{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T10:30:50Z","timestamp":1790677850345,"version":"4.1.0"},"reference-count":27,"publisher":"Springer Science and Business Media LLC","issue":"8","license":[{"start":{"date-parts":[[2016,5,24]],"date-time":"2016-05-24T00:00:00Z","timestamp":1464048000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"funder":[{"name":"the State Key Program of National Natural Science of China","award":["grant no. 81230039"],"award-info":[{"award-number":["grant no. 81230039"]}]},{"name":"Young Scholar of National Natural Science Foundation of China","award":["grant no. 81201327"],"award-info":[{"award-number":["grant no. 81201327"]}]},{"name":"Natural Science Foundation of Zhejiang province, China","award":["Grant No. LY15H190004"],"award-info":[{"award-number":["Grant No. LY15H190004"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Eur J Clin Microbiol Infect Dis"],"published-print":{"date-parts":[[2016,8]]},"DOI":"10.1007\/s10096-016-2674-0","type":"journal-article","created":{"date-parts":[[2016,5,24]],"date-time":"2016-05-24T17:34:12Z","timestamp":1464111252000},"page":"1371-1375","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":29,"title":["Abrp, a new gene, confers reduced susceptibility to tetracycline, glycylcine, chloramphenicol and fosfomycin classes in Acinetobacter baumannii"],"prefix":"10.1007","volume":"35","author":[{"given":"X.","family":"Li","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"Quan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Y.","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"Ji","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L.","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Y.","family":"Fu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"X.","family":"Hua","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Y.","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B.","family":"Pi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Y.","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Y.","family":"Yu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2016,5,24]]},"reference":[{"issue":"12","key":"2674_CR1","doi-asserted-by":"crossref","first-page":"939","DOI":"10.1038\/nrmicro1789","volume":"5","author":"L Dijkshoorn","year":"2007","unstructured":"Dijkshoorn L, Nemec A, Seifert H (2007) An increasing threat in hospitals: multidrug-resistant Acinetobacter baumannii. Nat Rev Microbiol 5(12):939\u2013951","journal-title":"Nat Rev Microbiol"},{"issue":"4","key":"2674_CR2","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1016\/j.jhin.2009.03.032","volume":"73","author":"KJ Towner","year":"2009","unstructured":"Towner KJ (2009) Acinetobacter: an old friend, but a new enemy. J Hosp Infect 73(4):355\u2013363","journal-title":"J Hosp Infect"},{"issue":"9","key":"2674_CR3","doi-asserted-by":"crossref","first-page":"2578","DOI":"10.1093\/jac\/dku170","volume":"69","author":"S Gottig","year":"2014","unstructured":"Gottig S, Gruber TM, Higgins PG, Wachsmuth M, Seifert H, Kempf VA (2014) Detection of pan drug-resistant Acinetobacter baumannii in Germany. J Antimicrob Chemother 69(9):2578\u20132579","journal-title":"J Antimicrob Chemother"},{"issue":"3","key":"2674_CR4","doi-asserted-by":"crossref","first-page":"268","DOI":"10.1111\/j.1469-0691.2011.03570.x","volume":"18","author":"AP Magiorakos","year":"2012","unstructured":"Magiorakos AP, Srinivasan A, Carey RB, Carmeli Y, Falagas ME, Giske CG, Harbarth S, Hindler JF, Kahlmeter G, Olsson-Liljequist B, Paterson DL, Rice LB, Stelling J, Struelens