{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,28]],"date-time":"2026-03-28T18:29:59Z","timestamp":1774722599782,"version":"3.50.1"},"reference-count":34,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2016,9,17]],"date-time":"2016-09-17T00:00:00Z","timestamp":1474070400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"funder":[{"name":"Belgian Society for Infectiology and Clinical Microbiology","award":["KW\/1392\/LBV\/001\/013"],"award-info":[{"award-number":["KW\/1392\/LBV\/001\/013"]}]},{"name":"Belgian Antibiotic Policy Coordination Committee","award":["KW\/1392\/LBV\/001\/013\/023"],"award-info":[{"award-number":["KW\/1392\/LBV\/001\/013\/023"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Eur J Clin Microbiol Infect Dis"],"published-print":{"date-parts":[[2017,1]]},"DOI":"10.1007\/s10096-016-2776-8","type":"journal-article","created":{"date-parts":[[2016,9,17]],"date-time":"2016-09-17T10:39:26Z","timestamp":1474108766000},"page":"105-113","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":27,"title":["Uropathogen distribution and antimicrobial susceptibility in uncomplicated cystitis in Belgium, a high antibiotics prescribing country: 20-year surveillance"],"prefix":"10.1007","volume":"36","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1097-4987","authenticated-orcid":false,"given":"S.","family":"Heytens","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.","family":"Boelens","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G.","family":"Claeys","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"DeSutter","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"T.","family":"Christiaens","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2016,9,17]]},"reference":[{"key":"2776_CR1","unstructured":"Verheij RA, van Dijk CE, Abrahamse H, Davids R, van den Hoogen H, Braspenning J et al (2009) Landelijk informatienetwerk Huisartsenzorg. Feiten en cijfers over huisartsenzorg in Nederland. NIVEL\/IQ healthcare, Utrecht\/Nijmegen"},{"key":"2776_CR2","doi-asserted-by":"crossref","first-page":"5S","DOI":"10.1016\/S0002-9343(02)01054-9","volume":"113","author":"B Foxman","year":"2002","unstructured":"Foxman B (2002) Epidemiology of urinary tract infections: incidence, morbidity, and economic costs. Am J Med 113:5S\u201313S","journal-title":"Am J Med"},{"key":"2776_CR3","doi-asserted-by":"crossref","first-page":"1164","DOI":"10.1016\/j.eururo.2008.05.010","volume":"54","author":"KG Naber","year":"2008","unstructured":"Naber KG, Schito G, Botto H, Palou J, Mazzei T (2008) Surveillance study in Europe and Brazil on clinical aspects and Antimicrobial Resistance Epidemiology in Females with Cystitis (ARESC): implications for empiric therapy. Eur Urol 54:1164\u20131178","journal-title":"Eur Urol"},{"key":"2776_CR4","doi-asserted-by":"crossref","first-page":"364","DOI":"10.1093\/jac\/dkn197","volume":"62","author":"D Backer De","year":"2008","unstructured":"De Backer D, Christiaens T, Heytens S, De Sutter A, Stobberingh EE, Verschraegen G (2008) Evolution of bacterial susceptibility pattern of Escherichia coli in uncomplicated urinary tract infections in a country with high antibiotic consumption: a comparison of two surveys with a 10 year interval. J Antimicrob Chemother 62:364\u2013368","journal-title":"J Antimicrob Chemother"},{"key":"2776_CR5","doi-asserted-by":"crossref","first-page":"c199","DOI":"10.1136\/bmj.c199","volume":"340","author":"P Little","year":"2010","unstructured":"Little P, Moore MV, Turner S, Rumsby K, Warner G, Lowes JA et al (2010) Effectiveness of five different approaches in management of urinary tract infection: randomised controlled trial. BMJ 340:c199","journal-title":"BMJ"},{"key":"2776_CR6","unstructured":"Scottish Intercollegiate Guidelines Network (SIGN) (2012) Management of suspected bacterial urinary tract infection in adults. SIGN publication no. 88 [July 2012]. SIGN: