{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T15:15:17Z","timestamp":1787066117735,"version":"build-2736575974"},"reference-count":28,"publisher":"Springer Science and Business Media LLC","issue":"10","license":[{"start":{"date-parts":[[2020,5,6]],"date-time":"2020-05-06T00:00:00Z","timestamp":1588723200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2020,5,6]],"date-time":"2020-05-06T00:00:00Z","timestamp":1588723200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Eur J Clin Microbiol Infect Dis"],"published-print":{"date-parts":[[2020,10]]},"DOI":"10.1007\/s10096-020-03909-5","type":"journal-article","created":{"date-parts":[[2020,7,8]],"date-time":"2020-07-08T06:03:43Z","timestamp":1594188223000},"page":"1845-1853","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Implementation of the eazyplex\u00ae CSF direct panel assay for rapid laboratory diagnosis of bacterial meningitis: 32-month experience at a tertiary care university hospital"],"prefix":"10.1007","volume":"39","author":[{"given":"Tiziana","family":"D\u2019Inzeo","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giulia","family":"Menchinelli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giulia","family":"De Angelis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Barbara","family":"Fiori","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Flora Marzia","family":"Liotti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Grazia Angela","family":"Morandotti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maurizio","family":"Sanguinetti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brunella","family":"Posteraro","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Teresa","family":"Spanu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2020,5,6]]},"reference":[{"key":"3909_CR1","doi-asserted-by":"publisher","first-page":"1294","DOI":"10.1111\/imj.14102","volume":"48","author":"N Young","year":"2018","unstructured":"Young N, Thomas M (2018) Meningitis in adults: diagnosis and management. Intern Med J 48:1294\u20131307","journal-title":"Intern Med J"},{"key":"3909_CR2","doi-asserted-by":"publisher","first-page":"514","DOI":"10.1542\/pir.36-12-514","volume":"36","author":"D Swanson","year":"2015","unstructured":"Swanson D (2015) Meningitis. Pediatr Rev 36:514\u2013526","journal-title":"Pediatr Rev"},{"key":"3909_CR3","doi-asserted-by":"publisher","first-page":"36","DOI":"10.1136\/bmj.39409.673657.AE","volume":"336","author":"SA Logan","year":"2008","unstructured":"Logan SA, MacMahon E (2008) Viral meningitis. BMJ 336:36\u201340","journal-title":"BMJ"},{"key":"3909_CR4","doi-asserted-by":"publisher","first-page":"467","DOI":"10.1128\/CMR.00070-09","volume":"23","author":"MC Brouwer","year":"2010","unstructured":"Brouwer MC, Tunkel AR, van de Beek D (2010) Epidemiology, diagnosis, and antimicrobial treatment of acute bacterial meningitis. Clin Microbiol Rev 23:467\u2013492","journal-title":"Clin Microbiol Rev"},{"key":"3909_CR5","doi-asserted-by":"publisher","first-page":"e20170476","DOI":"10.1542\/peds.2017-0476","volume":"140","author":"L Ouchenir","year":"2017","unstructured":"Ouchenir L, Renaud C, Khan S et al (2017) The epidemiology, management, and outcomes of bacterial meningitis in infants. Pediatrics 140:e20170476","journal-title":"Pediatrics"},{"key":"3909_CR6","doi-asserted-by":"publisher","first-page":"339","DOI":"10.1016\/S1473-3099(15)00430-2","volume":"16","author":"MW Bijlsma","year":"2016","unstructured":"Bijlsma MW, Brouwer MC, Kasanmoentalib ES et al (2016) Community-acquired bacterial meningitis in adults in the Netherlands, 2006-14: a prospective cohort study. Lancet Infect Dis 16:339\u2013347","journal-title":"Lancet Infect Dis"},{"key":"3909_CR7","doi-asserted-by":"publisher","first-page":"992","DOI":"10.1016\/S1473-3099(18)30245-7","volume":"18","author":"F McGill","year":"2018","unstructured":"McGill F, Griffiths MJ, Bonnett LJ et al (2018) Incidence, aetiology, and sequelae of viral meningitis in UK adults: a multicentre prospective observational cohort study. Lancet Infect Dis 18:992\u20131003","journal-title":"Lancet Infect Dis"},{"key":"3909_CR8","doi-asserted-by":"publisher","first-page":"291","DOI":"10.1093\/qjmed\/hci047","volume":"98","author":"N Proulx","year":"2005","unstructured":"Proulx N, Fr\u00e9chette D, Toye B, Chan J, Kravcik S (2005) Delays in the administration of antibiotics are associated with mortality from adult acute bacterial meningitis. QJM 