MJ, Vatopoulos A, Weber JT, Monnet DL (2012) Multidrug-resistant, extensively drug-resistant and pandrug-resistant bacteria: an international expert proposal for interim standard definitions for acquired resistance. Clin Microbiol Infect 18(3):268\u2013281","journal-title":"Clin Microbiol Infect"},{"issue":"10","key":"2674_CR5","doi-asserted-by":"crossref","first-page":"3471","DOI":"10.1128\/AAC.01464-06","volume":"51","author":"F Perez","year":"2007","unstructured":"Perez F, Hujer AM, Hujer KM, Decker BK, Rather PN, Bonomo RA (2007) Global challenge of multidrug-resistant Acinetobacter baumannii. Antimicrob Agents Chemother 51(10):3471\u20133484","journal-title":"Antimicrob Agents Chemother"},{"issue":"3","key":"2674_CR6","doi-asserted-by":"crossref","first-page":"538","DOI":"10.1128\/CMR.00058-07","volume":"21","author":"AY Peleg","year":"2008","unstructured":"Peleg AY, Seifert H, Paterson DL (2008) Acinetobacter baumannii: emergence of a successful pathogen. Clin Microbiol Rev 21(3):538\u2013582","journal-title":"Clin Microbiol Rev"},{"issue":"10","key":"2674_CR7","doi-asserted-by":"crossref","first-page":"4506","DOI":"10.1128\/AAC.01134-10","volume":"55","author":"H Zhou","year":"2011","unstructured":"Zhou H, Zhang T, Yu D, Pi B, Yang Q, Zhou J, Hu S, Yu Y (2011) Genomic analysis of the multidrug-resistant Acinetobacter baumannii strain MDR-ZJ06 widely spread in China. Antimicrob Agents Chemother 55(10):4506\u20134512","journal-title":"Antimicrob Agents Chemother"},{"issue":"2","key":"2674_CR8","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1089\/mdr.2009.0131","volume":"16","author":"A Ruzin","year":"2010","unstructured":"Ruzin A, Immermann FW, Bradford PA (2010) RT-PCR and statistical analyses of adeABC expression in clinical isolates of Acinetobacter calcoaceticus-Acinetobacter baumannii complex. Microb Drug Resist (Larchmont, NY) 16(2):87\u201389","journal-title":"Microb Drug Resist (Larchmont, NY)"},{"issue":"10","key":"2674_CR9","doi-asserted-by":"crossref","first-page":"4389","DOI":"10.1128\/AAC.00155-10","volume":"54","author":"S Coyne","year":"2010","unstructured":"Coyne S, Rosenfeld N, Lambert T, Courvalin P, Perichon B (2010) Overexpression of resistance-nodulation-cell division pump AdeFGH confers multidrug resistance in Acinetobacter baumannii. Antimicrob Agents Chemother 54(10):4389\u20134393","journal-title":"Antimicrob Agents Chemother"},{"issue":"4","key":"2674_CR10","doi-asserted-by":"crossref","first-page":"1432","DOI":"10.1128\/AAC.49.4.1432-1440.2005","volume":"49","author":"MA Mussi","year":"2005","unstructured":"Mussi MA, Limansky AS, Viale AM (2005) Acquisition of resistance to carbapenems in multidrug-resistant clinical strains of Acinetobacter baumannii: natural insertional inactivation of a gene encoding a member of a novel family of beta-barrel outer membrane proteins. Antimicrob Agents Chemother 49(4):1432\u20131440","journal-title":"Antimicrob Agents Chemother"},{"issue":"4","key":"2674_CR11","doi-asserted-by":"crossref","first-page":"593","DOI":"10.1128\/MMBR.67.4.593-656.2003","volume":"67","author":"H Nikaido","year":"2003","unstructured":"Nikaido H (2003) Molecular basis of bacterial outer membrane permeability revisited. Microbiol Mol Biol Rev 67(4):593\u2013656","journal-title":"Microbiol Mol Biol Rev"},{"key":"2674_CR12","volume-title":"Performance standards for antimicrobial susceptibility testing. Twenty-Fifth Informational Supplement M100-S25","author":"Clinical and Laboratory Standards Institute","year":"2015","unstructured":"Clinical and Laboratory Standards