{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T15:28:17Z","timestamp":1786980497158,"version":"build-2736575974"},"reference-count":35,"publisher":"Springer Science and Business Media LLC","issue":"6","license":[{"start":{"date-parts":[[2016,4,2]],"date-time":"2016-04-02T00:00:00Z","timestamp":1459555200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Eur J Clin Microbiol Infect Dis"],"published-print":{"date-parts":[[2016,6]]},"DOI":"10.1007\/s10096-016-2633-9","type":"journal-article","created":{"date-parts":[[2016,4,2]],"date-time":"2016-04-02T05:52:02Z","timestamp":1459576322000},"page":"1023-1032","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Impact of systemic antifungal therapy on the detection of Candida species in blood cultures in clinical cases of candidemia"],"prefix":"10.1007","volume":"35","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2179-4650","authenticated-orcid":false,"given":"S.","family":"Bailly","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.","family":"Garnaud","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Cornet","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P.","family":"Pavese","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R.","family":"Hamidfar-Roy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L.","family":"Foroni","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"Boisset","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.-F.","family":"Timsit","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D.","family":"Maubon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2016,4,2]]},"reference":[{"issue":"Pt 7","key":"2633_CR1","doi-asserted-by":"crossref","first-page":"809","DOI":"10.1099\/jmm.0.46548-0","volume":"55","author":"DA Enoch","year":"2006","unstructured":"Enoch DA, Ludlam HA, Brown NM (2006) Invasive fungal infections: a review of epidemiology and management options. J Med Microbiol 55(Pt 7):809\u2013818","journal-title":"J Med Microbiol"},{"issue":"3","key":"2633_CR2","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1086\/421946","volume":"39","author":"H Wisplinghoff","year":"2004","unstructured":"Wisplinghoff H, Bischoff T, Tallent SM, Seifert H, Wenzel RP, Edmond MB (2004) Nosocomial bloodstream infections in US hospitals: analysis of 24,179 cases from a prospective nationwide surveillance study. Clin Infect Dis 39(3):309\u2013317","journal-title":"Clin Infect Dis"},{"issue":"9","key":"2633_CR3","doi-asserted-by":"crossref","first-page":"3640","DOI":"10.1128\/AAC.49.9.3640-3645.2005","volume":"49","author":"M Morrell","year":"2005","unstructured":"Morrell M, Fraser VJ, Kollef MH (2005) Delaying the empiric treatment of candida bloodstream infection until positive blood culture results are obtained: a potential risk factor for hospital mortality. Antimicrob Agents Chemother 49(9):3640\u20133645","journal-title":"Antimicrob Agents Chemother"},{"issue":"1","key":"2633_CR4","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1086\/504810","volume":"43","author":"KW Garey","year":"2006","unstructured":"Garey KW, Rege M, Pai MP, Mingo DE, Suda KJ, Turpin RS, Bearden DT (2006) Time to initiation of fluconazole therapy impacts mortality in patients with candidemia: a multi-institutional study. Clin Infect Dis 43(1):25\u201331","journal-title":"Clin Infect Dis"},{"issue":"6","key":"2633_CR5","doi-asserted-by":"crossref","first-page":"839","DOI":"10.1007\/s00134-014-3310-z","volume":"40","author":"M Bassetti","year":"2014","unstructured":"Bassetti M, Righi E, Ansaldi F, Merelli M, Cecilia T, De Pascale G, Diaz-Martin A, Luzzati R, Rosin C, Lagunes L, Trecarichi EM, Sanguinetti M, Posteraro B, Garnacho-Montero J, Sartor A, Rello J, Rocca GD, Antonelli M, Tumbarello