{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,24]],"date-time":"2026-07-24T20:44:23Z","timestamp":1784925863009,"version":"3.55.0"},"reference-count":40,"publisher":"Springer Science and Business Media LLC","issue":"5","license":[{"start":{"date-parts":[[2016,3,4]],"date-time":"2016-03-04T00:00:00Z","timestamp":1457049600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Eur J Clin Microbiol Infect Dis"],"published-print":{"date-parts":[[2016,5]]},"DOI":"10.1007\/s10096-016-2608-x","type":"journal-article","created":{"date-parts":[[2016,3,4]],"date-time":"2016-03-04T12:07:13Z","timestamp":1457093233000},"page":"857-866","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":18,"title":["MALDI-TOF MS performance compared to direct examination, culture, and 16S rDNA PCR for the rapid diagnosis of bone and joint infections"],"prefix":"10.1007","volume":"35","author":[{"given":"E.","family":"Lallemand","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G.","family":"Coiffier","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.","family":"Arvieux","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E.","family":"Brillet","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P.","family":"Guggenbuhl","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Jolivet-Gougeon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2016,3,4]]},"reference":[{"key":"2608_CR1","doi-asserted-by":"crossref","first-page":"1210","DOI":"10.1111\/j.1532-5415.2005.53373.x","volume":"53","author":"F Gavet","year":"2005","unstructured":"Gavet F, Tournadre A, Soubrier M, Ristori JM, Dubost JJ (2005) Septic arthritis in patients aged 80 and older: a comparison with younger adults. J Am Geriatr Soc 53:1210\u20131213","journal-title":"J Am Geriatr Soc"},{"key":"2608_CR2","volume-title":"Principles and practice of infectious diseases","author":"GL Mandell","year":"2010","unstructured":"Mandell GL, Bennett JE, Dolin R (2010) Principles and practice of infectious diseases. Churchill Livingstone\/Elsevier, Philadelphia. https:\/\/books.google.fr\/books?id=ovVLAQAAIAAJ"},{"key":"2608_CR3","doi-asserted-by":"crossref","first-page":"214","DOI":"10.1136\/ard.58.4.214","volume":"58","author":"VC Weston","year":"1999","unstructured":"Weston VC, Jones AC, Bradbury N, Fawthrop F, Doherty M (1999) Clinical features and outcome of septic arthritis in a single UK Health District 1982\u20131991. Ann Rheum Dis 58:214\u2013219","journal-title":"Ann Rheum Dis"},{"key":"2608_CR4","doi-asserted-by":"crossref","first-page":"745","DOI":"10.1016\/j.medmal.2009.05.003","volume":"39","author":"Soci\u00e9t\u00e9 de Pathologie Infectieuse de Langue Fran\u00e7aise (SPILF)","year":"2009","unstructured":"Soci\u00e9t\u00e9 de Pathologie Infectieuse de Langue Fran\u00e7aise (SPILF); Coll\u00e8ge des Universitaires de Maladies Infectieuses et Tropicales (CMIT); Groupe de Pathologie Infectieuse P\u00e9diatrique (GPIP); Soci\u00e9t\u00e9 Fran\u00e7aise d\u2019Anesth\u00e9sie et de R\u00e9animation (SFAR); Soci\u00e9t\u00e9 Fran\u00e7aise de Chirurgie Orthop\u00e9dique et Traumatologique (SOFCOT); Soci\u00e9t\u00e9 Fran\u00e7aise d\u2019Hygi\u00e8ne Hospitali\u00e8re (SFHH) et al (2009) Recommendations for clinical practice. Osteo-articular infection therapy according to materials used (prosthesis, implants, osteosynthesis). M\u00e9d Mal Infect 39:745\u2013774","journal-title":"M\u00e9d. Mal Infect"},{"key":"2608_CR5","doi-asserted-by":"crossref","first-page":"e1","DOI":"10.1093\/cid\/cis803","volume":"56","author":"DR Osmon","year":"2013","unstructured":"Osmon DR, Berbari EF, Berendt AR, Lew D, Zimmerli W, Steckelberg JM et al (2013) Diagnosis and management of prosthetic joint infection: clinical practice guidelines by the Infectious Diseases Society of America. Clin Infect Dis 56:e1\u2013e25. doi: 10.1093\/cid\/cis803","journal-title":"Clin Infect Dis"},{"key":"2608_CR6","unstructured":"Soci\u00e9t\u00e9 