{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,20]],"date-time":"2026-09-20T11:25:21Z","timestamp":1789903521909,"version":"4.0.1"},"reference-count":67,"publisher":"Springer Science and Business Media LLC","issue":"4","license":[{"start":{"date-parts":[[2019,1,24]],"date-time":"2019-01-24T00:00:00Z","timestamp":1548288000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"funder":[{"DOI":"10.13039\/501100004160","name":"Mazandaran University of Medical Sciences","doi-asserted-by":"publisher","award":["10221"],"award-info":[{"award-number":["10221"]}],"id":[{"id":"10.13039\/501100004160","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Eur J Clin Microbiol Infect Dis"],"published-print":{"date-parts":[[2019,4]]},"DOI":"10.1007\/s10096-018-03442-6","type":"journal-article","created":{"date-parts":[[2019,1,25]],"date-time":"2019-01-25T02:08:43Z","timestamp":1548382123000},"page":"617-629","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":27,"title":["A systematic review on efficiency of microneme proteins to induce protective immunity against Toxoplasma gondii"],"prefix":"10.1007","volume":"38","author":[{"given":"Samira","family":"Dodangeh","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ahmad","family":"Daryani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mehdi","family":"Sharif","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sargis A.","family":"Aghayan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abdol Satar","family":"Pagheh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shahabeddin","family":"Sarvi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fatemeh","family":"Rezaei","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2019,1,24]]},"reference":[{"issue":"6","key":"3442_CR1","doi-asserted-by":"publisher","first-page":"467","DOI":"10.1111\/j.1550-7408.2008.00345.x","volume":"55","author":"JP Dubey","year":"2008","unstructured":"Dubey JP (2008) The history of Toxoplasma gondii\u2014the first 100\u00a0years. J Eukaryot Microbiol 55(6):467\u2013475","journal-title":"J Eukaryot Microbiol"},{"issue":"3","key":"3442_CR2","first-page":"289","volume":"29","author":"D Buxton","year":"1998","unstructured":"Buxton D (1998) Protozoan infections (Toxoplasma gondii, Neospora caninum and Sarcocystis spp.) in sheep and goats: recent advances. Vet Res 29(3):289\u2013310","journal-title":"Vet Res"},{"issue":"2","key":"3442_CR3","doi-asserted-by":"publisher","first-page":"120","DOI":"10.1016\/S1995-7645(14)60301-1","volume":"8","author":"S Sarvi","year":"2015","unstructured":"Sarvi S, Daryani A, Rahimi MT, Aarabi M, Shokri A, Ahmadpour E, Mizani A, Sharif M (2015) Cattle toxoplasmosis in Iran: a systematic review and meta-analysis. Asian Pac J Trop Med 8(2):120\u2013126","journal-title":"Asian Pac J Trop Med"},{"issue":"12","key":"3442_CR4","doi-asserted-by":"publisher","first-page":"1503","DOI":"10.3855\/jidc.4796","volume":"8","author":"E Ahmadpour","year":"2014","unstructured":"Ahmadpour E, Daryani A, Sharif M, Sarvi S, Aarabi M, Mizani A, Rahimi MT, Shokri A (2014) Toxoplasmosis in immunocompromised patients in Iran: a systematic review and meta-analysis. The Journal of Infection in Developing Countries 8(12):1503\u20131510","journal-title":"The Journal of Infection in Developing Countries"},{"issue":"3","key":"3442_CR5","doi-asserted-by":"publisher","first-page":"207","DOI":"10.1097\/01.rti.0000131756.13179.ae","volume":"19","author":"DL Escuissato","year":"2004","unstructured":"Escuissato DL, de Aguiar RO, Gasparetto EL, M\u00fcller NL (2004) Disseminated toxoplasmosis after bone marrow transplantation: high-resolution CT appearance. J Thorac Imaging 19(3):207\u2013209","journal-title":"J Thorac Imaging"},{"issue":"Supplement 2","key":"3442_CR6","doi-asserted-by":"publisher","first-page":"S423","DOI":"10.1093\/clinids\/17.Supplement_2.S423","volume":"17","author":"DM