{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,4]],"date-time":"2026-09-04T12:22:34Z","timestamp":1788524554747,"version":"build-2803163510"},"reference-count":28,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2018,10,27]],"date-time":"2018-10-27T00:00:00Z","timestamp":1540598400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Eur J Clin Microbiol Infect Dis"],"published-print":{"date-parts":[[2019,1]]},"DOI":"10.1007\/s10096-018-3403-7","type":"journal-article","created":{"date-parts":[[2018,10,27]],"date-time":"2018-10-27T14:22:59Z","timestamp":1540650179000},"page":"125-134","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":25,"title":["Predictors of unfavorable outcome in neurosyphilis: Multicenter ID-IRI Study"],"prefix":"10.1007","volume":"38","author":[{"given":"Derya","family":"Ozturk-Engin","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hakan","family":"Erdem","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rodrigo","family":"Hasbun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8246-1422","authenticated-orcid":false,"given":"Shu-Hua","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hulya","family":"Tireli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pierre","family":"Tattevin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xavier","family":"Argemi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Enora","family":"Ouamara-Digue","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea","family":"Gombos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Botond","family":"Lakatos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fatma","family":"S\u0131rmatel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yasemin","family":"Cag","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abdullah Umut","family":"Pekok","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seniha","family":"Senbayrak","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ilker Inan\u00e7","family":"Balkan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marie","family":"Gheno","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nuray","family":"Uzun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sel\u00e7uk","family":"Kaya","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G\u00f6n\u00fcl","family":"Cicek-Senturk","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G\u00f6n\u00fcl","family":"\u015eeng\u00f6z","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Recep","family":"Tekin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mustafa Kemal","family":"\u00c7elen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sayg\u0131n","family":"Nayman-Alpat","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P\u0131nar","family":"Ergen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alper","family":"\u015eener","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Canan","family":"Agalar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S\u00fckran","family":"K\u00f6se","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ahmet \u00c7agkan","family":"Inkaya","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Figen","family":"Kaptan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fahad","family":"Al-majid","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Umit","family":"Savasci","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haluk","family":"Vahaboglu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2018,10,27]]},"reference":[{"issue":"5","key":"3403_CR1","doi-asserted-by":"publisher","first-page":"481","DOI":"10.1007\/s11908-015-0481-x","volume":"17","author":"S Bhai","year":"2015","unstructured":"Bhai S, Lyons JL (2015) Neurosyphilis update: atypical is the new typical. Curr Infect