M (2014) A multicenter study of septic shock due to candidemia: outcomes and predictors of mortality. Intensive Care Med 40(6):839\u2013845","journal-title":"Intensive Care Med"},{"key":"2633_CR6","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1111\/1469-0691.12038","volume":"18","author":"M Cuenca-Estrella","year":"2012","unstructured":"Cuenca-Estrella M, Verweij PE, Arendrup MC, Arikan-Akdagli S, Bille J, Donnelly JP, Jensen HE, Lass-Fl\u00f6rl C, Richardson MD, Akova M, Bassetti M, Calandra T, Castagnola E, Cornely OA, Garbino J, Groll AH, Herbrecht R, Hope WW, Kullberg BJ, Lortholary O, Meersseman W, Petrikkos G, Roilides E, Viscoli C, Ullmann AJ, EFISG (2012) ESCMID* guideline for the diagnosis and management of\u2009Candida\u2009diseases 2012: diagnostic procedures. Clin Microbiol Infect 18:9\u201318","journal-title":"Clin Microbiol Infect"},{"issue":"6","key":"2633_CR7","doi-asserted-by":"crossref","first-page":"846","DOI":"10.1038\/bmt.2011.178","volume":"47","author":"O Marchetti","year":"2012","unstructured":"Marchetti O, Lamoth F, Mikulska M, Viscoli C, Verweij P, Bretagne S (2012) ECIL recommendations for the use of biological markers for the diagnosis of invasive fungal diseases in leukemic patients and hematopoietic SCT recipients. Bone Marrow Transplant 47(6):846\u2013854","journal-title":"Bone Marrow Transplant"},{"key":"2633_CR8","doi-asserted-by":"crossref","unstructured":"Pappas PG, Kauffman CA, Andes D, Benjamin DK Jr, Calandra TF, Edwards JE Jr, Filler SG, Fisher JF, Kullberg BJ, Ostrosky\u2010Zeichner L, Reboli AC, Rex JH, Walsh TJ, Sobel JD (2009) Clinical practice guidelines for the management of candidiasis: 2009 update by the Infectious Diseases Society of America. Clin Infect Dis 48(5):503\u2013535","DOI":"10.1086\/596757"},{"issue":"2","key":"2633_CR9","doi-asserted-by":"crossref","first-page":"773","DOI":"10.1128\/JCM.42.2.773-777.2004","volume":"42","author":"MH Meyer","year":"2004","unstructured":"Meyer MH, Letscher-Bru V, Jaulhac B, Waller J, Candolfi E (2004) Comparison of Mycosis IC\/F and plus Aerobic\/F media for diagnosis of fungemia by the bactec 9240 system. J Clin Microbiol 42(2):773\u2013777","journal-title":"J Clin Microbiol"},{"issue":"1","key":"2633_CR10","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1128\/JCM.01811-10","volume":"49","author":"MC Arendrup","year":"2011","unstructured":"Arendrup MC, Bruun B, Christensen JJ, Fuursted K, Johansen HK, Kjaeldgaard P, Knudsen JD, Kristensen L, M\u00f8ller J, Nielsen L, Rosenvinge FS, R\u00f8der B, Sch\u00f8nheyder HC, Thomsen MK, Truberg K (2011) National surveillance of fungemia in Denmark (2004 to 2009). J Clin Microbiol 49(1):325\u2013334","journal-title":"J Clin Microbiol"},{"issue":"2","key":"2633_CR11","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1016\/j.diagmicrobio.2012.02.020","volume":"73","author":"E-L Ericson","year":"2012","unstructured":"Ericson E-L, Klingspor L, Ullberg M, Ozenci V (2012) Clinical comparison of the Bactec Mycosis IC\/F, BacT\/Alert FA, and BacT\/Alert FN blood culture vials for the detection of candidemia. Diagn Microbiol Infect Dis 73(2):153\u2013156","journal-title":"Diagn Microbiol Infect Dis"},{"issue":"1","key":"2633_CR12","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1128\/JCM.43.1.433-435.2005","volume":"43","author":"BJ George","year":"2005","unstructured":"George BJ, Horvath LL, Hospenthal DR (2005) Effect of inoculum size on detection of Candida growth by the BACTEC 9240 automated blood culture system using aerobic and anaerobic media. J Clin Microbiol 43(1):433\u2013435","journal-title":"J Clin Microbiol"},{"issue":"6","key":"2633_CR13","doi-asserted-by":"crossref","first-page":"412","DOI":"10.1002\/jcla.21535","volume":"26","author":"DW