Israelski","year":"1993","unstructured":"Israelski DM, Remington JS (1993) Toxoplasmosis in patients with cancer. Clin Infect Dis 17(Supplement 2):S423\u2013S435","journal-title":"Clin Infect Dis"},{"issue":"4","key":"3442_CR7","doi-asserted-by":"publisher","first-page":"150","DOI":"10.1016\/S0169-4758(97)01212-X","volume":"14","author":"L Kasper","year":"1998","unstructured":"Kasper L, Buzoni-Gatel D (1998) Some opportunistic parasitic infections in AIDS: candidiasis, pneumocystosis, cryptosporidiosis, toxoplasmosis. Parasitol Today 14(4):150\u2013156","journal-title":"Parasitol Today"},{"issue":"1","key":"3442_CR8","doi-asserted-by":"publisher","first-page":"7","DOI":"10.1186\/s41182-017-0048-7","volume":"45","author":"A Mizani","year":"2017","unstructured":"Mizani A, Alipour A, Sharif M, Sarvi S, Amouei A, Shokri A, Rahimi M-T, Hosseini SA, Daryani A (2017) Toxoplasmosis seroprevalence in Iranian women and risk factors of the disease: a systematic review and meta-analysis. Tropical Medicine and Health 45(1):7","journal-title":"Tropical Medicine and Health"},{"key":"3442_CR9","doi-asserted-by":"crossref","unstructured":"Montazeri M, Sharif M, Sarvi S, Mehrzadi S, Ahmadpour E, Daryani A (2017) A systematic review of in vitro and in vivo activities of anti-toxoplasma drugs and compounds (2006\u20132016). Front Microbiol 8","DOI":"10.3389\/fmicb.2017.00025"},{"issue":"3","key":"3442_CR10","doi-asserted-by":"publisher","first-page":"526","DOI":"10.1007\/s12639-013-0390-6","volume":"39","author":"HME Eldin","year":"2015","unstructured":"Eldin HME, Kamel HH, Badawy AF, Shash LS (2015) A comparative study between excretory\/secretory and autoclaved vaccines against RH strain of Toxoplasma gondii in murine models. J Parasit Dis 39(3):526\u2013535","journal-title":"J Parasit Dis"},{"issue":"5","key":"3442_CR11","doi-asserted-by":"publisher","first-page":"2001","DOI":"10.1007\/s00436-012-3047-y","volume":"111","author":"X-N Wu","year":"2012","unstructured":"Wu X-N, Lin J, Lin X, Chen J, Chen Z-L, Lin J-Y (2012) Multicomponent DNA vaccine-encoding Toxoplasma gondii GRA1 and SAG1 primes: anti-Toxoplasma immune response in mice. Parasitol Res 111(5):2001\u20132009","journal-title":"Parasitol Res"},{"issue":"5","key":"3442_CR12","doi-asserted-by":"publisher","first-page":"883","DOI":"10.4269\/ajtmh.12-0727","volume":"88","author":"S Parthasarathy","year":"2013","unstructured":"Parthasarathy S, Fong MY, Ramaswamy K, Lau YL (2013) Protective immune response in BALB\/c mice induced by DNA vaccine of the ROP8 gene of Toxoplasma gondii. The American Journal of Tropical Medicine and Hygiene 88(5):883\u2013887","journal-title":"The American Journal of Tropical Medicine and Hygiene"},{"issue":"11","key":"3442_CR13","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0143087","volume":"10","author":"CF Pinzan","year":"2015","unstructured":"Pinzan CF, Sardinha-Silva A, Almeida F, Lai L, Lopes CD, Louren\u00e7o EV, Panunto-Castelo A, Matthews S, Roque-Barreira MC (2015) Vaccination with recombinant microneme proteins confers protection against experimental toxoplasmosis in mice. PLoS One 10(11):e0143087","journal-title":"PLoS One"},{"key":"3442_CR14","doi-asserted-by":"crossref","unstructured":"Mac\u00eado Junior AG, Cunha Junior JP, Cardoso THS, Silva MV, M Santiago F, Silva JS, Pirovani CP, Silva DAO, Mineo JR, Mineo TWP (2013) SAG2A protein from Toxoplasma gondii interacts with both innate and adaptive immune compartments of infected hosts. Parasit Vectors 6:163","DOI":"10.1186\/1756-3305-6-163"},{"issue":"1","key":"3442_CR15","doi-asserted-by":"publisher","first-page":"163","DOI":"10.1046\/j.1365-2958.1997.5671913.x","volume":"26","author":"JM Dobrowolski","year":"1997","unstructured":"Dobrowolski JM, Carruthers VB, Sibley LD (1997) Participation of myosin in gliding motility and host cell invasion by Toxoplasma gondii. Mol Microbiol 