{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,18]],"date-time":"2026-06-18T13:09:53Z","timestamp":1781788193479,"version":"3.54.5"},"reference-count":58,"publisher":"Springer Science and Business Media LLC","issue":"10","license":[{"start":{"date-parts":[[2017,5,3]],"date-time":"2017-05-03T00:00:00Z","timestamp":1493769600000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"funder":[{"DOI":"10.13039\/501100003407","name":"Ministero dell\u2019Istruzione, dell\u2019Universit\u00e0 e della Ricerca","doi-asserted-by":"publisher","award":["2012WJSX8K_005"],"award-info":[{"award-number":["2012WJSX8K_005"]}],"id":[{"id":"10.13039\/501100003407","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Eur J Clin Microbiol Infect Dis"],"published-print":{"date-parts":[[2017,10]]},"DOI":"10.1007\/s10096-017-2987-7","type":"journal-article","created":{"date-parts":[[2017,5,3]],"date-time":"2017-05-03T11:44:40Z","timestamp":1493811880000},"page":"1739-1748","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":37,"title":["Synergistic activity of synthetic N-terminal peptide of human lactoferrin in combination with various antibiotics against carbapenem-resistant Klebsiella pneumoniae strains"],"prefix":"10.1007","volume":"36","author":[{"given":"P.","family":"Morici","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"W.","family":"Florio","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.","family":"Rizzato","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E.","family":"Ghelardi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Tavanti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G. M.","family":"Rossolini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6975-8114","authenticated-orcid":false,"given":"A.","family":"Lupetti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2017,5,3]]},"reference":[{"key":"2987_CR1","doi-asserted-by":"publisher","first-page":"895","DOI":"10.3389\/fmicb.2016.00895","volume":"7","author":"CR Lee","year":"2016","unstructured":"Lee CR, Lee JH, Park KS, Kim YB, Jeong BC, Lee SH (2016) Global dissemination of carbapenemase-producing Klebsiella pneumoniae: epidemiology, genetic context, treatment options, and detection methods. Front Microbiol 7:895. doi: 10.3389\/fmicb.2016.00895","journal-title":"Front Microbiol"},{"issue":"8","key":"2987_CR2","doi-asserted-by":"publisher","first-page":"1664","DOI":"10.1093\/jac\/dkq210","volume":"65","author":"A Tsakris","year":"2010","unstructured":"Tsakris A, Poulou A, Pournaras S, Voulgari E, Vrioni G, Themeli-Digalaki K et al (2010) A simple phenotypic method for the differentiation of metallo-beta-lactamases and class a KPC carbapenemases in Enterobacteriaceae clinical isolates. J Antimicrob Chemother 65(8):1664\u20131671. doi: 10.1093\/jac\/dkq210","journal-title":"J Antimicrob Chemother"},{"issue":"3","key":"2987_CR3","doi-asserted-by":"publisher","first-page":"S8","DOI":"10.1016\/S0924-8579(10)70004-2","volume":"36","author":"TR Walsh","year":"2010","unstructured":"Walsh TR (2010) Emerging carbapenemases: a global perspective. Int J Antimicrob Agents 36(3):S8\u2013S14. doi: 10.1016\/S0924-8579(10)70004-2","journal-title":"Int J Antimicrob Agents"},{"issue":"10","key":"2987_CR4","doi-asserted-by":"publisher","first-page":"1791","DOI":"10.3201\/eid1710.110655","volume":"17","author":"P Nordmann","year":"2011","unstructured":"Nordmann P, Naas T, Poirel L (2011) Global spread of carbapenemase-producing Enterobacteriaceae. Emerg Infect Dis 17(10):1791\u20131798. doi: 