Jekarl","year":"2012","unstructured":"Jekarl DW, Lee S-Y, Lee S, Park Y-J, Lee J, Baek SM, An YJ, Ock SM, Lee M-K (2012) Comparison of the Bactec Fx Plus, Mycosis IC\/F, Mycosis\/F Lytic blood culture media and the BacT\/Alert 3D FA media for detection of Candida species in seeded blood culture specimens containing therapeutic peak levels of fluconazole. J Clin Lab Anal 26(6):412\u2013419","journal-title":"J Clin Lab Anal"},{"issue":"11","key":"2633_CR14","doi-asserted-by":"crossref","first-page":"3683","DOI":"10.1128\/JCM.02048-13","volume":"51","author":"R Kock","year":"2013","unstructured":"Kock R, Eissing LC, Boschin MG, Ellger B, Horn D, Idelevich EA, Becker K (2013) Evaluation of bactec mycosis IC\/F and Plus Aerobic\/F blood culture bottles for detection of Candida in the presence of antifungal agents. J Clin Microbiol 51(11):3683\u20133687","journal-title":"J Clin Microbiol"},{"issue":"4","key":"2633_CR15","doi-asserted-by":"crossref","first-page":"1855","DOI":"10.1128\/JCM.42.4.1855-1856.2004","volume":"42","author":"H Fricker-Hidalgo","year":"2004","unstructured":"Fricker-Hidalgo H, Lebeau B, Pelloux H, Grillot R (2004) Use of the BACTEC 9240 System with Mycosis-IC\/F blood culture bottles for detection of fungemia. J Clin Microbiol 42(4):1855\u20131856","journal-title":"J Clin Microbiol"},{"issue":"5","key":"2633_CR16","doi-asserted-by":"crossref","first-page":"e539","DOI":"10.1111\/j.1439-0507.2010.01977.x","volume":"54","author":"PP Bosshard","year":"2011","unstructured":"Bosshard PP (2011) Incubation of fungal cultures: how long is long enough? Mycoses 54(5):e539\u2013e545","journal-title":"Mycoses"},{"issue":"2","key":"2633_CR17","doi-asserted-by":"crossref","first-page":"587","DOI":"10.1093\/jac\/dku414","volume":"70","author":"Y Takesue","year":"2015","unstructured":"Takesue Y, Ueda T, Mikamo H, Oda S, Takakura S, Kitagawa Y, Kohno S (2015) Management bundles for candidaemia: the impact of compliance on clinical outcomes. J Antimicrob Chemother 70(2):587\u2013593","journal-title":"J Antimicrob Chemother"},{"issue":"10","key":"2633_CR18","doi-asserted-by":"crossref","first-page":"1139","DOI":"10.1164\/rccm.201409-1701OC","volume":"191","author":"S Bailly","year":"2015","unstructured":"Bailly S, Bouadma L, Azoulay E, Orgeas MG, Adrie C, Souweine B, Schwebel C, Maubon D, Hamidfar-Roy R, Darmon M, Wolff M, Cornet M, Timsit J-F (2015) Failure of empirical systemic antifungal therapy in mechanically ventilated critically ill patients. Am J Respir Crit Care Med 191(10):1139\u20131146","journal-title":"Am J Respir Crit Care Med"},{"issue":"3","key":"2633_CR19","doi-asserted-by":"crossref","first-page":"813","DOI":"10.1097\/CCM.0b013e318236f297","volume":"40","author":"E Azoulay","year":"2012","unstructured":"Azoulay E, Dupont H, Tabah A, Lortholary O, Stahl J-P, Francais A, Martin C, Guidet B, Timsit J-F (2012) Systemic antifungal therapy in critically ill patients without invasive fungal infection*. Crit Care Med 40(3):813\u2013822","journal-title":"Crit Care Med"},{"issue":"3","key":"2633_CR20","doi-asserted-by":"crossref","first-page":"816","DOI":"10.1128\/JCM.02064-06","volume":"45","author":"D Flayhart","year":"2007","unstructured":"Flayhart D, Borek AP, Wakefield T, Dick J, Carroll KC (2007) Comparison of BACTEC PLUS blood culture media to BacT\/Alert FA blood culture media for detection of bacterial pathogens in samples containing therapeutic levels of antibiotics. J Clin Microbiol 45(3):816\u2013821","journal-title":"J Clin Microbiol"},{"issue":"1","key":"2633_CR21","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1128\/JCM.42.1.115-118.2004","volume":"42","author":"LL Horvath","year":"2004","unstructured":"Horvath