26(1):163\u2013173","journal-title":"Mol Microbiol"},{"issue":"5594","key":"3442_CR16","doi-asserted-by":"publisher","first-page":"837","DOI":"10.1126\/science.1074553","volume":"298","author":"M Meissner","year":"2002","unstructured":"Meissner M, Schluter D, Soldati D (2002) Role of Toxoplasma gondii myosin A in powering parasite gliding and host cell invasion. Science 298(5594):837\u2013840","journal-title":"Science"},{"key":"3442_CR17","doi-asserted-by":"publisher","first-page":"89","DOI":"10.1016\/j.exppara.2017.03.001","volume":"176","author":"Q Liu","year":"2017","unstructured":"Liu Q, Li FC, Zhou CX, Zhu XQ (2017) Research advances in interactions related to Toxoplasma gondii microneme proteins. Exp Parasitol 176:89\u201398","journal-title":"Exp Parasitol"},{"issue":"3","key":"3442_CR18","doi-asserted-by":"publisher","first-page":"453","DOI":"10.1084\/jem.20041672","volume":"201","author":"O C\u00e9r\u00e8de","year":"2005","unstructured":"C\u00e9r\u00e8de O, Dubremetz JF, So\u00eate M, Desl\u00e9e D, Vial H, Bout D, Lebrun M (2005) Synergistic role of micronemal proteins in Toxoplasma gondii virulence. J Exp Med 201(3):453\u2013463","journal-title":"J Exp Med"},{"issue":"1","key":"3442_CR19","doi-asserted-by":"publisher","first-page":"384","DOI":"10.1186\/s13071-015-1001-4","volume":"8","author":"Y Wang","year":"2015","unstructured":"Wang Y, Yin H (2015) Research advances in microneme protein 3 of Toxoplasma gondii. Parasit Vectors 8(1):384","journal-title":"Parasit Vectors"},{"issue":"7","key":"3442_CR20","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pmed.1000097","volume":"6","author":"D Moher","year":"2009","unstructured":"Moher D, Liberati A, Tetzlaff J, Altman DG, Group P (2009) Preferred reporting items for systematic reviews and meta-analyses: the PRISMA statement. PLoS Med 6(7):e1000097","journal-title":"PLoS Med"},{"key":"3442_CR21","doi-asserted-by":"publisher","first-page":"43","DOI":"10.1186\/1471-2288-14-43","volume":"14","author":"CR Hooijmans","year":"2014","unstructured":"Hooijmans CR, Rovers MM, de Vries RB, Leenaars M, Ritskes-Hoitinga M, Langendam MW (2014) SYRCLE\u2019s risk of bias tool for animal studies. BMC Med Res Methodol 14:43","journal-title":"BMC Med Res Methodol"},{"issue":"5","key":"3442_CR22","doi-asserted-by":"publisher","first-page":"1244","DOI":"10.1016\/j.micinf.2005.11.013","volume":"8","author":"EV Louren\u00e7o","year":"2006","unstructured":"Louren\u00e7o EV, Bernardes ES, Silva NM, Mineo JR, Panunto-Castelo A, Roque-Barreira M-C (2006) Immunization with MIC1 and MIC4 induces protective immunity against Toxoplasma gondii. Microbes Infect 8(5):1244\u20131251","journal-title":"Microbes Infect"},{"issue":"4","key":"3442_CR23","doi-asserted-by":"publisher","first-page":"637","DOI":"10.1086\/427660","volume":"191","author":"E Beghetto","year":"2005","unstructured":"Beghetto E, Nielsen HV, Del Porto P, Buffolano W, Guglietta S, Felici F, Petersen E, Gargano N (2005) A combination of antigenic regions of Toxoplasma gondii microneme proteins induces protective immunity against oral infection with parasite cysts. J Infect Dis 191(4):637\u2013645","journal-title":"J Infect Dis"},{"issue":"3","key":"3442_CR24","doi-asserted-by":"publisher","first-page":"273","DOI":"10.1016\/j.exppara.2007.01.017","volume":"116","author":"G Dautu","year":"2007","unstructured":"Dautu G, Munyaka B, Carmen G, Zhang G, Omata Y, Xuenan X, Igarashi M (2007) Toxoplasma gondii: DNA vaccination with genes encoding antigens MIC2, M2AP, AMA1 and BAG1 and evaluation of their immunogenic potential. Exp Parasitol 116(3):273\u2013282","journal-title":"Exp Parasitol"},{"issue":"18","key":"3442_CR25","doi-asserted-by":"publisher","first-page":"2489","DOI":"10.1016\/j.vaccine.2009.02.058","volume":"27","author":"C Rosenberg","year":"2009","unstructured":"Rosenberg C, De Craeye S, Jongert E, Gargano N, Beghetto E, Del Porto