{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,15]],"date-time":"2026-05-15T02:07:49Z","timestamp":1778810869669,"version":"3.51.4"},"reference-count":27,"publisher":"Springer Science and Business Media LLC","issue":"9","license":[{"start":{"date-parts":[[2019,7,14]],"date-time":"2019-07-14T00:00:00Z","timestamp":1563062400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2019,7,14]],"date-time":"2019-07-14T00:00:00Z","timestamp":1563062400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Eur J Clin Microbiol Infect Dis"],"published-print":{"date-parts":[[2019,9]]},"DOI":"10.1007\/s10096-019-03603-1","type":"journal-article","created":{"date-parts":[[2019,7,13]],"date-time":"2019-07-13T23:02:56Z","timestamp":1563058976000},"page":"1709-1717","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":19,"title":["Health sequelae of human cryptosporidiosis\u2014a 12-month prospective follow-up study"],"prefix":"10.1007","volume":"38","author":[{"given":"B. L.","family":"Carter","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R. E.","family":"Stiff","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K.","family":"Elwin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H. A.","family":"Hutchings","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"B. W.","family":"Mason","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4190-8894","authenticated-orcid":false,"given":"A. P.","family":"Davies","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R. M.","family":"Chalmers","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2019,7,14]]},"reference":[{"key":"3603_CR1","doi-asserted-by":"publisher","first-page":"b4168","DOI":"10.1136\/bmj.b4168","volume":"339","author":"A Davies","year":"2009","unstructured":"Davies A, Chalmers R (2009) Cryptosporidiosis. Br Med J 339:b4168","journal-title":"Br Med J"},{"key":"3603_CR2","unstructured":"Public Health England (2017) Cryptosporidium data 2006 to 2015 November 2016 - national laboratory data for residents of England and Wales"},{"key":"3603_CR3","doi-asserted-by":"publisher","first-page":"109","DOI":"10.3329\/bjvm.v14i2.31376","volume":"14","author":"M Ehsan","year":"2016","unstructured":"Ehsan M, Akter M, Ahammed M, Ali M, Ahmed M (2016) Prevalence and clinical importance of Cryptosporidium and Giardia in humans and animals. Bangladesh J Vet Med 14:109\u2013122","journal-title":"Bangladesh J Vet Med"},{"issue":"4","key":"3603_CR4","doi-asserted-by":"publisher","first-page":"504","DOI":"10.1086\/422649","volume":"39","author":"P Hunter","year":"2004","unstructured":"Hunter P, Hughes S, Woodhouse S, Nicholas R, Syed Q, Chalmers R et al (2004) Health sequelae of human cryptosporidiosis in immunocompetent patients. Clin Infect Dis 39(4):504\u2013510","journal-title":"Clin Infect Dis"},{"issue":"4","key":"3603_CR5","doi-asserted-by":"publisher","first-page":"581","DOI":"10.3201\/eid2004.121415","volume":"20","author":"M Widerstr\u00f6m","year":"2014","unstructured":"Widerstr\u00f6m M, Sch\u00f6nning C, Lilja M, Lebbad M, Ljung T, Allestam G et al (2014) Large outbreak of Cryptosporidium hominis infection transmitted through the public water supply, Sweden. Emerg Infect Dis 20(4):581\u2013589","journal-title":"Emerg Infect Dis"},{"issue":"1","key":"3603_CR6","doi-asserted-by":"publisher","first-page":"57","DOI":"10.1093\/clinids\/21.1.57","volume":"21","author":"W Mac Kenzie","year":"1995","unstructured":"Mac Kenzie W, Schell W, Blair K, Addiss D, Peterson D, Hoxie N et al (1995) Massive outbreak of waterborne Cryptosporidium infection in Milwaukee, Wisconsin: recurrence of illness and risk of secondary transmission. Clin Infect Dis 21(1):57\u201362","journal-title":"Clin Infect Dis"},{"issue":"1","key":"3603_CR7","doi-asserted-by":"publisher","first-page":"145","DOI":"10.1128\/CMR.15.1.145-154.2002","volume":"15","author":"P Hunter","year":"2002","unstructured":"Hunter P, Nichols G (2002) Epidemiology and clinical features of Cryptosporidium infection in immunocompromised patients. Clin Microbiol Rev 15(1):145\u2013154","journal-title":"Clin Microbiol Rev"},{"issue":"1","key":"3603_CR8","doi-asserted-by":"publisher","first-page":"5","DOI":"10.1097\/00042737-200501000-00002","volume":"17","author":"S Parry","year":"2005","unstructured":"Parry S, Forgacs I (2005) Intestinal infection and irritable bowel syndrome. Eur J Gastroenterol Hepatol 