LL, George BJ, Murray CK, Harrison LS, Hospenthal DR (2004) Direct comparison of the BACTEC 9240 and BacT\/ALERT 3D automated blood culture systems for Candida growth detection. J Clin Microbiol 42(1):115\u2013118","journal-title":"J Clin Microbiol"},{"issue":"9","key":"2633_CR22","doi-asserted-by":"crossref","first-page":"3062","DOI":"10.1128\/JCM.00966-07","volume":"45","author":"LL Horvath","year":"2007","unstructured":"Horvath LL, George BJ, Hospenthal DR (2007) Detection of fifteen species of Candida in an automated blood culture system. J Clin Microbiol 45(9):3062\u20133064","journal-title":"J Clin Microbiol"},{"issue":"4","key":"2633_CR23","doi-asserted-by":"crossref","first-page":"1524","DOI":"10.1128\/JCM.02260-10","volume":"49","author":"S Riedel","year":"2011","unstructured":"Riedel S, Eisinger SW, Dam L, Stamper PD, Carroll KC (2011)Comparison of BD Bactec Plus Aerobic\/F medium to VersaTREK Redox 1 blood culture medium for detection of Candida spp. in seeded blood culture specimens containing therapeutic levels of antifungal agents. J Clin Microbiol 49(4):1524\u20131529","journal-title":"J Clin Microbiol"},{"issue":"11","key":"2633_CR24","doi-asserted-by":"crossref","first-page":"2983","DOI":"10.1007\/s10096-012-1650-6","volume":"31","author":"L Klingspor","year":"2012","unstructured":"Klingspor L, Muhammed SA, Ozenci V (2012) Comparison of the two blood culture systems, Bactec 9240 and BacT\/Alert 3D, in the detection of Candida spp. and bacteria with polymicrobial sepsis. Eur J Clin Microbiol Infect Dis 31(11):2983\u20132987","journal-title":"Eur J Clin Microbiol Infect Dis"},{"issue":"1","key":"2633_CR25","doi-asserted-by":"crossref","first-page":"184","DOI":"10.1128\/AAC.00945-09","volume":"54","author":"Y Taur","year":"2010","unstructured":"Taur Y, Cohen N, Dubnow S, Paskovaty A, Seo SK (2010) Effect of antifungal therapy timing on mortality in cancer patients with candidemia. Antimicrob Agents Chemother 54(1):184\u2013190","journal-title":"Antimicrob Agents Chemother"},{"issue":"7","key":"2633_CR26","doi-asserted-by":"crossref","first-page":"917","DOI":"10.1007\/s10096-013-1826-8","volume":"32","author":"L Huang","year":"2013","unstructured":"Huang L, Zhang YY, Sun LY (2013) Time to positivity of blood culture can predict different Candida species instead of pathogen concentration in candidemia. Eur J Clin Microbiol Infect Dis 32(7):917\u2013922","journal-title":"Eur J Clin Microbiol Infect Dis"},{"issue":"12","key":"2633_CR27","doi-asserted-by":"crossref","first-page":"2839","DOI":"10.1093\/jac\/dkt285","volume":"68","author":"N Cobos-Trigueros","year":"2013","unstructured":"Cobos-Trigueros N, Morata L, Torres J, Zboromyrska Y, Soriano A, Pitart C, Calle CDL, Marco F, Hernandez C, Almela M, Mensa J, Martinez JA (2013) Usefulness of time-to-positivity in aerobic and anaerobic vials to predict the presence of Candida glabrata in patients with candidaemia. J Antimicrob Chemother 68(12):2839\u20132841","journal-title":"J Antimicrob Chemother"},{"issue":"1","key":"2633_CR28","doi-asserted-by":"crossref","first-page":"486","DOI":"10.1186\/1471-2334-13-486","volume":"13","author":"CZ Nunes","year":"2013","unstructured":"Nunes CZ, Marra AR, Edmond MB, Victor ES, Pereira CAP (2013) Time to blood culture positivity as a predictor of clinical outcome in patients with Candida albicans bloodstream infection. BMC Infect Dis 13(1):486","journal-title":"BMC Infect Dis"},{"issue":"12","key":"2633_CR29","doi-asserted-by":"crossref","first-page":"2890","DOI":"10.1093\/jac\/dkt256","volume":"68","author":"S-H Kim","year":"2013","unstructured":"Kim S-H, Yoon YK, Kim MJ, Sohn JW (2013) Clinical impact of time to positivity for Candida species on mortality in patients with