aspergillus-associated airway disease, inflammation, and the innate immune response. Biomed Res Int 2013:723129. doi: 10.1155\/2013\/723129","journal-title":"Biomed Res Int"},{"issue":"4","key":"2474_CR2","doi-asserted-by":"crossref","first-page":"535","DOI":"10.1128\/CMR.00014-09","volume":"22","author":"SJ Park","year":"2009","unstructured":"Park SJ, Mehrad B (2009) Innate immunity to Aspergillus species. Clin Microbiol Rev 22(4):535\u2013551. doi: 10.1128\/cmr.00014-09","journal-title":"Clin Microbiol Rev"},{"key":"2474_CR3","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1016\/j.biocel.2014.03.001","volume":"52","author":"SH Chotirmall","year":"2014","unstructured":"Chotirmall SH, McElvaney NG (2014) Fungi in the cystic fibrosis lung: bystanders or pathogens? Int J Biochem Cell Biol 52:161\u2013173. doi: 10.1016\/j.biocel.2014.03.001","journal-title":"Int J Biochem Cell Biol"},{"issue":"6","key":"2474_CR4","doi-asserted-by":"crossref","first-page":"632","DOI":"10.1097\/MCP.0b013e328358d50b","volume":"18","author":"JJ Speirs","year":"2012","unstructured":"Speirs JJ, van der Ent CK, Beekman JM (2012) Effects of Aspergillus fumigatus colonization on lung function in cystic fibrosis. Curr Opin Pulm Med 18(6):632\u2013638. doi: 10.1097\/MCP.0b013e328358d50b","journal-title":"Curr Opin Pulm Med"},{"issue":"11","key":"2474_CR5","doi-asserted-by":"crossref","first-page":"835","DOI":"10.1016\/S0954-6111(99)90270-6","volume":"93","author":"J Bargon","year":"1999","unstructured":"Bargon J, Dauletbaev N, K\u00f6hler B, Wolf M, Posselt HG, Wagner TO (1999) Prophylactic antibiotic therapy is associated with an increased prevalence of Aspergillus colonization in adult cystic fibrosis patients. Respir Med 93(11):835\u2013838","journal-title":"Respir Med"},{"issue":"5","key":"2474_CR6","doi-asserted-by":"crossref","first-page":"1190","DOI":"10.1086\/314727","volume":"179","author":"JL Burns","year":"1999","unstructured":"Burns JL, Van Dalfsen JM, Shawar RM, Otto KL, Garber RL, Quan JM, Montgomery AB, Albers GM, Ramsey BW, Smith AL (1999) Effect of chronic intermittent administration of inhaled tobramycin on respiratory microbial flora in patients with cystic fibrosis. J Infect Dis 179(5):1190\u20131196. doi: 10.1086\/314727","journal-title":"J Infect Dis"},{"issue":"2","key":"2474_CR7","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1016\/j.jcf.2009.11.010","volume":"9","author":"CR Sudfeld","year":"2010","unstructured":"Sudfeld CR, Dasenbrook EC, Merz WG, Carroll KC, Boyle MP (2010) Prevalence and risk factors for recovery of filamentous fungi in individuals with cystic fibrosis. J Cyst Fibros 9(2):110\u2013116. doi: 10.1016\/j.jcf.2009.11.010","journal-title":"J Cyst Fibros"},{"issue":"7","key":"2474_CR8","doi-asserted-by":"crossref","first-page":"715","DOI":"10.1093\/mmy\/myu038","volume":"52","author":"M Noni","year":"2014","unstructured":"Noni M, Katelari A, Dimopoulos G, Kourlaba G, Spoulou V, Alexandrou-Athanassoulis H, Doudounakis SE, Tzoumaka-Bakoula C (2014) Inhaled corticosteroids and Aspergillus fumigatus isolation in cystic fibrosis. Med Mycol 52(7):715\u2013722. doi: 10.1093\/mmy\/myu038","journal-title":"Med Mycol"},{"issue":"6","key":"2474_CR9","doi-asserted-by":"crossref","first-page":"598","DOI":"10.1097\/MCP.0b013e32833e24a6","volume":"16","author":"RB Moss","year":"2010","unstructured":"Moss RB (2010) Allergic bronchopulmonary aspergillosis and Aspergillus infection in cystic fibrosis. Curr Opin Pulm Med 16(6):598\u2013603. doi: 10.1097\/MCP.0b013e32833e24a6","journal-title":"Curr Opin Pulm Med"},{"issue":"3","key":"2474_CR10","doi-asserted-by":"crossref","first-page":"560","DOI":"10.1016\/j.jaci.2013.04.007","volume":"132","author":"CG Baxter","year":"2013","unstructured":"Baxter CG, Dunn G, Jones AM, Webb K, Gore R, Richardson MD, Denning DW (2013) Novel immunologic classification of aspergillosis in adult cystic fibrosis. J Allergy Clin Immunol 132(3):560\u2013566.e510. doi: 10.1016\/j.jaci.2013.04.007","journal-title":"J Allergy Clin