Edinburgh. Available online at: http:\/\/www.sign.ac.uk\/pdf\/sign88.pdf"},{"key":"2776_CR7","doi-asserted-by":"crossref","first-page":"e103","DOI":"10.1093\/cid\/ciq257","volume":"52","author":"K Gupta","year":"2011","unstructured":"Gupta K, Hooton TM, Naber KG, Wullt B, Colgan R, Miller LG et al (2011) International clinical practice guidelines for the treatment of acute uncomplicated cystitis and pyelonephritis in women: a 2010 update by the Infectious Diseases Society of America and the European Society for Microbiology and Infectious Diseases. Clin Infect Dis 52:e103\u2013e120","journal-title":"Clin Infect Dis"},{"key":"2776_CR8","doi-asserted-by":"crossref","first-page":"1000","DOI":"10.1093\/jac\/dkl368","volume":"58","author":"CA McNulty","year":"2006","unstructured":"McNulty CA, Richards J, Livermore DM, Little P, Charlett A, Freeman E et al (2006) Clinical relevance of laboratory-reported antibiotic resistance in acute uncomplicated urinary tract infection in primary care. J Antimicrob Chemother 58:1000\u20131008","journal-title":"J Antimicrob Chemother"},{"key":"2776_CR9","doi-asserted-by":"crossref","first-page":"S34","DOI":"10.1128\/JCM.00788-11","volume":"49","author":"EM Burd","year":"2011","unstructured":"Burd EM, Kehl KS (2011) A critical appraisal of the role of the clinical microbiology laboratory in the diagnosis of urinary tract infections. J Clin Microbiol 49:S34\u2013S38","journal-title":"J Clin Microbiol"},{"key":"2776_CR10","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1080\/028134302317282743","volume":"20","author":"TC Christiaens","year":"2002","unstructured":"Christiaens TC, Digranes A, Baerheim A (2002) The relation between sale of antimicrobial drugs and antibiotic resistance in uropathogens in general practice. Scand J Prim Health Care 20:45\u201349","journal-title":"Scand J Prim Health Care"},{"key":"2776_CR11","doi-asserted-by":"crossref","first-page":"1396","DOI":"10.1093\/jac\/dkr088","volume":"66","author":"CA McNulty","year":"2011","unstructured":"McNulty CA, Lasseter GM, Charlett A, Lovering A, Howell-Jones R, MacGowan A et al (2011) Does laboratory antibiotic susceptibility reporting influence primary care prescribing in urinary tract infection and other infections? J Antimicrob Chemother 66:1396\u20131404","journal-title":"J Antimicrob Chemother"},{"issue":"4","key":"2776_CR12","doi-asserted-by":"crossref","first-page":"744","DOI":"10.1128\/CMR.00023-13","volume":"26","author":"PL Woerther","year":"2013","unstructured":"Woerther PL, Burdet C, Chachaty E, Andremont A (2013) Trends in human fecal carriage of extended-spectrum \u03b2-lactamases in the community: toward the globalization of CTX-M. Clin Microbiol Rev 26(4):744\u2013758","journal-title":"Clin Microbiol Rev"},{"key":"2776_CR13","doi-asserted-by":"crossref","first-page":"1076","DOI":"10.1093\/jac\/dkv441","volume":"71","author":"EA Reuland","year":"2016","unstructured":"Reuland EA, Al Naiemi N, Kaiser AM, Heck M, Kluytmans JA, Savelkoul PH et al (2016) Prevalence and risk factors for carriage of ESBL-producing Enterobacteriaceae in Amsterdam. J Antimicrob Chemother 71:1076\u20131082","journal-title":"J Antimicrob Chemother"},{"key":"2776_CR14","doi-asserted-by":"crossref","first-page":"501","DOI":"10.1111\/joim.12342","volume":"277","author":"T T\u00e4ngd\u00e9n","year":"2015","unstructured":"T\u00e4ngd\u00e9n T, Giske CG (2015) Global dissemination of extensively drug-resistant carbapenemase-producing Enterobacteriaceae: clinical perspectives on detection, treatment and infection control. J Intern Med 277:501\u2013512","journal-title":"J Intern Med"},{"key":"2776_CR15","doi-asserted-by":"crossref","first-page":"184","DOI":"10.1080\/17843286.1998.11754161","volume":"53","author":"TH Christiaens","year":"1998","unstructured":"Christiaens TH, Heytens S, Verschraegen G, De Meyere M, De Maeseneer J (1998) Which bacteria are found in Belgian women with