{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,21]],"date-time":"2026-02-21T11:44:37Z","timestamp":1771674277231,"version":"3.50.1"},"reference-count":29,"publisher":"Springer Science and Business Media LLC","issue":"11","license":[{"start":{"date-parts":[[2017,6,17]],"date-time":"2017-06-17T00:00:00Z","timestamp":1497657600000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"funder":[{"name":"CIBERES","award":["PCI Pneumonia"],"award-info":[{"award-number":["PCI Pneumonia"]}]},{"name":"FISS","award":["12\/02903"],"award-info":[{"award-number":["12\/02903"]}]},{"name":"Sociedad Espa\u00f1ola de Neumolog\u00eda y Cirug\u00eda Tor\u00e1cica (ES)","award":["155\/2015"],"award-info":[{"award-number":["155\/2015"]}]},{"DOI":"10.13039\/501100003030","name":"AGAUR","doi-asserted-by":"crossref","award":["2014-SGR-278"],"award-info":[{"award-number":["2014-SGR-278"]}],"id":[{"id":"10.13039\/501100003030","id-type":"DOI","asserted-by":"crossref"}]},{"name":"FISS- Rio Hortega","award":["CM14-212"],"award-info":[{"award-number":["CM14-212"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Eur J Clin Microbiol Infect Dis"],"published-print":{"date-parts":[[2017,11]]},"DOI":"10.1007\/s10096-017-3039-z","type":"journal-article","created":{"date-parts":[[2017,6,17]],"date-time":"2017-06-17T04:37:45Z","timestamp":1497674265000},"page":"2155-2163","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":25,"title":["The clinical significance of pneumonia in patients with respiratory specimens harbouring multidrug-resistant Pseudomonas aeruginosa: a 5-year retrospective study following 5667 patients in four general ICUs"],"prefix":"10.1007","volume":"36","author":[{"given":"B.","family":"Borgatta","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S.","family":"Gattarello","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C. A.","family":"Mazo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A. T.","family":"Imbiscuso","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M. N.","family":"Larrosa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Luj\u00e0n","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.","family":"Rello","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2017,6,17]]},"reference":[{"key":"3039_CR1","doi-asserted-by":"crossref","first-page":"2323","DOI":"10.1001\/jama.2009.1754","volume":"302","author":"JL Vincent","year":"2009","unstructured":"Vincent JL, Rello J, Marshall J et al (2009) International study of the prevalence and outcomes of infection in intensive care units. JAMA 302:2323\u20132329","journal-title":"JAMA"},{"key":"3039_CR2","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1186\/2047-2994-3-32","volume":"3","author":"D Nathwani","year":"2014","unstructured":"Nathwani D, Raman G, Sulham K et al (2014) Clinical and economic consequences of hospital-acquired resistant and multidrug-resistant Pseudomonas aeruginosa infections: a systematic review and meta-analysis. Antimicrob Resist Infect Control 3:32","journal-title":"Antimicrob Resist Infect Control"},{"key":"3039_CR3","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1016\/j.jcrc.2005.08.005","volume":"21","author":"E Tejerina","year":"2006","unstructured":"Tejerina E, Frutos-Vivar F, Restrepo MI et al (2006) Incidence, risk factors, and outcome of ventilator-associated pneumonia. J Crit Care 21:56\u201365","journal-title":"J Crit Care"},{"key":"3039_CR4","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1016\/j.jcrc.2008.02.001","volume":"23","author":"CM Parker","year":"2008","unstructured":"Parker CM, Kutsogiannis J, Muscedere J