Dis Rep 17(5):481","journal-title":"Curr Infect Dis Rep"},{"issue":"9","key":"3403_CR2","doi-asserted-by":"publisher","first-page":"363","DOI":"10.15698\/mic2016.09.523","volume":"3","author":"LV Stamm","year":"2016","unstructured":"Stamm LV (2016) Syphilis: re-emergence of an old foe. Microb Cell 3(9):363\u2013370","journal-title":"Microb Cell"},{"issue":"4","key":"3403_CR3","doi-asserted-by":"publisher","first-page":"720","DOI":"10.1007\/s00415-011-6252-1","volume":"259","author":"SU Jantzen","year":"2012","unstructured":"Jantzen SU, Ferrea S, Langebner T, Gaebel W, Griese M, Arendt G, Dihne M (2012) Late-stage neurosyphilis presenting with severe neuropsychiatric deficits: diagnosis, therapy, and course of three patients. J Neurol 259(4):720\u2013728","journal-title":"J Neurol"},{"issue":"2","key":"3403_CR4","doi-asserted-by":"publisher","first-page":"148","DOI":"10.1159\/000347109","volume":"226","author":"HL Zhang","year":"2013","unstructured":"Zhang HL, Lin LR, Liu GL, Zeng YL, Wu JY, Zheng WH, Tong ML, Dong J, Su YH, Liu LL et al (2013) Clinical spectrum of neurosyphilis among HIV-negative patients in the modern era. Dermatology 226(2):148\u2013156","journal-title":"Dermatology"},{"issue":"2","key":"3403_CR5","doi-asserted-by":"publisher","first-page":"184","DOI":"10.7861\/clinmedicine.16-2-184","volume":"16","author":"F Nyatsanza","year":"2016","unstructured":"Nyatsanza F, Tipple C (2016) Syphilis: presentations in general medicine. Clin Med (Lond) 16(2):184\u2013188","journal-title":"Clin Med (Lond)"},{"issue":"4","key":"3403_CR6","first-page":"703","volume":"16","author":"TC Brightbill","year":"1995","unstructured":"Brightbill TC, Ihmeidan IH, Post MJ, Berger JR, Katz DA (1995) Neurosyphilis in HIV-positive and HIV-negative patients: neuroimaging findings. AJNR Am J Neuroradiol 16(4):703\u2013711","journal-title":"AJNR Am J Neuroradiol"},{"issue":"6","key":"3403_CR7","doi-asserted-by":"publisher","first-page":"726","DOI":"10.1001\/jama.1972.03190320032011","volume":"219","author":"H Hooshmand","year":"1972","unstructured":"Hooshmand H, Escobar MR, Kopf SW (1972) Neurosyphilis. A study of 241 patients. JAMA 219(6):726\u2013729","journal-title":"JAMA"},{"issue":"9","key":"3403_CR8","doi-asserted-by":"publisher","first-page":"1595","DOI":"10.1007\/s10096-017-2973-0","volume":"36","author":"H Erdem","year":"2017","unstructured":"Erdem H, Inan A, Guven E, Hargreaves S, Larsen L, Shehata G, Pernicova E, Khan E, Bastakova L, Namani S et al (2017) The burden and epidemiology of community-acquired central nervous system infections: a multinational study. Eur J Clin Microbiol Infect Dis 36(9):1595\u20131611","journal-title":"Eur J Clin Microbiol Infect Dis"},{"issue":"9","key":"3403_CR9","first-page":"1180","volume":"63","author":"C Vanhaecke","year":"2016","unstructured":"Vanhaecke C, Grange P, Benhaddou N, Blanche P, Salmon D, Parize P, Lortholary O, Caumes E, Pelloux I, Epaulard O et al (2016) Clinical and biological characteristics of 40 patients with neaAurosyphilis and evaluation of Treponema pallidum nested polymerase chain reaction in cerebrospinal fluid samples. Clin Infect Dis 63(9):1180\u20131186","journal-title":"Clin Infect Dis"},{"issue":"11","key":"3403_CR10","doi-asserted-by":"crossref","first-page":"1886","DOI":"10.1111\/jdv.13753","volume":"30","author":"F Drago","year":"2016","unstructured":"Drago F, Merlo G, Ciccarese G, Agnoletti AF, Cozzani E, Rebora A, Parodi A (2016) Changes in neurosyphilis presentation: a survey on 286 patients. J Eur Acad Dermatol Venereol 30(11):1886\u20131900","journal-title":"J Eur Acad Dermatol Venereol"},{"key":"3403_CR11","volume-title":"Prevention: STD surveillance case definitions","author":"Control CfD","year":"2014","unstructured":"Control