{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,4]],"date-time":"2026-08-04T00:18:44Z","timestamp":1785802724512,"version":"3.56.0"},"reference-count":29,"publisher":"Springer Science and Business Media LLC","issue":"8","license":[{"start":{"date-parts":[[2017,3,23]],"date-time":"2017-03-23T00:00:00Z","timestamp":1490227200000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"funder":[{"name":"Asan Institute for Life Sciences, Asan Medical Center (KR)","award":["2015-616"],"award-info":[{"award-number":["2015-616"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Eur J Clin Microbiol Infect Dis"],"published-print":{"date-parts":[[2017,8]]},"DOI":"10.1007\/s10096-017-2956-1","type":"journal-article","created":{"date-parts":[[2017,3,24]],"date-time":"2017-03-24T01:55:02Z","timestamp":1490320502000},"page":"1473-1481","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Phenotypic changes of methicillin-resistant Staphylococcus aureus during vancomycin therapy for persistent bacteraemia and related clinical outcome"],"prefix":"10.1007","volume":"36","author":[{"given":"T.","family":"Kim","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E. S.","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S. Y.","family":"Park","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H.","family":"Sung","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.-N.","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.-H.","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.-O.","family":"Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.-H.","family":"Choi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.-Y.","family":"Jeong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J. H.","family":"Woo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1672-3185","authenticated-orcid":false,"given":"Y. P.","family":"Chong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Y. S.","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2017,3,23]]},"reference":[{"issue":"17","key":"2956_CR1","doi-asserted-by":"crossref","first-page":"1861","DOI":"10.1001\/archinte.167.17.1861","volume":"167","author":"C Hawkins","year":"2007","unstructured":"Hawkins C, Huang J, Jin N, Noskin GA, Zembower TR, Bolon M (2007) Persistent Staphylococcus aureus bacteremia: an analysis of risk factors and outcomes. Arch Intern Med 167(17):1861\u20131867","journal-title":"Arch Intern Med"},{"issue":"1","key":"2956_CR2","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1080\/00365540802441711","volume":"41","author":"R Khatib","year":"2009","unstructured":"Khatib R, Johnson LB, Sharma M, Fakih MG, Ganga R, Riederer K (2009) Persistent Staphylococcus aureus bacteremia: incidence and outcome trends over time. Scand J Infect Dis 41(1):4\u20139","journal-title":"Scand J Infect Dis"},{"issue":"6","key":"2956_CR3","doi-asserted-by":"crossref","first-page":"1140","DOI":"10.1086\/423145","volume":"190","author":"VG Fowler Jr","year":"2004","unstructured":"Fowler VG Jr, Sakoulas G, McIntyre LM, Meka VG, Arbeit RD, Cabell CH, Stryjewski ME, Eliopoulos GM, Reller LB, Corey GR, Jones T, Lucindo N, Yeaman MR, Bayer AS (2004) Persistent bacteremia due to methicillin-resistant Staphylococcus aureus infection is associated with agr dysfunction and low-level in vitro resistance to thrombin-induced platelet microbicidal protein. J Infect Dis 190(6):1140\u20131149","journal-title":"J Infect Dis"},{"issue":"2","key":"2956_CR4","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1097\/MD.0b013e318289ff1e","volume":"92","author":"YP Chong","year":"2013","unstructured":"Chong YP, Park SJ, Kim HS, Kim ES, Kim MN, Park KH, Kim SH, Lee SO, Choi SH, Jeong JY, Woo JH, Kim YS (2013) Persistent Staphylococcus aureus bacteremia: a prospective analysis of risk factors, outcomes, and microbiologic and genotypic characteristics of isolates. Medicine 92(2):98\u2013108","journal-title":"Medicine"},{"issue":"1","key":"2956_CR5","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1007\/s15010-012-0348-0","volume":"41","author":"SY Park","year":"2013","unstructured":"Park