et al (2008) Ventilator-associated pneumonia caused by multidrug-resistant organisms or Pseudomonas aeruginosa: prevalence, incidence, risk factors, and outcomes. J Crit Care 23:18\u201326","journal-title":"J Crit Care"},{"key":"3039_CR5","doi-asserted-by":"crossref","first-page":"973","DOI":"10.1093\/clinids\/23.5.973","volume":"23","author":"J Rello","year":"1996","unstructured":"Rello J, Jubert P, Vall\u00e9s J et al (1996) Evaluation of outcome for intubated patients with pneumonia due to Pseudomonas aeruginosa. Clin Infect Dis 23:973\u2013978","journal-title":"Clin Infect Dis"},{"key":"3039_CR6","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1128\/AAC.50.1.43-48.2006","volume":"50","author":"V Aloush","year":"2006","unstructured":"Aloush V, Navon-Venezia S, Seigman-Igra Y et al (2006) Multidrug-resistant Pseudomonas aeruginosa: risk factors and clinical impact. Antimicrob Agents Chemother 50:43\u201348","journal-title":"Antimicrob Agents Chemother"},{"key":"3039_CR7","doi-asserted-by":"crossref","first-page":"2178","DOI":"10.1097\/CCM.0000000000000510","volume":"42","author":"MH Kollef","year":"2014","unstructured":"Kollef MH, Chastre J, Fagon JY et al (2014) Global prospective epidemiologic and surveillance study of ventilator-associated pneumonia due to Pseudomonas aeruginosa. Crit Care Med 42:2178\u20132187","journal-title":"Crit Care Med"},{"key":"3039_CR8","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1186\/s13054-015-0926-5","volume":"19","author":"ST Micek","year":"2015","unstructured":"Micek ST, Wunderink RG, Kollef MH et al (2015) An international multicenter retrospective study of Pseudomonas aeruginosa nosocomial pneumonia: impact of multidrug resistance. Crit Care 19:219","journal-title":"Crit Care"},{"key":"3039_CR9","doi-asserted-by":"crossref","first-page":"R112","DOI":"10.1186\/cc10136","volume":"15","author":"C Kaminski","year":"2011","unstructured":"Kaminski C, Timsit JF, Dubois Y et al (2011) Impact of ureido\/carboxypenicillin resistance on the prognosis of ventilator-associated pneumonia due to Pseudomonas aeruginosa. Crit Care 15:R112","journal-title":"Crit Care"},{"key":"3039_CR10","doi-asserted-by":"publisher","unstructured":"Borgatta B, Lagunes L, Imbiscuso AT et al (2017) Infections in intensive care unit adult patients harboring multidrug-resistant Pseudomonas aeruginosa: implications for prevention and therapy. Eur J Clin Microbiol Infect Dis. doi: 10.1007\/s10096-016-2894-3","DOI":"10.1007\/s10096-016-2894-3"},{"key":"3039_CR11","doi-asserted-by":"crossref","first-page":"382","DOI":"10.1055\/s-0038-1634956","volume":"32","author":"W D\u2019Hoore","year":"1993","unstructured":"D\u2019Hoore W, Sicotte C, Tilquin C (1993) Risk adjustment in outcome assessment: the Charlson comorbidity index. Methods Inf Med 32:382\u2013387","journal-title":"Methods Inf Med"},{"key":"3039_CR12","doi-asserted-by":"crossref","first-page":"818","DOI":"10.1097\/00003246-198510000-00009","volume":"13","author":"WA Knaus","year":"1985","unstructured":"Knaus WA, Draper EA, Wagner DP et al (1985) APACHE II: a severity of disease classification system. Crit Care Med 13:818\u2013829","journal-title":"Crit Care Med"},{"key":"3039_CR13","doi-asserted-by":"crossref","first-page":"1793","DOI":"10.1097\/00003246-199811000-00016","volume":"26","author":"JL Vincent","year":"1998","unstructured":"Vincent JL, de Mendon\u00e7a A, Cantraine F et al (1998) Use of the SOFA score to assess the incidence of organ dysfunction\/failure in intensive care units: results of a multicenter, prospective study. Working group on \u201csepsis-related