CfD (2014) Prevention: STD surveillance case definitions. Centers for Disease Control and Prevention, Atlanta: http:\/\/www.cdc.gov\/std\/stats\/casedefinitions-2014.pdf"},{"issue":"1","key":"3403_CR12","doi-asserted-by":"publisher","first-page":"29","DOI":"10.1128\/CMR.19.1.29-49.2006","volume":"19","author":"RE Lafond","year":"2006","unstructured":"Lafond RE, Lukehart SA (2006) Biological basis for syphilis. Clin Microbiol Rev 19(1):29\u201349","journal-title":"Clin Microbiol Rev"},{"key":"3403_CR13","unstructured":"https:\/\/www.cdc.gov\/std\/syphilis\/stdfact-syphilis-detailed.htm . Accessed 30 April 2018"},{"issue":"5","key":"3403_CR14","doi-asserted-by":"publisher","first-page":"e157","DOI":"10.1111\/j.1755-5949.2010.00183.x","volume":"16","author":"KG Ghanem","year":"2010","unstructured":"Ghanem KG (2010) Review: neurosyphilis: a historical perspective and review. CNS Neurosci Ther 16(5):e157\u2013e168","journal-title":"CNS Neurosci Ther"},{"issue":"Suppl A","key":"3403_CR15","doi-asserted-by":"publisher","first-page":"18A","DOI":"10.1155\/2015\/167484","volume":"26","author":"T Wong","year":"2015","unstructured":"Wong T, Fonseca K, Chernesky MA, Garceau R, Levett PN, Serhir B (2015) Canadian public health laboratory network laboratory guidelines for the diagnosis of neurosyphilis in Canada. Can J Infect Dis Med Microbiol 26(Suppl A):18A\u201322A","journal-title":"Can J Infect Dis Med Microbiol"},{"key":"3403_CR16","unstructured":"cdc.gov\/std\/syphilis\/Syphilis-Pocket-Guide-FINAL-508.pdf : Syphilis: a provider\u2019s guide to treatment and prevention. November 30, 2017"},{"key":"3403_CR17","unstructured":"Amarenco P CLR, Pessin M (1998) Vertebrobasilar occlusive diseases. In: Barnett HJM, Mohr JP, Stein BM (eds) Stroke Pathophysiology, diagnosis and management, 3rd edn. Churchill Livingstone, pp 513\u2013527"},{"issue":"7","key":"3403_CR18","doi-asserted-by":"publisher","first-page":"812","DOI":"10.1111\/ijd.12095","volume":"53","author":"Z Khamaysi","year":"2014","unstructured":"Khamaysi Z, Bergman R, Telman G, Goldsher D (2014) Clinical and imaging findings in patients with neurosyphilis: a study of a cohort and review of the literature. Int J Dermatol 53(7):812\u2013819","journal-title":"Int J Dermatol"},{"issue":"1","key":"3403_CR19","doi-asserted-by":"publisher","first-page":"29","DOI":"10.1159\/000079391","volume":"52","author":"MA Conde-Sendin","year":"2004","unstructured":"Conde-Sendin MA, Amela-Peris R, Aladro-Benito Y, Maroto AA (2004) Current clinical spectrum of neurosyphilis in immunocompetent patients. Eur Neurol 52(1):29\u201335","journal-title":"Eur Neurol"},{"issue":"9","key":"3403_CR20","doi-asserted-by":"publisher","first-page":"1251","DOI":"10.1080\/00207450701239426","volume":"118","author":"CH Mitsonis","year":"2008","unstructured":"Mitsonis CH, Kararizou E, Dimopoulos N, Triantafyllou N, Kapaki E, Mitropoulos P, Sfagos K, Vassilopoulos D (2008) Incidence and clinical presentation of neurosyphilis: a retrospective study of 81 cases. Int J Neurosci 118(9):1251\u20131257","journal-title":"Int J Neurosci"},{"issue":"5","key":"3403_CR21","doi-asserted-by":"publisher","first-page":"538","DOI":"10.1016\/j.bjid.2013.01.016","volume":"17","author":"MAMM Fatima de","year":"2013","unstructured":"de Fatima MAMM, Bezerra PC, Guedes DL, Cabral DB, de Barros Miranda-Filho D (2013) Prognostic indicators in bacterial meningitis: a case-control study. Braz J Infect Dis 17(5):538\u2013544","journal-title":"Braz J Infect Dis"},{"issue":"1","key":"3403_CR22","doi-asserted-by":"publisher","first-page":"51","DOI":"10.1186\/s12879-016-2126-6","volume":"17","author":"J Qu","year":"2017","unstructured":"Qu J, Zhou T, Zhong C, Deng R, Lu X (2017) Comparison