10.3201\/eid1710.110655","journal-title":"Emerg Infect Dis"},{"issue":"5","key":"2987_CR5","doi-asserted-by":"publisher","first-page":"413","DOI":"10.1111\/j.1469-0691.2012.03821.x","volume":"18","author":"R Cant\u00f2n","year":"2012","unstructured":"Cant\u00f2n R, Ak\u00f2va M, Carmeli Y, Giske CG, Glupczynski Y, Gniadkowski M et al (2012) The European network on Carbapenemases. Rapid evolution and spread of carbapenemases among Enterobacteriaceae in Europe. Clin Microbiol Infect 18(5):413\u2013431. doi: 10.1111\/j.1469-0691.2012.03821.x","journal-title":"Clin Microbiol Infect"},{"issue":"4","key":"2987_CR6","doi-asserted-by":"publisher","first-page":"228","DOI":"10.1016\/S1473-3099(09)70054-4","volume":"9","author":"P Nordmann","year":"2009","unstructured":"Nordmann P, Cuzon G, Naas T (2009) The real threat of Klebsiella pneumoniae carbapenemase-producing bacteria. Lancet Infect Dis 9(4):228\u2013236. doi: 10.1016\/S1473-3099(09)70054-4","journal-title":"Lancet Infect Dis"},{"issue":"10","key":"2987_CR7","doi-asserted-by":"publisher","first-page":"3558","DOI":"10.1128\/JCM.01106-10","volume":"48","author":"A Elemam","year":"2010","unstructured":"Elemam A, Rahimian J, Doymaz M (2010) In vitro evaluation of antibiotic synergy for polymyxin B-resistant carbapenemase-producing Klebsiella pneumoniae. J Clin Microbiol 48(10):3558\u20133562. doi: 10.1128\/JCM.01106-10","journal-title":"J Clin Microbiol"},{"issue":"Suppl 1","key":"2987_CR8","doi-asserted-by":"publisher","first-page":"i29","DOI":"10.1093\/jac\/dkp255","volume":"64","author":"D Livermore","year":"2009","unstructured":"Livermore D (2009) Has the era of untreatable infections arrived? J Antimicrob Chemother 64(Suppl 1):i29\u2013i36. doi: 10.1093\/jac\/dkp255","journal-title":"J Antimicrob Chemother"},{"issue":"10","key":"2987_CR9","doi-asserted-by":"publisher","first-page":"972","DOI":"10.1086\/605922","volume":"30","author":"A Borer","year":"2009","unstructured":"Borer A, Saidel-Odes L, Riesenberg K, Eskira S, Peled N, Nativ R et al (2009) Attributable mortality rate for carbapenem resistant Klebsiella pneumoniae bacteremia. Infect Control Hosp Epidemiol 30(10):972\u2013976. doi: 10.1086\/605922","journal-title":"Infect Control Hosp Epidemiol"},{"issue":"3","key":"2987_CR10","doi-asserted-by":"publisher","first-page":"364","DOI":"10.1086\/649865","volume":"50","author":"M Souli","year":"2010","unstructured":"Souli M, Galani I, Antoniadou A, Papadomichelakis E, Poulakou G, Panagea T et al (2010) An outbreak of infection due to \u03b2-lactamase Klebsiella pneumoniae carbapenemase 2-producing K. pneumoniae in a Greek University hospital: molecular characterization, epidemiology, and outcomes. Clin Infect Dis 50(3):364\u2013373. doi: 10.1086\/649865","journal-title":"Clin Infect Dis"},{"issue":"5","key":"2987_CR11","doi-asserted-by":"publisher","first-page":"895","DOI":"10.1093\/jac\/dkn311","volume":"62","author":"T Kelesidis","year":"2008","unstructured":"Kelesidis T, Karageorgopoulos DE, Kelesidis I, Falagas ME (2008) Tigecycline for the treatment of multidrug-resistant Enterobacteriaceae: a systematic review of the evidence from microbiological and clinical studies. J Antimicrob Chemoter 62(5):895\u2013904. doi: 10.1093\/jac\/dkn311","journal-title":"J Antimicrob Chemoter"},{"key":"2987_CR12","doi-asserted-by":"publisher","first-page":"133","DOI":"10.2147\/IDR.S26613","volume":"5","author":"LF Chen","year":"2012","unstructured":"Chen LF, Anderson DJ, Paterson DL (2012) Overview of the epidemiology and the threat of K. pneumoniae