{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,17]],"date-time":"2026-05-17T09:27:39Z","timestamp":1779010059272,"version":"3.51.4"},"reference-count":30,"publisher":"Springer Science and Business Media LLC","issue":"9","license":[{"start":{"date-parts":[[2016,6,2]],"date-time":"2016-06-02T00:00:00Z","timestamp":1464825600000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"funder":[{"DOI":"10.13039\/501100004587","name":"Instituto de Salud Carlos III","doi-asserted-by":"publisher","award":["PI12\/01808"],"award-info":[{"award-number":["PI12\/01808"]}],"id":[{"id":"10.13039\/501100004587","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Eur J Clin Microbiol Infect Dis"],"published-print":{"date-parts":[[2016,9]]},"DOI":"10.1007\/s10096-016-2696-7","type":"journal-article","created":{"date-parts":[[2016,6,2]],"date-time":"2016-06-02T05:09:34Z","timestamp":1464844174000},"page":"1549-1556","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":20,"title":["Neisseria gonorrhoeae antimicrobial susceptibility in Barcelona: penA, ponA, mtrR, and porB mutations and NG-MAST sequence types associated with decreased susceptibility to cephalosporins"],"prefix":"10.1007","volume":"35","author":[{"given":"J.","family":"Serra-Pladevall","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M. J.","family":"Barber\u00e1","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S.","family":"Rodriguez","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R.","family":"Bartolom\u00e9-Comas","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G.","family":"Roig","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R.","family":"Juv\u00e9","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"Andreu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2016,6,2]]},"reference":[{"issue":"12","key":"2696_CR1","doi-asserted-by":"crossref","first-page":"1401","DOI":"10.2217\/fmb.12.117","volume":"7","author":"M Unemo","year":"2012","unstructured":"Unemo M, Nicholas RA (2012) Emergence of multidrug-resistant, extensively drug-resistant and untreatable gonorrhea. Future Microbiol 7(12):1401\u20131422","journal-title":"Future Microbiol"},{"issue":"4","key":"2696_CR2","doi-asserted-by":"crossref","first-page":"555","DOI":"10.1517\/14656560902731993","volume":"10","author":"PM Barry","year":"2009","unstructured":"Barry PM, Klausner JD (2009) The use of cephalosporins for gonorrhea: the impending problem of resistance. Expert Opin Pharmacother 10(4):555\u2013577","journal-title":"Expert Opin Pharmacother"},{"issue":"6","key":"2696_CR3","doi-asserted-by":"crossref","first-page":"485","DOI":"10.1056\/NEJMp1112456","volume":"366","author":"GA Bolan","year":"2012","unstructured":"Bolan GA, Sparling PF, Wasserheit JN (2012) The emerging threat of untreatable gonococcal infection. N Engl J Med 366(6):485\u2013487","journal-title":"N Engl J Med"},{"key":"2696_CR4","first-page":"1","volume":"63","author":"JR Papp","year":"2014","unstructured":"Papp JR, Schachter J, Gaydos CA et al (2014) Recommendations for the laboratory-based detection of Chlamydia trachomatis and Neisseria gonorrhoeae\u20142014. MMWR 63:1\u201319","journal-title":"MMWR"},{"issue":"45","key":"2696_CR5","doi-asserted-by":"crossref","first-page":"20955","DOI":"10.2807\/1560-7917.ES2014.19.45.20955","volume":"19","author":"MJ Cole","year":"2014","unstructured":"Cole MJ, Spiteri G, Chisholm SA et al (2014) Emerging cephalosporin and multidrug-resistant gonorrhoea in Europe. Euro Surveill 19(45):20955","journal-title":"Euro Surveill"},{"key":"2696_CR6","doi-asserted-by":"crossref","unstructured":"Ison CA, Hussey J, Sankar KN et al (2011) Gonorrhoea treatment failures to cefixime and azithromycin in England, 2010. Euro Surveill 