of clinical features and prognostic factors in HIV-negative adults with cryptococcal meningitis and tuberculous meningitis: a retrospective study. BMC Infect Dis 17(1):51","journal-title":"BMC Infect Dis"},{"issue":"4 Neuro-ophthal","key":"3403_CR23","first-page":"942","volume":"20","author":"M Dinkin","year":"2014","unstructured":"Dinkin M (2014) Diagnostic approach to diplopia. Continuum (Minneap Minn) 20(4 Neuro-ophthalmology):942\u2013965","journal-title":"Continuum (Minneap Minn)"},{"issue":"5","key":"3403_CR24","doi-asserted-by":"publisher","first-page":"526","DOI":"10.1016\/j.annemergmed.2015.07.526","volume":"66","author":"CD Control","year":"2015","unstructured":"Control CD (2015) Prevention: sexually transmitted diseases treatment guidelines, 2015. Ann Emerg Med 66(5):526\u2013528","journal-title":"Ann Emerg Med"},{"issue":"5","key":"3403_CR25","doi-asserted-by":"publisher","first-page":"415","DOI":"10.1136\/sti.79.5.415","volume":"79","author":"S Shann","year":"2003","unstructured":"Shann S, Wilson J (2003) Treatment of neurosyphilis with ceftriaxone. Sex Transm Infect 79(5):415\u2013416","journal-title":"Sex Transm Infect"},{"issue":"4","key":"3403_CR26","doi-asserted-by":"publisher","first-page":"119e","DOI":"10.1592\/phco.30.4.418","volume":"30","author":"SL Kang-Birken","year":"2010","unstructured":"Kang-Birken SL, Castel U, Prichard JG (2010) Oral doxycycline for treatment of neurosyphilis in two patients infected with human immunodeficiency virus. Pharmacotherapy 30(4):119e\u2013122e","journal-title":"Pharmacotherapy"},{"issue":"2","key":"3403_CR27","doi-asserted-by":"publisher","first-page":"193","DOI":"10.3201\/eid2402.171167","volume":"24","author":"AC Pratas","year":"2018","unstructured":"Pratas AC, Goldschmidt P, Lebeaux D, Aguilar C, Ermak N, Benesty J, Charlier C, Benveniste E, Merabet L, Sedira N et al (2018) Increase in ocular syphilis cases at ophthalmologic reference center, France, 2012-2015. Emerg Infect Dis 24(2):193\u2013200","journal-title":"Emerg Infect Dis"},{"issue":"22","key":"3403_CR28","doi-asserted-by":"publisher","first-page":"e188","DOI":"10.1212\/WNL.0000000000001033","volume":"83","author":"N Karsan","year":"2014","unstructured":"Karsan N, Barker R, O'Dwyer JP (2014) Clinical reasoning: the \u201cgreat imitator\u201d. Neurology 83(22):e188\u2013e196","journal-title":"Neurology"}],"container-title":["European Journal of Clinical Microbiology & Infectious Diseases"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s10096-018-3403-7\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s10096-018-3403-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s10096-018-3403-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,9,4]],"date-time":"2022-09-04T16:05:53Z","timestamp":1662307553000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s10096-018-3403-7"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,10,27]]},"references-count":28,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2019,1]]}},"alternative-id":["3403"],"URL":"https:\/\/doi.org\/10.1007\/s10096-018-3403-7","relation":{},"ISSN":["0934-9723","1435-4373"],"issn-type":[{"value":"0934-9723","type":"print"},{"value":"1435-4373","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,10,27]]},"assertion":[{"value":"13 June 2018","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"12 October 2018","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"27 October 2018","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"We have no competing interests to declare. The neurosyphilis study protocol was approved by Fatih Sultan Mehmet Training and Research Hospital in Istanbul.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Compliance with ethical standards"}}]}}