carbapenemases (KPC) resistance. Infect Drug Resist 5:133\u2013141. doi: 10.2147\/IDR.S26613","journal-title":"Infect Drug Resist"},{"issue":"10","key":"2987_CR13","doi-asserted-by":"publisher","first-page":"3341","DOI":"10.1128\/JCM.01017-15","volume":"53","author":"T Giani","year":"2015","unstructured":"Giani T, Arena F, Vaggelli G, Conte V, Chiarelli A, Henrici De Angelis L et al (2015) Large nosocomial outbreak of colistin-resistant, carbapenemase-producing Klebsiella pneumoniae traced to clonal expansion of an mgrB deletion mutant. J Clin Microbiol 53(10):3341\u20133344. doi: 10.1128\/JCM.01017-15","journal-title":"J Clin Microbiol"},{"issue":"8","key":"2987_CR14","doi-asserted-by":"publisher","first-page":"4516","DOI":"10.1128\/AAC.00234-12","volume":"56","author":"T Spanu","year":"2012","unstructured":"Spanu T, De Angelis G, Cipriani M, Pedruzzi B, D\u2019Inzeo T, Cataldo MA et al (2012) In vivo emergence of tigecycline resistance in multidrug-resistant Klebsiella pneumoniae and Escherichia coli. Antimicrob Agents Chemother 56(8):4516\u20134518. doi: 10.1128\/AAC.00234-12","journal-title":"Antimicrob Agents Chemother"},{"issue":"1","key":"2987_CR15","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1086\/595011","volume":"48","author":"HW Boucher","year":"2009","unstructured":"Boucher HW, Talbot GH, Bradley JS, Edwards JE, Gilbert D, Rice LB et al (2009) Bad bugs, no drugs: no eskape! An update from the Infectious Diseases Society of America. Clin Infect Dis 48(1):1\u201312. doi: 10.1086\/595011","journal-title":"Clin Infect Dis"},{"issue":"4","key":"2987_CR16","doi-asserted-by":"publisher","first-page":"228","DOI":"10.1159\/000331009","volume":"20","author":"SA Baltzer","year":"2011","unstructured":"Baltzer SA, Brown MH (2011) Antimicrobial peptides\u2014promising alternatives to conventional antibiotics. J Mol Microbiol Biotechnol 20(4):228\u2013235. doi: 10.1159\/000331009","journal-title":"J Mol Microbiol Biotechnol"},{"issue":"8","key":"2987_CR17","doi-asserted-by":"crossref","first-page":"2334","DOI":"10.1016\/j.bmcl.2007.01.075","volume":"17","author":"C Appelt","year":"2007","unstructured":"Appelt C, Schrey AK, Soderhall JA, Schmieder P (2007) Design of antimicrobial compounds based on peptide structures. Bioorg Med Chem Lett 17(8):2334\u20132337","journal-title":"Bioorg Med Chem Lett"},{"issue":"4","key":"2987_CR18","doi-asserted-by":"publisher","first-page":"301.e1","DOI":"10.1016\/j.ijantimicag.2008.07.020","volume":"33","author":"SA Gonz\u00e1lez-Ch\u00e1vez","year":"2009","unstructured":"Gonz\u00e1lez-Ch\u00e1vez SA, Ar\u00e9valo-Gallegos S, Rasc\u00f3n-Cruz Q (2009) Lactoferrin: structure, function and applications. Int J Antimicrob Agents 33(4):301.e1\u2013301.e8. doi: 10.1016\/j.ijantimicag.2008.07.020","journal-title":"Int J Antimicrob Agents"},{"issue":"1","key":"2987_CR19","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1006\/bbrc.2000.3284","volume":"275","author":"LV Deriy","year":"2000","unstructured":"Deriy LV, Chor J, Thomas LL (2000) Surface expression of lactoferrin by resting neutrophils. Biochem Biophys Res Commun 275(1):241\u2013246","journal-title":"Biochem Biophys Res Commun"},{"issue":"12","key":"2987_CR20","doi-asserted-by":"crossref","first-page":"3257","DOI":"10.1128\/AAC.44.12.3257-3263.2000","volume":"44","author":"A Lupetti","year":"2000","unstructured":"Lupetti A, Paulusma-Annema A, Welling MM, Senesi S, van Dissel JT, Nibbering PH (2000) Candidacidal activities of human lactoferrin peptides derived from the N