{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,6]],"date-time":"2026-11-06T20:56:07Z","timestamp":1793998567592,"version":"4.8.0"},"reference-count":21,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2019,9,9]],"date-time":"2019-09-09T00:00:00Z","timestamp":1567987200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2019,9,9]],"date-time":"2019-09-09T00:00:00Z","timestamp":1567987200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Eur J Clin Microbiol Infect Dis"],"published-print":{"date-parts":[[2020,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    The three main causes of vaginitis are bacterial vaginosis (BV), vulvovaginal candidiasis (VVC), and trichomoniasis (TV). Two multiplex assays are commercially available for detection of DNA from organisms associated with vaginitis: BD Affirm\u2122 VPIII Microbial Identification Test (Affirm) and BD MAX\u2122 Vaginal Panel (MAX VP). Here, the performance of MAX VP was compared to that of Affirm, which was considered the standard of care. Four vaginal swabs were collected from each subject with the following: BD Affirm\u2122 VPIII Ambient Temperature Transport System (ATTS), BD MAX\u2122 UVE Specimen Collection Kit, Hologic Aptima\u00ae Vaginal Swab Specimen Collection Kit, and BD ESwab\u2122 collection and transport system (ESwab).\n                    <jats:italic>Candida<\/jats:italic>\n                    culture, Gram stain followed by Nugent scoring, and the Hologic Aptima\u00ae\n                    <jats:italic>Trichomonas vaginalis<\/jats:italic>\n                    assay were used for discordant analysis. Results were considered true positive if there were at least two tests positive for any vaginitis target. A total of 200 symptomatic women were evaluated in the study. The sensitivity and specificity of MAX VP for BV was 96.2% and 96.1%, respectively, compared to 96.2% and 81.6% for Affirm. The sensitivity and specificity of MAX VP for\n                    <jats:italic>Candida<\/jats:italic>\n                    spp. was 98.4% and 95.4%, respectively, compared to 69.4% and 100% for Affirm. MAX VP and Affirm showed 100% concordance for detection of TV. These results demonstrate improved accuracy of MAX VP compared to Affirm for the detection of BV and\n                    <jats:italic>Candida<\/jats:italic>\n                    spp. and no difference for detection of TV between the two tests.\n                  <\/jats:p>","DOI":"10.1007\/s10096-019-03694-w","type":"journal-article","created":{"date-parts":[[2019,9,9]],"date-time":"2019-09-09T11:03:03Z","timestamp":1568026983000},"page":"39-44","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":21,"title":["Diagnostic performance of two molecular assays for the detection of vaginitis in symptomatic women"],"prefix":"10.1007","volume":"39","author":[{"given":"Alexandra","family":"Thompson","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karen","family":"Timm","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Noelle","family":"Borders","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liz","family":"Montoya","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2363-1553","authenticated-orcid":false,"given":"Karissa","family":"Culbreath","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2019,9,9]]},"reference":[{"issue":"Rr-03","key":"3694_CR1","first-page":"1","volume":"64","author":"KA Workowski","year":"2015","unstructured":"Workowski KA, Bolan GA (2015) Sexually transmitted diseases treatment guidelines, 2015. 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