Institute (2015) Performance standards for antimicrobial susceptibility testing. Twenty-Fifth Informational Supplement M100-S25. Clinical and Laboratory Standards Institute, Wayne"},{"issue":"1","key":"2674_CR13","doi-asserted-by":"crossref","first-page":"158","DOI":"10.1186\/1471-2180-13-158","volume":"13","author":"IM Amin","year":"2013","unstructured":"Amin IM, Richmond GE, Sen P, Koh TH, Piddock LJ, Chua KL (2013) A Method for generating marker-less gene deletions in multidrug-resistant Acinetobacter baumannii. BMC Microbiol 13(1):158","journal-title":"BMC Microbiol"},{"key":"2674_CR14","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1186\/1471-2180-10-279","volume":"10","author":"J Aranda","year":"2010","unstructured":"Aranda J, Poza M, Pardo BG, Rumbo S, Rumbo C, Parreira JR, Rodriguez-Velo P, Bou G (2010) A rapid and simple method for constructing stable mutants of Acinetobacter baumannii. BMC Microbiol 10:279","journal-title":"BMC Microbiol"},{"issue":"3","key":"2674_CR15","doi-asserted-by":"crossref","first-page":"625","DOI":"10.1007\/s10096-014-2272-y","volume":"34","author":"X Li","year":"2015","unstructured":"Li X, Liu L, Ji J, Chen Q, Hua X, Jiang Y, Feng Y, Yu Y (2015) Tigecycline resistance in Acinetobacter baumannii mediated by frameshift mutation in plsC, encoding 1-acyl-sn-glycerol-3-phosphate acyltransferase. Eur J Clin Microbiol Infect Dis 34(3):625\u2013631","journal-title":"Eur J Clin Microbiol Infect Dis"},{"issue":"2","key":"2674_CR16","doi-asserted-by":"crossref","first-page":"432","DOI":"10.1093\/jac\/dku423","volume":"70","author":"H Lofton","year":"2015","unstructured":"Lofton H, Anwar N, Rhen M, Andersson DI (2015) Fitness of Salmonella mutants resistant to antimicrobial peptides. J Antimicrob Chemother 70(2):432\u2013440","journal-title":"J Antimicrob Chemother"},{"key":"2674_CR17","doi-asserted-by":"crossref","unstructured":"Rost B, Yachdav G, Liu J (2004) The PredictProtein server. Nucleic acids research 32 (Web Server issue):W321-326","DOI":"10.1093\/nar\/gkh377"},{"issue":"4","key":"2674_CR18","doi-asserted-by":"crossref","first-page":"827","DOI":"10.1128\/AAC.44.4.827-834.2000","volume":"44","author":"DJ Novo","year":"2000","unstructured":"Novo DJ, Perlmutter NG, Hunt RH, Shapiro HM (2000) Multiparameter flow cytometric analysis of antibiotic effects on membrane potential, membrane permeability, and bacterial counts of Staphylococcus aureus and Micrococcus luteus. Antimicrob Agents Chemother 44(4):827\u2013834","journal-title":"Antimicrob Agents Chemother"},{"issue":"1","key":"2674_CR19","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1002\/(SICI)1097-0320(19990101)35:1<55::AID-CYTO8>3.0.CO;2-2","volume":"35","author":"D Novo","year":"1999","unstructured":"Novo D, Perlmutter NG, Hunt RH, Shapiro HM (1999) Accurate flow cytometric membrane potential measurement in bacteria using diethyloxacarbocyanine and a ratiometric technique. Cytometry 35(1):55\u201363","journal-title":"Cytometry"},{"issue":"5","key":"2674_CR20","doi-asserted-by":"crossref","first-page":"559","DOI":"10.1515\/hsz-2013-0292","volume":"395","author":"FSA Nguyen","year":"2014","unstructured":"Nguyen FSA, Arenz S, Sohmen D, D\u00f6nh\u00f6fer A, Wilson DN (2014) Tetracycline antibiotics and resistance mechanisms. Biol Chem 395(5):559\u2013575","journal-title":"Biol Chem"},{"issue":"6870","key":"2674_CR21","doi-asserted-by":"publisher","first-page":"389","DOI":"10.1038\/415389a","volume":"415","author":"M Zasloff","year":"2002","unstructured":"Zasloff M (2002) Antimicrobial peptides of multicellular