SY, Chong YP, Park HJ, Park KH, Moon SM, Jeong JY, Kim MN, Kim SH, Lee SO, Choi SH, Woo JH, Kim YS (2013) agr Dysfunction and persistent methicillin-resistant Staphylococcus aureus bacteremia in patients with removed eradicable foci. Infection 41(1):111\u2013119","journal-title":"Infection"},{"issue":"3","key":"2956_CR6","doi-asserted-by":"crossref","first-page":"228","DOI":"10.1016\/j.diagmicrobio.2010.02.026","volume":"67","author":"EA Neuner","year":"2010","unstructured":"Neuner EA, Casabar E, Reichley R, McKinnon PS (2010) Clinical, microbiologic, and genetic determinants of persistent methicillin-resistant Staphylococcus aureus bacteremia. Diagn Microbiol Infect Dis 67(3):228\u2013233","journal-title":"Diagn Microbiol Infect Dis"},{"issue":"5","key":"2956_CR7","doi-asserted-by":"crossref","first-page":"390","DOI":"10.1016\/j.ijantimicag.2013.07.010","volume":"42","author":"JL Wang","year":"2013","unstructured":"Wang JL, Lai CH, Lin HH, Chen WF, Shih YC, Hung CH (2013) High vancomycin minimum inhibitory concentrations with heteroresistant vancomycin-intermediate Staphylococcus aureus in meticillin-resistant S. aureus bacteraemia patients. Int J Antimicrob Agents 42(5):390\u2013394","journal-title":"Int J Antimicrob Agents"},{"issue":"2","key":"2956_CR8","doi-asserted-by":"crossref","first-page":"575","DOI":"10.1128\/AAC.01028-10","volume":"55","author":"K Seidl","year":"2011","unstructured":"Seidl K, Bayer AS, Fowler VG Jr, McKinnell JA, Abdel Hady W, Sakoulas G, Yeaman MR, Xiong YQ (2011) Combinatorial phenotypic signatures distinguish persistent from resolving methicillin-resistant Staphylococcus aureus bacteremia isolates. Antimicrob Agents Chemother 55(2):575\u2013582","journal-title":"Antimicrob Agents Chemother"},{"issue":"9","key":"2956_CR9","doi-asserted-by":"crossref","first-page":"3039","DOI":"10.1128\/AAC.00422-06","volume":"50","author":"BP Howden","year":"2006","unstructured":"Howden BP, Johnson PD, Ward PB, Stinear TP, Davies JK (2006) Isolates with low-level vancomycin resistance associated with persistent methicillin-resistant Staphylococcus aureus bacteremia. Antimicrob Agents Chemother 50(9):3039\u20133047","journal-title":"Antimicrob Agents Chemother"},{"issue":"9","key":"2956_CR10","doi-asserted-by":"crossref","first-page":"1328","DOI":"10.1086\/383036","volume":"38","author":"A Khosrovaneh","year":"2004","unstructured":"Khosrovaneh A, Riederer K, Saeed S, Tabriz MS, Shah AR, Hanna MM, Sharma M, Johnson LB, Fakih MG, Khatib R (2004) Frequency of reduced vancomycin susceptibility and heterogeneous subpopulation in persistent or recurrent methicillin-resistant Staphylococcus aureus bacteremia. Clin Infect Dis 38(9):1328\u20131330","journal-title":"Clin Infect Dis"},{"issue":"5","key":"2956_CR11","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1016\/0021-9681(87)90171-8","volume":"40","author":"ME Charlson","year":"1987","unstructured":"Charlson ME, Pompei P, Ales KL, MacKenzie CR (1987) A new method of classifying prognostic comorbidity in longitudinal studies: development and validation. J Chronic Dis 40(5):373\u2013383","journal-title":"J Chronic Dis"},{"issue":"8","key":"2956_CR12","doi-asserted-by":"crossref","first-page":"585","DOI":"10.7326\/0003-4819-115-8-585","volume":"115","author":"JW Chow","year":"1991","unstructured":"Chow JW, Fine MJ, Shlaes DM, Quinn JP, Hooper DC, Johnson MP, Ramphal R, Wagener MM, Miyashiro DK, Yu VL (1991) Enterobacter bacteremia: clinical features and emergence of antibiotic resistance during therapy. Ann Intern Med 115(8):585\u2013590","journal-title":"Ann Intern Med"},{"issue":"3","key":"2956_CR13","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1016\/0196-6553(88)90053-3","volume":"16","author":"JS Garner","year":"1988","unstructured":"Garner JS, Jarvis WR, Emori TG, Horan TC, Hughes JM (1988) CDC definitions for nosocomial infections, 1988. Am J Infect Control 16(3):128\u2013140","journal-title":"Am J Infect Control"},{"issue":"1","key":"2956_CR14","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1086\/599376","volume":"49","author":"LA