{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T19:15:07Z","timestamp":1792782907346,"version":"4.5.0"},"reference-count":26,"publisher":"Springer Science and Business Media LLC","issue":"2","license":[{"start":{"date-parts":[[2018,12,5]],"date-time":"2018-12-05T00:00:00Z","timestamp":1543968000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"name":"The Department of Microbiology, Leeds Teaching Hospitals Charitable Account funded serum antibiotic assays"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Eur J Clin Microbiol Infect Dis"],"published-print":{"date-parts":[[2019,2]]},"DOI":"10.1007\/s10096-018-3435-z","type":"journal-article","created":{"date-parts":[[2018,12,4]],"date-time":"2018-12-04T23:54:51Z","timestamp":1543967691000},"page":"357-363","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Colo-Pro: a pilot randomised controlled trial to compare standard bolus-dosed cefuroxime prophylaxis to bolus-continuous infusion\u2013dosed cefuroxime prophylaxis for the prevention of infections after colorectal surgery"],"prefix":"10.1007","volume":"38","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2440-9316","authenticated-orcid":false,"given":"Andrew","family":"Kirby","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eduardo","family":"As\u00edn-Prieto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Flora Agnes","family":"Burns","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Duncan","family":"Ewin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kavi","family":"Fatania","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mithun","family":"Kailavasan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Saira","family":"Nisar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Agamemnon","family":"Pericleous","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"I\u00f1aki F.","family":"Troc\u00f3niz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dermot","family":"Burke","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2018,12,5]]},"reference":[{"key":"3435_CR1","unstructured":"HES data: Health and Social Care Information Centre. Hospital Episode Statistics. \n                    http:\/\/www.hesonline.nhs.uk\/Ease\/servlet\/ContentServer?siteID=1937\n                    \n                  . Accessed 11June 2018"},{"key":"3435_CR2","doi-asserted-by":"publisher","first-page":"825","DOI":"10.3109\/23744235.2015.1055584","volume":"47","author":"A Kirby","year":"2015","unstructured":"Kirby A, Burnside G, Bretsztajn L, Burke D (2015) Post-operative infections following colorectal surgery in an English teaching hospital. Infect Dis (Lond) 47:825\u2013829","journal-title":"Infect Dis (Lond)"},{"key":"3435_CR3","doi-asserted-by":"publisher","first-page":"4","DOI":"10.1186\/1471-2334-8-34","volume":"8","author":"N Petrosillo","year":"2008","unstructured":"Petrosillo N, Drapeau CM, Nicastri E, Martini L, Ippolito G, Moro ML (2008) Surgical site infections in Italian hospitals: a prospective multicenter study. BMC Infect Dis 8:4","journal-title":"BMC Infect Dis"},{"key":"3435_CR4","doi-asserted-by":"publisher","first-page":"599","DOI":"10.1097\/01.sla.0000124292.21605.99","volume":"239","author":"RL Smith","year":"2004","unstructured":"Smith RL, Bohl JK, Mcelearney ST, Friel CM, Barclay MM, Sawyer RG, Foley EF (2004) Wound infection after elective colorectal resection. Ann Surg 239:599\u2013605","journal-title":"Ann Surg"},{"key":"3435_CR5","doi-asserted-by":"publisher","first-page":"1004","DOI":"10.1007\/s10350-007-9142-y","volume":"51","author":"EC Wick","year":"2008","unstructured":"Wick EC, Gibbs L, Indorf LA, Varma MG, Garcia-Aguilar J (2008) Implementation of quality measures to reduce surgical site infection in colorectal patients. Dis Colon Rectum 51:1004\u20131009","journal-title":"Dis Colon Rectum"},{"key":"3435_CR6","doi-asserted-by":"publisher","first-page":"243","DOI":"10.1016\/j.jhin.2009.03.021","volume":"72","author":"J Tanner","year":"2009","unstructured":"Tanner J, Khan D, Aplin C, Ball J, Thomas M, Bankart J (2009) Post-discharge surveillance to identify colorectal surgical site infection rates and related costs. J Hosp Infect 72:243\u2013250","journal-title":"J Hosp Infect"},{"key":"3435_CR7","doi-asserted-by":"publisher","first-page":"24","DOI":"10.1016\/j.jhin.2013.09.012","volume":"86","author":"PJ Jenks","year":"2014","unstructured":"Jenks PJ, Laurent M, McQuarry S, Watkins R (2014) Clinical and economic burden of surgical site infection (SSI) and predicted financial consequences of elimination of SSI from an English hospital. J Hosp Infect 86:24\u201333","journal-title":"J