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The prevalence of GE caused by protozoa may be underestimated in Swedish patients. The purpose was to compare the prevalence of <jats:italic>E. histolytica<\/jats:italic>, <jats:italic>Cryptosporidium<\/jats:italic> spp., <jats:italic>G. intestinalis<\/jats:italic>, and <jats:italic>C. cayetanensis<\/jats:italic> in samples from patients where the clinician had requested testing for gastrointestinal parasites only (<jats:italic>n<\/jats:italic>\u2009=\u2009758) to where testing for bacterial GE only (<jats:italic>n<\/jats:italic>\u2009=\u2009803) or where both parasite and bacterial testing (<jats:italic>n<\/jats:italic>\u2009=\u20091259) was requested and a healthy control group (<jats:italic>n<\/jats:italic>\u2009=\u2009197). This prospective cohort study was conducted in Region J\u00f6nk\u00f6ping County, Sweden (October 2018\u2013March 2019). Fecal samples were analyzed with microscopy and real-time PCR. <jats:italic>Cryptosporidium<\/jats:italic> spp. was detected in 16 patients in the bacterial GE group and in 13 in the both bacterial and parasite group; no cases were detected in the group were only parasite infection was suspected. <jats:italic>C. cayetanensis<\/jats:italic> was detected in two patients in the bacterial GE group. One case of <jats:italic>E. histolytica<\/jats:italic> was detected in the bacterial group and one in the both bacterial and parasite group. <jats:italic>G. intestinalis<\/jats:italic> was detected in 14 patients in the parasite only group, 12 in the both parasite and bacterial group, three in the bacterial GE group, and one in the control group. Diarrhea caused by protozoa, especially Cryptosporidium was under\u2013recognized by clinicians and is likely more common than hitherto estimated in Sweden. A more symptom-based diagnostic algorithm may increase detection and knowledge about protozoan infections.<\/jats:p>","DOI":"10.1007\/s10096-020-03974-w","type":"journal-article","created":{"date-parts":[[2020,7,7]],"date-time":"2020-07-07T22:02:27Z","timestamp":1594159347000},"page":"2153-2160","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["Protozoan infections are under-recognized in Swedish patients with gastrointestinal symptoms"],"prefix":"10.1007","volume":"39","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6253-5180","authenticated-orcid":false,"given":"Jessica","family":"\u00d6gren","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olaf","family":"Dienus","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jessica","family":"Beser","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna J.","family":"Henningsson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andreas","family":"Matussek","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2020,7,7]]},"reference":[{"key":"3974_CR1","doi-asserted-by":"publisher","first-page":"420","DOI":"10.1128\/CMR.05038-11","volume":"25","author":"SM Fletcher","year":"2012","unstructured":"Fletcher SM, Stark D, Harkness J, Ellis J (2012) Enteric Protozoa in the developed world: a public health perspective. 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