{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,5]],"date-time":"2026-06-05T02:11:12Z","timestamp":1780625472682,"version":"3.54.1"},"reference-count":34,"publisher":"Springer Science and Business Media LLC","issue":"11","license":[{"start":{"date-parts":[[2017,8,30]],"date-time":"2017-08-30T00:00:00Z","timestamp":1504051200000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"DOI":"10.13039\/100010418","name":"Defence Science and Technology Laboratory","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100010418","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Eur J Clin Microbiol Infect Dis"],"published-print":{"date-parts":[[2017,11]]},"DOI":"10.1007\/s10096-017-3038-0","type":"journal-article","created":{"date-parts":[[2017,8,30]],"date-time":"2017-08-30T21:33:15Z","timestamp":1504128795000},"page":"2147-2154","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Mitogen-activated protein kinases (MAPKs) are modulated during in vitro and in vivo infection with the intracellular bacterium Burkholderia pseudomallei"],"prefix":"10.1007","volume":"36","author":[{"given":"R. V.","family":"D\u2019Elia","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R. J.","family":"Saint","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S. L.","family":"Newstead","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G. C.","family":"Clark","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H. S.","family":"Atkins","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2017,8,30]]},"reference":[{"key":"3038_CR1","doi-asserted-by":"crossref","first-page":"240","DOI":"10.1128\/CMR.00046-08","volume":"22","author":"TH Mogensen","year":"2009","unstructured":"Mogensen TH (2009) Pathogen recognition and inflammatory signaling in innate immune defenses. Clin Microbiol Rev 22:240\u2013273","journal-title":"Clin Microbiol Rev"},{"key":"3038_CR2","doi-asserted-by":"crossref","first-page":"352","DOI":"10.1016\/j.it.2006.06.003","volume":"27","author":"EM Creagh","year":"2006","unstructured":"Creagh EM, O\u2019Neill LAJ (2006) TLRs, NLRs and RLRs: a trinity of pathogen sensors that co-operate in innate immunity. Trends Immunol 27:352\u2013357","journal-title":"Trends Immunol"},{"key":"3038_CR3","doi-asserted-by":"crossref","first-page":"947","DOI":"10.1038\/ni712","volume":"2","author":"M Schnare","year":"2001","unstructured":"Schnare M, Barton GM, Holt AC, Takeda K, Akira S et al (2001) Toll-like receptors control activation of adaptive immune responses. Nat Immunol 2:947\u2013950","journal-title":"Nat Immunol"},{"key":"3038_CR4","doi-asserted-by":"crossref","first-page":"2734","DOI":"10.1016\/j.molimm.2008.02.010","volume":"45","author":"N Hirata","year":"2008","unstructured":"Hirata N, Yanagawa Y, Ebihara T, Seya T, Uematsu S et al (2008) Selective synergy in anti-inflammatory cytokine production upon cooperated signaling via TLR4 and TLR2 in murine conventional dendritic cells. Mol Immunol 45:2734\u20132742","journal-title":"Mol Immunol"},{"key":"3038_CR5","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1007\/s00418-003-0497-4","volume":"119","author":"D Droemann","year":"2003","unstructured":"Droemann D, Goldmann T, Branscheid D, Clark R, Dalhoff K et al (2003) Toll-like receptor 2 is expressed by alveolar epithelial cells type II and macrophages in the human lung. Histochem Cell Biol 119:103\u2013108","journal-title":"Histochem Cell Biol"},{"key":"3038_CR6","doi-asserted-by":"crossref","first-page":"2712","DOI":"10.1074\/jbc.M305790200","volume":"279","author":"L Guillot","year":"2004","unstructured":"Guillot L, Medjane S, Le-Barillec K, Balloy V, Danel C et al (2004) Response of human pulmonary epithelial cells to lipopolysaccharide involves toll-like receptor 4 (TLR4)-dependent signaling pathways - evidence for an intracellular compartmentalization