P, Vorup-Jensen T, Petersen E (2009) Induction of partial protection against infection with Toxoplasma gondii genotype II by DNA vaccination with recombinant chimeric tachyzoite antigens. Vaccine 27(18):2489\u20132498","journal-title":"Vaccine"},{"issue":"11","key":"3442_CR26","doi-asserted-by":"publisher","first-page":"6222","DOI":"10.1128\/IAI.71.11.6222-6228.2003","volume":"71","author":"AB Ismael","year":"2003","unstructured":"Ismael AB, Sekkai D, Collin C, Bout D, M\u00e9v\u00e9lec M-N (2003) The MIC3 gene of Toxoplasma gondii is a novel potent vaccine candidate against toxoplasmosis. Infect Immun 71(11):6222\u20136228","journal-title":"Infect Immun"},{"key":"3442_CR27","doi-asserted-by":"publisher","first-page":"1):1","DOI":"10.1016\/j.vetpar.2009.08.014","volume":"166","author":"W Xiang","year":"2009","unstructured":"Xiang W, Qiong Z, Li-peng L, Kui T, Jian-wu G, Heng-ping S (2009) The location of invasion-related protein MIC3 of Toxoplasma gondii and protective effect of its DNA vaccine in mice. Vet Parasitol 166:1):1\u20131):7","journal-title":"Vet Parasitol"},{"issue":"2","key":"3442_CR28","doi-asserted-by":"publisher","first-page":"134","DOI":"10.1016\/j.vetpar.2009.06.012","volume":"164","author":"R Fang","year":"2009","unstructured":"Fang R, Nie H, Wang Z, Tu P, Zhou D, Wang L, He L, Zhou Y, Zhao J (2009) Protective immune response in BALB\/c mice induced by a suicidal DNA vaccine of the MIC3 gene of Toxoplasma gondii. Vet Parasitol 164(2):134\u2013140","journal-title":"Vet Parasitol"},{"issue":"22","key":"3442_CR29","doi-asserted-by":"publisher","first-page":"2959","DOI":"10.1016\/j.vaccine.2009.02.107","volume":"27","author":"AB Ismael","year":"2009","unstructured":"Ismael AB, Hedhli D, C\u00e9r\u00e8de O, Lebrun M, Dimier-Poisson I, M\u00e9v\u00e9lec M-N (2009) Further analysis of protection induced by the MIC3 DNA vaccine against T. gondii: CD4 and CD8 T cells are the major effectors of the MIC3 DNA vaccine-induced protection, both lectin-like and EGF-like domains of MIC3 conferred protection. Vaccine 27(22):2959\u20132966","journal-title":"Vaccine"},{"issue":"3","key":"3442_CR30","doi-asserted-by":"publisher","first-page":"220","DOI":"10.1016\/j.vetpar.2009.08.016","volume":"166","author":"D Qu","year":"2009","unstructured":"Qu D, Yu H, Wang S, Cai W, Du A (2009) Induction of protective immunity by multiantigenic DNA vaccine delivered in attenuated Salmonella typhimurium against Toxoplasma gondii infection in mice. Vet Parasitol 166(3):220\u2013227","journal-title":"Vet Parasitol"},{"issue":"1","key":"3442_CR31","doi-asserted-by":"publisher","first-page":"140","DOI":"10.1016\/j.vetpar.2011.12.007","volume":"187","author":"R Fang","year":"2012","unstructured":"Fang R, Feng H, Hu M, Khan MK, Wang L, Zhou Y, Zhao J (2012) Evaluation of immune responses induced by SAG1 and MIC3 vaccine cocktails against Toxoplasma gondii. Vet Parasitol 187(1):140\u2013146","journal-title":"Vet Parasitol"},{"issue":"7","key":"3442_CR32","doi-asserted-by":"publisher","first-page":"2593","DOI":"10.1007\/s00436-013-3425-0","volume":"112","author":"D Qu","year":"2013","unstructured":"Qu D, Han J, Du A (2013) Evaluation of protective effect of multiantigenic DNA vaccine encoding MIC3 and ROP18 antigen segments of Toxoplasma gondii in mice. Parasitol Res 112(7):2593\u20132599","journal-title":"Parasitol Res"},{"key":"3442_CR33","doi-asserted-by":"crossref","unstructured":"Ghaffarifar F, Naserifar R, Jafari Madrak M (2014) Eukaryotic plasmids with Toxoplasma gondii dense granule antigen (GRA 5) and microneme 3 (MIC3) genes as a cocktail DNA vaccine and evaluation of immune responses in BALB\/C mice. J Clin Med Genom 3 (121):2","DOI":"10.4172\/2472-128X.1000121"},{"key":"3442_CR34","doi-asserted-by":"publisher","first-page":"131","DOI":"10.1016\/j.exppara.2016.04.003","volume":"166","author":"P Gong","year":"2016","unstructured":"Gong