Hosp Infect"},{"key":"3435_CR8","first-page":"CD001181","volume":"5","author":"RL Nelson","year":"2014","unstructured":"Nelson RL, Gladman E, Barbateskovic M (2014) Antimicrobial prophylaxis for colorectal surgery. Cochrane Database Syst Rev 5:CD001181","journal-title":"Cochrane Database Syst Rev"},{"key":"3435_CR9","doi-asserted-by":"publisher","first-page":"131","DOI":"10.1089\/sur.2007.034","volume":"9","author":"KM Itani","year":"2008","unstructured":"Itani KM, Jensen EH, Finn TS, Tomassini JE, Abramson MA (2008) Effect of body mass index and ertapenem versus cefotetan prophylaxis on surgical site infection in elective colorectal surgery. Surg Infect 9:131\u2013137","journal-title":"Surg Infect"},{"key":"3435_CR10","doi-asserted-by":"publisher","first-page":"1429","DOI":"10.1016\/S1473-3099(15)00270-4","volume":"15","author":"A Teillant","year":"2015","unstructured":"Teillant A, Gandra S, Barter D, Morgan DJ, Laxminarayan R (2015) Potential burden of antibiotic resistance on surgery and cancer chemotherapy antibiotic prophylaxis in the USA: a literature review and modelling study. Lancet Infect Dis 15:1429\u20131437","journal-title":"Lancet Infect Dis"},{"key":"3435_CR11","doi-asserted-by":"publisher","first-page":"271","DOI":"10.1016\/j.jhin.2015.03.002","volume":"90","author":"A Kirby","year":"2015","unstructured":"Kirby A, Bretsztajn L, Santoni N, Patel H, Burke D, Horner C (2015) Microbiological prediction of surgical site infection risk after colorectal surgery: a feasibility study. J Hosp Infect 90:271\u2013272","journal-title":"J Hosp Infect"},{"key":"3435_CR12","doi-asserted-by":"publisher","first-page":"504","DOI":"10.1016\/j.ijantimicag.2015.01.008","volume":"45","author":"E As\u00edn-Prieto","year":"2015","unstructured":"As\u00edn-Prieto E, Soraluce A, Troc\u00f3niz IF, Campo Cimarras E, S\u00e1enz de Ugarte Sobr\u00f3n J, Rodr\u00edguez-Gasc\u00f3n A, Isla A (2015) Population pharmacokinetic models for cefuroxime and metronidazole used in combination as prophylactic agents in colorectal surgery: model-based evaluation of standard dosing regimens. Int J Antimicrob Agents 45:504\u2013511","journal-title":"Int J Antimicrob Agents"},{"key":"3435_CR13","doi-asserted-by":"publisher","first-page":"470","DOI":"10.1016\/j.coph.2011.07.006","volume":"11","author":"AP MacGowan","year":"2011","unstructured":"MacGowan AP (2011) Revisiting Beta-lactams - PK\/PD improves dosing of old antibiotics. Curr Opin Pharmacol 11:470\u2013476","journal-title":"Curr Opin Pharmacol"},{"key":"3435_CR14","doi-asserted-by":"publisher","first-page":"257","DOI":"10.1590\/S1807-59322007000300009","volume":"62","author":"JW Nascimento","year":"2007","unstructured":"Nascimento JW, Carmona MJ, Strabelli TM, Auler JO Jr, Santos SR (2007) Perioperative cefuroxime pharmacokinetics in cardiac surgery. Clinics (Sao Paulo) 62:257\u2013260","journal-title":"Clinics (Sao Paulo)"},{"key":"3435_CR15","doi-asserted-by":"publisher","first-page":"604","DOI":"10.7326\/0003-4819-150-9-200905050-00006","volume":"150","author":"AS Levey","year":"2009","unstructured":"Levey AS, Stevens LA, Schmid CH, Zhang YL, Castro AF 3rd, Feldman HI, Kusek JW, Eggers P, Van Lente F, Greene T, Coresh J, CKD-EPI (Chronic Kidney Disease Epidemiology Collaboration) (2009) A new equation to estimate glomerular filtration rate. Ann Intern Med 150:604\u2013612","journal-title":"Ann Intern Med"},{"key":"3435_CR16","doi-asserted-by":"publisher","first-page":"705","DOI":"10.1007\/s00228-008-0493-7","volume":"64","author":"K Ogungbenro","year":"2008","unstructured":"Ogungbenro K, Aarons L (2008) How many subjects are necessary for population pharmacokinetic experiments? Confidence interval approach. Eur J Clin Pharmacol 64:705\u2013713","journal-title":"Eur J Clin Pharmacol"},{"key":"3435_CR17","doi-asserted-by":"publisher","first-page":"97","DOI":"10.1016\/S0196-6553(99)70088-X","volume":"27","author":"A Mangram","year":"1999","unstructured":"Mangram A, Horan TC, Pearson ML, Silver L, Jarvis WR (1999) Guideline for prevention of surgical site infection. Am J Infect Control 27:97\u2013132","journal-title":"Am J Infect Control"},{"key":"3435_CR18","unstructured":"Public Health England. Surveillance of surgical site infections in NHS hospitals in England, 2016 to 2017. Public health England, December 2017. Available from: \n                    www.gov.uk\/phe\n                    \n                  . Accessed 11 June 2017"},{"key":"3435_CR19","unstructured":"Health Protection Agency (2012) English national point prevalence survey on healthcare associated infections and antimicrobial use, 2011: preliminary data