Immunol"},{"issue":"7","key":"2474_CR11","doi-asserted-by":"crossref","first-page":"887","DOI":"10.1016\/j.rmed.2004.11.018","volume":"99","author":"M Skov","year":"2005","unstructured":"Skov M, McKay K, Koch C, Cooper PJ (2005) Prevalence of allergic bronchopulmonary aspergillosis in cystic fibrosis in an area with a high frequency of atopy. Respir Med 99(7):887\u2013893. doi: 10.1016\/j.rmed.2004.11.018","journal-title":"Respir Med"},{"issue":"4","key":"2474_CR12","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1080\/13693780802609604","volume":"47","author":"M Pihet","year":"2009","unstructured":"Pihet M, Carrere J, Cimon B, Chabasse D, Delhaes L, Symoens F, Bouchara JP (2009) Occurrence and relevance of filamentous fungi in respiratory secretions of patients with cystic fibrosis\u2014a review. Med Mycol 47(4):387\u2013397. doi: 10.1080\/13693780802609604","journal-title":"Med Mycol"},{"issue":"1","key":"2474_CR13","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1378\/chest.09-1103","volume":"137","author":"R Amin","year":"2010","unstructured":"Amin R, Dupuis A, Aaron SD, Ratjen F (2010) The effect of chronic infection with Aspergillus fumigatus on lung function and hospitalization in patients with cystic fibrosis. Chest 137(1):171\u2013176. doi: 10.1378\/chest.09-1103","journal-title":"Chest"},{"issue":"8","key":"2474_CR14","doi-asserted-by":"crossref","first-page":"764","DOI":"10.1002\/ppul.21240","volume":"45","author":"V Jubin","year":"2010","unstructured":"Jubin V, Ranque S, Stremler Le Bel N, Sarles J, Dubus JC (2010) Risk factors for Aspergillus colonization and allergic bronchopulmonary aspergillosis in children with cystic fibrosis. Pediatr Pulmonol 45(8):764\u2013771. doi: 10.1002\/ppul.21240","journal-title":"Pediatr Pulmonol"},{"issue":"1","key":"2474_CR15","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1016\/S1569-1993(02)00141-8","volume":"2","author":"TW Lee","year":"2003","unstructured":"Lee TW, Brownlee KG, Conway SP, Denton M, Littlewood JM (2003) Evaluation of a new definition for chronic Pseudomonas aeruginosa infection in cystic fibrosis patients. J Cyst Fibros 2(1):29\u201334. doi: 10.1016\/s1569-1993(02)00141-8","journal-title":"J Cyst Fibros"},{"issue":"11","key":"2474_CR16","doi-asserted-by":"crossref","first-page":"842","DOI":"10.3109\/00365548.2012.695454","volume":"44","author":"J Fillaux","year":"2012","unstructured":"Fillaux J, Br\u00e9mont F, Murris M, Cassaing S, Ritti\u00e9 JL, T\u00e9tu L, Segonds C, Abbal M, Bieth E, Berry A, Pipy B, Magnaval JF (2012) Assessment of Aspergillus sensitization or persistent carriage as a factor in lung function impairment in cystic fibrosis patients. Scand J Infect Dis 44(11):842\u2013847. doi: 10.3109\/00365548.2012.695454","journal-title":"Scand J Infect Dis"},{"issue":"9","key":"2474_CR17","doi-asserted-by":"crossref","first-page":"1381","DOI":"10.1111\/j.1469-0691.2010.03429.x","volume":"17","author":"AM Vrankrijker de","year":"2011","unstructured":"de Vrankrijker AM, van der Ent CK, van Berkhout FT, Stellato RK, Willems RJ, Bonten MJ, Wolfs TF (2011) Aspergillus fumigatus colonization in cystic fibrosis: implications for lung function? Clin Microbiol Infect 17(9):1381\u20131386. doi: 10.1111\/j.1469-0691.2010.03429.x","journal-title":"Clin Microbiol Infect"},{"issue":"1","key":"2474_CR18","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1002\/(SICI)1099-0496(199601)21:1<6::AID-PPUL1>3.0.CO;2-R","volume":"21","author":"CE Milla","year":"1996","unstructured":"Milla CE, Wielinski CL, Regelmann WE (1996) Clinical significance of the recovery of Aspergillus species from the respiratory secretions of cystic fibrosis patients. Pediatr Pulmonol 21(1):6\u201310. doi: 10.1002\/(sici)1099-0496(199601)21:1<6::aid-ppul1>3.0.co;2-r","journal-title":"Pediatr Pulmonol"},{"issue":"3","key":"2474_CR19","doi-asserted-by":"crossref","first-page":"e197","DOI":"10.1016\/j.ejrad.2011.01.114","volume":"81","author":"MA McMahon","year":"2012","unstructured":"McMahon MA, Chotirmall