candidaemia. J Antimicrob Chemother 68(12):2890\u20132897","journal-title":"J Antimicrob Chemother"},{"issue":"2","key":"2633_CR30","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1007\/BF01682167","volume":"17","author":"H Fricker-Hidalgo","year":"1998","unstructured":"Fricker-Hidalgo H, Chazot F, Lebeau B, Pelloux H, Ambroise-Thomas P, Grillot R (1998) Use of simulated blood cultures to compare a specific fungal medium with a standard microorganism medium for yeast detection. Eur J Clin Microbiol Infect Dis 17(2):113\u2013116","journal-title":"Eur J Clin Microbiol Infect Dis"},{"issue":"12","key":"2633_CR31","doi-asserted-by":"crossref","first-page":"4047","DOI":"10.1128\/JCM.01314-11","volume":"49","author":"R Patel","year":"2011","unstructured":"Patel R, Vetter EA, Harmsen WS, Schleck CD, Fadel HJ, Cockerill FR (2011) Optimized pathogen detection with 30- compared to 20-milliliter blood culture draws. J Clin Microbiol 49(12):4047\u20134051","journal-title":"J Clin Microbiol"},{"issue":"7","key":"2633_CR32","doi-asserted-by":"crossref","first-page":"709","DOI":"10.1111\/j.1469-0691.2007.01736.x","volume":"13","author":"JA Martinez","year":"2007","unstructured":"Martinez JA, Pozo L, Almela M, Marco F, Soriano A, L\u00f3pez F, Balasso V, Aguilar J, Mensa J (2007) Microbial and clinical determinants of time-to-positivity in patients with bacteraemia. Clin Microbiol Infect 13(7):709\u2013716","journal-title":"Clin Microbiol Infect"},{"issue":"7","key":"2633_CR33","doi-asserted-by":"crossref","first-page":"1993","DOI":"10.1097\/CCM.0b013e31816fc4cd","volume":"36","author":"JK Chow","year":"2008","unstructured":"Chow JK, Golan Y, Ruthazer R, Karchmer AW, Carmeli Y, Lichtenberg DA, Chawla V, Young JA, Hadley S (2008) Risk factors for albicans and non-albicans candidemia in the intensive care unit. Crit Care Med 36(7):1993\u20131998","journal-title":"Crit Care Med"},{"issue":"2","key":"2633_CR34","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1016\/j.diagmicrobio.2014.11.001","volume":"81","author":"J Chang","year":"2015","unstructured":"Chang J, Park JS, Park S, Choi B, Yoon NS, Sung H, Kim M-N (2015) Impact of monitoring blood volume in the BD BACTEC\u2122 FX blood culture system: virtual volume versus actual volume. Diagn Microbiol Infect Dis 81(2):89\u201393","journal-title":"Diagn Microbiol Infect Dis"},{"issue":"9","key":"2633_CR35","doi-asserted-by":"crossref","first-page":"1303","DOI":"10.1007\/s00134-014-3408-3","volume":"40","author":"O Lortholary","year":"2014","unstructured":"Lortholary O, Renaudat C, Sitbon K, Madec Y, Denoeud-Ndam L, Wolff M, Fontanet A, Bretagne S, Dromer F (2014) Worrisome trends in incidence and mortality of candidemia in intensive care units (Paris area, 2002\u20132010). Intensive Care Med 40(9):1303\u20131312","journal-title":"Intensive Care Med"}],"container-title":["European Journal of Clinical Microbiology & Infectious Diseases"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s10096-016-2633-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s10096-016-2633-9\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s10096-016-2633-9","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,5,29]],"date-time":"2019-05-29T05:35:20Z","timestamp":1559108120000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s10096-016-2633-9"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,4,2]]},"references-count":35,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2016,6]]}},"alternative-id":["2633"],"URL":"https:\/\/doi.org\/10.1007\/s10096-016-2633-9","relation":{},"ISSN":["0934-9723","1435-4373"],"issn-type":[{"value":"0934-9723","type":"print"},{"value":"1435-4373","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,4,2]]}}}