P, Cao L, Guo Y, Dong H, Yuan S, Yao X, Ren W, Yao L, Xu Z, Sun Q (2016) Toxoplasma gondii: protective immunity induced by a DNA vaccine expressing GRA1 and MIC3 against toxoplasmosis in BALB\/c mice. Exp Parasitol 166:131\u2013136","journal-title":"Exp Parasitol"},{"issue":"3","key":"3442_CR35","doi-asserted-by":"publisher","first-page":"226","DOI":"10.1016\/j.exppara.2009.04.002","volume":"122","author":"H Wang","year":"2009","unstructured":"Wang H, He S, Yao Y, Cong H, Zhao H, Li T, Zhu X-Q (2009) Toxoplasma gondii: protective effect of an intranasal SAG1 and MIC4 DNA vaccine in mice. Exp Parasitol 122(3):226\u2013232","journal-title":"Exp Parasitol"},{"key":"3442_CR36","doi-asserted-by":"publisher","first-page":"1463","DOI":"10.3923\/javaa.2010.1463.1468","volume":"9","author":"G Peng","year":"2010","unstructured":"Peng G, Yuan Z, Zhou D, He X, Yan C, Yin C, He Y, Lin R, Song H, Zhu X (2010) Sequence variation in Toxoplasma gondii MIC4 gene and protective effect of an MIC4 DNA vaccine in a murine model against toxoplasmosis. J Anim Vet Adv 9:1463\u20131468","journal-title":"J Anim Vet Adv"},{"issue":"47","key":"3442_CR37","doi-asserted-by":"publisher","first-page":"6570","DOI":"10.1016\/j.vaccine.2009.08.043","volume":"27","author":"G-H Peng","year":"2009","unstructured":"Peng G-H, Yuan Z-G, Zhou D-H, He X-H, Liu M-M, Yan C, Yin C-C, He Y, Lin R-Q, Zhu X-Q (2009) Toxoplasma gondii microneme protein 6 (MIC6) is a potential vaccine candidate against toxoplasmosis in mice. Vaccine 27(47):6570\u20136574","journal-title":"Vaccine"},{"key":"3442_CR38","unstructured":"Yan H-K, Yuan Z-G, Song H-Q, Petersen E, Zhou Y, Ren D, Zhou D-H, Li H-X, Lin R-Q, Yang G-L (2012) Vaccination with a DNA vaccine coding perforin-like protein 1 (TgPLP1) and MIC6 induces significant protective immunity against Toxoplasma gondii. Clin Vaccine Immunol:CVI. 05578\u201305511"},{"issue":"1","key":"3442_CR39","doi-asserted-by":"publisher","first-page":"498","DOI":"10.1186\/s13071-015-1108-7","volume":"8","author":"H Yin","year":"2015","unstructured":"Yin H, Zhao L, Wang T, Zhou H, He S, Cong H (2015) A Toxoplasma gondii vaccine encoding multistage antigens in conjunction with ubiquitin confers protective immunity to BALB\/c mice against parasite infection. Parasit Vectors 8(1):498","journal-title":"Parasit Vectors"},{"issue":"5","key":"3442_CR40","doi-asserted-by":"publisher","first-page":"1079","DOI":"10.1007\/s00436-010-1742-0","volume":"106","author":"M Liu","year":"2010","unstructured":"Liu M, Yuan Z, Peng G, Zhou D, He X, Yan C, Yin C, He Y, Lin R, Song H (2010) Toxoplasma gondii microneme protein 8 (MIC8) is a potential vaccine candidate against toxoplasmosis. Parasitol Res 106(5):1079\u20131084","journal-title":"Parasitol Res"},{"issue":"2","key":"3442_CR41","first-page":"81","volume":"28","author":"Y Yao","year":"2010","unstructured":"Yao Y, He S, Wang H, Zhou H, Zhao H, Li T, Xue M, Zhu X (2010) Protective immunity induced in mice by multiantigenic DNA vaccine with genes encoding SAG1 and MIC8 of Toxoplasma gondii. Zhongguo ji sheng chong xue yu ji sheng chong bing za zhi = Chinese Journal of Parasitology & Parasitic Diseases 28(2):81\u201388","journal-title":"Zhongguo ji sheng chong xue yu ji sheng chong bing za zhi = Chinese Journal of Parasitology & Parasitic Diseases"},{"issue":"4","key":"3442_CR42","first-page":"284","volume":"31","author":"H Zhao","year":"2013","unstructured":"Zhao H, Huang F, Guo J, Tan G (2013) Evaluation on the immune response induced by DNA vaccine encoding MIC8 co-immunized with IL-12 genetic adjuvant against Toxoplasma gondii infection. Zhongguo ji sheng chong xue yu ji sheng chong bing za zhi = Chinese Journal of Parasitology & Parasitic Diseases 31(4):284\u2013289","journal-title":"Zhongguo ji sheng chong xue yu ji sheng chong bing za zhi = Chinese Journal of Parasitology & Parasitic