16(14). pii: 19833","DOI":"10.2807\/ese.16.14.19833-en"},{"issue":"7","key":"2696_CR7","doi-asserted-by":"crossref","first-page":"3538","DOI":"10.1128\/AAC.00325-11","volume":"55","author":"M Ohnishi","year":"2011","unstructured":"Ohnishi M, Golparian D, Shimuta K et al (2011) Is Neisseria gonorrhoeae initiating a future Era of untreatable gonorrhea?: detailed characterization of the first strain with high-level resistance to ceftriaxone. Antimicrob Agents Chemother 55(7):3538\u20133545","journal-title":"Antimicrob Agents Chemother"},{"key":"2696_CR8","doi-asserted-by":"crossref","unstructured":"Unemo M, Golparian D, Hestner A (2011) Ceftriaxone treatment failure of pharyngeal gonorrhoea verified by international recommendations, Sweden, July 2010. Euro Surveill 16(6). pii: 19792","DOI":"10.2807\/ese.16.06.19792-en"},{"issue":"3","key":"2696_CR9","doi-asserted-by":"crossref","first-page":"1273","DOI":"10.1128\/AAC.05760-11","volume":"56","author":"M Unemo","year":"2012","unstructured":"Unemo M, Golparian D, Nicholas R et al (2012) High-level cefixime- and ceftriaxone-resistant Neisseria gonorrhoeae in France: novel penA mosaic allele in a successful international clone causes treatment failure. Antimicrob Agents Chemother 56(3):1273\u20131280","journal-title":"Antimicrob Agents Chemother"},{"key":"2696_CR10","doi-asserted-by":"crossref","unstructured":"Unemo M, Golparian D, Stary A et al (2011) First Neisseria gonorrhoeae strain with resistance to cefixime causing gonorrhoea treatment failure in Austria, 2011. Euro Surveill 16(43). pii: 19998","DOI":"10.2807\/ese.16.43.19998-en"},{"issue":"4","key":"2696_CR11","doi-asserted-by":"crossref","first-page":"218","DOI":"10.1016\/j.eimc.2011.11.010","volume":"30","author":"D Carnicer-Pont","year":"2012","unstructured":"Carnicer-Pont D, Smithson A, Fina-Homar E et al (2012) First cases of Neisseria gonorrhoeae resistant to ceftriaxone in Catalonia, Spain, May 2011. Enferm Infecc Microbiol Clin 30(4):218\u2013219","journal-title":"Enferm Infecc Microbiol Clin"},{"issue":"8","key":"2696_CR12","doi-asserted-by":"crossref","first-page":"1858","DOI":"10.1093\/jac\/dks162","volume":"67","author":"J C\u00e1mara","year":"2012","unstructured":"C\u00e1mara J, Serra J, Ayats J et al (2012) Molecular characterization of two high-level ceftriaxone-resistant Neisseria gonorrhoeae isolates detected in Catalonia, Spain. J Antimicrob Chemother 67(8):1858\u20131860","journal-title":"J Antimicrob Chemother"},{"key":"2696_CR13","volume-title":"Gonococcal antimicrobial susceptibility surveillance in Europe, 2013","author":"European Centre for Disease Prevention and Control (ECDC)","year":"2015","unstructured":"European Centre for Disease Prevention and Control (ECDC) (2015) Gonococcal antimicrobial susceptibility surveillance in Europe, 2013. ECDC, Stockholm"},{"key":"2696_CR14","doi-asserted-by":"crossref","unstructured":"Chisholm SA, Unemo M, Quaye N et al (2013) Molecular epidemiological typing within the European Gonococcal Antimicrobial Resistance Surveillance Programme reveals predominance of a multidrug-resistant clone. Euro Surveill 18(3). pii: 20358","DOI":"10.2807\/ese.18.03.20358-en"},{"key":"2696_CR15","doi-asserted-by":"crossref","unstructured":"Unemo M, Golparian D, Syversen G et al (2010) Two cases of verified clinical failures using internationally recommended first-line cefixime for gonorrhoea treatment, Norway, 2010. Euro Surveill 15(47). pii: 19721","DOI":"10.2807\/ese.15.47.19721-en"},{"key":"2696_CR16","unstructured":"European Committee on Antimicrobial Susceptibility Testing (EUCAST). Breakpoint tables for interpretation of MICs and zone diameters. Version 3.1, valid from 2013-02-11, pp 50\u201353. Available online at: http:\/\/www.eucast.org\/fileadmin\/src\/media\/PDFs\/EUCAST_files\/Breakpoint_tables\/Breakpoint_table_v_3.1.pdf"},{"issue":"1","key":"2696_CR17","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1016\/j.ijantimicag.2005.08.021","volume":"27","author":"M Tanaka","year":"2006","unstructured":"Tanaka M, Nakayama H, Huruya K et al (2006) Analysis of mutations within multiple genes associated with resistance in a clinical isolate of Neisseria gonorrhoeae with reduced ceftriaxone susceptibility that shows a multidrug-resistant phenotype. Int J Antimicrob Agents 27(1):20\u201326","journal-title":"Int J Antimicrob Agents"},{"issue":"2","key":"2696_CR18","doi-asserted-by":"crossref","first-page":"703","DOI":"10.1128\/AAC.00788-10","volume":"55","author":"VG Allen","year":"2011","unstructured":"Allen VG, Farrell DJ, Rebbapragada A et al (2011) Molecular analysis of antimicrobial resistance mechanisms in Neisseria gonorrhoeae isolates from Ontario, Canada. Antimicrob Agents Chemother 55(2):703\u2013712","journal-title":"Antimicrob Agents Chemother"},{"issue":"10","key":"2696_CR19","doi-asserted-by":"crossref","first-page":"3741","DOI":"10.1128\/JCM.40.10.3741-3749.2002","volume":"40","author":"M Unemo","year":"2002","unstructured":"Unemo M, Olc\u00e9n P, Berglund T et al (2002) Molecular epidemiology of Neisseria gonorrhoeae: sequence analysis of the porB gene confirms presence of Two circulating strains. J Clin Microbiol 40(10):3741\u20133749","journal-title":"J Clin Microbiol"},{"issue":"8","key":"2696_CR20","doi-asserted-by":"crossref","first-page":"1497","DOI":"10.1086\/383047","volume":"189","author":"IM Martin","year":"2004","unstructured":"Martin IM, Ison CA, Aanensen DM et al (2004) Rapid sequence-based identification of gonococcal transmission clusters in a large metropolitan area. J Infect Dis 189(8):1497\u20131505","journal-title":"J Infect Dis"},{"issue":"12","key":"2696_CR21","doi-asserted-by":"crossref","first-page":"665","DOI":"10.1016\/j.jfma.2012.03.015","volume":"111","author":"C-C Chen","year":"2012","unstructured":"Chen C-C, Lin K-Y, Li S-Y (2012) The role of penicillin-binding protein 2 (PBP2) in the cephalosporin susceptibility of Neisseria gonorrhoeae and the need for consensus in naming of PBP2. J Formos Med Assoc 111(12):665\u2013666","journal-title":"J Formos Med Assoc"},{"issue":"9","key":"2696_CR22","doi-asserted-by":"crossref","first-page":"579","DOI":"10.1016\/j.eimc.2013.03.010","volume":"31","author":"J Serra-Pladevall","year":"2013","unstructured":"Serra-Pladevall J, Barber\u00e1-Gracia MJ, Roig-Carbajosa G et al (2013) Neisseria gonorrhoeae: resistencias antimicrobianas y estudio de la din\u00e1mica poblacional. Situaci\u00f3n en 2011 en Barcelona. Enferm Infecc Microbiol Clin 31(9):579\u2013583","journal-title":"Enferm Infecc Microbiol Clin"},{"issue":"9","key":"2696_CR23","doi-asserted-by":"crossref","first-page":"3744","DOI":"10.1128\/AAC.00304-09","volume":"53","author":"S Zhao","year":"2009","unstructured":"Zhao S, Duncan M, Tomberg J et al (2009) Genetics of chromosomally mediated intermediate resistance to ceftriaxone and cefixime in Neisseria gonorrhoeae. Antimicrob Agents Chemother 53(9):3744\u20133751","journal-title":"Antimicrob Agents Chemother"},{"issue":"3","key":"2696_CR24","doi-asserted-by":"crossref","first-page":"769","DOI":"10.1128\/AAC.46.3.769-777.2002","volume":"46","author":"PA Ropp","year":"2002","unstructured":"Ropp PA, Hu M, Olesky M et al (2002) Mutations in ponA, the gene encoding penicillin-binding protein 1, and a novel locus, penC, are required for high-level chromosomally mediated penicillin resistance in Neisseria gonorrhoeae. Antimicrob Agents Chemother 46(3):769\u2013777","journal-title":"Antimicrob Agents