98:291\u2013298","journal-title":"QJM"},{"key":"3909_CR9","doi-asserted-by":"publisher","first-page":"1162","DOI":"10.1093\/cid\/civ011","volume":"60","author":"M Glim\u00e5ker","year":"2015","unstructured":"Glim\u00e5ker M, Johansson B, Grindborg \u00d6, Bottai M, Lindquist L, Sj\u00f6lin J (2015) Adult bacterial meningitis: earlier treatment and improved outcome following guideline revision promoting prompt lumbar puncture. Clin Infect Dis 60:1162\u20131169","journal-title":"Clin Infect Dis"},{"key":"3909_CR10","doi-asserted-by":"crossref","unstructured":"Lucas MJ, Brouwer MC, van de Beek D (2016) Neurological sequelae of bacterial meningitis. J Inf 73:18\u201327","DOI":"10.1016\/j.jinf.2016.04.009"},{"key":"3909_CR11","doi-asserted-by":"crossref","unstructured":"Kloek AT, Brouwer MC, Schmand B, Tanck MWT, van de Beek D (2020) Long-term neurologic and cognitive outcome and quality of life in adults after pneumococcal meningitis. Clin Microbiol Infect S1198-743X(20)30045-8.","DOI":"10.1016\/j.cmi.2020.01.020"},{"key":"3909_CR12","doi-asserted-by":"publisher","first-page":"929","DOI":"10.3389\/fneur.2018.00929","volume":"9","author":"DH Mao","year":"2018","unstructured":"Mao DH, Miao JK, Zou X et al (2018) Risk factors in predicting prognosis of neonatal bacterial meningitis\u2014a systematic review. Front Neurol 9:929","journal-title":"Front Neurol"},{"key":"3909_CR13","doi-asserted-by":"publisher","first-page":"e0175024","DOI":"10.1371\/journal.pone.0175024","volume":"12","author":"D Christie","year":"2017","unstructured":"Christie D, Rashid H, El-Bashir H et al (2017) Impact of meningitis on intelligence and development: a systematic review and meta-analysis. PLoS One 12:e0175024","journal-title":"PLoS One"},{"key":"3909_CR14","doi-asserted-by":"publisher","first-page":"16074","DOI":"10.1038\/nrdp.2016.74","volume":"2","author":"D van de Beek","year":"2016","unstructured":"van de Beek D, Brouwer M, Hasbun R, Koedel U, Whitney CG, Wijdicks E (2016) Community-acquired bacterial meningitis. Nat Rev Dis Primers 2:16074","journal-title":"Nat Rev Dis Primers"},{"key":"3909_CR15","doi-asserted-by":"publisher","first-page":"S37","DOI":"10.1016\/j.cmi.2016.01.007","volume":"22","author":"D van de Beek","year":"2016","unstructured":"van de Beek D, Cabellos C, Dzupova O et al (2016) ESCMID guideline: diagnosis and treatment of acute bacterial meningitis. Clin Microbiol Infect 22:S37\u2013S62","journal-title":"Clin Microbiol Infect"},{"key":"3909_CR16","doi-asserted-by":"crossref","unstructured":"McGill F, Heyderman RS, Michael BD et al (2016) The UK joint specialist societies guideline on the diagnosis and management of acute meningitis and meningococcal sepsis in immunocompetent adults. J Inf 72:405\u2013438","DOI":"10.1016\/j.jinf.2016.01.007"},{"key":"3909_CR17","doi-asserted-by":"publisher","first-page":"1197","DOI":"10.1128\/JCM.00289-16","volume":"54","author":"CR Polage","year":"2016","unstructured":"Polage CR, Cohen SH (2016) State-of-the-art microbiologic testing for community-acquired meningitis and encephalitis. J Clin Microbiol 54:1197\u20131202","journal-title":"J Clin Microbiol"},{"key":"3909_CR18","doi-asserted-by":"publisher","first-page":"601","DOI":"10.1016\/j.cmi.2017.04.019","volume":"23","author":"CN van Ettekoven","year":"2017","unstructured":"van Ettekoven CN, van de Beek D, Brouwer MC (2017) Update on community-acquired bacterial meningitis: guidance and challenges. Clin Microbiol Infect 23:601\u2013606","journal-title":"Clin Microbiol Infect"},{"key":"3909_CR19","doi-asserted-by":"crossref","unstructured":"Vetter P, Schibler M, Herrmann JL, Boutolleau D (2019) Diagnostic challenges of central nervous system infection: extensive multiplex panels versus stepwise guided approach. Clin Microbiol Infect S1198-743X(19)30670-6","DOI":"10.1016\/j.cmi.2019.12.013"},{"key":"3909_CR20","doi-asserted-by":"publisher","first-page":"2251","DOI":"10.1128\/JCM.00730-16","volume":"54","author":"AL Leber","year":"2016","unstructured":"Leber AL, Everhart K, Balada-Llasat JM et al (2016) Multicenter evaluation of BioFire FilmArray meningitis\/encephalitis panel for detection of bacteria, viruses, and yeast in cerebrospinal fluid specimens. J Clin Microbiol 54:2251\u20132261","journal-title":"J Clin Microbiol"},{"key":"3909_CR21","doi-asserted-by":"publisher","first-page":"e22","DOI":"10.1093\/cid\/cit278","volume":"57","author":"EJ Baron","year":"2013","unstructured":"Baron EJ, Miller JM, Weinstein MP et al (2013) A guide to utilization of the microbiology laboratory for diagnosis of infectious diseases: 2013 recommendations by the Infectious