SH, McCullagh B, Branagan P, McElvaney NG, Logan PM (2012) Radiological abnormalities associated with Aspergillus colonization in a cystic fibrosis population. Eur J Radiol 81(3):e197\u2013e202. doi: 10.1016\/j.ejrad.2011.01.114","journal-title":"Eur J Radiol"},{"issue":"1","key":"2474_CR20","doi-asserted-by":"crossref","first-page":"300","DOI":"10.1086\/517272","volume":"176","author":"JF Tomee","year":"1997","unstructured":"Tomee JF, Wierenga AT, Hiemstra PS, Kauffman HK (1997) Proteases from Aspergillus fumigatus induce release of proinflammatory cytokines and cell detachment in airway epithelial cell lines. J Infect Dis 176(1):300\u2013303","journal-title":"J Infect Dis"},{"issue":"9","key":"2474_CR21","doi-asserted-by":"crossref","first-page":"3266","DOI":"10.1128\/IAI.63.9.3266-3271.1995","volume":"63","author":"R Amitani","year":"1995","unstructured":"Amitani R, Taylor G, Elezis EN, Llewellyn-Jones C, Mitchell J, Kuze F, Cole PJ, Wilson R (1995) Purification and characterization of factors produced by Aspergillus fumigatus which affect human ciliated respiratory epithelium. Infect Immun 63(9):3266\u20133271","journal-title":"Infect Immun"},{"issue":"1","key":"2474_CR22","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1378\/chest.105.1.32","volume":"105","author":"S Mroueh","year":"1994","unstructured":"Mroueh S, Spock A (1994) Allergic bronchopulmonary aspergillosis in patients with cystic fibrosis. Chest 105(1):32\u201336","journal-title":"Chest"},{"issue":"1\u20132","key":"2474_CR23","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1046\/j.1439-0507.2003.00830.x","volume":"46","author":"N Bakare","year":"2003","unstructured":"Bakare N, Rickerts V, Bargon J, Just-N\u00fcbling G (2003) Prevalence of Aspergillus fumigatus and other fungal species in the sputum of adult patients with cystic fibrosis. Mycoses 46(1\u20132):19\u201323. doi: 10.1046\/j.1439-0507.2003.00830.x","journal-title":"Mycoses"},{"issue":"7","key":"2474_CR24","doi-asserted-by":"crossref","first-page":"680","DOI":"10.1097\/INF.0000000000000231","volume":"33","author":"J Fillaux","year":"2014","unstructured":"Fillaux J, Br\u00e9mont F, Murris M, Cassaing S, T\u00e9tu L, Segonds C, Pipy B, Magnaval JF (2014) Aspergillus sensitization or carriage in cystic fibrosis patients. Pediatr Infect Dis J 33(7):680\u2013686. doi: 10.1097\/inf.0000000000000231","journal-title":"Pediatr Infect Dis J"},{"issue":"Suppl 1","key":"2474_CR25","doi-asserted-by":"crossref","first-page":"S125","DOI":"10.3109\/13693786.2010.521522","volume":"48","author":"LW Leclair","year":"2010","unstructured":"Leclair LW, Hogan DA (2010) Mixed bacterial-fungal infections in the CF respiratory tract. Med Mycol 48(Suppl 1):S125\u2013S132. doi: 10.3109\/13693786.2010.521522","journal-title":"Med Mycol"},{"issue":"Suppl 1","key":"2474_CR26","doi-asserted-by":"crossref","first-page":"S32","DOI":"10.3109\/13693786.2010.503665","volume":"48","author":"A Paugam","year":"2010","unstructured":"Paugam A, Baixench M-T, Demazes-Dufeu N, Burgel P-R, Sauter E, Kanaan R, Dusser D, Dupouy-Camet J, Hubert D (2010) Characteristics and consequences of airway colonization by filamentous fungi in 201 adult patients with cystic fibrosis in France. Med Mycol 48(Suppl 1):S32\u2013S36. doi: 10.3109\/13693786.2010.503665","journal-title":"Med Mycol"},{"issue":"3","key":"2474_CR27","doi-asserted-by":"crossref","first-page":"658","DOI":"10.1183\/09031936.02.00248102","volume":"20","author":"ME Hodson","year":"2002","unstructured":"Hodson ME, Gallagher CG, Govan JR (2002) A randomised clinical trial of nebulised tobramycin or colistin in cystic fibrosis. Eur Respir J 20(3):658\u2013664","journal-title":"Eur Respir J"},{"issue":"6","key":"2474_CR28","doi-asserted-by":"crossref","first-page":"658","DOI":"10.3109\/13693786.2012.676739","volume":"50","author":"TA Warren","year":"2012","unstructured":"Warren TA, Yau Y, Ratjen F, Tullis E, Waters V (2012) Serum galactomannan in cystic fibrosis patients colonized with Aspergillus species. Med Mycol 