of TLR4. J Biol Chem 279:2712\u20132718","journal-title":"J Biol Chem"},{"key":"3038_CR7","doi-asserted-by":"crossref","first-page":"80","DOI":"10.3389\/fcimb.2015.00080","volume":"5","author":"J David","year":"2015","unstructured":"David J, Bell RE, Clark GC (2015) Mechanisms of disease: host-pathogen interactions between Burkholderia species and lung epithelial cells. Front Cell Infect Microbiol 5:80","journal-title":"Front Cell Infect Microbiol"},{"key":"3038_CR8","doi-asserted-by":"crossref","first-page":"1268","DOI":"10.1371\/journal.pmed.0040248","volume":"4","author":"WJ Wiersinga","year":"2007","unstructured":"Wiersinga WJ, Wieland CW, Dessing MC, Chantratita N, Cheng AC et al (2007) Toll-like receptor 2 impairs host defense in gram-negative sepsis caused by Burkholderia pseudomallei (Melioidosis). PLoS Med 4:1268\u20131280","journal-title":"PLoS Med"},{"key":"3038_CR9","doi-asserted-by":"crossref","first-page":"868","DOI":"10.1016\/j.micinf.2008.04.019","volume":"10","author":"W Joost Wiersinga","year":"2008","unstructured":"Joost Wiersinga W, Dessing MC, van der Poll T (2008) Gene-expression profiles in murine melioidosis. Microbes Infect 10:868\u2013877","journal-title":"Microbes Infect"},{"key":"3038_CR10","doi-asserted-by":"crossref","first-page":"3248","DOI":"10.4049\/jimmunol.1500641","volume":"195","author":"L Conejero","year":"2015","unstructured":"Conejero L, Potempa K, Graham CM, Spink N, Blankley S et al (2015) The blood transcriptome of experimental Melioidosis reflects disease severity and shows considerable similarity with the human disease. J Immunol 195:3248\u20133261","journal-title":"J Immunol"},{"key":"3038_CR11","doi-asserted-by":"crossref","first-page":"569","DOI":"10.1097\/CCM.0b013e318194b1bf","volume":"37","author":"WJ Wiersinga","year":"2009","unstructured":"Wiersinga WJ, van\u2019t Veer C, van den Pangaart PS, Dondorp AM, Day NP et al (2009) Immunosuppression associated with interleukin-1R-associated-kinase-M upregulation predicts mortality in gram-negative sepsis (melioidosis). Crit Care Med 37:569\u2013576","journal-title":"Crit Care Med"},{"key":"3038_CR12","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1186\/1471-2172-9-46","volume":"9","author":"TE West","year":"2008","unstructured":"West TE, Ernst RK, Jansson-Hutson MJ, Skerrett SJ (2008) Activation of toll-like receptors by Burkholderia pseudomallei. BMC Immunol 9:46","journal-title":"BMC Immunol"},{"key":"3038_CR13","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1111\/j.1365-2958.2006.05519.x","volume":"63","author":"PJ Brett","year":"2007","unstructured":"Brett PJ, Burtnick MN, Snyder DS, Shannon JG, Azadi P et al (2007) Burkholderia mallei expresses a unique lipopolysaccharide mixture that is a potent activator of human toll-like receptor 4 complexes. Mol Microbiol 63:379\u2013390","journal-title":"Mol Microbiol"},{"key":"3038_CR14","doi-asserted-by":"crossref","unstructured":"West T, Hawn T, Skerrett S (2009) Toll-like receptor signaling in airborne Burkholderia thailandensis infection. Infect Immun 77(12):5612\u20135622","DOI":"10.1128\/IAI.00618-09"},{"key":"3038_CR15","doi-asserted-by":"crossref","unstructured":"Oda K, Kitano H (2006) A comprehensive map of the toll-like receptor signaling network. Mol Syst Biol 2:2006.0015","DOI":"10.1038\/msb4100057"},{"key":"3038_CR16","doi-asserted-by":"crossref","first-page":"1512","DOI":"10.1128\/IAI.72.3.1512-1518.2004","volume":"72","author":"CT Welsh","year":"2004","unstructured":"Welsh CT, Summersgill JT, Miller RD (2004) Increases in c-jun n-terminal kinase\/stress-activated protein kinase and p38 activity in monocyte-derived macrophages following the uptake of Legionella pneumophila. Infect Immun 72:1512\u20131518","journal-title":"Infect