problems\u201d of the European Society of Intensive Care Medicine. Crit Care Med 26:1793\u20131800","journal-title":"Crit Care Med"},{"key":"3039_CR14","doi-asserted-by":"crossref","first-page":"1208","DOI":"10.1378\/chest.08-1106","volume":"134","author":"T Lisboa","year":"2008","unstructured":"Lisboa T, Diaz E, Sa-Borges M et al (2008) The ventilator-associated pneumonia PIRO score: a tool for predicting ICU mortality and health-care resources use in ventilator-associated pneumonia. Chest 134:1208\u20131216","journal-title":"Chest"},{"key":"3039_CR15","unstructured":"European Committee on Antimicrobial Susceptibility Testing (EUCAST) Breakpoint tables for interpretation of MICs and zone diameters, versions 1.3 and 2.0. Available online at: http:\/\/www.eucast.org\/clinical_breakpoints\/ . Last accessed 20th June 2016"},{"key":"3039_CR16","doi-asserted-by":"crossref","first-page":"268","DOI":"10.1111\/j.1469-0691.2011.03570.x","volume":"18","author":"AP Magiorakos","year":"2012","unstructured":"Magiorakos AP, Srinivasan A, Carey RB et al (2012) Multidrug-resistant, extensively drug-resistant and pandrug-resistant bacteria: an international expert proposal for interim standard definitions for acquired resistance. Clin Microbiol Infect 18:268\u2013281","journal-title":"Clin Microbiol Infect"},{"key":"3039_CR17","doi-asserted-by":"crossref","first-page":"4851","DOI":"10.1128\/AAC.00627-10","volume":"54","author":"M Paul","year":"2010","unstructured":"Paul M, Shani V, Muchtar E et al (2010) Systematic review and meta-analysis of the efficacy of appropriate empiric antibiotic therapy for sepsis. Antimicrob Agents Chemother 54:4851\u20134863","journal-title":"Antimicrob Agents Chemother"},{"key":"3039_CR18","doi-asserted-by":"crossref","first-page":"388","DOI":"10.1164\/rccm.200405-644ST","volume":"171","author":"American Thoracic Society","year":"2005","unstructured":"American Thoracic Society; Infectious Diseases Society of America (2005) Guidelines for the management of adults with hospital-acquired, ventilator-associated, and healthcare-associated pneumonia. Am J Respir Crit Care Med 171:388\u2013416","journal-title":"Am J Respir Crit Care Med"},{"key":"3039_CR19","doi-asserted-by":"crossref","first-page":"S59","DOI":"10.1086\/653051","volume":"51","author":"DE Craven","year":"2010","unstructured":"Craven DE, Hjalmarson KI (2010) Ventilator-associated tracheobronchitis and pneumonia: thinking outside the box. Clin Infect Dis 51:S59\u2013S66","journal-title":"Clin Infect Dis"},{"key":"3039_CR20","first-page":"2526","volume":"307","author":"VM Ranieri","year":"2012","unstructured":"ARDS Definition Task Force, Ranieri VM, Rubenfeld GD et al (2012) Acute respiratory distress syndrome: the Berlin Definition. JAMA 307:2526\u20132533","journal-title":"JAMA"},{"key":"3039_CR21","unstructured":"Kidney International Supplements (2012) KDIGO Clinical Practice Guideline for Acute Kidney Injury. Available online at: http:\/\/kdigo.org\/wp-content\/uploads\/2016\/10\/KDIGO-2012-AKI-Guideline-English.pdf . Last accessed 14th June 2016"},{"key":"3039_CR22","doi-asserted-by":"crossref","first-page":"513","DOI":"10.1016\/j.cmi.2016.01.023","volume":"22","author":"C Hauck","year":"2016","unstructured":"Hauck C, Cober E, Richter SS et al (2016) Spectrum of excess mortality due to carbapenem-resistant Klebsiella pneumoniae infections. Clin Microbiol Infect 22:513\u2013519","journal-title":"Clin Microbiol Infect"},{"key":"3039_CR23","doi-asserted-by":"crossref","first-page":"859","DOI":"10.1016\/S2213-2600(15)00326-4","volume":"3","author":"I