Fran\u00e7aise de Microbiologie (SFM) (2010) R\u00e9mic 2010: r\u00e9f\u00e9rentiel en microbiologie m\u00e9dicale (bact\u00e9riologie et mycologie), 4\u00e8me ed. SFM, Paris"},{"key":"2608_CR7","unstructured":"Denis F, Bingen E, Martin C, Ploy M-C, Quentin R (2011) Bact\u00e9riologie m\u00e9dicale. Techniques usuelles. Elsevier Masson, Paris"},{"issue":"11","key":"2608_CR8","doi-asserted-by":"crossref","first-page":"1403","DOI":"10.1086\/592973","volume":"47","author":"P Sch\u00e4fer","year":"2008","unstructured":"Sch\u00e4fer P, Fink B, Sandow D, Margull A, Berger I, Frommelt L (2008) Prolonged bacterial culture to identify late periprosthetic joint infection: a promising strategy. Clin Infect Dis 47(11):1403\u20131409","journal-title":"Clin Infect Dis"},{"key":"2608_CR9","doi-asserted-by":"crossref","first-page":"447","DOI":"10.1111\/j.1469-0691.2010.03359.x","volume":"17","author":"AL Roux","year":"2011","unstructured":"Roux AL, Sivadon-Tardy V, Bauer T, Lortat-Jacob A, Herrmann JL, Gaillard JL et al (2011) Diagnosis of prosthetic joint infection by beadmill processing of a periprosthetic specimen. Clin Microbiol Infect 17:447\u2013450","journal-title":"Clin Microbiol Infect"},{"issue":"7","key":"2608_CR10","doi-asserted-by":"crossref","first-page":"654","DOI":"10.1056\/NEJMoa061588","volume":"357","author":"A Trampuz","year":"2007","unstructured":"Trampuz A, Piper KE, Jacobson MJ, Hanssen AD, Unni KK, Osmon DR et al (2007) Sonication of removed hip and knee prostheses for diagnosis of infection. N Engl J Med 357(7):654\u2013663","journal-title":"N Engl J Med"},{"key":"2608_CR11","doi-asserted-by":"crossref","first-page":"3501","DOI":"10.1128\/JCM.00834-12","volume":"50","author":"E Gomez","year":"2012","unstructured":"Gomez E, Cazanave C, Cunningham SA, Greenwood-Quaintance KE, Steckelberg JM, Uhl JR et al (2012) Prosthetic joint infection diagnosis using broad-range PCR of biofilms dislodged from knee and hip arthroplasty surfaces using sonication. J Clin Microbiol 50:3501\u20133508","journal-title":"J Clin Microbiol"},{"key":"2608_CR12","doi-asserted-by":"crossref","first-page":"1401","DOI":"10.1099\/jmm.0.013334-0","volume":"58","author":"GB Rogers","year":"2009","unstructured":"Rogers GB, Carroll MP, Bruce KD (2009) Studying bacterial infections through culture-independent approaches. J Med Microbiol 58:1401\u20131418","journal-title":"J Med Microbiol"},{"key":"2608_CR13","first-page":"289","volume":"55","author":"U Eigner","year":"2009","unstructured":"Eigner U, Holfelder M, Oberdorfer K, Betz-Wild U, Bertsch D, Fahr A-M (2009) Performance of a matrix-assisted laser desorption ionization-time-of-flight mass spectrometry system for the identification of bacterial isolates in the clinical routine laboratory. Clin Lab 55:289\u2013296","journal-title":"Clin Lab"},{"key":"2608_CR14","doi-asserted-by":"crossref","first-page":"693","DOI":"10.1128\/JCM.01463-10","volume":"49","author":"A Bizzini","year":"2011","unstructured":"Bizzini A, Jaton K, Romo D, Bille J, Prod\u2019hom G, Greub G (2011) Matrix-assisted laser desorption ionization-time of flight mass spectrometry as an alternative to 16S rRNA gene sequencing for identification of difficult-to-identify bacterial strains. J Clin Microbiol 49:693\u2013696","journal-title":"J Clin Microbiol"},{"key":"2608_CR15","doi-asserted-by":"crossref","first-page":"1007","DOI":"10.1111\/j.1469-0691.2010.03339.x","volume":"17","author":"L Ferreira","year":"2011","unstructured":"Ferreira L, S\u00e1nchez-Juanes F, Mu\u00f1oz-Bellido JL, Gonz\u00e1lez-Buitrago JM (2011) Rapid method for direct identification of bacteria in urine and blood culture samples by matrix-assisted laser desorption ionization time-of-flight mass spectrometry: intact cell vs. extraction method. Clin Microbiol Infect 17:1007\u20131012","journal-title":"Clin Microbiol