50(6):658\u2013660. doi: 10.3109\/13693786.2012.676739","journal-title":"Med Mycol"},{"issue":"2","key":"2474_CR29","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1016\/j.jcf.2008.10.003","volume":"8","author":"HA Valk de","year":"2009","unstructured":"de Valk HA, Klaassen CH, Yntema JB, Hebestreit A, Seidler M, Haase G, M\u00fcller FM, Meis JF (2009) Molecular typing and colonization patterns of Aspergillus fumigatus in patients with cystic fibrosis. J Cyst Fibros 8(2):110\u2013114. doi: 10.1016\/j.jcf.2008.10.003","journal-title":"J Cyst Fibros"},{"issue":"4","key":"2474_CR30","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1099\/0022-1317-50-4-367","volume":"50","author":"B Cimon","year":"2001","unstructured":"Cimon B, Symoens F, Zouhair R, Chabasse D, Nolard N, Defontaine A, Bouchara JP (2001) Molecular epidemiology of airway colonisation by Aspergillus fumigatus in cystic fibrosis patients. J Med Microbiol 50(4):367\u2013374","journal-title":"J Med Microbiol"},{"issue":"10","key":"2474_CR31","doi-asserted-by":"crossref","first-page":"747","DOI":"10.1007\/BF01709257","volume":"16","author":"C Neuv\u00e9glise","year":"1997","unstructured":"Neuv\u00e9glise C, Sarfati J, Debeaupuis JP, Vu Thien H, Just J, Tournier G, Latg\u00e9 JP (1997) Longitudinal study of Aspergillus fumigatus strains isolated from cystic fibrosis patients. Eur J Clin Microbiol Infect Dis 16(10):747\u2013750","journal-title":"Eur J Clin Microbiol Infect Dis"},{"issue":"10","key":"2474_CR32","doi-asserted-by":"crossref","first-page":"2595","DOI":"10.1128\/JCM.34.10.2595-2597.1996","volume":"34","author":"PE Verweij","year":"1996","unstructured":"Verweij PE, Meis JF, Sarfati J, Hoogkamp-Korstanje JA, Latg\u00e9 JP, Melchers WJ (1996) Genotypic characterization of sequential Aspergillus fumigatus isolates from patients with cystic fibrosis. J Clin Microbiol 34(10):2595\u20132597","journal-title":"J Clin Microbiol"},{"issue":"2","key":"2474_CR33","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1136\/adc.70.2.139","volume":"70","author":"EJ Simmonds","year":"1994","unstructured":"Simmonds EJ, Littlewood JM, Hopwood V, Evans EG (1994) Aspergillus fumigatus colonisation and population density of place of residence in cystic fibrosis. Arch Dis Child 70(2):139\u2013140","journal-title":"Arch Dis Child"},{"issue":"3","key":"2474_CR34","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1016\/j.fbr.2011.07.002","volume":"25","author":"CM O\u2019Gorman","year":"2011","unstructured":"O\u2019Gorman CM (2011) Airborne Aspergillus fumigatus conidia: a risk factor for aspergillosis. Fungal Biol Rev 25(3):151\u2013157. doi: 10.1016\/j.fbr.2011.07.002","journal-title":"Fungal Biol Rev"},{"issue":"1","key":"2474_CR35","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1097\/MRM.0b013e3282e1c70a","volume":"18","author":"Y Nagano","year":"2007","unstructured":"Nagano Y, Millar BC, Johnson E, Goldsmith CE, Elborn JS, Rendall J, Moore JE (2007) Fungal infections in patients with cystic fibrosis. Rev Med Microbiol 18(1):11\u201316. doi: 10.1097\/MRM.0b013e3282e1c70a","journal-title":"Rev Med Microbiol"}],"container-title":["European Journal of Clinical Microbiology &amp; Infectious Diseases"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s10096-015-2474-y.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s10096-015-2474-y\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s10096-015-2474-y","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,9,7]],"date-time":"2020-09-07T19:15:01Z","timestamp":1599506101000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s10096-015-2474-y"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,8,30]]},"references-count":35,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2015,11]]}},"alternative-id":["2474"],"URL":"https:\/\/doi.org\/10.1007\/s10096-015-2474-y","relation":{},"ISSN":["0934-9723","1435-4373"],"issn-type":[{"value":"0934-9723","type":"print"},{"value":"1435-4373","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,8,30]]}}}