Diseases"},{"issue":"8","key":"3442_CR43","doi-asserted-by":"publisher","first-page":"2871","DOI":"10.1007\/s00436-013-3458-4","volume":"112","author":"Q Tao","year":"2013","unstructured":"Tao Q, Fang R, Zhang W, Wang Y, Cheng J, Li Y, Fang K, Khan MK, Hu M, Zhou Y (2013) Protective immunity induced by a DNA vaccine-encoding Toxoplasma gondii microneme protein 11 against acute toxoplasmosis in BALB\/c mice. Parasitol Res 112(8):2871\u20132877","journal-title":"Parasitol Res"},{"issue":"31","key":"3442_CR44","doi-asserted-by":"publisher","first-page":"3135","DOI":"10.1016\/j.vaccine.2013.05.040","volume":"31","author":"Z-G Yuan","year":"2013","unstructured":"Yuan Z-G, Ren D, Zhou D-H, Zhang X-X, Petersen E, Li X-Z, Zhou Y, Yang G-L, Zhu X-Q (2013) Evaluation of protective effect of pVAX-TgMIC13 plasmid against acute and chronic Toxoplasma gondii infection in a murine model. Vaccine 31(31):3135\u20133139","journal-title":"Vaccine"},{"issue":"41","key":"3442_CR45","doi-asserted-by":"publisher","first-page":"5289","DOI":"10.1016\/j.vaccine.2008.07.032","volume":"26","author":"E Jongert","year":"2008","unstructured":"Jongert E, Verhelst D, Abady M, Petersen E, Gargano N (2008) Protective Th1 immune responses against chronic toxoplasmosis induced by a protein\u2013protein vaccine combination but not by its DNA\u2013protein counterpart. Vaccine 26(41):5289\u20135295","journal-title":"Vaccine"},{"issue":"2","key":"3442_CR46","doi-asserted-by":"publisher","first-page":"215","DOI":"10.1016\/j.vetpar.2011.04.039","volume":"181","author":"H Nie","year":"2011","unstructured":"Nie H, Fang R, Xiong B-Q, Wang L-X, Hu M, Zhou Y-Q, Zhao J-L (2011) Immunogenicity and protective efficacy of two recombinant pseudorabies viruses expressing Toxoplasma gondii SAG1 and MIC3 proteins. Vet Parasitol 181(2):215\u2013221","journal-title":"Vet Parasitol"},{"issue":"10","key":"3442_CR47","doi-asserted-by":"publisher","first-page":"3791","DOI":"10.1007\/s00436-015-4609-6","volume":"114","author":"D Yang","year":"2015","unstructured":"Yang D, Liu J, Hao P, Wang J, Lei T, Shan D, Liu Q (2015) MIC3, a novel cross-protective antigen expressed in Toxoplasma gondii and Neospora caninum. Parasitol Res 114(10):3791\u20133799","journal-title":"Parasitol Res"},{"issue":"4","key":"3442_CR48","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0175644","volume":"12","author":"S Lee","year":"2017","unstructured":"Lee S, Kim A, Lee D, Rubino I, Choi H, Quan F (2017) Protection induced by virus-like particles containing Toxoplasma gondii microneme protein 8 against highly virulent RH strain of Toxoplasma gondii infection. PLoS One 12(4):e0175644","journal-title":"PLoS One"},{"issue":"5","key":"3442_CR49","doi-asserted-by":"publisher","first-page":"89","DOI":"10.1136\/vr.129.5.89","volume":"129","author":"D Buxton","year":"1991","unstructured":"Buxton D, Thomson K, Maley S, Wright S, Bos H (1991) Vaccination of sheep with a live incomplete strain (S48) of Toxoplasma gondii and their immunity to challenge when pregnant. The Veterinary Record 129(5):89\u201393","journal-title":"The Veterinary Record"},{"issue":"S1","key":"3442_CR50","doi-asserted-by":"publisher","first-page":"S11","DOI":"10.1017\/S003118200000144X","volume":"110","author":"D Buxton","year":"1995","unstructured":"Buxton D, Innes E (1995) A commercial vaccine for ovine toxoplasmosis. Parasitology 110(S1):S11\u2013S16","journal-title":"Parasitology"},{"issue":"10","key":"3442_CR51","doi-asserted-by":"publisher","first-page":"1117","DOI":"10.1586\/erv.10.113","volume":"9","author":"EA Innes","year":"2010","unstructured":"Innes EA (2010) Vaccination against Toxoplasma gondii: an increasing priority for collaborative research? Expert Review of Vaccines 9(10):1117\u20131119","journal-title":"Expert Review of Vaccines"},{"issue":"11","key":"3442_CR52","doi-asserted-by":"publisher","first-page":"2526","DOI":"10.1093\/emboj\/21.11.2526","volume":"21","author":"O