17(1):5\u20139","journal-title":"Eur J Gastroenterol Hepatol"},{"issue":"11","key":"3603_CR9","doi-asserted-by":"publisher","first-page":"5163","DOI":"10.1128\/IAI.00220-09","volume":"77","author":"S Khaldi","year":"2009","unstructured":"Khaldi S, Gargala G, Le Goff L, Parey S, Francois A, Fioramonti J et al (2009) Cryptosporidium parvum isolate-dependent postinfectious jejunal hypersensitivity and mast cell accumulation in an immunocompetent rat model. Infect Immun 77(11):5163\u20135169","journal-title":"Infect Immun"},{"issue":"11","key":"3603_CR10","doi-asserted-by":"publisher","first-page":"1607","DOI":"10.1099\/jmm.0.000609","volume":"66","author":"RE Stiff","year":"2017","unstructured":"Stiff RE et al (2017) Long-term health effects after resolution of acute Cryptosporidium parvum infection: a 1-year follow-up of outbreak-associated cases. J Med Microbiol 66(11):1607\u20131611","journal-title":"J Med Microbiol"},{"issue":"1","key":"3603_CR11","doi-asserted-by":"publisher","first-page":"529","DOI":"10.1186\/s12889-015-1871-6","volume":"15","author":"M Rehn","year":"2015","unstructured":"Rehn M, Wallensten A, Widerstr\u00f6m M, Lilja M, Grunewald M, Stenmark S et al (2015) Post-infection symptoms following two large waterborne outbreaks of Cryptosporidium hominis in Northern Sweden, 2010\u20132011. BMC Public Health 15(1):529","journal-title":"BMC Public Health"},{"issue":"05","key":"3603_CR12","doi-asserted-by":"publisher","first-page":"1009","DOI":"10.1017\/S0950268812001665","volume":"141","author":"M Insulander","year":"2012","unstructured":"Insulander M, Silverl\u00e5s C, Lebbad M, Karlsson L, Mattsson J, Svenungsson B (2012) Molecular epidemiology and clinical manifestations of human cryptosporidiosis in Sweden. Epidemiol Infect 141(05):1009\u20131020","journal-title":"Epidemiol Infect"},{"key":"3603_CR13","doi-asserted-by":"crossref","unstructured":"Igl\u00f3i Z et al (2018) Long-term sequelae of sporadic cryptosporidiosis: a follow-up study. Eur J Clin Microbiol 1\u20138","DOI":"10.1007\/s10096-018-3268-9"},{"issue":"5","key":"3603_CR14","doi-asserted-by":"publisher","first-page":"1377","DOI":"10.1053\/j.gastro.2006.03.008","volume":"130","author":"D Drossman","year":"2006","unstructured":"Drossman D (2006) The functional gastrointestinal disorders and the Rome III process. Gastroenterology 130(5):1377\u20131390","journal-title":"Gastroenterology"},{"issue":"3","key":"3603_CR15","doi-asserted-by":"publisher","first-page":"918","DOI":"10.1128\/JCM.01733-10","volume":"49","author":"SJ Hadfield","year":"2011","unstructured":"Hadfield SJ, Robinson G, Elwin K, Chalmers RM (2011) Detection and differentiation of Cryptosporidium spp. in human clinical samples by use of real-time PCR. J Clin Microbiol 49(3):918\u2013924","journal-title":"J Clin Microbiol"},{"issue":"4","key":"3603_CR16","doi-asserted-by":"publisher","first-page":"606","DOI":"10.1016\/j.parint.2010.08.011","volume":"59","author":"F Tosini","year":"2010","unstructured":"Tosini F, Drumo R, Elwin K, Chalmers RM, Pozio E, Cacci\u00f2 SM (2010) The CpA135 gene as a marker to identify Cryptosporidium species infecting humans. Parasitol Int 59(4):606\u2013609","journal-title":"Parasitol Int"},{"key":"3603_CR17","doi-asserted-by":"publisher","first-page":"4446","DOI":"10.1128\/AEM.71.8.4446-4454.2005","volume":"71","author":"J Jiang","year":"2005","unstructured":"Jiang J, Alderisio KA, Xiao L (2005) Distribution of Cryptosporidium genotypes in storm event water samples from three watersheds in New York. Appl Environ Microbiol 71:4446\u20134454","journal-title":"Appl Environ Microbiol"},{"issue":"6592","key":"3603_CR18","doi-asserted-by":"publisher","first-page":"248","DOI":"10.1136\/bmj.295.6592.248","volume":"295","author":"E Hay","year":"1987","unstructured":"Hay E, Winfield J, McKendrick M (1987) Reactive arthritis associated with Cryptosporidium enteritis. Br Med J 295(6592):248","journal-title":"Br Med J"},{"issue":"5","key":"3603_CR19","doi-asserted-by":"publisher","first-page":"743","DOI":"10.1136\/adc.64.5.743","volume":"64","author":"R Shepherd","year":"1989","unstructured":"Shepherd R, Smail P, Sinha G (1989) Reactive arthritis complicating cryptosporidial infection. Arch Dis Child 64(5):743\u2013744","journal-title":"Arch Dis Child"},{"issue":"2","key":"3603_CR20","first-page":"181","volume":"47","author":"A Sing","year":"2003","unstructured":"Sing