Infect"},{"key":"2608_CR16","doi-asserted-by":"crossref","first-page":"2110","DOI":"10.1128\/JCM.02215-09","volume":"48","author":"L Ferreira","year":"2010","unstructured":"Ferreira L, S\u00e1nchez-Juanes F, Gonz\u00e1lez-Avila M, Cembrero-Fuci\u00f1os D, Herrero-Hern\u00e1ndez A, Gonz\u00e1lez-Buitrago JM et al (2010) Direct identification of urinary tract pathogens from urine samples by matrix-assisted laser desorption ionization-time of flight mass spectrometry. J Clin Microbiol 48:2110\u20132115","journal-title":"J Clin Microbiol"},{"key":"2608_CR17","doi-asserted-by":"crossref","first-page":"1834","DOI":"10.1128\/JCM.02654-12","volume":"51","author":"B Schulthess","year":"2013","unstructured":"Schulthess B, Brodner K, Bloemberg GV, Zbinden R, B\u00f6ttger EC, Hombach M (2013) Identification of Gram-positive cocci by use of matrix-assisted laser desorption ionization-time of flight mass spectrometry: comparison of different preparation methods and implementation of a practical algorithm for routine diagnostics. J Clin Microbiol 51:1834\u20131840","journal-title":"J Clin Microbiol"},{"key":"2608_CR18","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0008041","volume":"4","author":"B Scola La","year":"2009","unstructured":"La Scola B, Raoult D (2009) Direct identification of bacteria in positive blood culture bottles by matrix-assisted laser desorption ionisation time-of-flight mass spectrometry. PLoS One 4, e8041","journal-title":"PLoS One"},{"key":"2608_CR19","doi-asserted-by":"crossref","first-page":"1631","DOI":"10.1111\/j.1469-0691.2010.03356.x","volume":"16","author":"W Moussaoui","year":"2010","unstructured":"Moussaoui W, Jaulhac B, Hoffmann A-M, Ludes B, Kostrzewa M, Riegel P et al (2010) Matrix-assisted laser desorption ionization time-of-flight mass spectrometry identifies 90% of bacteria directly from blood culture vials. Clin Microbiol Infect 16:1631\u20131638","journal-title":"Clin Microbiol Infect"},{"key":"2608_CR20","doi-asserted-by":"crossref","first-page":"871","DOI":"10.1111\/apm.12050","volume":"121","author":"B Nonnemann","year":"2013","unstructured":"Nonnemann B, Tvede M, Bjarnsholt T (2013) Identification of pathogenic microorganisms directly from positive blood vials by matrix-assisted laser desorption\/ionization time of flight mass spectrometry. APMIS Acta Pathol Microbiol Immunol Scand 121:871\u2013877","journal-title":"APMIS Acta Pathol Microbiol Immunol Scand"},{"key":"2608_CR21","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1128\/JCM.38.1.32-39.2000","volume":"38","author":"K Rantakokko-Jalava","year":"2000","unstructured":"Rantakokko-Jalava K, Nikkari S, Jalava J, Eerola E, Skurnik M, Meurman O et al (2000) Direct amplification of rRNA genes in diagnosis of bacterial infections. J Clin Microbiol 38:32\u201339","journal-title":"J Clin Microbiol"},{"key":"2608_CR22","doi-asserted-by":"crossref","first-page":"1946","DOI":"10.1128\/JCM.00157-08","volume":"46","author":"A Mellmann","year":"2008","unstructured":"Mellmann A, Cloud J, Maier T, Keckevoet U, Ramminger I, Iwen P et al (2008) Evaluation of matrix-assisted laser desorption ionization-time-of-flight mass spectrometry in comparison to 16S rRNA gene sequencing for species identification of nonfermenting bacteria. J Clin Microbiol 46:1946\u20131954","journal-title":"J Clin Microbiol"},{"key":"2608_CR23","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1016\/j.mimet.2012.03.003","volume":"89","author":"E Carbonnelle","year":"2012","unstructured":"Carbonnelle E, Grohs P, Jacquier H, Day N, Tenza S, Dewailly A et al (2012) Robustness of two MALDI-TOF mass spectrometry systems for bacterial identification. J Microbiol Methods 89:133\u2013136","journal-title":"J Microbiol Methods"},{"key":"2608_CR24","doi-asserted-by":"crossref","first-page":"380","DOI":"10.1111\/j.1574-6976.2011.00298.x","volume":"36","author":"A Croxatto","year":"2012","unstructured":"Croxatto A, Prod\u2019hom G, Greub G (2012) Applications