uncomplicated urinary tract infections in primary health care, and what is their susceptibility pattern anno 95\u201396? Acta Clin Belg 53:184\u2013188","journal-title":"Acta Clin Belg"},{"key":"2776_CR16","doi-asserted-by":"crossref","first-page":"547","DOI":"10.1128\/CMR.00072-12","volume":"26","author":"AE Clark","year":"2013","unstructured":"Clark AE, Kaleta EJ, Arora A, Wolk DM (2013) Matrix-assisted laser desorption ionization-time of flight mass spectrometry: a fundamental shift in the routine practice of clinical microbiology. Clin Microbiol Rev 26:547\u2013603","journal-title":"Clin Microbiol Rev"},{"issue":"4","key":"2776_CR17","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1046\/j.1198-743x.2001.00237.x","volume":"7","author":"O Aspevall","year":"2001","unstructured":"Aspevall O, Hallander H, Gant V, Kouri T (2001) European guidelines for urinalysis: a collaborative document produced by European clinical microbiologists and clinical chemists under ECLM in collaboration with ESCMID. Clin Microbiol Infect 7(4):173\u2013178","journal-title":"Clin Microbiol Infect"},{"key":"2776_CR18","unstructured":"European Committee on Antimicrobial Susceptibility Testing (EUCAST). Clinical breakpoints. Available online at: http:\/\/www.eucast.org\/clinical_breakpoints\/"},{"key":"2776_CR19","unstructured":"Clinical and Laboratory Standards Institute (CLSI) (2006) Performance standards for antimicrobial disk susceptibility tests; Approved standard\u2014Ninth edition. CLSI document M2-A9. CLSI, Wayne, PA, USA"},{"key":"2776_CR20","unstructured":"National Committee for Clinical Laboratory Standards (NCCLS) (1995) Urinalysis and collection, transportation, and preservation of urine specimens. NCCLS document GP16-A. NCCLS, Wayne, PA, USA"},{"issue":"4","key":"2776_CR21","doi-asserted-by":"crossref","first-page":"810","DOI":"10.1093\/jac\/dkl545","volume":"59","author":"L L\u00f3pez-Cerero","year":"2007","unstructured":"L\u00f3pez-Cerero L, de Cueto M, D\u00edaz-Guerrero MA, Morillo C, Pascual A (2007) Evaluation of the Etest method for fosfomycin susceptibility of ESBL-producing Klebsiella pneumoniae. J Antimicrob Chemother 59(4):810\u2013812","journal-title":"J Antimicrob Chemother"},{"key":"2776_CR22","unstructured":"Clinical and Laboratory Standards Institute (CLSI) (2013) Performance standards for antimicrobial susceptibility testing; Twenty-third informational supplement. CLSI document M100-S23. CLSI, Wayne, PA, USA"},{"key":"2776_CR23","unstructured":"European Committee on Antimicrobial Susceptibility Testing (EUCAST). Rationale documents. Fosfomycin trometamol. Available online at: http:\/\/www.eucast.org\/fileadmin\/src\/media\/PDFs\/EUCAST_files\/Rationale_documents\/Fosfomycin_trometamol_rationale_1.0_20130203.pdf"},{"key":"2776_CR24","unstructured":"European Committee on Antimicrobial Susceptibility Testing (EUCAST). MIC distributions and ECOFFs. Available online at: http:\/\/www.eucast.org\/mic_distributions_and_ecoffs\/"},{"key":"2776_CR25","doi-asserted-by":"crossref","first-page":"41","DOI":"10.7326\/0003-4819-135-1-200107030-00012","volume":"135","author":"K Gupta","year":"2001","unstructured":"Gupta K, Hooton TM, Stamm WE (2001) Increasing antimicrobial resistance and the management of uncomplicated community-acquired urinary tract infections. Ann Intern Med 135:41\u201350","journal-title":"Ann Intern Med"},{"key":"2776_CR26","unstructured":"den Heijer CDJ, Donker GA, Maes J, Stobberingh EE (2011) Antibiotica bij ongecompliceerde urineweginfecties: geen toename van resistentie in de afgelopen 5 jaar. Ned Tijdschr Geneesk 154(A2858)"},{"key":"2776_CR27","doi-asserted-by":"crossref","first-page":"222","DOI":"10.1186\/1471-2334-12-222","volume":"12","author":"G Kamenski","year":"2012","unstructured":"Kamenski G, Wagner G, Zehetmayer S, Fink W, Spiegel W, Hoffmann K (2012) Antibacterial resistances in uncomplicated urinary tract infections