A, Bechtold S, Heesemann J, Belohradsky B, Schmidt H (2003) Reactive arthritis associated with prolonged cryptosporidial infection. J Inf Secur 47(2):181\u2013184","journal-title":"J Inf Secur"},{"issue":"10","key":"3603_CR21","first-page":"1962","volume":"22","author":"RQ Cron","year":"1995","unstructured":"Cron RQ, Sherry DD (1995) Reiter\u2019s syndrome associated with cryptosporidial gastroenteritis. J Rheumatol 22(10):1962\u20131963","journal-title":"J Rheumatol"},{"issue":"6570","key":"3603_CR22","doi-asserted-by":"publisher","first-page":"483","DOI":"10.1136\/bmj.294.6570.483-a","volume":"294","author":"SP Hawkins","year":"1987","unstructured":"Hawkins SP, Thomas RP, Teasdale C (1987) Acute pancreatitis: a new finding in Cryptosporidium enteritis. Br Med J (Clin Res Ed) 294(6570):483","journal-title":"Br Med J (Clin Res Ed)"},{"issue":"1","key":"3603_CR23","doi-asserted-by":"publisher","first-page":"223","DOI":"10.1086\/517686","volume":"27","author":"S Norby","year":"1998","unstructured":"Norby S, Bharucha A, Larson M, Temesgen Z (1998) Acute pancreatitis associated with Cryptosporidium parvum enteritis in an immunocompetent man. Clin Infect Dis 27(1):223\u2013224","journal-title":"Clin Infect Dis"},{"issue":"6","key":"3603_CR24","doi-asserted-by":"publisher","first-page":"788","DOI":"10.1111\/ped.12127","volume":"55","author":"N Printza","year":"2013","unstructured":"Printza N, Sapountzi E, Dotis J, Papachristou F (2013) Hemolytic uremic syndrome related to Cryptosporidium infection in an immunocompetent child. Pediatr Int 55(6):788\u2013790","journal-title":"Pediatr Int"},{"key":"3603_CR25","doi-asserted-by":"publisher","first-page":"625","DOI":"10.1186\/s13104-018-3721-y","volume":"11","author":"M Lilja","year":"2018","unstructured":"Lilja M, Widerstr\u00f6m M, Lindh J (2018) Persisting post-infection symptoms 2 years after a large waterborne outbreak of Cryptosporidium hominis in northern Sweden. BMC Res Notes 11:625","journal-title":"BMC Res Notes"},{"issue":"Suppl II","key":"3603_CR26","first-page":"ii1","volume":"47","author":"J Jones","year":"2000","unstructured":"Jones J, Boorman J, Cann P, Forbes A, Gomborone J, Heaton K et al (2000) British Society of Gastroenterology guidelines for the management of the irritable bowel syndrome. Gut 47(Suppl II):ii1\u2013ii19","journal-title":"Gut"},{"key":"3603_CR27","doi-asserted-by":"publisher","first-page":"779","DOI":"10.1136\/bmj.314.7083.779","volume":"314","author":"KR Neal","year":"1997","unstructured":"Neal KR, Hebden J, Spiller R (1997) Prevalence of gastrointestinal symptoms six months after bacterial gastroenteritis and risk factors for development of the irritable bowel syndrome: postal survey of patients (see comments). BMJ 314:779\u2013782","journal-title":"BMJ"}],"container-title":["European Journal of Clinical Microbiology &amp; Infectious Diseases"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s10096-019-03603-1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s10096-019-03603-1\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s10096-019-03603-1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,7,12]],"date-time":"2020-07-12T23:02:45Z","timestamp":1594594965000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s10096-019-03603-1"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,7,14]]},"references-count":27,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2019,9]]}},"alternative-id":["3603"],"URL":"https:\/\/doi.org\/10.1007\/s10096-019-03603-1","relation":{},"ISSN":["0934-9723","1435-4373"],"issn-type":[{"value":"0934-9723","type":"print"},{"value":"1435-4373","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,7,14]]},"assertion":[{"value":"10 April 2019","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"24 May 2019","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"14 July 2019","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Compliance with ethical standards"}},{"value":"The authors declare that they have no conflict of interest.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"Ethical approval was in place for this study. UK REC reference \/LO\/1659; IRAS project ID 94686.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval"}},{"value":"All participants gave their signed informed consent to be included in this study.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Informed consent"}}]}}