Diseases Society of America (IDSA) and the American Society for Microbiology (ASM). Clin Infect Dis 57:e22\u2013e121","journal-title":"Clin Infect Dis"},{"key":"3909_CR22","doi-asserted-by":"publisher","first-page":"576","DOI":"10.1128\/JCM.02590-15","volume":"54","author":"B Fiori","year":"2016","unstructured":"Fiori B, D'Inzeo T, Giaquinto A et al (2016) Optimized use of the MALDI BioTyper system and the FilmArray BCID panel for direct identification of microbial pathogens from positive blood cultures. J Clin Microbiol 54:576\u2013584","journal-title":"J Clin Microbiol"},{"key":"3909_CR23","doi-asserted-by":"publisher","first-page":"iv20","DOI":"10.1093\/jac\/dky049","volume":"73","author":"G De Angelis","year":"2018","unstructured":"De Angelis G, Posteraro B, De Carolis E et al (2018) T2Bacteria magnetic resonance assay for the rapid detection of ESKAPEc pathogens directly in whole blood. J Antimicrob Chemother 73:iv20\u2013iv26","journal-title":"J Antimicrob Chemother"},{"key":"3909_CR24","doi-asserted-by":"publisher","first-page":"908","DOI":"10.1111\/j.1469-0691.2008.02070.x","volume":"14","author":"PC Woo","year":"2008","unstructured":"Woo PC, Lau SK, Teng JL, Tse H, Yuen KY (2008) Then and now: use of 16S rDNA gene sequencing for bacterial identification and discovery of novel bacteria in clinical microbiology laboratories. Clin Microbiol Infect 14:908\u2013934","journal-title":"Clin Microbiol Infect"},{"key":"3909_CR25","doi-asserted-by":"publisher","first-page":"1233","DOI":"10.1086\/508462","volume":"43","author":"MC Brouwer","year":"2006","unstructured":"Brouwer MC, van de Beek D, Heckenberg SG, Spanjaard L, de Gans J (2006) Community-acquired Listeria monocytogenes meningitis in adults. Clin Infect Dis 43:1233\u20131238","journal-title":"Clin Infect Dis"},{"key":"3909_CR26","doi-asserted-by":"publisher","first-page":"170","DOI":"10.1186\/s12879-020-4904-4","volume":"20","author":"S Pfefferle","year":"2020","unstructured":"Pfefferle S, Christner M, Aepfelbacher M, L\u00fctgehetmann M, Rohde H (2020) Implementation of the FilmArray ME panel in laboratory routine using a simple sample selection strategy for diagnosis of meningitis and encephalitis. BMC Infect Dis 20:170","journal-title":"BMC Infect Dis"},{"key":"3909_CR27","doi-asserted-by":"publisher","first-page":"S139","DOI":"10.1093\/cid\/cit578","volume":"57","author":"AM Caliendo","year":"2013","unstructured":"Caliendo AM, Gilbert DN, Ginocchio CC et al (2013) Better tests, better care: improved diagnostics for infectious diseases. Clin Infect Dis 57:S139\u2013S170","journal-title":"Clin Infect Dis"},{"key":"3909_CR28","doi-asserted-by":"publisher","first-page":"2327","DOI":"10.1056\/NEJMoa1803396","volume":"380","author":"MR Wilson","year":"2019","unstructured":"Wilson MR, Sample HA, Zorn KC et al (2019) Clinical metagenomic sequencing for diagnosis of meningitis and encephalitis. N Engl J Med 380:2327\u20132340","journal-title":"N Engl J Med"}],"container-title":["European Journal of Clinical Microbiology &amp; Infectious Diseases"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10096-020-03909-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s10096-020-03909-5\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10096-020-03909-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,5,5]],"date-time":"2021-05-05T19:26:07Z","timestamp":1620242767000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s10096-020-03909-5"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,5,6]]},"references-count":28,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2020,10]]}},"alternative-id":["3909"],"URL":"https:\/\/doi.org\/10.1007\/s10096-020-03909-5","relation":{},"ISSN":["0934-9723","1435-4373"],"issn-type":[{"value":"0934-9723","type":"print"},{"value":"1435-4373","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,5,6]]},"assertion":[{"value":"18 March 2020","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"13 April 2020","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"6 May 2020","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Compliance with ethical standards"}},{"value":"The authors declare that they have no conflict of interest.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"The Ethics Committee of our institution approved the study (approval number 34253\/17), and informed consent was waived because of testing patients\u2019 CSF samples that were collected as part of routine clinical care.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and informed consent"}}]}}