Immun"},{"key":"3038_CR17","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1016\/j.virusres.2010.02.007","volume":"150","author":"H Zhang","year":"2010","unstructured":"Zhang H, Feng H, Luo LQ, Zhou Q, Luo ZJ et al (2010) Distinct effects of knocking down MEK1 and MEK2 on replication of herpes simplex virus type 2. Virus Res 150:22\u201327","journal-title":"Virus Res"},{"key":"3038_CR18","doi-asserted-by":"crossref","first-page":"1545","DOI":"10.1016\/j.micinf.2007.08.008","volume":"9","author":"C Souza","year":"2007","unstructured":"Souza C, Evanson O, Weiss D (2007) Role of the mitogen-activated protein kinase pathway in the differential response of bovine monocytes to Mycobacterium avium subsp. paratuberculosis and Mycobacterium avium subsp. avium. Microbes Infect 9:1545\u20131552","journal-title":"Microbes Infect"},{"key":"3038_CR19","doi-asserted-by":"crossref","first-page":"320","DOI":"10.1128\/MMBR.68.2.320-344.2004","volume":"68","author":"PP Roux","year":"2004","unstructured":"Roux PP, Blenis J (2004) ERK and p38 MAPK-activated protein kinases: a family of protein kinases with diverse biological functions. Microbiol Mol Biol Rev 68:320\u2013344","journal-title":"Microbiol Mol Biol Rev"},{"key":"3038_CR20","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1186\/s12866-015-0593-3","volume":"15","author":"CY Chiang","year":"2015","unstructured":"Chiang CY, Ulrich RL, Ulrich MP, Eaton B, Ojeda JF et al (2015) Characterization of the murine macrophage response to infection with virulent and avirulent Burkholderia species. BMC Microbiol 15:259","journal-title":"BMC Microbiol"},{"key":"3038_CR21","doi-asserted-by":"crossref","first-page":"e7308","DOI":"10.1371\/journal.pone.0007308","volume":"4","author":"SH Sim","year":"2009","unstructured":"Sim SH, Liu Y, Wang D, Novem V, Sivalingam SP et al (2009) Innate immune responses of pulmonary epithelial cells to Burkholderia pseudomallei infection. PLoS One 4:e7308","journal-title":"PLoS One"},{"key":"3038_CR22","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1017\/S0022172400041851","volume":"67","author":"HA Druett","year":"1969","unstructured":"Druett HA (1969) A mobile form of the Henderson apparatus. J Hyg (Lond) 67:437\u2013448","journal-title":"J Hyg (Lond)"},{"key":"3038_CR23","doi-asserted-by":"crossref","first-page":"2015","DOI":"10.1007\/s10096-016-2754-1","volume":"35","author":"RJ Saint","year":"2016","unstructured":"Saint RJ, D\u2019Elia RV, Bryant C, Clark GC, Atkins HS (2016) Mitogen-activated protein kinases (MAPKs) are modulated during Francisella tularensis infection, but inhibition of extracellular-signal-regulated kinases (ERKs) is of limited therapeutic benefit. Eur J Clin Microbiol Infect Dis 35:2015\u20132024","journal-title":"Eur J Clin Microbiol Infect Dis"},{"key":"3038_CR24","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1111\/j.1365-2613.2008.00619.x","volume":"90","author":"MS Lever","year":"2009","unstructured":"Lever MS, Nelson M, Stagg AJ, Beedham RJ, Simpson AJH (2009) Experimental acute respiratory Burkholderia pseudomallei infection in BALB\/c mice. Int J Exp Pathol 90:16\u201325","journal-title":"Int J Exp Pathol"},{"key":"3038_CR25","doi-asserted-by":"crossref","first-page":"348","DOI":"10.1111\/j.1574-695X.2011.00817.x","volume":"62","author":"R D\u2019Elia","year":"2011","unstructured":"D\u2019Elia R, Jenner DC, Laws TR, Stokes MGM, Jackson MC et al (2011) Inhibition of Francisella tularensis LVS infection of macrophages results in a reduced inflammatory response: evaluation of a therapeutic strategy for intracellular bacteria. FEMS Immunol Med Microbiol 62:348\u2013361","journal-title":"FEMS Immunol Med Microbiol"},{"key":"3038_CR26","doi-asserted-by":"crossref","first-page":"268","DOI":"10.1016\/j.tibs.2006.03.009","volume":"31","author":"LO Murphy","year":"2006","unstructured":"Murphy LO, Blenis J (2006) MAPK signal