C\u00e9r\u00e8de","year":"2002","unstructured":"C\u00e9r\u00e8de O, Dubremetz JF, Bout D, Lebrun M (2002) The Toxoplasma gondii protein MIC3 requires pro-peptide cleavage and dimerization to function as adhesin. EMBO J 21(11):2526\u20132536","journal-title":"EMBO J"},{"issue":"9","key":"3442_CR53","doi-asserted-by":"crossref","first-page":"4902","DOI":"10.4049\/jimmunol.161.9.4902","volume":"161","author":"AC Lepage","year":"1998","unstructured":"Lepage AC, Buzoni-Gatel D, Bout DT, Kasper LH (1998) Gut-derived intraepithelial lymphocytes induce long term immunity against Toxoplasma gondii. J Immunol 161(9):4902\u20134908","journal-title":"J Immunol"},{"issue":"1","key":"3442_CR54","doi-asserted-by":"publisher","first-page":"13","DOI":"10.1016\/S0022-1759(02)00137-0","volume":"267","author":"R Frank","year":"2002","unstructured":"Frank R (2002) The SPOT-synthesis technique: synthetic peptide arrays on membrane supports\u2014principles and applications. J Immunol Methods 267(1):13\u201326","journal-title":"J Immunol Methods"},{"issue":"2","key":"3442_CR55","doi-asserted-by":"publisher","first-page":"459","DOI":"10.1007\/s00436-015-4824-1","volume":"115","author":"Y Wang","year":"2016","unstructured":"Wang Y, Wang G, Cai J, Yin H (2016) Review on the identification and role of Toxoplasma gondii antigenic epitopes. Parasitol Res 115(2):459\u2013468","journal-title":"Parasitol Res"},{"issue":"21","key":"3442_CR56","doi-asserted-by":"publisher","first-page":"2852","DOI":"10.1016\/S0264-410X(03)00157-9","volume":"21","author":"RM Mohamed","year":"2003","unstructured":"Mohamed RM, Aosai F, Chen M, Mun H-S, Norose K, Belal US, Piao L-X, Yano A (2003) Induction of protective immunity by DNA vaccination with Toxoplasma gondii HSP70, HSP30 and SAG1 genes. Vaccine 21(21):2852\u20132861","journal-title":"Vaccine"},{"issue":"1","key":"3442_CR57","doi-asserted-by":"publisher","first-page":"213","DOI":"10.1186\/1756-3305-4-213","volume":"4","author":"X-M Sun","year":"2011","unstructured":"Sun X-M, Zou J, AA ES, Yan W-C, Liu X-Y, Suo X, Wang H, Chen Q-J (2011) DNA vaccination with a gene encoding Toxoplasma gondii GRA6 induces partial protection against toxoplasmosis in BALB\/c mice. Parasit Vectors 4(1):213","journal-title":"Parasit Vectors"},{"issue":"2","key":"3442_CR58","doi-asserted-by":"publisher","first-page":"252","DOI":"10.1590\/S0074-02762009000200019","volume":"104","author":"E Jongert","year":"2009","unstructured":"Jongert E, Roberts CW, Gargano N, F\u00f6rster-Waldl E, Petersen E (2009) Vaccines against Toxoplasma gondii: challenges and opportunities. Memorias do Instituto Oswaldo Cruz 104(2):252\u2013266","journal-title":"Memorias do Instituto Oswaldo Cruz"},{"issue":"1","key":"3442_CR59","doi-asserted-by":"publisher","first-page":"3","DOI":"10.2478\/v10181-011-0107-7","volume":"15","author":"E Hiszczy\u0144ska-Sawicka","year":"2012","unstructured":"Hiszczy\u0144ska-Sawicka E, Li H, Xu J, Akhtar M, Holec-G\u0105sior L, Kur J, Bickerstaffe R, Stankiewicz M (2012) Induction of immune responses in sheep by vaccination with liposome-entrapped DNA complexes encoding Toxoplasma gondii MIC3 gene. Pol J Vet Sci 15(1):3\u20139","journal-title":"Pol J Vet Sci"},{"issue":"11","key":"3442_CR60","doi-asserted-by":"publisher","first-page":"550","DOI":"10.1016\/j.pt.2010.06.004","volume":"26","author":"FL Henriquez","year":"2010","unstructured":"Henriquez FL, Woods S, Cong H, McLeod R, Roberts CW (2010) Immunogenetics of Toxoplasma gondii informs vaccine design. Trends Parasitol 26(11):550\u2013555","journal-title":"Trends Parasitol"},{"issue":"27","key":"3442_CR61","doi-asserted-by":"publisher","first-page":"10514","DOI":"10.1073\/pnas.0510319103","volume":"103","author":"JP Boyle","year":"2006","unstructured":"Boyle JP, Rajasekar B, Saeij JP, Ajioka JW, Berriman M, Paulsen I, Roos DS, Sibley LD, White MW, Boothroyd