{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,3]],"date-time":"2026-08-03T05:09:07Z","timestamp":1785733747834,"version":"3.56.0"},"reference-count":18,"publisher":"Springer Science and Business Media LLC","issue":"4","license":[{"start":{"date-parts":[[2016,11,28]],"date-time":"2016-11-28T00:00:00Z","timestamp":1480291200000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Eur J Clin Microbiol Infect Dis"],"published-print":{"date-parts":[[2017,4]]},"DOI":"10.1007\/s10096-016-2855-x","type":"journal-article","created":{"date-parts":[[2016,11,28]],"date-time":"2016-11-28T12:47:27Z","timestamp":1480337247000},"page":"603-609","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["The slippery difficulty of ever containing drug resistance with current practices"],"prefix":"10.1007","volume":"36","author":[{"given":"R.","family":"Fullybright","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2016,11,28]]},"reference":[{"issue":"1","key":"2855_CR1","doi-asserted-by":"publisher","first-page":"184","DOI":"10.1111\/j.1476-5381.2011.01250.x","volume":"163","author":"A Coates","year":"2011","unstructured":"Coates A, Halls G, Hu Y (2011) Novel classes of antibiotics or more of the same? Br J Pharmacol 163(1):184\u2013194. doi: 10.1111\/j.1476-5381.2011.01250.x","journal-title":"Br J Pharmacol"},{"key":"2855_CR2","doi-asserted-by":"publisher","first-page":"7","DOI":"10.1038\/ja.2013.49","volume":"67","author":"C Walsh","year":"2014","unstructured":"Walsh C, Wencewicz T (2014) Prospects for new antibiotics: a molecule-centered perspective. J Antibiot 67:7\u201322. doi: 10.1038\/ja.2013.49","journal-title":"J Antibiot"},{"issue":"8","key":"2855_CR3","doi-asserted-by":"publisher","first-page":"1259","DOI":"10.1007\/s10096-016-2659-z","volume":"35","author":"R Fullybright","year":"2016","unstructured":"Fullybright R, Dwivedi A, Mallawaarachchi I et al (2016) Modeling and predicting drug resistance rate and strength. Eur J Clin Microbiol Infect Dis 35(8):1259\u20131267. doi: 10.1007\/s10096-016-2659-z","journal-title":"Eur J Clin Microbiol Infect Dis"},{"key":"2855_CR4","unstructured":"US Food and Drug Administration (2016) Battle of the bugs: fighting antibiotic resistance. US Food and Drug Administration. 2016. Retrieved September 2016 from http:\/\/www.fda.gov\/drugs\/resourcesforyou\/consumers\/ucm143568.htm"},{"issue":"4","key":"2855_CR5","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1099\/00222615-2-4-457","volume":"2","author":"ME Thomas","year":"1969","unstructured":"Thomas ME, Datta N (1969) Emergence of Shigella sonnei resistant to kanamycin and to nalidixic acid without exposure to these drugs. J Med Microbiol 2(4):457\u2013461","journal-title":"J Med Microbiol"},{"key":"2855_CR6","unstructured":"Fullybright R. Characterization of biological resistance and successful drug resistance control in medicine. [Under review with the journal Front Microbiol]"},{"key":"2855_CR7","doi-asserted-by":"publisher","unstructured":"Fullybright R (2016) Quantification of biological resistance: a unifying unit and scale of resistance. SDRP J Biomed Eng. doi: 10.15436\/SDRP-JBE.1.1.4","DOI":"10.15436\/SDRP-JBE.1.1.4"},{"key":"2855_CR8","unstructured":"Review on Antimicrobial Resistance (2016) Tackling drug-resistant infections globally: An overview of our work. Wellcome Trust. London. February 2016. Retrieved September 2016 from https:\/\/amr-review.org\/sites\/default\/files\/Tackling%20drug-resistant%20infections%20-%20An%20overview%20of%20our%20work_IncVaccineLR_NOCROPS.pdf"},{"key":"2855_CR9","unstructured":"World Health Organization (2015) Global action plan on antimicrobial resistance. Geneva. World Health Organization; 2015. Retrieved September 2016 from