terminus. Antimicrob Agents Chemother 44(12):3257\u20133263","journal-title":"Antimicrob Agents Chemother"},{"issue":"3","key":"2987_CR21","doi-asserted-by":"crossref","first-page":"1469","DOI":"10.1128\/IAI.69.3.1469-1476.2001","volume":"69","author":"PH Nibbering","year":"2001","unstructured":"Nibbering PH, Ravensbergen WMM, van Berkel LA, van Berkel PH, Pauwels EK et al (2001) Human lactoferrin and peptides derived from its N terminus are highly effective against infection with antibiotic-resistant bacteria. Infect Immun 69(3):1469\u20131476","journal-title":"Infect Immun"},{"issue":"1","key":"2987_CR22","doi-asserted-by":"crossref","first-page":"262","DOI":"10.1128\/AAC.47.1.262-267.2003","volume":"47","author":"A Lupetti","year":"2003","unstructured":"Lupetti A, Paulusma-Annema A, Welling MM, Dogterom-Ballering H, Brouwer CP, Senesi S et al (2003) Synergistic activity of the N-terminal peptide of human lactoferrin and fluconazole against Candida species. Antimicrob Agents Chemother 47(1):262\u2013267","journal-title":"Antimicrob Agents Chemother"},{"issue":"12","key":"2987_CR23","doi-asserted-by":"crossref","first-page":"4919","DOI":"10.1128\/AAC.48.12.4919-4921.2004","volume":"48","author":"L Dijkshoorn","year":"2004","unstructured":"Dijkshoorn L, Brouwer CP, Bogaards SJ, Nemec A, van den Broek PJ, Nibbering PH (2004) The synthetic N-terminal peptide of human lactoferrin, hLF(1-11), is highly effective against experimental infection caused by multidrug-resistant Acinetobacter baumannii. Antimicrob Agents Chemother 48(12):4919\u20134921","journal-title":"Antimicrob Agents Chemother"},{"issue":"9","key":"2987_CR24","doi-asserted-by":"crossref","first-page":"1416","DOI":"10.1086\/522427","volume":"196","author":"A Lupetti","year":"2007","unstructured":"Lupetti A, Brouwer PJM, Bogaards SJP, Welling MM, de Heer E, Campa M et al (2007) Human lactoferrin-derived peptide\u2019s antifungal activities against disseminated Candida albicans infection. J Infect Dis 196(9):1416\u20131424","journal-title":"J Infect Dis"},{"issue":"11","key":"2987_CR25","doi-asserted-by":"publisher","first-page":"1125","DOI":"10.1007\/s10096-008-0553-z","volume":"27","author":"A Lupetti","year":"2008","unstructured":"Lupetti A, van Dissel JT, Brouwer CPJM, Nibbering PH (2008) Human antimicrobial peptides\u2019 antifungal activity against Aspergillus fumigatus. Eur J Clin Microbiol Infect Dis 27(11):1125\u20131129. doi: 10.1007\/s10096-008-0553-z","journal-title":"Eur J Clin Microbiol Infect Dis"},{"issue":"4","key":"2987_CR26","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1016\/S1473-3099(03)00579-6","volume":"3","author":"A Lupetti","year":"2003","unstructured":"Lupetti A, Welling MM, Pauwels EK, Nibbering PH (2003) Radiolabelled antimicrobial peptides for infection detection. Lancet Infect Dis 3(4):223\u2013229","journal-title":"Lancet Infect Dis"},{"issue":"10","key":"2987_CR27","doi-asserted-by":"publisher","first-page":"582","DOI":"10.1016\/j.tibtech.2009.07.004","volume":"27","author":"DM Easton","year":"2009","unstructured":"Easton DM, Nijnik A, Mayer ML, Hancock RE (2009) Potential of immunomodulatory host defense peptides as novel anti-infectives. Trends Biotechnol 27(10):582\u2013590. doi: 10.1016\/j.tibtech.2009.07.004","journal-title":"Trends Biotechnol"},{"issue":"21","key":"2987_CR28","doi-asserted-by":"crossref","first-page":"2393","DOI":"10.2174\/138161209788682271","volume":"15","author":"F Niyonsaba","year":"2009","unstructured":"Niyonsaba F, Nagaoka I, Ogawa H, Okumura K (2009) Multifunctional antimicrobial proteins and peptides: natural activators of immune systems. Curr Pharm Des 15(21):2393\u20132413","journal-title":"Curr Pharm Des"},{"issue":"3","key":"2987_CR29","doi-asserted-by":"publisher","first-page":"284","DOI":"10.1159\/000332941","volume":"4","author":"AM Does van der","year":"2012","unstructured":"van der Does AM, Joosten SA, Vroomans E, Bogaards SJ, van Meijgaarden KE, Ottenhoff TH et al (2012) The antimicrobial peptide hLF1-11 drives monocyte-dendritic cell differentiation toward dendritic cells that promote antifungal responses and enhance Th17 polarization. J Innate Immun 4(3):284\u2013292. doi: 10.1159\/000332941","journal-title":"J Innate Immun"},{"issue":"3","key":"2987_CR30","doi-asserted-by":"publisher","first-page":"493","DOI":"10.1007\/s10534-010-9322-4","volume":"23","author":"AM Does van der","year":"2010","unstructured":"van der Does AM, Bogaards SJ, Jonk L, Wulferink M, Velders MP, Nibbering PH (2010) The human lactoferrin-derived peptide hLF1-11 primes monocytes for an enhanced TLR-mediated immune response. Biometals 23(3):493\u2013505. doi: 10.1007\/s10534-010-9322-4","journal-title":"Biometals"},{"issue":"10","key":"2987_CR31","doi-asserted-by":"publisher","first-page":"5012","DOI":"10.4049\/jimmunol.1102777","volume":"188","author":"AM Does van der","year":"2012","unstructured":"van der Does AM, Hensbergen PJ, Bogaards SJ, Cansoy M, Deelder AM, van Leeuwen HC et al (2012) The human lactoferrin-derived peptide hLF1-11 exerts immunomodulatory effects by specific inhibition of myeloperoxidase activity. J Immunol 188(10):5012\u20135019. doi: 10.4049\/jimmunol.1102777","journal-title":"J Immunol"},{"key":"2987_CR32","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1002\/j.1875-9114.1992.tb04478.x","volume":"12","author":"SL Barriere","year":"1992","unstructured":"Barriere SL (1992) Bacterial resistance to beta-lactams, and its prevention with combination antimicrobial therapy. Pharmacotherapy 12:397\u2013402","journal-title":"Pharmacotherapy"},{"issue":"6","key":"2987_CR33","first-page":"585","volume":"107","author":"YL Wu","year":"1999","unstructured":"Wu YL, Scott EM, Po AL, Tariq VN (1999) Development of resistance and cross-resistance in Pseudomonas aeruginosa exposed to subinhibitory antibiotic concentrations. APMIS 107(6):585\u2013592","journal-title":"APMIS"},{"issue":"6","key":"2987_CR34","doi-asserted-by":"publisher","first-page":"703","DOI":"10.1586\/eri.10.38","volume":"8","author":"M Cassone","year":"2010","unstructured":"Cassone M, Otvos L Jr (2010) Synergy among antibacterial peptides and between peptides and small-molecule antibiotics. Expert Rev Anti-Infect Ther 8(6):703\u2013716. doi: 10.1586\/eri.10.38","journal-title":"Expert Rev Anti-Infect Ther"},{"issue":"6","key":"2987_CR35","doi-asserted-by":"publisher","first-page":"685","DOI":"10.1007\/s00284-014-0529-4","volume":"68","author":"Y Zhang","year":"2014","unstructured":"Zhang Y, Liu Y, Sun Y, Liu Q, Wang X, Li Z et al (2014) In vitro synergistic activities of antimicrobial peptide Brevinin-2CE with five kinds of antibiotics against multidrug resistant clinical isolates. Curr Microbiol 68(6):685\u2013692. doi: 10.1007\/s00284-014-0529-4","journal-title":"Curr Microbiol"},{"issue":"11","key":"2987_CR36","doi-asserted-by":"publisher","first-page":"3692","DOI":"10.1128\/JCM.00766-09","volume":"47","author":"L Chen","year":"2009","unstructured":"Chen L, Mediavilla JR, Oliveira DC, Willey BM, de Lencastre H, Kreiswirth BN (2009) Multiplex real-time