in women: ECO\u00b7SENS II data from primary health care in Austria. BMC Infect Dis 12:222","journal-title":"BMC Infect Dis"},{"key":"2776_CR28","doi-asserted-by":"crossref","first-page":"844","DOI":"10.1001\/jama.2014.303","volume":"311","author":"L Mody","year":"2014","unstructured":"Mody L, Juthani-Mehta M (2014) Urinary tract infections in older women: a clinical review. JAMA 311:844\u2013854","journal-title":"JAMA"},{"key":"2776_CR29","doi-asserted-by":"crossref","first-page":"1159","DOI":"10.1007\/s10096-011-1202-5","volume":"30","author":"H Str\u00f6mdahl","year":"2011","unstructured":"Str\u00f6mdahl H, Tham J, Melander E, Walder M, Edquist PJ, Odenholt I (2011) Prevalence of faecal ESBL carriage in the community and in a hospital setting in a county of southern Sweden. Eur J Clin Microbiol Infect Dis 30:1159\u20131162","journal-title":"Eur J Clin Microbiol Infect Dis"},{"key":"2776_CR30","unstructured":"Rijksinstituut voor ziekte- en invaliditeitsverzekering (RIZIV). Farmaceutische kengetallen (2013) An annual overview of the antibiotic prescriptions in DDD (defined daily doses) of general practitioners, specialists and dentists from 2005 up to 2013. Available online at: http:\/\/www.riziv.fgov.be\/nl\/statistieken\/geneesmiddel\/Paginas\/statistieken-geneesmiddelen-farmanet-01.aspx#.Vjk9gMuFN-E"},{"key":"2776_CR31","doi-asserted-by":"crossref","first-page":"320","DOI":"10.1016\/j.prevetmed.2012.02.020","volume":"105","author":"D Persoons","year":"2012","unstructured":"Persoons D, Dewulf J, Smet A, Herman L, Heyndrickx M, Martel A et al (2012) Antimicrobial use in Belgian broiler production. Prev Vet Med 105:320\u2013325","journal-title":"Prev Vet Med"},{"key":"2776_CR32","doi-asserted-by":"crossref","first-page":"4508","DOI":"10.1128\/AAC.00721-09","volume":"53","author":"S Maraki","year":"2009","unstructured":"Maraki S, Samonis G, Rafailidis PI, Vouloumanou EK, Mavromanolakis E, Falagas ME (2009) Susceptibility of urinary tract bacteria to fosfomycin. Antimicrob Agents Chemother 53:4508\u20134510","journal-title":"Antimicrob Agents Chemother"},{"key":"2776_CR33","doi-asserted-by":"crossref","first-page":"1951","DOI":"10.1007\/s40265-013-0143-y","volume":"73","author":"GM Keating","year":"2013","unstructured":"Keating GM (2013) Fosfomycin trometamol: a review of its use as a single-dose oral treatment for patients with acute lower urinary tract infections and pregnant women with asymptomatic bacteriuria. Drugs 73:1951\u20131966","journal-title":"Drugs"},{"key":"2776_CR34","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1016\/S0924-8579(98)00021-1","volume":"10","author":"MA Minassian","year":"1998","unstructured":"Minassian MA, Lewis DA, Chattopadhyay D, Bovill B, Duckworth GJ, Williams JD (1998) A comparison between single-dose fosfomycin trometamol (Monuril) and a 5-day course of trimethoprim in the treatment of uncomplicated lower urinary tract infection in women. Int J Antimicrob Agents 10:39\u201347","journal-title":"Int J Antimicrob Agents"}],"container-title":["European Journal of Clinical Microbiology &amp; Infectious Diseases"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s10096-016-2776-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s10096-016-2776-8\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s10096-016-2776-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,9,13]],"date-time":"2019-09-13T13:46:53Z","timestamp":1568382413000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s10096-016-2776-8"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,9,17]]},"references-count":34,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2017,1]]}},"alternative-id":["2776"],"URL":"https:\/\/doi.org\/10.1007\/s10096-016-2776-8","relation":{},"ISSN":["0934-9723","1435-4373"],"issn-type":[{"value":"0934-9723","type":"print"},{"value":"1435-4373","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,9,17]]}}}