JC (2006) Just one cross appears capable of dramatically altering the population biology of a eukaryotic pathogen like Toxoplasma gondii. Proc Natl Acad Sci 103(27):10514\u201310519","journal-title":"Proc Natl Acad Sci"},{"issue":"3","key":"3442_CR62","doi-asserted-by":"publisher","first-page":"901","DOI":"10.1128\/JCM.02502-12","volume":"51","author":"ACAV Carneiro","year":"2013","unstructured":"Carneiro ACAV, Andrade GMQ, Costa JGL, Pinheiro BV, Vasconcelos-Santos DV, Ferreira AM, Su C, Januario JN, Vitor RWA (2013) Genetic characterization of Toxoplasma gondii revealed highly diverse genotypes for isolates from newborns with congenital toxoplasmosis in southeastern Brazil. J Clin Microbiol 51(3):901\u2013907","journal-title":"J Clin Microbiol"},{"issue":"1","key":"3442_CR63","doi-asserted-by":"publisher","first-page":"22","DOI":"10.1016\/j.meegid.2004.12.004","volume":"6","author":"ADM Ferreira","year":"2006","unstructured":"Ferreira ADM, Vitor RWA, Gazzinelli RT, Melo MN (2006) Genetic analysis of natural recombinant Brazilian Toxoplasma gondii strains by multilocus PCR\u2013RFLP. Infect Genet Evol 6(1):22\u201331","journal-title":"Infect Genet Evol"},{"issue":"6","key":"3442_CR64","doi-asserted-by":"crossref","first-page":"1411","DOI":"10.1128\/JCM.35.6.1411-1414.1997","volume":"35","author":"DK Howe","year":"1997","unstructured":"Howe DK, Honore S, Derouin F, Sibley LD (1997) Determination of genotypes of Toxoplasma gondii strains isolated from patients with toxoplasmosis. J Clin Microbiol 35(6):1411\u20131414","journal-title":"J Clin Microbiol"},{"key":"3442_CR65","unstructured":"Mordue DG, Hunter CA Innate immunity toToxoplasma gondii\u2014chapter 24"},{"issue":"6","key":"3442_CR66","doi-asserted-by":"publisher","first-page":"791","DOI":"10.1586\/erv.09.27","volume":"8","author":"J Kur","year":"2009","unstructured":"Kur J, Holec-G\u0105sior L, Hiszczy\u0144ska-Sawicka E (2009) Current status of toxoplasmosis vaccine development. Expert Review of Vaccines 8(6):791\u2013808","journal-title":"Expert Review of Vaccines"},{"issue":"2","key":"3442_CR67","doi-asserted-by":"publisher","first-page":"93","DOI":"10.7774\/cevr.2018.7.2.93","volume":"7","author":"M Foroutan","year":"2018","unstructured":"Foroutan M, Zaki L, Ghaffarifar F (2018) Recent progress in microneme-based vaccines development against Toxoplasma gondii. Clinical and Experimental Vaccine Research 7(2):93\u2013103","journal-title":"Clinical and Experimental Vaccine Research"}],"container-title":["European Journal of Clinical Microbiology & Infectious Diseases"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s10096-018-03442-6\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s10096-018-03442-6.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s10096-018-03442-6.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,13]],"date-time":"2023-09-13T05:04:34Z","timestamp":1694581474000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s10096-018-03442-6"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,1,24]]},"references-count":67,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2019,4]]}},"alternative-id":["3442"],"URL":"https:\/\/doi.org\/10.1007\/s10096-018-03442-6","relation":{},"ISSN":["0934-9723","1435-4373"],"issn-type":[{"value":"0934-9723","type":"print"},{"value":"1435-4373","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,1,24]]},"assertion":[{"value":"5 October 2018","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"22 November 2018","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"24 January 2019","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Compliance with ethical standards"}},{"value":"The authors report that they have no conflicts of interest. The authors alone are responsible for the content and writing of the paper.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declaration of interests"}}]}}