Martin-Loeches","year":"2015","unstructured":"Martin-Loeches I, Povoa P, Rodr\u00edguez A et al (2015) Incidence and prognosis of ventilator-associated tracheobronchitis (TAVeM): a multicentre, prospective, observational study. Lancet Respir Med 3:859\u2013868","journal-title":"Lancet Respir Med"},{"key":"3039_CR24","doi-asserted-by":"crossref","first-page":"262","DOI":"10.1378\/chest.122.1.262","volume":"122","author":"M Iregui","year":"2002","unstructured":"Iregui M, Ward S, Sherman G et al (2002) Clinical importance of delays in the initiation of appropriate antibiotic treatment for ventilator-associated pneumonia. Chest 122:262\u2013268","journal-title":"Chest"},{"key":"3039_CR25","doi-asserted-by":"crossref","first-page":"1888","DOI":"10.1097\/01.CCM.0000275389.31974.22","volume":"35","author":"J Garnacho-Montero","year":"2007","unstructured":"Garnacho-Montero J, Sa-Borges M, Sole-Violan J et al (2007) Optimal management therapy for Pseudomonas aeruginosa ventilator-associated pneumonia: an observational, multicenter study comparing monotherapy with combination antibiotic therapy. Cit Care Med 35:1888\u20131895","journal-title":"Cit Care Med"},{"key":"3039_CR26","doi-asserted-by":"publisher","unstructured":"Munita JM, Aitken SL, Miller WR et al (2017) Multicenter evaluation of ceftolozane\/tazobactam for serious infections caused by carbapenem-resistant Pseudomonas aeruginosa. Clin Infect Dis. doi: 10.1093\/cid\/cix014","DOI":"10.1093\/cid\/cix014"},{"key":"3039_CR27","doi-asserted-by":"crossref","first-page":"1275","DOI":"10.1016\/j.ajic.2016.04.218","volume":"44","author":"WR Judd","year":"2016","unstructured":"Judd WR, Ratliff PD, Hickson RP et al (2016) Clinical and economic impact of meropenem resistance in Pseudomonas aeruginosa-infected patients. Am J Infect Control 44:1275\u20131279","journal-title":"Am J Infect Control"},{"key":"3039_CR28","doi-asserted-by":"crossref","first-page":"e61","DOI":"10.1093\/cid\/ciw353","volume":"63","author":"AC Kalil","year":"2016","unstructured":"Kalil AC, Metersky ML, Klompas M et al (2016) Management of adults with hospital-acquired and ventilator-associated pneumonia: 2016 clinical practice guidelines by the Infectious Diseases Society of America and the American Thoracic Society. Clin Infect Dis 63:e61\u2013e111","journal-title":"Clin Infect Dis"},{"key":"3039_CR29","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1016\/j.jinf.2016.11.008","volume":"74","author":"L Fern\u00e1ndez-Barat","year":"2017","unstructured":"Fern\u00e1ndez-Barat L, Ferrer M, De Rosa F et al (2017) Intensive care unit-acquired pneumonia due to Pseudomonas aeruginosa with and without multidrug resistance. J Infect 74:142\u2013152","journal-title":"J Infect"}],"container-title":["European Journal of Clinical Microbiology & Infectious Diseases"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s10096-017-3039-z\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s10096-017-3039-z.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s10096-017-3039-z.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,9,26]],"date-time":"2019-09-26T03:04:27Z","timestamp":1569467067000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s10096-017-3039-z"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,6,17]]},"references-count":29,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2017,11]]}},"alternative-id":["3039"],"URL":"https:\/\/doi.org\/10.1007\/s10096-017-3039-z","relation":{},"ISSN":["0934-9723","1435-4373"],"issn-type":[{"value":"0934-9723","type":"print"},{"value":"1435-4373","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,6,17]]}}}