Mermel","year":"2009","unstructured":"Mermel LA, Allon M, Bouza E, Craven DE, Flynn P, O\u2019Grady NP, Raad II, Rijnders BJ, Sherertz RJ, Warren DK (2009) Clinical practice guidelines for the diagnosis and management of intravascular catheter-related infection: 2009 Update by the Infectious Diseases Society of America. Clin Infect Dis 49(1):1\u201345","journal-title":"Clin Infect Dis"},{"issue":"3","key":"2956_CR15","doi-asserted-by":"crossref","first-page":"200","DOI":"10.1016\/0002-9343(94)90143-0","volume":"96","author":"DT Durack","year":"1994","unstructured":"Durack DT, Lukes AS, Bright DK (1994) New criteria for diagnosis of infective endocarditis: utilization of specific echocardiographic findings. Duke Endocarditis Service. Am J Med 96(3):200\u2013209","journal-title":"Am J Med"},{"issue":"14","key":"2956_CR16","doi-asserted-by":"crossref","first-page":"1422","DOI":"10.1056\/NEJMra035415","volume":"350","author":"RO Darouiche","year":"2004","unstructured":"Darouiche RO (2004) Treatment of infections associated with surgical implants. N Engl J Med 350(14):1422\u20131429","journal-title":"N Engl J Med"},{"issue":"10","key":"2956_CR17","doi-asserted-by":"crossref","first-page":"791","DOI":"10.7326\/0003-4819-137-10-200211190-00007","volume":"137","author":"ND Friedman","year":"2002","unstructured":"Friedman ND, Kaye KS, Stout JE, McGarry SA, Trivette SL, Briggs JP, Lamm W, Clark C, MacFarquhar J, Walton AL, Reller LB, Sexton DJ (2002) Health care-associated bloodstream infections in adults: a reason to change the accepted definition of community-acquired infections. Ann Intern Med 137(10):791\u2013797","journal-title":"Ann Intern Med"},{"issue":"4","key":"2956_CR18","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1093\/jac\/47.4.399","volume":"47","author":"M Wootton","year":"2001","unstructured":"Wootton M, Howe RA, Hillman R, Walsh TR, Bennett PM, MacGowan AP (2001) A modified population analysis profile (PAP) method to detect hetero-resistance to vancomycin in Staphylococcus aureus in a UK hospital. J Antimicrob Chemother 47(4):399\u2013403","journal-title":"J Antimicrob Chemother"},{"issue":"2","key":"2956_CR19","doi-asserted-by":"crossref","first-page":"631","DOI":"10.1128\/IAI.70.2.631-641.2002","volume":"70","author":"S Jarraud","year":"2002","unstructured":"Jarraud S, Mougel C, Thioulouse J, Lina G, Meugnier H, Forey F, Nesme X, Etienne J, Vandenesch F (2002) Relationships between Staphylococcus aureus genetic background, virulence factors, agr groups (alleles), and human disease. Infect Immun 70(2):631\u2013641","journal-title":"Infect Immun"},{"issue":"Pt 8","key":"2956_CR20","doi-asserted-by":"crossref","first-page":"2265","DOI":"10.1099\/mic.0.2007\/011874-0","volume":"154","author":"KE Traber","year":"2008","unstructured":"Traber KE, Lee E, Benson S, Corrigan R, Cantera M, Shopsin B, Novick RP (2008) agr function in clinical Staphylococcus aureus isolates. Microbiol (Reading, England) 154(Pt 8):2265\u20132274","journal-title":"Microbiol (Reading, England)"},{"issue":"7","key":"2956_CR21","doi-asserted-by":"crossref","first-page":"2155","DOI":"10.1128\/AAC.46.7.2155-2161.2002","volume":"46","author":"DC Oliveira","year":"2002","unstructured":"Oliveira DC, de Lencastre H (2002) Multiplex PCR strategy for rapid identification of structural types and variants of the mec element in methicillin-resistant Staphylococcus aureus. Antimicrob Agents Chemother 46(7):2155\u20132161","journal-title":"Antimicrob Agents Chemother"},{"issue":"3","key":"2956_CR22","doi-asserted-by":"crossref","first-page":"1509","DOI":"10.1128\/AAC.01260-12","volume":"57","author":"YP Chong","year":"2013","unstructured":"Chong YP, Kim ES, Park S-J, Park K-H, Kim T, Kim M-N, Kim S-H, Lee S-O, Choi S-H, Woo JH, Jeong J-Y, Kim YS (2013) Accessory gene regulator (agr) dysfunction in Staphylococcus aureus bloodstream isolates from South Korean patients. Antimicrob Agents Chemother 57(3):1509\u20131512","journal-title":"Antimicrob Agents Chemother"},{"issue":"3","key":"2956_CR23","doi-asserted-by":"crossref","first-page":"1008","DOI":"10.1128\/JCM.38.3.1008-1015.2000","volume":"38","author":"MC