specificity: the right place at the right time. Trends Biochem Sci 31:268\u2013275","journal-title":"Trends Biochem Sci"},{"key":"3038_CR27","doi-asserted-by":"crossref","first-page":"200","DOI":"10.1080\/07853890600551037","volume":"38","author":"M Kohno","year":"2006","unstructured":"Kohno M, Pouyssegur J (2006) Targeting the ERK signaling pathway in cancer therapy. Ann Med 38:200\u2013211","journal-title":"Ann Med"},{"key":"3038_CR28","doi-asserted-by":"crossref","first-page":"318","DOI":"10.1016\/j.tree.2008.02.011","volume":"23","author":"P Schmid-Hempel","year":"2008","unstructured":"Schmid-Hempel P (2008) Parasite immune evasion: a momentous molecular war. Trends Ecol Evol 23:318\u2013326","journal-title":"Trends Ecol Evol"},{"key":"3038_CR29","doi-asserted-by":"crossref","unstructured":"Ramos JW (2008) The regulation of extracellular signal-regulated kinase (ERK) in mammalian cells. Int J Biochem Cell Biol 40(12):2707\u20132719","DOI":"10.1016\/j.biocel.2008.04.009"},{"key":"3038_CR30","doi-asserted-by":"crossref","first-page":"619","DOI":"10.1016\/j.micinf.2004.12.020","volume":"7","author":"R Hrstka","year":"2005","unstructured":"Hrstka R, Stulik J, Vojtesek B (2005) The role of MAPK signal pathways during Francisella tularensis LVS infection-induced apoptosis in murine macrophages. Microbes Infect 7:619\u2013625","journal-title":"Microbes Infect"},{"key":"3038_CR31","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1007\/s00284-011-9985-2","volume":"63","author":"K Du","year":"2011","unstructured":"Du K, Zheng Q, Zhou M, Zhu L, Ai B et al (2011) Chlamydial Antiapoptotic activity involves activation of the Raf\/MEK\/ERK survival pathway. Curr Microbiol 63:341\u2013346","journal-title":"Curr Microbiol"},{"key":"3038_CR32","doi-asserted-by":"crossref","first-page":"20343","DOI":"10.1074\/jbc.M110.116988","volume":"285","author":"M Asim","year":"2010","unstructured":"Asim M, Chaturvedi R, Hoge S, Lewis ND, Singh K et al (2010) Helicobacter pylori induces ERK-dependent formation of a Phospho-c-Fos.C-Jun activator protein-1 complex that causes apoptosis in macrophages. J Biol Chem 285:20343\u201320357","journal-title":"J Biol Chem"},{"key":"3038_CR33","first-page":"471","volume":"51","author":"TR Laws","year":"2011","unstructured":"Laws TR, Smither SJ, Lukaszewski RA, Atkins HS (2011) Neutrophils are the predominant cell-type to associate with Burkholderia pseudomallei in a BALB\/c mouse model of respiratory melioidosis. MicrobPathog 51:471\u2013475","journal-title":"MicrobPathog"},{"key":"3038_CR34","doi-asserted-by":"crossref","first-page":"1071","DOI":"10.1016\/S0092-8674(00)00210-5","volume":"103","author":"CD Dumitru","year":"2000","unstructured":"Dumitru CD, Ceci JD, Tsatsanis C, Kontoyiannis D, Stamatakis K et al (2000) TNF-alpha induction by LPS is regulated posttranscriptionally via a Tpl2\/ERK-dependent pathway. Cell 103:1071\u20131083","journal-title":"Cell"}],"container-title":["European Journal of Clinical Microbiology & Infectious Diseases"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s10096-017-3038-0\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s10096-017-3038-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s10096-017-3038-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,10,16]],"date-time":"2020-10-16T18:13:26Z","timestamp":1602872006000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s10096-017-3038-0"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,8,30]]},"references-count":34,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2017,11]]}},"alternative-id":["3038"],"URL":"https:\/\/doi.org\/10.1007\/s10096-017-3038-0","relation":{},"ISSN":["0934-9723","1435-4373"],"issn-type":[{"value":"0934-9723","type":"print"},{"value":"1435-4373","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,8,30]]}}}