PCR for rapid staphylococcal cassette chromosome mec typing. J Clin Microbiol 47(11):3692\u20133706. doi: 10.1128\/JCM.00766-09","journal-title":"J Clin Microbiol"},{"issue":"4","key":"2987_CR37","doi-asserted-by":"crossref","first-page":"1151","DOI":"10.1128\/AAC.45.4.1151-1161.2001","volume":"45","author":"H Yigit","year":"2001","unstructured":"Yigit H, Queenan AM, Anderson GJ, Domenech-Sanchez A, Biddle JW, Steward CD et al (2001) Novel carbapenem-hydrolyzing beta-lactamase, KPC-1, from a carbapenem-resistant strain of Klebsiella pneumoniae. Antimicrob Agents Chemother 45(4):1151\u20131161","journal-title":"Antimicrob Agents Chemother"},{"issue":"12","key":"2987_CR38","doi-asserted-by":"publisher","first-page":"1647","DOI":"10.1093\/bioinformatics\/bts199","volume":"28","author":"M Kearse","year":"2012","unstructured":"Kearse M, Moir R, Wilson A, Stones-Havas S, Cheung M, Sturrock S et al (2012) Geneious basic: an integrated and extendable desktop software platform for the organization and analysis of sequence data. Bioinformatics 28(12):1647\u20131649. doi: 10.1093\/bioinformatics\/bts199","journal-title":"Bioinformatics"},{"issue":"22","key":"2987_CR39","doi-asserted-by":"crossref","DOI":"10.2807\/ese.18.22.20489-en","volume":"18","author":"T Giani","year":"2013","unstructured":"Giani T, Pini B, Arena F, Conte V, Bracco S, Migliavacca R, Pantosti A, Pagani L, Luzzaro F, Rossolini GM; AMCLI-CRE Survey Participants (2013) Epidemic diffusion of KPC carbapenemase-producing Klebsiella pneumoniae in Italy: results of the first countrywide survey, 15 May to 30 June 2011. Euro Surveill 18(22):pii 20489","journal-title":"Euro Surveill"},{"key":"2987_CR40","doi-asserted-by":"crossref","first-page":"2071","DOI":"10.1016\/S0196-9781(02)00244-9","volume":"23","author":"M Cudic","year":"2002","unstructured":"Cudic M, Condie BA, Weiner DJ, Lysenko ES, Xiang ZQ, Insug O, Bulet P, Otvos L Jr (2002) Development of novel antibacterial peptides that kill resistant isolates. Peptides 23:2071\u20132083","journal-title":"Peptides"},{"issue":"5","key":"2987_CR41","doi-asserted-by":"crossref","first-page":"1558","DOI":"10.1128\/AAC.45.5.1558-1560.2001","volume":"45","author":"H Yan","year":"2001","unstructured":"Yan H, Hancock REW (2001) Synergistic interactions between mammalian antimicrobial defence peptides. Antimicrob Agents Chemother 45(5):1558\u20131560","journal-title":"Antimicrob Agents Chemother"},{"issue":"11","key":"2987_CR42","doi-asserted-by":"publisher","first-page":"1878","DOI":"10.1016\/j.peptides.2008.07.016","volume":"29","author":"M Cassone","year":"2008","unstructured":"Cassone M, Vogiatzi P, La Montagna R, De Olivier IV, Cudic P, Wade JD, Otvos L Jr (2008) Scope and limitations of the designer proline-rich antibacterial peptide dimer, A3-APO, alone or in synergy with conventional antibiotics. Peptides 29(11):1878\u20131886. doi: 10.1016\/j.peptides.2008.07.016","journal-title":"Peptides"},{"key":"2987_CR43","first-page":"5.18.1","volume-title":"Clinical procedures handbook","author":"JA Moody","year":"1992","unstructured":"Moody JA (1992) Synergism testing: broth microdilution checkerboard and broth macrodilution methods. In: Isenberg HD (ed) Clinical procedures handbook. ASM Press, Washington, pp 5.18.1\u20135.18.28"},{"issue":"1","key":"2987_CR44","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1093\/jac\/dkg301","volume":"52","author":"FC Odds","year":"2003","unstructured":"Odds FC (2003) Synergy, antagonism, and what the chequerboard puts between them. J Antimicrob