organisms. Nature 415(6870):389\u2013395. doi: 10.1038\/415389a","journal-title":"Nature"},{"issue":"51","key":"2674_CR22","doi-asserted-by":"crossref","first-page":"15730","DOI":"10.1021\/ja039307z","volume":"125","author":"KL Fillgrove","year":"2003","unstructured":"Fillgrove KL, Pakhomova S, Newcomer ME, Armstrong RN (2003) Mechanistic diversity of fosfomycin resistance in pathogenic microorganisms. J Am Chem Soc 125(51):15730\u201315731","journal-title":"J Am Chem Soc"},{"issue":"44","key":"2674_CR23","doi-asserted-by":"crossref","first-page":"30121","DOI":"10.1074\/jbc.M806092200","volume":"283","author":"R Fluhrer","year":"2008","unstructured":"Fluhrer R, Fukumori A, Martin L, Grammer G, Haug-Kroper M, Klier B, Winkler E, Kremmer E, Condron MM, Teplow DB, Steiner H, Haass C (2008) Intramembrane proteolysis of GXGD-type aspartyl proteases is slowed by a familial Alzheimer disease-like mutation. J Biol Chem 283(44):30121\u201330128","journal-title":"J Biol Chem"},{"issue":"17","key":"2674_CR24","doi-asserted-by":"crossref","first-page":"4521","DOI":"10.1128\/JB.06678-11","volume":"194","author":"RD Waite","year":"2012","unstructured":"Waite RD, Rose RS, Rangarajan M, Aduse-Opoku J, Hashim A, Curtis MA (2012) Pseudomonas aeruginosa possesses two putative type I signal peptidases, LepB and PA1303, each with distinct roles in physiology and virulence. J Bacteriol 194(17):4521\u20134536","journal-title":"J Bacteriol"},{"issue":"12","key":"2674_CR25","doi-asserted-by":"crossref","first-page":"3236","DOI":"10.1093\/jac\/dku309","volume":"69","author":"Y Personne","year":"2014","unstructured":"Personne Y, Curtis MA, Wareham DW, Waite RD (2014) Activity of the type I signal peptidase inhibitor MD3 against multidrug-resistant Gram-negative bacteria alone and in combination with colistin. J Antimicrob Chemother 69(12):3236\u20133243","journal-title":"J Antimicrob Chemother"},{"issue":"10","key":"2674_CR26","doi-asserted-by":"crossref","first-page":"897","DOI":"10.2174\/1389201014666131226123511","volume":"14","author":"M Garcia-Quintanilla","year":"2013","unstructured":"Garcia-Quintanilla M, Pulido MR, McConnell MJ (2013) First steps towards a vaccine against Acinetobacter baumannii. Curr Pharm Biotechnol 14(10):897\u2013902","journal-title":"Curr Pharm Biotechnol"},{"issue":"34","key":"2674_CR27","doi-asserted-by":"crossref","first-page":"5705","DOI":"10.1016\/j.vaccine.2011.06.001","volume":"29","author":"MJRC McConnell","year":"2011","unstructured":"McConnell MJRC, Bou G, Pach\u00f3n J (2011) Outer membrane vesicles as an acellular vaccine against Acinetobacter baumannii. Vaccine 29(34):5705\u20135710","journal-title":"Vaccine"}],"container-title":["European Journal of Clinical Microbiology &amp; Infectious Diseases"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s10096-016-2674-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s10096-016-2674-0\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s10096-016-2674-0","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,9,21]],"date-time":"2020-09-21T02:02:33Z","timestamp":1600653753000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s10096-016-2674-0"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,5,24]]},"references-count":27,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2016,8]]}},"alternative-id":["2674"],"URL":"https:\/\/doi.org\/10.1007\/s10096-016-2674-0","relation":{},"ISSN":["0934-9723","1435-4373"],"issn-type":[{"value":"0934-9723","type":"print"},{"value":"1435-4373","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,5,24]]}}}