Enright","year":"2000","unstructured":"Enright MC, Day NP, Davies CE, Peacock SJ, Spratt BG (2000) Multilocus sequence typing for characterization of methicillin-resistant and methicillin-susceptible clones of Staphylococcus aureus. J Clin Microbiol 38(3):1008\u20131015","journal-title":"J Clin Microbiol"},{"issue":"8","key":"2956_CR24","doi-asserted-by":"crossref","first-page":"1792","DOI":"10.1093\/jac\/dkq188","volume":"65","author":"SH Lin","year":"2010","unstructured":"Lin SH, Liao WH, Lai CC, Liao CH, Tan CK, Wang CY, Huang YT, Hsueh PR (2010) Risk factors for mortality in patients with persistent methicillin-resistant Staphylococcus aureus bacteraemia in a tertiary care hospital in Taiwan. J Antimicrob Chemother 65(8):1792\u20131798","journal-title":"J Antimicrob Chemother"},{"issue":"5","key":"2956_CR25","doi-asserted-by":"crossref","first-page":"1492","DOI":"10.1128\/AAC.46.5.1492-1502.2002","volume":"46","author":"G Sakoulas","year":"2002","unstructured":"Sakoulas G, Eliopoulos GM, Moellering RC Jr, Wennersten C, Venkataraman L, Novick RP, Gold HS (2002) Accessory gene regulator (agr) locus in geographically diverse Staphylococcus aureus isolates with reduced susceptibility to vancomycin. Antimicrob Agents Chemother 46(5):1492\u20131502","journal-title":"Antimicrob Agents Chemother"},{"issue":"Suppl 1","key":"2956_CR26","doi-asserted-by":"crossref","first-page":"S40","DOI":"10.1086\/491713","volume":"42","author":"G Sakoulas","year":"2006","unstructured":"Sakoulas G, Moellering RC Jr, Eliopoulos GM (2006) Adaptation of methicillin-resistant Staphylococcus aureus in the face of vancomycin therapy. Clin Infect Dis 42(Suppl 1):S40\u201350","journal-title":"Clin Infect Dis"},{"issue":"3","key":"2956_CR27","doi-asserted-by":"crossref","first-page":"1082","DOI":"10.1128\/AAC.00918-10","volume":"55","author":"ML Schweizer","year":"2011","unstructured":"Schweizer ML, Furuno JP, Sakoulas G, Johnson JK, Harris AD, Shardell MD, McGregor JC, Thom KA, Perencevich EN (2011) Increased mortality with accessory gene regulator (agr) dysfunction in Staphylococcus aureus among bacteremic patients. Antimicrob Agents Chemother 55(3):1082\u20131087","journal-title":"Antimicrob Agents Chemother"},{"issue":"6","key":"2956_CR28","doi-asserted-by":"crossref","first-page":"1688","DOI":"10.1086\/317606","volume":"182","author":"C Vuong","year":"2000","unstructured":"Vuong C, Saenz HL, Gotz F, Otto M (2000) Impact of the agr quorum-sensing system on adherence to polystyrene in Staphylococcus aureus. J Infect Dis 182(6):1688\u20131693","journal-title":"J Infect Dis"},{"issue":"9","key":"2956_CR29","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pbio.1002229","volume":"13","author":"M Laabei","year":"2015","unstructured":"Laabei M, Uhlemann A-C, Lowy FD, Austin ED, Yokoyama M, Ouadi K, Feil E, Thorpe HA, Williams B, Perkins M, Peacock SJ, Clarke SR, Dordel J, Holden M, Votintseva AA, Bowden R, Crook DW, Young BC, Wilson DJ, Recker M, Massey RC (2015) Evolutionary trade-offs underlie the multi-faceted virulence of staphylococcus aureus. PLoS Biol 13(9), e1002229","journal-title":"PLoS Biol"}],"container-title":["European Journal of Clinical Microbiology & Infectious Diseases"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s10096-017-2956-1\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s10096-017-2956-1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s10096-017-2956-1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,10,4]],"date-time":"2020-10-04T08:57:03Z","timestamp":1601801823000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s10096-017-2956-1"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,3,23]]},"references-count":29,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2017,8]]}},"alternative-id":["2956"],"URL":"https:\/\/doi.org\/10.1007\/s10096-017-2956-1","relation":{},"ISSN":["0934-9723","1435-4373"],"issn-type":[{"value":"0934-9723","type":"print"},{"value":"1435-4373","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,3,23]]}}}