{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,28]],"date-time":"2026-10-28T08:10:41Z","timestamp":1793175041441,"version":"4.5.0"},"reference-count":29,"publisher":"Springer Science and Business Media LLC","issue":"6","license":[{"start":{"date-parts":[[2020,1,27]],"date-time":"2020-01-27T00:00:00Z","timestamp":1580083200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2020,1,27]],"date-time":"2020-01-27T00:00:00Z","timestamp":1580083200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"name":"Universit\u00e4tsklinikum Frankfurt"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Eur J Clin Microbiol Infect Dis"],"published-print":{"date-parts":[[2020,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Human cytomegalovirus (CMV) is a significant cause of morbidity and mortality in patient groups at risk. We have previously shown that the anti-CMV IgG seroprevalence in an urban region of Germany has changed over the last decades. Overall, a decline from 63.7 to 57.25% had been observed between 1988\u20131997 and 1998\u20132008 (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090,001). Here, we continuously follow the trends to the most recent decade 2009 to 2018. In a retrospective analysis, we determined the seroprevalence of CMV IgG antibodies in our patient cohort, stratified by gender and selected groups at risk (e.g., patients with HIV infection; women of childbearing age). The overall prevalence of anti-CMV IgG non-significantly declined further from 57.25% in 1998\u20132008 to 56.48% in 2009\u20132018 (<jats:italic>p<\/jats:italic>\u2009=\u20090.881). Looking at gender differences, overall CMV seroprevalence in males declined to 52.82% (from 55.54% in 1998\u20132008;<jats:italic>p<\/jats:italic>\u2009=\u20090.0254), while it non-significantly increased in females to 59.80%. The high seroprevalence in patients with a known HIV infection further increased from 87.46% in 1998\u20132008 to 92.93% in the current period (<jats:italic>p<\/jats:italic>\u2009=\u20090.9999). In women of childbearing age, no significant changes over the last three decades could be observed. The CMV seroprevalence in oncological patients was determined to be 60.64%. Overall, the former significant decline of CMV seroprevalence between the decades 1988\u20131997 and 1998\u20132008 in this urban region of Germany slowed down to a non-significant decrease of 0.77% (1998\u20132008 vs. 2009\u20132018). This might be an indicator that CMV seroprevalence has reached a plateau.<\/jats:p>","DOI":"10.1007\/s10096-020-03814-x","type":"journal-article","created":{"date-parts":[[2020,1,27]],"date-time":"2020-01-27T15:02:36Z","timestamp":1580137356000},"page":"1095-1102","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":47,"title":["Thirty years of CMV seroprevalence\u2014a longitudinal analysis in a German university hospital"],"prefix":"10.1007","volume":"39","author":[{"given":"Sebastian","family":"Hoehl","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Annemarie","family":"Berger","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sandra","family":"Ciesek","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Holger F.","family":"Rabenau","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2020,1,27]]},"reference":[{"key":"3814_CR1","doi-asserted-by":"publisher","first-page":"123","DOI":"10.1016\/j.idcr.2017.10.008","volume":"10","author":"N Nolan","year":"2017","unstructured":"Nolan N, Halai U-A, Regunath H et al (2017) Primary cytomegalovirus infection in immunocompetent adults in the United States\u2014a case series. 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Informed consent was not obtainable, and not required by vote of our University Hospital\u2019s ethics board.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Informed consent"}}]}}