Chemother 52(1):1. doi: 10.1093\/jac\/dkg301","journal-title":"J Antimicrob Chemother"},{"issue":"1","key":"2987_CR45","doi-asserted-by":"publisher","first-page":"1","DOI":"10.2165\/11597960-000000000-00000","volume":"72","author":"C Schultsz","year":"2012","unstructured":"Schultsz C, Geerlings S (2012) Plasmid-mediated resistance in Enterobacteriaceae: changing landscape and implications for therapy. Drugs 72(1):1\u201316. doi: 10.2165\/11597960-000000000-00000","journal-title":"Drugs"},{"issue":"7","key":"2987_CR46","doi-asserted-by":"publisher","first-page":"4301","DOI":"10.1128\/AAC.00323-15","volume":"59","author":"PV Toledo","year":"2015","unstructured":"Toledo PV, Aranha AA Jr, Arend LN, Ribeiro V, Zavascki AP, Tuon FF (2015) Activity of antimicrobial combinations against KPC-2-producing Klebsiella pneumoniae in a rat model and time-kill assay. Antimicrob Agents Chemother 59(7):4301\u20134304. doi: 10.1128\/AAC.00323-15","journal-title":"Antimicrob Agents Chemother"},{"issue":"3","key":"2987_CR47","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1128\/mBio.00139-10","volume":"1","author":"GL Drusano","year":"2010","unstructured":"Drusano GL, Sgambati N, Eichas A (2010) The combination of rifampin plus moxifloxacin is synergistic for suppression of resistance but antagonistic for cell kill of Mycobacterium tuberculosis as determined in a hollow-fiber infection model. MBio 1(3):1\u20138. doi: 10.1128\/mBio.00139-10","journal-title":"MBio"},{"key":"2987_CR48","doi-asserted-by":"crossref","first-page":"1175","DOI":"10.1093\/molbev\/msv006","volume":"32","author":"M Rodriguez De Evgrafov","year":"2015","unstructured":"Rodriguez De Evgrafov M, Gumpert H, Munck C et al (2015) Collateral resistance and sensitivity modulate evolution of high-level resistance to drug combination treatment in Staphylococcus aureus. Mol Biol Evol 32:1175\u20131185","journal-title":"Mol Biol Evol"},{"key":"2987_CR49","doi-asserted-by":"crossref","first-page":"13977","DOI":"10.1073\/pnas.0805965105","volume":"105","author":"MJ Hegreness","year":"2008","unstructured":"Hegreness MJ, Shoresh N, Damian D et al (2008) Accelerated evolution of resistance in multidrug environments. Proc Natl Acad Sci 105:13977\u201313981","journal-title":"Proc Natl Acad Sci"},{"key":"2987_CR50","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pbio.1001540","volume":"11","author":"R Pena-Miller","year":"2013","unstructured":"Pena-Miller R, Laehnemann D, Jansen G et al (2013) When the most potent combination of antibiotics selects for the greatest bacterial load: the smile\u2013frown transition. PLoS Biol 11:e1001540","journal-title":"PLoS Biol"},{"issue":"1","key":"2987_CR51","doi-asserted-by":"publisher","first-page":"197","DOI":"10.1007\/s10096-014-2219-3","volume":"34","author":"Q Feng","year":"2015","unstructured":"Feng Q, Huang Y, Chen M, Li G, Chen Y (2015) Functional synergy of \u03b1-helical antimicrobial peptides and traditional antibiotics against Gram-negative and Gram-positive bacteria in vitro and in vivo. Eur J Clin Microbiol Infect Dis 34(1):197\u2013204. doi: 10.1007\/s10096-014-2219-3","journal-title":"Eur J Clin Microbiol Infect Dis"},{"issue":"12","key":"2987_CR52","doi-asserted-by":"crossref","first-page":"6366","DOI":"10.1128\/AAC.01180-12","volume":"56","author":"E Mataraci","year":"2012","unstructured":"Mataraci E, Dosler S (2012) In vitro activities of antibiotics and antimicrobial cationic peptides alone and in combination against methicillin-resistant Staphylococcus aureus biofilms. Antimicrob