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The prevalence of antimicrobial resistance in general practice patients is expected to be relatively high in Rotterdam, the Dutch city with the largest proportion non-Western immigrants. The aim of this study was to assess the prevalence of antibiotic-resistant uropathogens (<jats:italic>Escherichia coli<\/jats:italic>,<jats:italic>Klebsiella pneumoniae<\/jats:italic>, and<jats:italic>Proteus mirabilis<\/jats:italic>) in general practices in Rotterdam, and to find a possible association between the prevalence of antibiotic-resistant<jats:italic>E. coli<\/jats:italic>and age, gender, and socioeconomic status (SES). A retrospective analysis was performed of urine samples from general practice patients in 2016. The prevalence of AMR in uropathogens was compared with national resistance data, as was the prevalence of highly and multidrug resistant and extended spectrum \u03b2-lactamase (ESBL) producing<jats:italic>E. coli<\/jats:italic>and<jats:italic>K. pneumoniae.<\/jats:italic>Univariate logistic regression was used to study associations between antibiotic-resistant<jats:italic>E. coli<\/jats:italic>and age, gender, and SES area score. No clinically relevant differences were observed in the prevalence of antibiotic-resistant uropathogens in Rotterdam compared with the national prevalence. For<jats:italic>E. coli<\/jats:italic>and<jats:italic>K. pneumoniae<\/jats:italic>, the prevalence\u00a0was 3.6% for ESBL\u00a0production (both pathogens together), while the prevalence ranged between 4.2%\u20135.0% for high resistance\u00a0and between\u00a01.2%\u20133.3% for multidrug resistance. Ciprofloxacin-resistant<jats:italic>E. coli<\/jats:italic>was significantly associated with higher age. Although Rotterdam has a high percentage of non-western immigrants and a low SES, AMR is low among general practice patients. This indicates that adherence to national guidelines in general practice enables maintenance of low AMR, even in high-risk populations.<\/jats:p>","DOI":"10.1007\/s10096-019-03804-8","type":"journal-article","created":{"date-parts":[[2020,1,6]],"date-time":"2020-01-06T12:02:43Z","timestamp":1578312163000},"page":"929-935","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Low antimicrobial resistance in general practice patients in Rotterdam, the city with the largest proportion of immigrants in the Netherlands"],"prefix":"10.1007","volume":"39","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5372-4526","authenticated-orcid":false,"given":"Maaike","family":"Honsbeek","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aim\u00e9e","family":"Tjon-A-Tsien","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ellen","family":"Stobberingh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jurriaan","family":"de Steenwinkel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Damian C.","family":"Melles","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jan","family":"Lous","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jan Hendrik","family":"Richardus","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H\u00e9l\u00e8ne","family":"Voeten","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2020,1,6]]},"reference":[{"key":"3804_CR1","unstructured":"European Centre for Disease Prevention and Control (2018) Disease data from ECDC Surveillance Atlas - Escherichia coli infection. https:\/\/ecdc.europa.eu\/en\/escherichia-coli-ecoli\/surveillance\/atlas. 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For this study, we received only anonymous data from the laboratory. Therefore, the microbiological results of the patients\u2019 urine samples were analysed anonymously. GP patients are informed that their test results could be used anonymously for research purposes. Separate approval by an ethics review committee was therefore not required.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval"}}]}}