http:\/\/www.wpro.who.int\/entity\/drug_resistance\/resources\/global_action_plan_eng.pdf"},{"key":"2855_CR10","unstructured":"Review on Antimicrobial Resistance (2015) Securing new drugs for future generations: the pipeline of antibiotics. Wellcome Trust. London. May 2015. Retrieved September 2016 from http:\/\/amr-review.org\/sites\/default\/files\/SECURING%20NEW%20DRUGS%20FOR%20FUTURE%20GENERATIONS%20FINAL%20WEB_0.pdf"},{"key":"2855_CR11","volume-title":"The killers within: the deadly rise of drug-resistant bacteria","author":"M Plotkin","year":"2002","unstructured":"Plotkin M, Shnayerson M (2002) The killers within: the deadly rise of drug-resistant bacteria. Little, Brown, & Co., Boston, 320 pp"},{"key":"2855_CR12","volume-title":"Antimicrobial resistance in bacteria","author":"C Amabile-Cuevas","year":"2006","unstructured":"Amabile-Cuevas C (2006) Antimicrobial resistance in bacteria. Taylor & Francis, London, 210 pp"},{"key":"2855_CR13","volume-title":"Rising Plague: the global threat from deadly bacteria and our dwindling arsenal to fight them","author":"B Spellberg","year":"2009","unstructured":"Spellberg B (2009) Rising Plague: the global threat from deadly bacteria and our dwindling arsenal to fight them. Prometheus Books, Amherst, 264 pp"},{"key":"2855_CR14","unstructured":"Chan M (2012) Antimicrobial resistance in the European Union and the world: keynote address at the conference on combating antimicrobial resistance: time for action. Copenhagen, Denmark. March 2012. World Health Organization. Retrieved September 2016 from http:\/\/www.who.int\/dg\/speeches\/2012\/amr_20120314\/en\/"},{"key":"2855_CR15","unstructured":"Alliance for the Prudent Use of Antibiotics (2016) General background: about antibiotic resistance. Tufts University School of Medicine. 136 Harrison Ave, Boston, MA. Retrieved September 2016 from http:\/\/www.tufts.edu\/med\/apua\/about_issue\/about_antibioticres.shtml"},{"issue":"6","key":"2855_CR16","doi-asserted-by":"publisher","first-page":"697","DOI":"10.1016\/j.arcmed.2005.06.009","volume":"36","author":"A Alanis","year":"2005","unstructured":"Alanis A (2005) Resistance to antibiotics: are we in the post-antibiotic era? Arch Med Res 36(6):697\u2013705. doi: 10.1016\/j.arcmed.2005.06.009","journal-title":"Arch Med Res"},{"key":"2855_CR17","unstructured":"PEW Charitable Trusts (.) How antibiotic resistance happens. The Pew Campaign on Human Health and Industrial Farming. Retrieved September 2016 from www.saveantibiotics.org"},{"issue":"1A","key":"2855_CR18","first-page":"139","volume":"20","author":"S Martin-Aragon","year":"2000","unstructured":"Martin-Aragon S, Mukherjee SK, Taylor BJ, Ivy SP, Fu CH, Ardi VC, Avramis VI (2000) Cytosine arabinoside (ara-C) resistance confers cross-resistance or collateral sensitivity to other classes of anti-leukemic drugs. Anticancer Res 20(1A):139\u2013150","journal-title":"Anticancer Res"}],"container-title":["European Journal of Clinical Microbiology &amp; Infectious Diseases"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s10096-016-2855-x.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s10096-016-2855-x\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s10096-016-2855-x.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2017,6,25]],"date-time":"2017-06-25T04:37:48Z","timestamp":1498365468000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s10096-016-2855-x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,11,28]]},"references-count":18,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2017,4]]}},"alternative-id":["2855"],"URL":"https:\/\/doi.org\/10.1007\/s10096-016-2855-x","relation":{},"ISSN":["0934-9723","1435-4373"],"issn-type":[{"value":"0934-9723","type":"print"},{"value":"1435-4373","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,11,28]]}}}