Agents Chemother 56(12):6366\u20136371","journal-title":"Antimicrob Agents Chemother"},{"issue":"3","key":"2987_CR53","doi-asserted-by":"publisher","first-page":"e00021","DOI":"10.1128\/mBio.00021-13","volume":"4","author":"BA Napier","year":"2013","unstructured":"Napier BA, Burd EM, Satola SW, Cagle SM, Ray SM, McGann P et al (2013) Clinical use of colistin induces cross-resistance to host antimicrobials in Acinetobacter baumannii. MBio 4(3):e00021\u2013e00013. doi: 10.1128\/mBio.00021-13","journal-title":"MBio"},{"issue":"8","key":"2987_CR54","doi-asserted-by":"publisher","first-page":"2261","DOI":"10.1093\/jac\/dkv118","volume":"70","author":"C Formosa","year":"2015","unstructured":"Formosa C, Herold M, Vidaillac C, Duval RE, Dague E (2015) Unravelling of a mechanism of resistance to colistin in Klebsiella pneumoniae using atomic force microscopy. J Antimicrob Chemother 70(8):2261\u20132270. doi: 10.1093\/jac\/dkv118","journal-title":"J Antimicrob Chemother"},{"issue":"5","key":"2987_CR55","doi-asserted-by":"crossref","first-page":"853","DOI":"10.1128\/AAC.34.5.853","volume":"34","author":"M Vaara","year":"1990","unstructured":"Vaara M (1990) Antimicrobial susceptibility of Salmonella typhimurium carrying the outer membrane permeability mutation SS-B. Antimicrob Agents Chemother 34(5):853\u2013857","journal-title":"Antimicrob Agents Chemother"},{"key":"2987_CR56","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1093\/jac\/dkt322","volume":"69","author":"H Kim","year":"2014","unstructured":"Kim H, Jang JH, Kim SC, Cho JH (2014) De novo generation of short antimicrobial peptides with enhanced stability and cell specificit\u00e0. J Antimicrob Chemother 69:121\u2013132","journal-title":"J Antimicrob Chemother"},{"key":"2987_CR57","doi-asserted-by":"publisher","first-page":"16020","DOI":"10.1038\/nmicrobiol.2016.20","volume":"1","author":"B Van den Bergh","year":"2016","unstructured":"Van den Bergh B, Michiels JE, Wenseleers T, Windels EM, Boer PV, Kestemont D, De Meester L, Verstrepen KJ, Verstraeten N, Fauvart M, Michiels J (2016) Frequency of antibiotic application drives rapid evolutionary adaptation of Escherichia coli persistence. Nat Microbiol 1:16020. doi: 10.1038\/nmicrobiol.2016.20","journal-title":"Nat Microbiol"},{"key":"2987_CR58","doi-asserted-by":"publisher","first-page":"123","DOI":"10.1016\/j.tox.2012.10.006","volume":"302","author":"M Abed","year":"2012","unstructured":"Abed M, Towhid ST, Shaik N, Lang F (2012) Stimulation of suicidal death of erythrocytes by rifampicin. Toxicology 302:123\u2013128. doi: 10.1016\/j.tox.2012.10.006","journal-title":"Toxicology"}],"container-title":["European Journal of Clinical Microbiology &amp; Infectious Diseases"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s10096-017-2987-7\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s10096-017-2987-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s10096-017-2987-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,6,23]],"date-time":"2024-06-23T22:36:11Z","timestamp":1719182171000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s10096-017-2987-7"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,5,3]]},"references-count":58,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2017,10]]}},"alternative-id":["2987"],"URL":"https:\/\/doi.org\/10.1007\/s10096-017-2987-7","relation":{},"ISSN":["0934-9723","1435-4373"],"issn-type":[{"value":"0934-9723","type":"print"},{"value":"1435-4373","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,5,3]]}}}