of MALDI-TOF mass spectrometry in clinical diagnostic microbiology. FEMS Microbiol Rev 36:380\u2013407","journal-title":"FEMS Microbiol Rev"},{"key":"2608_CR25","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1016\/j.mimet.2012.10.014","volume":"92","author":"S Biswas","year":"2013","unstructured":"Biswas S, Rolain J-M (2013) Use of MALDI-TOF mass spectrometry for identification of bacteria that are difficult to culture. J Microbiol Methods 92:14\u201324","journal-title":"J Microbiol Methods"},{"key":"2608_CR26","doi-asserted-by":"crossref","first-page":"900","DOI":"10.1128\/JCM.02071-09","volume":"48","author":"SQ Veen van","year":"2010","unstructured":"van Veen SQ, Claas ECJ, Kuijper EJ (2010) High-throughput identification of bacteria and yeast by matrix-assisted laser desorption ionization-time of flight mass spectrometry in conventional medical microbiology laboratories. J Clin Microbiol 48:900\u2013907","journal-title":"J Clin Microbiol"},{"key":"2608_CR27","first-page":"267","volume":"66","author":"D Steensels","year":"2011","unstructured":"Steensels D, Verhaegen J, Lagrou K (2011) Matrix-assisted laser desorption ionization-time of flight mass spectrometry for the identification of bacteria and yeasts in a clinical microbiological laboratory: a review. Acta Clin Belg 66:267\u2013273","journal-title":"Acta Clin Belg"},{"key":"2608_CR28","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1099\/jmm.0.032284-0","volume":"61","author":"HL K\u00f6hling","year":"2012","unstructured":"K\u00f6hling HL, Bittner A, M\u00fcller K-D, Buer J, Becker M, R\u00fcbben H et al (2012) Direct identification of bacteria in urine samples by matrix-assisted laser desorption\/ionization time-of-flight mass spectrometry and relevance of defensins as interfering factors. J Med Microbiol 61:339\u2013344","journal-title":"J Med Microbiol"},{"key":"2608_CR29","doi-asserted-by":"crossref","first-page":"1584","DOI":"10.1128\/JCM.01831-09","volume":"48","author":"M Christner","year":"2010","unstructured":"Christner M, Rohde H, Wolters M, Sobottka I, Wegscheider K, Aepfelbacher M (2010) Rapid identification of bacteria from positive blood culture bottles by use of matrix-assisted laser desorption-ionization time of flight mass spectrometry fingerprinting. J Clin Microbiol 48:1584\u20131591","journal-title":"J Clin Microbiol"},{"key":"2608_CR30","first-page":"388","volume":"68","author":"AA Faraj","year":"2002","unstructured":"Faraj AA, Omonbude OD, Godwin P (2002) Gram staining in the diagnosis of acute septic arthritis. Acta Orthop Belg 68:388\u2013391","journal-title":"Acta Orthop Belg"},{"key":"2608_CR31","doi-asserted-by":"crossref","first-page":"2205","DOI":"10.1128\/JCM.36.8.2205-2209.1998","volume":"36","author":"P Kotilainen","year":"1998","unstructured":"Kotilainen P, Jalava J, Meurman O, Lehtonen OP, Rintala E, Sepp\u00e4l\u00e4 OP et al (1998) Diagnosis of meningococcal meningitis by broad-range bacterial PCR with cerebrospinal fluid. J Clin Microbiol 36:2205\u20132209","journal-title":"J Clin Microbiol"},{"key":"2608_CR32","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1097\/MD.0b013e31811f44ec","volume":"86","author":"M Mar\u00edn","year":"2007","unstructured":"Mar\u00edn M, Mu\u00f1oz P, S\u00e1nchez M, del Rosal M, Alcal\u00e1 L, Rodr\u00edguez-Cr\u00e9ixems M et al (2007) Molecular diagnosis of infective endocarditis by real-time broad-range polymerase chain reaction (PCR) and sequencing directly from heart valve tissue. Medicine (Baltimore) 86:195\u2013202","journal-title":"Medicine (Baltimore)"},{"key":"2608_CR33","doi-asserted-by":"crossref","first-page":"1905","DOI":"10.1128\/JCM.33.7.1905-1908.1995","volume":"33","author":"JA Smith","year":"1995","unstructured":"Smith JA, Bryce EA, Ngui-Yen JH, Roberts FJ (1995) Comparison of BACTEC 9240 and BacT\/Alert blood culture systems in an adult hospital. J Clin Microbiol 