HPA, London"},{"key":"3435_CR20","doi-asserted-by":"publisher","first-page":"c869","DOI":"10.1136\/bmj.c869","volume":"340","author":"D Moher","year":"2010","unstructured":"Moher D, Hopewell S, Schulz KF, Montori V, G\u00f8tzsche PC, Devereaux PJ, Elbourne D, Egger M, Altman DG (2010) CONSORT 2010 explanation and elaboration: updated guidelines for reporting parallel group randomised trials. BMJ 340:c869","journal-title":"BMJ"},{"key":"3435_CR21","doi-asserted-by":"publisher","first-page":"i5239","DOI":"10.1136\/bmj.i5239","volume":"355","author":"SM Eldridge","year":"2016","unstructured":"Eldridge SM, Chan CL, Campbell MJ, Bond CM, Hopewell S, Thabane L, Lancaster GA, PAFS consensus group (2016) CONSORT 2010 statement: extension to randomised pilot and feasibility trials. BMJ 355:i5239","journal-title":"BMJ"},{"key":"3435_CR22","unstructured":"(EUCAST) ECoAST. Cefuroxime: rationale for the EUCAST clinical breakpoints (2010) \n                    http:\/\/www.eucast.org\/fileadmin\/src\/media\/PDFs\/EUCAST_files\/Rationale_documents\/Cefuroxime_iv_Rationale_Document_1.0_2010Nov.pdf\n                    \n                  . Accessed 11 June 2018"},{"key":"3435_CR23","doi-asserted-by":"publisher","first-page":"99","DOI":"10.1093\/jac\/40.1.99","volume":"40","author":"AM Lovering","year":"1997","unstructured":"Lovering AM, Perez J, Bowker KE, Reeves DS, MacGowan AP, Bannister G (1997) A comparison of the penetration of cefuroxime and cephamandole into bone, fat and haematoma fluid in patients undergoing total hip replacement. J Antimicrob Chemother 40:99\u2013104","journal-title":"J Antimicrob Chemother"},{"key":"3435_CR24","doi-asserted-by":"publisher","first-page":"3026","DOI":"10.1128\/AAC.46.9.3026-3030.2002","volume":"46","author":"SA Zelenitsky","year":"2002","unstructured":"Zelenitsky SA, Ariano RE, Harding GK, Silverman RE (2002) Antibiotic pharmacodynamics in surgical prophylaxis: an association between intraoperative antibiotic concentrations and efficacy. Antimicrob Agents Chemother 46:3026\u20133030","journal-title":"Antimicrob Agents Chemother"},{"key":"3435_CR25","doi-asserted-by":"publisher","first-page":"2538","DOI":"10.1007\/s00268-009-0158-4","volume":"33","author":"JC Woodfield","year":"2009","unstructured":"Woodfield JC, Beshay N, van Rij AM (2009) A meta-analysis of randomized, controlled trials assessing the prophylactic use of ceftriaxone. A study of wound, chest, and urinary infections. World J Surg 33:2538\u20132550","journal-title":"World J Surg"},{"key":"3435_CR26","doi-asserted-by":"publisher","first-page":"286ra68","DOI":"10.1126\/scitranslmed.3010658","volume":"7","author":"BD Shogan","year":"2015","unstructured":"Shogan BD, Belogortseva N, Luong PM, Zaborin A, Lax S, Bethel C, Ward M, Muldoon JP, Singer M, An G, Umanskiy K, Konda V, Shakhsheer B, Luo J, Klabbers R, Hancock LE, Gilbert J, Zaborina O, Alverdy JC (2015) Collagen degradation and MMP9 activation by Enterococcus faecalis contribute to intestinal anastomotic leak. Sci Transl Med 7:286ra68","journal-title":"Sci Transl Med"}],"container-title":["European Journal of Clinical Microbiology & Infectious Diseases"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s10096-018-3435-z\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s10096-018-3435-z.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s10096-018-3435-z.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,12,4]],"date-time":"2019-12-04T19:08:40Z","timestamp":1575486520000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s10096-018-3435-z"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,12,5]]},"references-count":26,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2019,2]]}},"alternative-id":["3435"],"URL":"https:\/\/doi.org\/10.1007\/s10096-018-3435-z","relation":{},"ISSN":["0934-9723","1435-4373"],"issn-type":[{"value":"0934-9723","type":"print"},{"value":"1435-4373","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,12,5]]},"assertion":[{"value":"6 August 2018","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"13 November 2018","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"5 December 2018","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Compliance with ethical standards"}},{"value":"The authors declare that they have no conflict of interest.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and\/or national research committee and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval"}},{"value":"Informed consent was obtained from all individual participants included in the study.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Informed consent"}}]}}