Chemother"},{"issue":"6","key":"2696_CR25","doi-asserted-by":"crossref","first-page":"1510","DOI":"10.1093\/jac\/dkt543","volume":"69","author":"SD Thakur","year":"2014","unstructured":"Thakur SD, Starnino S, Horsman GB et al (2014) Unique combined penA\/mtrR\/porB mutations and NG-MAST strain types associated with ceftriaxone and cefixime MIC increases in a \u2018susceptible\u2019 Neisseria gonorrhoeae population. J Antimicrob Chemother 69(6):1510\u20131516","journal-title":"J Antimicrob Chemother"},{"issue":"4","key":"2696_CR26","doi-asserted-by":"crossref","first-page":"316","DOI":"10.1097\/OLQ.0b013e3182401b69","volume":"39","author":"I Martin","year":"2012","unstructured":"Martin I, Sawatzky P, Allen V et al (2012) Emergence and characterization of Neisseria gonorrhoeae isolates with decreased susceptibilities to ceftriaxone and cefixime in Canada: 2001\u20132010. Sex Transm Dis 39(4):316\u2013323","journal-title":"Sex Transm Dis"},{"issue":"6","key":"2696_CR27","doi-asserted-by":"crossref","first-page":"2117","DOI":"10.1128\/AAC.01604-06","volume":"51","author":"R Lindberg","year":"2007","unstructured":"Lindberg R, Fredlund H, Nicholas R et al (2007) Neisseria gonorrhoeae isolates with reduced susceptibility to cefixime and ceftriaxone: association with genetic polymorphisms in penA, mtrR, porB1b, and ponA. Antimicrob Agents Chemother 51(6):2117\u20132122","journal-title":"Antimicrob Agents Chemother"},{"issue":"3","key":"2696_CR28","doi-asserted-by":"crossref","first-page":"1516","DOI":"10.1128\/AAC.05481-11","volume":"56","author":"R Heymans","year":"2012","unstructured":"Heymans R, Bruisten SM, Golparian D et al (2012) Clonally related Neisseria gonorrhoeae isolates with decreased susceptibility to the extended-spectrum cephalosporin cefotaxime in amsterdam, the Netherlands. Antimicrob Agents Chemother 56(3):1516\u20131522","journal-title":"Antimicrob Agents Chemother"},{"issue":"10","key":"2696_CR29","doi-asserted-by":"crossref","first-page":"5871","DOI":"10.1128\/AAC.00103-14","volume":"58","author":"A Carannante","year":"2014","unstructured":"Carannante A, Renna G, Dal Conte I et al (2014) Changing antimicrobial resistance profiles among Neisseria gonorrhoeae isolates in Italy, 2003 to 2012. Antimicrob Agents Chemother 58(10):5871\u20135876","journal-title":"Antimicrob Agents Chemother"},{"issue":"6","key":"2696_CR30","doi-asserted-by":"crossref","first-page":"1517","DOI":"10.1093\/jac\/dku026","volume":"69","author":"S Jeverica","year":"2014","unstructured":"Jeverica S, Golparian D, Mati\u010di\u010d M et al (2014) Phenotypic and molecular characterization of Neisseria gonorrhoeae isolates from Slovenia, 2006\u201312: rise and fall of the multidrug-resistant NG-MAST genogroup 1407 clone? J Antimicrob Chemother 69(6):1517\u20131525","journal-title":"J Antimicrob Chemother"}],"container-title":["European Journal of Clinical Microbiology &amp; Infectious Diseases"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s10096-016-2696-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s10096-016-2696-7\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s10096-016-2696-7","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,6,30]],"date-time":"2022-06-30T23:47:43Z","timestamp":1656632863000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s10096-016-2696-7"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,6,2]]},"references-count":30,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2016,9]]}},"alternative-id":["2696"],"URL":"https:\/\/doi.org\/10.1007\/s10096-016-2696-7","relation":{},"ISSN":["0934-9723","1435-4373"],"issn-type":[{"value":"0934-9723","type":"print"},{"value":"1435-4373","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,6,2]]}}}