33:1905\u20131908","journal-title":"J Clin Microbiol"},{"key":"2608_CR34","doi-asserted-by":"crossref","first-page":"816","DOI":"10.1128\/JCM.02064-06","volume":"45","author":"D Flayhart","year":"2007","unstructured":"Flayhart D, Borek AP, Wakefield T, Dick J, Carroll KC (2007) Comparison of BACTEC PLUS blood culture media to BacT\/Alert FA blood culture media for detection of bacterial pathogens in samples containing therapeutic levels of antibiotics. J Clin Microbiol 45:816\u2013821","journal-title":"J Clin Microbiol"},{"key":"2608_CR35","doi-asserted-by":"crossref","first-page":"669","DOI":"10.1007\/BF01708557","volume":"16","author":"H Leli\u00e8vre","year":"1997","unstructured":"Leli\u00e8vre H, Gimenez M, Vandenesch F, Reinhardt A, Lenhardt D, Just HM et al (1997) Multicenter clinical comparison of resin-containing bottles with standard aerobic and anaerobic bottles for culture of microorganisms from blood. Eur J Clin Microbiol Infect Dis 16:669\u2013674","journal-title":"Eur J Clin Microbiol Infect Dis"},{"key":"2608_CR36","doi-asserted-by":"crossref","first-page":"1601","DOI":"10.1128\/JCM.36.6.1601-1603.1998","volume":"36","author":"PR Murray","year":"1998","unstructured":"Murray PR, Hollick GE, Jerris RC, Wilson ML (1998) Multicenter comparison of BACTEC 9050 and BACTEC 9240 blood culture systems. J Clin Microbiol 36:1601\u20131603","journal-title":"J Clin Microbiol"},{"key":"2608_CR37","doi-asserted-by":"crossref","first-page":"510","DOI":"10.1016\/j.jinf.2007.09.001","volume":"55","author":"V Fihman","year":"2007","unstructured":"Fihman V, Hannouche D, Bousson V, Bardin T, Liot\u00e9 F, Raskine L et al (2007) Improved diagnosis specificity in bone and joint infections using molecular techniques. J Infect 55:510\u2013517","journal-title":"J Infect"},{"key":"2608_CR38","doi-asserted-by":"crossref","first-page":"1018","DOI":"10.1128\/JCM.44.3.1018-1028.2006","volume":"44","author":"F Fenollar","year":"2006","unstructured":"Fenollar F, Roux V, Stein A, Drancourt M, Raoult D (2006) Analysis of 525 samples to determine the usefulness of PCR amplification and sequencing of the 16S rRNA gene for diagnosis of bone and joint infections. J Clin Microbiol 44:1018\u20131028","journal-title":"J Clin Microbiol"},{"key":"2608_CR39","doi-asserted-by":"crossref","first-page":"685","DOI":"10.1099\/jmm.0.05213-0","volume":"52","author":"KA Harris","year":"2003","unstructured":"Harris KA, Hartley JC (2003) Development of broad-range 16S rDNA PCR for use in the routine diagnostic clinical microbiology service. J Med Microbiol 52:685\u2013691","journal-title":"J Med Microbiol"},{"key":"2608_CR40","doi-asserted-by":"crossref","first-page":"390","DOI":"10.1016\/j.diagmicrobio.2010.11.010","volume":"69","author":"H Bonilla","year":"2011","unstructured":"Bonilla H, Kepley R, Pawlak J, Belian B, Raynor A, Saravolatz LD (2011) Rapid diagnosis of septic arthritis using 16S rDNA PCR: a comparison of 3 methods. Diagn Microbiol Infect Dis 69:390\u2013395","journal-title":"Diagn Microbiol Infect Dis"}],"container-title":["European Journal of Clinical Microbiology & Infectious Diseases"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s10096-016-2608-x.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s10096-016-2608-x\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s10096-016-2608-x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,6,6]],"date-time":"2022-06-06T23:23:01Z","timestamp":1654557781000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s10096-016-2608-x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,3,4]]},"references-count":40,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2016,5]]}},"alternative-id":["2608"],"URL":"https:\/\/doi.org\/10.1007\/s10096-016-2608-x","relation":{},"ISSN":["0934-9723","1435-4373"],"issn-type":[{"value":"0934-9723","type":"print"},{"value":"1435-4373","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,3,4]]}}}