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Diabetic foot infections are caused by a multitude of microbes and\n                    <jats:italic>Staphylococcus aureus<\/jats:italic>\n                    , a major nosocomial and community-associated pathogen, significantly contributes to wound infections as well.\n                    <jats:italic>Staphylococcus aureus<\/jats:italic>\n                    is also the primary pathogen commonly associated with diabetic foot osteomyelitis and can cause chronic and recurrent bone infections. The virulence capability of the pathogen and host immune factors can determine the occurrence and progression of\n                    <jats:italic>S<\/jats:italic>\n                    .\n                    <jats:italic>aureus<\/jats:italic>\n                    infection. Pathogen-related factors include complexity of bacterial structure and functional characteristics that provide metabolic and adhesive properties to overcome host immune response. Even though, virulence markers and toxins of\n                    <jats:italic>S<\/jats:italic>\n                    .\n                    <jats:italic>aureus<\/jats:italic>\n                    are broadly similar in different wound models, certain distinguishing features can be observed in diabetic foot infection. Specific clonal lineages and virulence factors such as TSST-1, leukocidins, enterotoxins, and exfoliatins play a significant role in determining wound outcomes. In this review, we describe the role of specific virulence determinants and clonal lineages of\n                    <jats:italic>S<\/jats:italic>\n                    .\n                    <jats:italic>aureus<\/jats:italic>\n                    that influence wound colonization and infection with special reference to diabetic foot infections.\n                  <\/jats:p>","DOI":"10.1007\/s10096-020-03984-8","type":"journal-article","created":{"date-parts":[[2020,7,18]],"date-time":"2020-07-18T16:02:27Z","timestamp":1595088147000},"page":"2235-2246","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":129,"title":["Virulence factors and clonal diversity of Staphylococcus aureus in colonization and wound infection with emphasis on diabetic foot infection"],"prefix":"10.1007","volume":"39","author":[{"given":"Kavitha","family":"Shettigar","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1563-8077","authenticated-orcid":false,"given":"Thokur Sreepathy","family":"Murali","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2020,7,18]]},"reference":[{"key":"3984_CR1","doi-asserted-by":"crossref","first-page":"1288","DOI":"10.2337\/dc05-2425","volume":"29","author":"LA Lavery","year":"2006","unstructured":"Lavery LA, Armstrong DG, Wunderlich RP, Mohler MJ, Wendel CS, Lipsky BA (2006) Risk factors for foot infections in individuals with diabetes. 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